Refine your search
Journals
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Tripathi, P. K.
- Synthesis and Characterization of Spirochromanoid Chalcone Derivatives
Abstract Views :181 |
PDF Views:0
Authors
Affiliations
1 Research Lab. of Pure and Applied Chemistry, Maharashtra Mahavidhyalaya, Nilanga (MS), IN
2 Department of Chemistry, Shivneri Mahavidhyalaya, Shirur Anantpal (MS), IN
3 OCT Division, National Chemical Lab., Pune (MS), IN
1 Research Lab. of Pure and Applied Chemistry, Maharashtra Mahavidhyalaya, Nilanga (MS), IN
2 Department of Chemistry, Shivneri Mahavidhyalaya, Shirur Anantpal (MS), IN
3 OCT Division, National Chemical Lab., Pune (MS), IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 8 (2011), Pagination: 1281-1285Abstract
The chalcone derivatives of spirochromanoid frame have been synthesized starting from resorcinol. It is converted in to the spirochomanone protected by N-Boc-4-piperidone. The chalcones of this spirochromanone are synthesized by Claisen Schmidt condensation reacting with 2-chloro benzaldehyde, 2-fluro benzaldehyde, 4-methoxy benzaldehyde, 2,4-dimethoxy benzaldehyde, Benzo-1,3-dioxole-5-carbaldehyde. They are further characterized by their IR, NMR, C13, Depth analysis.Keywords
Spirochromanones, Chalcones, N-Boc-4-Piperidone.
- Novel Floating Insitu gel of Antihyperlipidemic Agent
Abstract Views :163 |
PDF Views:0
Authors
Affiliations
1 Dr. L. H. Hiranandani College of Pharmacy, Opp. Ulhasnagar Railway Station, Ulhasnagar, Maharashtra, 421003, IN
1 Dr. L. H. Hiranandani College of Pharmacy, Opp. Ulhasnagar Railway Station, Ulhasnagar, Maharashtra, 421003, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 3 (2019), Pagination: 1086-1090Abstract
Simvastatin is an antihypertensive agent used in treatment of hyperlipidemia. It has very short biological half life and it undergoes extensive first pass metabolism. The aim of present work is formulation and characterization of Gastroretentive Insitu gel based system of simvastatin. Different polymers like gellan gum, sodium alginate and HPMC were screened at different concentration to arrive at optimized formulation. Formulations were screened based on invitro gelling time and behavior and drug release. All the batches were evaluated for pH, viscosity, floating lag time and total floating time, water uptake The optimized batch (F8) followed the release as per Korsemeyer-Peppas model and drug release from the formulation can be best explained by the Higuchi model due to highest R-square value among all the models.Keywords
Simvastatin, gastroretentive, insitu Gel.References
- Shashi Kiran Mishra et.al., Formulation and evaluation of oil entrapped gastroretentive floating gel beads of loratadine, Acta Pharm. 58 (2008) 187–197.
- Modasiya, M.K., B.G. Prajapati, V.M. Patel and J.K. Patel, 2010. Sodium alginate based in situ gelling system of famotidine: preparation and in-vivo characterizations. E-Journal of Science and Technology, 5(1): 27-42.
- Kang, B. K.; Lee, J. S.; Chon, S. K.; Jeong, S. Y.; Yuk, S. H.; Khang, G.; Lee, B. H.; Cho, S. H. Development of self microemulsifying drug delivery systems (SMEDDS) for oral bioavailability enhancement of simvastatin in beagle dogs. Int. J. Pharm. 2004, 274 (1–2), 65–73.
- Ambike, A. A.; Mahadik, K. R.; Paradkar, A. Spray-Dried Amorphous Solid Dispersions of Simvastatin, a Low Tg Drug; In Vitro and In Vivo Evaluations. Pharm. Res. 2005, 22 (6), 990–998.
- Cheng, H.; Sutton, S. C.; Pipikin, J. D.; Zentner, G. M.; Rogers, J. D.; Schwartz, J. I.; Mitchel, Y. B.; Grasing, K.; Schwartz, M. S.; Amin, R. D.; Liu, L.; Ebel, D. L.; Coulter, A.; Engle, K.; McClelland, G. A.; Lui, C. Y.; Rork, G. S. Evaluation of sustained/controlled-release dosage forms of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor in dogs and humans. Pharm. Res. 1993, 10 (11), 683–1687.
- McClelland, C. A.; Stubbs, R. J.; Fix, J. A.; Pogany, S. A.; Zentner, G.M. Enhancement of 3-hydroxy-3- methylglutaryl-coenzyme A (HMGCoA) reductase inhibitor efficacy through administration of a controlled-porosity osmotic pump dosage form. Pharm. Res. 1991, 8 (7), 873–876.
