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Pandey, Parijat
- Pectin as Natural Polymer:An Overview
Authors
1 Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, 124001, IN
Source
Research Journal of Pharmacy and Technology, Vol 10, No 4 (2017), Pagination: 1225-1229Abstract
From last few decades natural sources are gaining much more importance because of easy availability, low cost, non-toxicity, biocompatibility etc. of these natural products make them potential carriers in the drug delivery systems. A variety of benefits have been offered by plants and plant derived products in the pharmaceutical industry and acts as a source for number of therapeutically active drugs and excipients. Pectin is a naturally derived polysaccharide and currently various plant sources like oranges, different citrus fruits and apple pomace have been used for extraction of pectin under acidic conditions. It has excellent biodegradable and biocompatible nature which leads to various potential applications of pectin in pharmaceutical and foods industries. An attempt has been made in this review to briefly highlight the sources of pectin, classification, chemistry and pharmaceutical uses of pectin.Keywords
Natural Products, Pectin, Sources of Pectin, Pharmaceutical Uses.
- Formulation and Characterization of Gastroretentive Floating Tablets of Atorvastatin Calcium Using Central Composite Design
Authors
1 Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak – 124001, IN
Source
Journal of Pharmaceutical Research, Vol 16, No 3 (2017), Pagination: 247-256Abstract
The aim of the study was to develop a gastroretentive floating drug delivery system of atorvastatin calcium by effervescence technique.
Design/methodology/approach: The objective behind the study was to investigate the effect of concentration of HPMC K4M (X), concentration of guar gum (X), concentration of sodium bicarbonate (X) on the release of 1 2 3 atorvastatin calcium using central composite design.The floating tablets were formulated using atorvastatin calcium (20% w/w), HPMC K4M (5-15% w/w), guar gum (5-15% w/w), sodium bicarbonate (4-12% w/w), lactose (q.s.), talc (2% w/w) and magnesium stearate (1% w/w). Atorvastatin calcium floating tablets were evaluated for physical characterization viz. hardness, swelling index, floating capacity, weight variation, friability, in vitro drug release and kinetic studies.
Findings: All tablets were floated for more than 12 hrs in 0.1 N HCl at 37±0.5°C and the in vitro drug release was found to be vary from 79% to 93%. The percentage cumulative drug released was maximum at low value of HPMC, low value of guar gum and high value of sodium bicarbonate. A mathematical model was developed to formulate floating tablets of atorvastatin calcium. The data fitting to Korsemeyer-Peppas equation revealed that the release mechanism from the dosage form followed the non-fickian transport.
Value: The gastroretentive floating tablets of atorvastatin calcium will enhance the patient compliance and play a vital role in improving patient's quality of life.
Keywords
Atorvastatin Calcium, Central Composite Design, In Vitro Drug Release, Floating Tablets.Full Text
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