Informatics Publishing Limited

Pankaj Savani ¹, Sudhanshu Chauhan ¹, Vineet Jain ², Hasumati Raj ¹, Sagar Patel ¹

Affiliations
1 Department of Quality Assurance, Shree Dhanvantary Pharmacy College, Kim, Dist: Surat, Gujarat 394110, IN
2 Department of Pharmacognosy, Shree Dhanvantary Pharmacy College, Kim, Dist: Surat, Gujarat 394110, IN

Abstract

A simple, accurate and precise spectroscopic method was developed for simultaneous estimation of Clopidogrel Bisulphate and Irbesartan in synthetic mixture using simultaneous equation Method. In this spectroscopic method, for Clopidogrel Bisulphate 220.00 nm and 250.00 nm wavelengths were selected for measurement of absorptivity. Both the drugs show linearity in a concentration range of 10-50 μg/ml at their respective λmax with correlation coefficient (r2) of 0.9996 and 0.9998 for Clopidogrel Bisulphate and Irbesartan, respectively. Accuracy, precision and recovery studies were done by QC samples covering lower, medium and high concentrations of the linearity range. The relative standard deviation for accuracy, precision studies were found to be within the acceptance range (< 2%). The limit of determination was 0.243 μg/ml and 0.323 μg/ml for Clopidogrel Bisulphate and Irbesartan, respectively. The limit of quantification was 0.737 μg/ml and 0.980 μg/ml for Clopidogrel Bisulphate and Irbesartan, respectively. Recovery of Clopidogrel Bisulphate and Irbesartan were found to be 99.57 % and 99.68 % respectively confirming the accuracy of the proposed method. % Assay was found to be 99.41 % and 99.22 % for Clopidogrel Bisulphate and Irbesartan, respectively. The proposed method is recommended for routine analysis since they are rapid, simple, accurate and also sensitive and specific by no heating and no organic solvent extraction.

Keywords

Clopidogrel Bisulphate, Irbesartan, Simultaneous Estimation, Validation Method.

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Pankaj Savani ¹, Vineet Jain ², Hasumati Raj ¹, Sagar Patel ¹

Affiliations
1 Department of Quality Assurance, Shree Dhanvantary Pharmacy College, Kim, Dist: Surat, Gujarat-394110, IN
2 Department of Pharmacognosy, Shree Dhanvantary Pharmacy College, Kim, Dist: Surat, Gujarat-394110, IN

Abstract

Clopidogrel Bisulphate is a mainly use in Anti platelet agent as a ADP receptor blocker and administration of oral tablet dosage form. Chemically, it is Methyl 2-(2- Chlorophenyl) -2-(6, 7-dihydro thieno [3,2-C] Pyridine- 5(4H)-yl) Acetate sulphate. It is used in the treatment of various cardiovascular diseases like Ischemic stroke as well as in Glomerular inflammation, Myocardial infarction, Atherosclerosis disease, Unstable Angina. An extensive survey of the literature published in various analytical and pharmaceutical chemistry related journals has been conducted and the instrumental analytical methods which were developed and used for determination as single or combination with other drugs in bulk drugs, formulations and biological fluids have been reviewed. These reviews of analytical methods including Spectrophotometric methods like Spectrophotometry, Chromatographic method including HPLC, HPTLC were reported.

Keywords

Clopidogrel Bisulphate, Analytical Methods, Compendial Method, UV Spectroscopic Method, Chromatographic Methods.

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Rashesh P. Mehta ¹, Sushil Joshi ², Pankaj Savani ¹, Aditya Danayak ¹, Mitul Munjani ¹

Affiliations
1 Electrical Engineering, Department, Birla Vishvakarma Mahavidyalaya., Vallabh Vidyanagar, Gujarat, IN
2 Distribution Automation, ABB India Ltd., Vadodara, Gujarat, IN

Abstract

T he d evelo pm en t o f a nu merical protection laboratory is implemented through industry-institute interaction under an MOU. This paper documents the contribution of the major project of final year students on using a digital over-current and earth-fault relay. The latest numerical protection relay has been provided as a replacement for an older version by ABB India Ltd. as a part of corporate social responsibility (CSR). The laboratory experimental panel has been developed through the major project of the final year student group. There was the active participation of ABB India Ltd. by way of providing dedicated training to the student group and faculty members involved in the installation, commissioning, and design of the experimental panel. The results obtained from various case studies are reported in this paper. The facilities created are used for regular laboratory practicals for undergraduate and post-graduate students. The laboratory manuals are prepared to facilitate the implementation of the experiments. The laboratory curriculum has been updated for the UG course "Power System Protection^" and the PG course "Advanced Power System Protection and Switchgear^". It has resulted in improvement in the placement of UG and PG students. The training of industry and state power utility engineers can also be performed on the experimental panel developed. The outcome of this academic innovation related to industry-institute interaction is that the industry readiness of students has increased.

Keywords

Industry Institute Interaction, Power system protection, laboratory development, Test setup, Over-current protection.

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