- Dixit, R. P.; Nagarsenker, M. S. In vitro and in vivo advantage of celecoxib surface solid dispersion and dosage form development. Ind. J. Pharm. Sci. 2007, 69 (3), 370–377.
- Monica Rao, Yogesh Mandage, Kaushik Thanki, Sucheta Bhise, Dissolution improvement of Simvastatin by surface solid dispersion technology, Dissolution technology, May 2010, 27-34.
- Arora S.; Ali J.; Ahuja A.; Khar RK.; Baboota S. Floating Drug Delivery System: A review. AAPS Pharm. Sci. Tech., 2005,6(3)
- Jaimini, M.; Rana A.C.; Tanwar, Y.S. Formulation and evaluation of famotidine floating tablets, Current Druf Delivery., 2007, 4,51-55
- Swati Jagdale, Prasad Kurhe, Bhanudas Kuchekar, Aniruddha Chabukswar, Application of Design of Experiments to Optimizing novel Gastroretentive Drug Delivery of Simvastatin.
- Jyotsana R Madan, Bhushan R Adokar, and Kamal Dua, Development and evaluation of in situ gel of pregabalin, Int J Pharm Investig. 2015 Oct-Dec; 5(4): 226–233.
- Vyas, J.; Ghedia, T.; Gajjar, V. Review on novel in-situ polymeric drug delivery system. Int. J. Pharm. Res. Dev. 2011, 3(5), 53–59.
- Tang, J.; Tung, M.; Zeng, Y. Gelling properties of gellan solutions containing monovalent and divalent cations. J. Food Sci. 1997, 62(4), 688–712.
- Design and Characterization of Self Emulsifying Drug Delivery System of Simvastatin:A Technical Note
Abstract Views :312 |
PDF Views:0
Authors
Affiliations
1 Dr. L. H. Hiranandani College of Pharmacy, Opp. Ulhasnagaar Railway Station, Ulhasnagar, Maharashtra, IN
2 Bharti Vidyapeet’s College of Pharmacy, Belapur CBD, Navi Mumbai Maharashtra, IN
1 Dr. L. H. Hiranandani College of Pharmacy, Opp. Ulhasnagaar Railway Station, Ulhasnagar, Maharashtra, IN
2 Bharti Vidyapeet’s College of Pharmacy, Belapur CBD, Navi Mumbai Maharashtra, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 7 (2019), Pagination: 3397-3404Abstract
The objective of the present study was to develop self emulsifying drug delivery system of simvastatin to improve solubility and dissolution rate of simvastatin. Simvastatin in a BCS class II drug (poor solubility, good permeability) and low bioavailability (less than 5%). In present study simvastatin self emulsifying drug delivery system was prepared with triacetin as oil, transcutol as surfactant and propylene glycol as co-surfactant. SMEDDS was characterized for stress study, invitro drug release, globule size, zeta potential, polydispersity index, transmission electron microscopy, exvivo permeation study and pharmacodynamic study. Improvement in antihyperlipidimic potential of SMEDDS as compared to plain drug can be attributed to improvement in solubility and drug dissolution rate of simvastatin.Keywords
Emulsification, Solubility, Particle Size.References
- Warrier D, Zagade A, Shai A, Pawar Y et al. An in-vitro evaluation for the effect of β- Cyclodextrin and PVP-K 30 on drug release pattern of Sertraline Hydrochloride. Int J Pharm and Chem Sci 2012; 1(1):407-13.
- Katteboina S, Chandrasekhar VSR, Balaji PS. Approaches for the development of solid self-emulsifying drug delivery systems and dosage forms. Asian J of Pharm Sci 2009; 4(4):240-53.
- Khoo SM, Humberstone AJ, Porter CJ, Edwards GA et al. Formulation design and bioavailability assessment of lipidic self-emulsifying formulations of Halofantrine. Int J Pharm1998; 167:155-64.
- Kyatanwar AU, Jadhav KR, Kadam VJ. Self micro-emulsifying drug delivery system (SMEDDS): Review. J Pharm Res arch 2010; 3(1):75-83.
- Kawakami K, Yoshikawa T, Moroto Y, Kanakao E et al. Microemulsion formulation for enhanced absorption of poorly soluble Drugs. J Controlled Release 2002; 81:75-82.
- Cortesi R, Espositi E, Maietti A, Menegatti E et al. Formulation study for the antitumor drug Camptothecin: liposomes, micellar solutions and a microemulsion. Int J Pharm 1997; 159:95-103.
