Informatics Publishing Limited

S. R. Tarke ¹, Palani Shanmugasundaram ²

Affiliations
1 Department of Pharmaceutical Analysis, School of Pharmaceutical Sciences, Vistas, Vels University, Chennai, Tamilnadu, IN
2 School of Pharmaceutical Sciences, VISTAS, Vels University, Chennai, Tamilnadu, IN

Abstract

Over a decade, the demand for development of fast dissolving tablets (FDT) enormously increased as it has significant impact on the patient compliance. Fast dissolving tablets are appreciated by a significant segment of populations particularly who have difficulty in swallowing. Hypertension is a medical condition in which blood pressure is chronically elevated, If not, effectively treated it may lead to stroke, myocardial infarction, heart failure and is a leading cause of chronic kidney failure. Antihypertensive are the class of drugs that are used to treat hypertension. Metoprolol tartarate is a β1-selective adrenergic blocking agent and is prescribed widely in cardiovascular diseases like hypertension. Administration of conventional tablets of Metoprolol tartarate has been reported to exhibit fluctuations in the plasma drug levels resulting in either manifestation of side effects or reduction in drug concentration at the receptor site. Administration to patients who cannot swallow, such as elderly, stroke victims, healthcare facility&bedridden patients such as those affected by renal failure; and the patient who refuse to swallow such as pediatric, geriatric and psychiatric patients which results in high evidence of inefficient therapy. The present study nine batches of fast dissolving tablets of Metoprolol tartarate were successfully prepared using Crospovidone, Sodium starch glycolate, Fenugreek and Isapghula husk by direct compression method. Based on results formulation containing Crospovidone (8%) and Sodium starch glycolate (8%) F(2), was identified as ideal and better formulation among all formulations developed for Metoprolol tartarate tablets. From study it is concluded that the formulated fast dissolving tablets of Metoprolol tartarate of batch F2, were superior and effective in achieving better patient compliance.

Keywords

Metoprolol, Hypertension, Crospovidone, Fast Dissolving Tablets, Direct Compression Method.

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Pulla Divya Sree ¹, M. Ashok Kumar ¹, Palani Shanmugasundaram ¹

Affiliations
1 Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels University (VISTAS), Chennai, Tamilnadu, IN

Abstract

Background: A computer is an electronic advanced device that can be programmed to carry out a set of arithmetic or logical functions automatically. The main Objective of this study is to assess knowledge of computer use among pharmacy students, and to assess the attitude and perception of computer knowledge and to use technology among students.

Methodology: A validated, observational questionnaire was given and the participation was voluntary. This survey consists of two groups of UG, PG Students. The questionnaires were distributed in appropriate lectures and retrieved immediately after completion and time was given to fill the questionnaire and collected them next day.

Results: 71% of the UG students and 80% of the PG students were feeling comfortable and exciting while using computer, 88% and 71% of UG % PG students feeling that computer s better than a book for gaining knowledge. 87% of UG and 80% of PG students thought that computer helps in communicating with others through internet and 80% of students feel that computers are the necessary tools for educational resources.

Conclusion: This present survey was done to identify the responder's skills and knowledge about informational technology by computer. Based on this responders data it was concluded that responders having more interest in social network students were not fully aware about the educational resources.

Keywords

Computer, Pharmacy Students, Education.

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Prathyusha Vikram ¹, Palani Shanmugasundaram ²

Affiliations
1 Department of Pharmaceutical Analysis, School of Pharmaceutical Sciences, Vels University, Chennai, Tamilnadu, IN
2 Department of Pharmaceutical Analysis, School of Pharmaceutical Sciences, Vels University, Chennai, Tamilnadu, IN

Abstract

A rapid, sensitive and selective ultra-performance liquid chromatography-tandem mass spectrometric (UPLC- MS/MS) method was developed and validated for the estimation of Riluzole in human plasma using Olanzapine as an internal standard. Riluzole and Internal standard were extracted from 0.5 mL plasma by solid phase extraction method. The analytical separation was carried out in a reverse liquid chromatography by using C18 (50 x 4.6mm 1.8,) 10mMAmmonium Acetate: Methanol (10:90) v/v at 0.5 mL/min at isocratic mode . The detection was performed on a triple quadruple tandem mass spectrometer by multiple reactions monitoring (MRM) mode via electro spray ionization (ESI) source. Analytes were monitored in multiple reactions monitoring mode using the respective [M+H] +ions, m/z 234.84/137.63 for Riluzole and m/z 313.15/256.14 for the internal standard, respectively. The proposed method was validated with linear range of 5 -1000ng/ml for Riluzole with a runtime 2.5 minutes. The %R.S.D of intra-day and inter-day assay was lower than 15%. For its sensitivity and reliability, the proposed method is particularly suitable for pharmacokinetic studies.

Keywords

Riluzole, UPLC-MS/MS, Human Plasma, SPE, Bioanalysis.

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