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Sharma, Nisha
- Sodium Bicarbonate Aqueous Matrix as Novel Industrial Solvent for Benzoylation of Some Ar-OH, Ar-NH and R-HN Functionalities
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PDF Views:76
Authors
Affiliations
1 University Institute of Pharmacy, CSJM University, Kanpur 208 024, IN
1 University Institute of Pharmacy, CSJM University, Kanpur 208 024, IN
Source
Current Science, Vol 113, No 10 (2017), Pagination: 1832-1834Abstract
It is a well accepted fact that chemical transformations can occur in solid, liquid and gaseous matrix; however, liquid matrix (solvent) dominates due to certain distinct multi-dimensional advantages especially at molecular level, making it a versatile tool for industrial manufacturing processes. It has been estimated that 28-million metric tonnes (MMT) of organic solvents are commercialized globally for different industrial purposes, majority of which get utilized in chemical and pharmaceutical manufacturing.Full Text
References
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- Chowrasia, D., Synthetic Paradigm, 2016, 8–9.
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- Paul, S., Nanda, P. and Gupta, R., Molecules, 2003, 8, 374–380.
- Antiproliferative and Antibacterial Activity of Some Para-Substituted Benzylideneacetophenones and Establishing their Structure Activity Relationship
Abstract Views :271 |
PDF Views:75
Authors
Deepak Chowrasia
1,
Nisha Sharma
1,
Ajay Kumar
1,
Vinod Dohrey
1,
Md. Arshad
2,
Asif Jafri
2,
Juhi Rais
2,
Madhu Gupta
2,
Sahabjada
2
Affiliations
1 University Institute of Pharmacy, Chhatrapati Shahu Ji Maharaj University, Kanpur 208 024, IN
2 Department of Zoology, Lucknow University, Lucknow 226 007, IN
1 University Institute of Pharmacy, Chhatrapati Shahu Ji Maharaj University, Kanpur 208 024, IN
2 Department of Zoology, Lucknow University, Lucknow 226 007, IN
Source
Current Science, Vol 114, No 02 (2018), Pagination: 391-396Abstract
We report here in-vitro antiproliferative and antibacterial activity of para-substituted benzylideneacetophenones and established their structure activity relationship to optimize para position as a biologically-oriented-synthetic target for design of small moleculebased future anticancer/antibacterial agents. Among synthesized compounds, 1c exhibits excellent antiproliferative activity against human osteosarcoma cell line (MG-63) compared to 1b and 1a suggesting dimethylamino (–N(CH3)2) functionality as a better para-substituted analogue for in-future anticancer agents. Similarly antibacterial screening of the aforesaid compounds against different strains of Gramnegative and Gram-positive bacteria reveals methoxy (–OCH3) rather than dimethylamino (–N(CH3)2) as a better para-substituted functionality on ring B comparatively. From our results, we justify our theory ‘lipophilicity affects antibacterial activity’.Keywords
Antiproliferative, Antibacterial Assay, Benzylideneacetophenone, MTT Assay.Full Text
References
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- Chowrasia, D., Karthikeyan, C., Choure L., Sahabjada, Gupta, G. and Arshad, M., Synthesis, characterization and anti cancer activity of some fluorinated 3,6-diaryl-[1,2,4]triazolo[3,4-b][1,3,4] thiadiazoles. Arab. J. Chem., 2013 (in press).
- Chowrasia, D., Sharma, N., Chaurasia, A., Bharti, A. and Pratap, A., Chalcone as a principle pharmacophore for design and development of novel anticancer agents. Pharmacophore, 2016, 7(5), 35–42.
- Chowrasia, D., Sharma, N. and Arshad, M., In vitro antiproliferative activity of M. Azedarach; Pharma. Tut. Magz., 2017, 5(02), 46–49.
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- Domyngueza, J. N., Charris, J. E., Loboa, G., De Domýnguezb, N. G., Moreno, M. M. and Riggione, F., Synthesis of quinolinylchalcones and evaluation of their antimalarial activity. Eur. J. Med. Chem., 2001, 36(6), 555–560.
- Hayat, F., Moseley, E., Salahuddin, A., Zyl, R. L. V. and Azam, A., