Refine your search
Collections
Co-Authors
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Upadhay, P. R.
- To Access the Efficacy of Rutin on 6-Hydroxydopamine Induced Animal Model of Memory Impairment in Parkinson's Disease
Abstract Views :248 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmacology, Agnihotri College of Pharmacy, Wardha, IN
1 Department of Pharmacology, Agnihotri College of Pharmacy, Wardha, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 5, No 6 (2013), Pagination: 331-336Abstract
The core finding of the present study is that administration of relevant doses of Ruin is remarkably neuroprotective in rats against 6-Hydroxydopamine induced neurotoxicity. Parkinson's disease (PD) is a chronic and progressive neurodegenerative disease with multiple motor and non-motor features that contribute to the impairment of health-related quality of life (QOL). It is characterized by reduced movement, rigidity, and tremor. It is characterized by a preferential loss of the dopaminergic neurons of the substantia nigra pars compacta. Rutin (3,3',4',5,7-pentahydroxyflavone-3-rhamnoglucoside) was a citrus flavonoid glycoside. Flavonoids are polyphenolic compounds that occur ubiquitously in foods of plant origin. It act as a antioxidant and can prevent injury caused by reactive oxygen species (ROS) in various ways. Rutin was found to be a neuroprotective agent. Rutin was identified as the major LDL antioxidant compound of mulberry in an in vitro study. Rutin acts as a memory enhancer and an anti-oxidant Rutin treatment protects behavioral changes, and significantly attenuated oxidative damage and improved mitochondrial complexes enzyme activities in different regions (striatum, cortex and hippocampus) of rat brain against 6-OHDA induced neurotoxicity. I.C.V. administration of 6-Hydroxydopamine is known to produce hypoactivity that resembles juvenile onset and advanced Parkinson's disease in rats. The results show that Rutin treatment is effective in various behavioural models, thus it could be used as an effective therapeutic agent in the management of Parkinson's disease and related conditions. We attempted to investigate the neuroprotective effect of Rutin in animal model of Parkinson's disease, and thus it shows the effect of Rutin on 6-hydroxydopamine onduced memory impairment in Parkinson's disease in Rodents.Keywords
6-OHDA, I.C.V., Parkinson Disease, Memory Impairment, Rutin.
References
- Igor Branchi, Ivana D'Andrea, Monica Armida, Tommaso Cassano, Antonella Pezzola, Rosa Luisa Potenza, Maria Grazia Morgese, Patrizia Popoli, & Enrico Alleva; 2008. Nonmotor Symptoms in Parkinson's Disease: Investigating Early-PhaseOnset of Behavioral Dysfunction in the 6-Hydroxydopamine-Lesioned Rat Model, Journal of Neuroscience Research, 86: pp. 2050-2061.
- A.R. Esteves, D. M. Arduino, D. F. F. Silva, C. R. Oliveira & S. M. Cardoso, 2008. Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD, pp. 1-20.
- Ajit V. Sontakke, Shashikant Nikam, Padmaja Nikam & S K Ahaley, 2009. Oxidative stress in Parkinson's disease, Indian journal of Clinical Biochemistry/24(1), pp. 98-101.
- Napatr Sriraksa, Jintanaporn Wattanathorn, Supaporn Muchimapura, Somsak Tiamkao, Kamoltip Brown, & Kowit Chaisiwamongkol, 2012. Cognitive enhancing effect of Quercetine in rat model of Parkinson disease induce by 6-OHDA and Antioxidant activity, on the cognitive function in a rat model of parkinson disease". Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine, Vol. 2012, Article ID 823206, pp. 1-9.
- Jordi Bove, Delphine Prou, Celine Perier, and Serge Przedborski; July 2005, Toxin-Induced Models of Parkinson's Disease, The Journal of the American Society for Experimental Neurotherapeutics, Vol. 2, pp. 484-494.
- Alin Ciobica, Lucian Hritcu, & Vlad Artenie, 2007, "Biochemical estimation in 6-OHDA induce rat model of Parkinson disease", Analele Stiintifice ale Universitatii, Alexandru Ioan Cuza, Sectiunea Genetic Biologie Moleculara, vol. VIII, pp.97-100.
- Bhutada P, Mundhada Y, Bansod K, Tawari S, Patil S, Dixit P, Umathe S, Mundhada D; Res. 2011. Protection of cholinergic and antioxidant system contributes to the effect of berberine ameliorating memory dysfunction in rat model of streptozotocin-induced diabetes. Behav Brain; 220: pp. 30-41.
- Thomas Debeir, Laure Ginestet, Chantal Francois, Stephanie Laurens, Jean-Claude Martel, Philippe Chopin, Marc Marien, Francis Colpaert, Rita Raisman-Vozari, 2005 "Effect of intrastriatal 6-OHDA lesion on dopaminergic innervation of therat cortex and globus pallidus". Experimental Neurology 193, pp. 444-454.
- Harquin Simplice Foyet, Lucian Hritcu, Alin Ciobica, Marius Stefan, Pierre Kamtchouing, Dumitru Cojocaru 2011. Methanolic extract of Hibiscus asper leaves improves spatial memory deficits in the 6-hydroxydopamine-lesion rodent model of Parkinson's disease, Journal of Ethnopharmacology 133; pp. 773-779.
- Wayne A. Cass*, Laura E. Peters, Michael P. Smith, 2005 "Reductions in spontaneous locomotor activity in aged male, but not female, rats in a model of early Parkinson's disease", Brain Research 1034; PP.153-161.
- David Blum, Sakina Torch, Nathalie Lambeng, Marie-France Nissou, Alim-Louis Benabid, Remy Sadoul, Jean-Marc Verna, 2001. Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease. Progress in Neurobiology 65; pp. 135-172.