- Tolle S, Zuberi T, Lawrence MJ. Physiochemical and solubilisation properties of N, Ndimethyl-N-(3-dodecyloxy propyl) amine oxide: a biodegradable nonionic surfactant. J Pharm Sci 2000; 89:798-806.
- Kang, B. K.; Lee, J. S.; Chon, S. K.; Jeong, S. Y.; Yuk, S. H.; Khang, G.; Lee, B. H.; Cho, S. H. Development of selfmicroemulsifying drug delivery systems (SMEDDS) for oral bioavailability enhancement of simvastatin in beagle dogs. Int. J. Pharm. 2004, 274 (1–2), 65–73.
- Ambike, A. A.; Mahadik, K. R.; Paradkar, A. Spray-Dried Amorphous Solid Dispersions of Simvastatin, a Low Tg Drug; In Vitro and In Vivo Evaluations. Pharm. Res. 2005, 22 (6), 990–998.
- Ghai D and Sinha VR. Nanoemulsions as self-emulsified drug delivery carriers for enhanced permeability of poorly water-soluble selective β-adrenoceptors blocker Talinolol. Nanomed: Nanotech, Biol, Med 2012; 8(5):618-26.
- Versantvoort CHM, Rompelberg CJM, Sips AJAM. Methodologies to study human intestinal absorption.A review. RIVM report 2000:1-55
- Borhade V, Nair H and Hegde D. Design and Evaluation of Self-Microemulsifying Drug Delivery System (SMEDDS) of Tacrolimus. AAPS Pharm Sci Tech 2008;9(1):13-21.
- Singh AK, Chaurasiya A, Singh M, Upadhyay SC et al. Exemestane Loaded Self- Microemulsifying Drug Delivery System (SMEDDS): Development and Optimization. AAPS Pharm Sci Tech 2008; 9(2):628-34.
- Shukla JB and Patel SJ. Formulation and Evaluation of Self Micro Emulsifying System of Candesartan cilexetil. Int J Pharm Pharm Sci 2010; 2(4):143-46.
- Singh B, Bandopadhyay S, Kapil R, Singh R et al. Self-Emulsifying Drug Delivery Systems (SEDDS): Formulation Development, Characterization and Applications. Crit Rev Therap Drug Carr Sys 2009; 26(5): 427-21 16. Hong JY, Kim JK, Song YK, Park JS et al. A new self-emulsifying formulation of Itraconazole with improved dissolution and oral absorption. J Controlled Release 2006; 110:332 -38.
- Shukla JB and Patel SJ. Formulation and Evaluation of Self Micro Emulsifying System of Candesartan cilexetil. Int J Pharm Pharm Sci 2010; 2(4):143-46.
- Gershanik T and Benita S. Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs. Eur J Pharm Bio- pharm 2000; 50:179-88.
- Barry R. and Eggenton J. Membrane potentials of epithelial cells in rat small intestine. J Physiol 1972; 227(1): 201-04
- Nutting DF , Tso P . Hypolipidemic effects of intravenous pluronic L-81 in fasted rats treated with Triton WR-1339: possible inhibition of hepatic lipoprotein secretion. Horm Metab Res . 1989 ; 21 : 113 - 115 .
- Schurr PE , Schultz JR , Parkinson TM . Triton-induced hyperlipidemia in rats as an animal model for screening hypolipidemic drugs. Lipids . 1972 ; 7 : 68 - 74 .
- Cheng, H.; Sutton, S. C.; Pipikin, J. D.; Zentner, G. M.; Rogers, J. D.; Schwartz, J. I.; Mitchel, Y. B.; Grasing, K.; Schwartz, M. S.; Amin, R. D.; Liu, L.; Ebel, D. L.; Coulter, A.; Engle, K.; McClelland, G. A.; Lui, C. Y.; Rork, G. S. Evaluation of sustained/controlled-release dosage forms of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor in dogs and humans. Pharm. Res. 1993, 10 (11), 683–1687.
- McClelland, C. A.; Stubbs, R. J.; Fix, J. A.; Pogany, S. A.; Zentner, G.M. Enhancement of 3-hydroxy-3-methylglutaryl-coenzyme A (HMGCoA) reductase inhibitor efficacy through administration of a controlled-porosity osmotic pump dosage form. Pharm. Res. 1991, 8 (7), 873–876.
- Dixit, R. P.; Nagarsenker, M. S. In vitro and in vivo advantage of celecoxib surface solid dispersion and dosage form development. Ind. J. Pharm. Sci. 2007, 69 (3), 370–377.
- Date AA and Nagarsenker MS. Design and evaluation of self-nanoemulsifying drug delivery systems (SNEDDS) for Cefpodoxime proxetil. Int J Pharm 2007; 329:166-72.
- Development, Validation and Confirmation of an Archetype Tool to Evaluate Prakriti
Abstract Views :282 |
PDF Views:173
Authors
P. K. Tripathi
1,
S. Gehlot
2
Affiliations
1 Department of Kriya Sharir, R. K. Ayurvedic Medical College and Hospital, Kashipur, Surai, Sathiaon, Azamgarh - 276608, Uttar Pradesh, IN
2 Department of Kriya Sharir, Institute of Medical Sciences, Banaras Hindu University, Varanasi – 221005, Uttar Pradesh, IN
1 Department of Kriya Sharir, R. K. Ayurvedic Medical College and Hospital, Kashipur, Surai, Sathiaon, Azamgarh - 276608, Uttar Pradesh, IN
2 Department of Kriya Sharir, Institute of Medical Sciences, Banaras Hindu University, Varanasi – 221005, Uttar Pradesh, IN
Source
Journal of Natural Remedies, Vol 19, No 4 (2019), Pagination: 206-213Abstract
Introduction: Notion of Prakriti as an indispensable concept in Ayurveda has attained remarkable contemplation now a day’s owing to its generous effect in clinical practice. Assessment of Prakriti finds a way with huge inter and intra-rater variability resulting in ambiguous results. This study aims to develop a reliable Prakriti assessment tool. Materials and Methods: Many classical text books of Ayurveda were scrutinized scrupulously to collect the features of different Prakriti individuals. Features related to different Prakriti were kept in simple form. For statistical verification of newly designed tool; 428 students aged between 18-40 years studying different courses at Banaras Hindu University were registered. For validation; Prakriti assessment results of the newly designed tool was compared with other two beforehand tools functional in the Department of Kriya Sharir, Faculty of Ayurveda, IMS BHU. Observations and Result: A Prakriti evaluation tool was designed which had 43, 36 and 42 features of Vata, Pitta and Kapha Prakriti individuals in a very undemanding form. Reliability test result in the form of Cronbach’s coefficient Alpha was found to be 69, 77 and 81 respectively for Vata, Pitta and Kapha. It shows that the newly designed tool is fairly consistent. Cohen kappa coefficient value for tool pairs is 0.51 and 0.57 that corroborate validity of new tool. Conclusion: Results show that newly designed Prakriti assessment tool amalgamates the basic construction of different Prakritis that can be catered with objective precision in a reproducible outcome manner.Keywords
Ayurveda, Ayurvedic Constitution, Prakriti Assessment Tool.Full Text
References
- Sushruta, Sushruta Samhita. English translation by Sharma P.V, Vol II, Sharir Sthan (4:64), ChaukhambhaVishvabharati, Varanasi; 2005.
- Agnivesha, Charaka Samhita. English translation by Sharma R.K., Dash B. Vol-II, VimanSthan (8:95), Chaukhambha Sanskrit Series Office, Varanasi; 2010.
- Kang G, Li S, Zhang J. Entropy-based model for interpreting life systems in traditional Chinese medicine. EvidenceBased Complementary and Alternative Medicine. 2008; 5(3):273-79. https://doi.org/10.1093/ecam/nem026. PMid: 18830452, PMCid: PMC2529388.
- Kanba S, Yamada K, Mizushima H, Asai A . Use of herbal medicine for treating psychiatric disorders in Japan. Psychiatry and Clinical Neurosciences. 1998; 52:S331-33. https://doi.org/10.1111/j.1440-1819.1998.tb03260.x. PMid: 9895185.
- Patwardhan B, Warude D, Pushpangadan P, Bhatt N. Ayurveda and traditional Chinese medicine: A comparative overview. Evidence Based Complementary and Alternative Medicine. 2005; 2(4):465-73. https://doi.org/10.1093/ecam/neh140 PMid: 16322803, PMCid: PMC1297513.
- Tripathi PK, Patwardhan K, Singh G. The Basic Cardiovascular Responses to Postural Changes, Exercise, and Cold Pressor Test: Do they vary in Accordance with the Dual Constitutional Types of Ayurveda? Hindawi Publishing Corporation, Evidence-Based Complementary and Alternative Medicine Volume 2011; 2011. Article ID 251850, https:// doi.org/10.1155/2011/251850. PMid: 20953421, PMCid: PMC2952295.
- Ghodke Y, Joshi K, Patwardhan B. Traditional medicine to modern pharmacogenomics: Ayurveda Prakriti type and CYP2C19 gene polymorphism associated with the metabolic variability. Evidence-Based Complementary and Alternative Medicine. 2011; 2011:249528. https://doi.org/10.1093/ecam/nep206. PMid: 20015960, PMCid: PMC3135904.
- Agarwal S, Negi S, Jha P, Singh PK, Stobdan T, Pasha MA, et al. EGLN1 involvement in high altitude adaptation revealed through genetic analysis of extreme constitution types defined in Ayurveda. Proc Natl Acad Sci USA. 2010; 107:18961-66.
- Rastogi S. Development and validation of a Prototype Prakriti Analysis Tool (PPAT): Inferences from a pilot study. Ayu. 2012 April-June; 33(2):209-18. https://doi.org/10.4103/0974-8520.105240 PMid: 23559792, PMCid: PMC3611641.
- Srivastava N, Gehlot S, Singh S, Singh BM. Do the anthropometric parameters vary as per Prakriti (Physical constitution) of Infants. International Journal of Innovative Knowledge Concepts. 2017 December; 5(12).
- Shilpa S, Murthy CG. Development and standardization of Mysore Tridosha scale. Ayu. 2011; 32:308-14. https://doi.org/10.4103/0974-8520.93905. PMid: 22529642, PMCid: PMC3326873.
- Tripathi PK, Gehlot S. Critical Analysis of concept of Prakriti and challenges in its assessment: A Review. International Journal of Research in Ayurveda and Pharmacy. 2016 MayJun; 7(3):1-4 https://doi.org/10.7897/2277-4343.07399.
- Kurande V, Waagepetersen R, Toft E, et al. Repeatability of pulse diagnosis and body constitution diagnosis in traditional Indian Ayurveda medicine. Global Advances in Health and Medicine. 2012; 1(5):34-40. https://doi.org/10.7453/gahmj.2012.1.5.011. PMid: 27257530, PMCid: PMC4890095.
- Kurande V, Bilgrau AE, Waagepetersen R, et al. Interrater Reliability of Diagnostic Methods in Traditional Indian Ayurvedic Medicine. Evidence-Based Complementary and Alternative Medicine, Volume 2013. Article ID 658275. https://doi.org/10.1155/2013/658275. PMid: 24191170, PMCid: PMC3803118.
- Agnivesha, Charaka Samhita. English translation by Sharma R.K., Dash B. Vol-1, Viman Sthan (8:96-100), Chaukhambha Sanskrit Series Office, Varanasi; 2010.
- Sushruta, Sushruta Samhita. English translation by Sharma P.V, Vol II, Sharir Sthana (4:64-76), Chaukhambha Vishvabharati, Varanasi; 2005.
- Vagbhata, Astanga Hridaya, English translation by Srikantha Murty K.R., Vol-I, Sharir Sthana (3:85-103), Chaukhambha, Krishnadas Academy, Varanasi; 2015.
- Vagbhata, Astanga Samgraha. English translation by Srikantha Murty K.R., Vol-II, Sharir Sthana, (8/6-14), Chaukhambha Orientalia, Varanasi; 2001.
- Bhavmishra, Bhava Prakasha. Commentary and English translation by Sitaram Balusu, Chunekar K.C., Vol-I Purvakhanda 4:54-58, Chaukhambha Orientalia, Varanasi; 2006.
- Bhela, Bhela Samhita. English translation by Krishnamurty K.H., Viman Sthana, 4:16-25, Chaukhambha Vishvabharati, Varanasi; Reprint year 2008.
- Harita, Harita Samhita. English translation by Pandey Gyanendra, Vol-1, Pratham-Sthana 5:17-22, Chaukhambha Sanskrit Series Office, Varanasi; 2016.
- Sharangadharacharya, Sharngadhara Samhita. English translation by Rao G. Prabhakar, 1st edition, Purvakhanda (6:21-23), Chaukhambha Sanskrit Sansthan, Varanasi; 2013.
- Martin BJ, Altman DG. Statistics notes: Cronbach’s alpha. BMJ. 1997; 314:572. https://doi.org/10.1136/bmj.314.7080.572 PMid: 9055718, PMCid: PMC2126061.
- Verma V, Tripathi JS, Gehlot S. Stress response as per Prakriti ID- 23483223. 2017. Available at http://www.lulu.com.
- Fleis JL. Statistical methods for rates and proportions (2nd ed.). New York:John Wiley; 1981. ISBN 0-471- 26370-2.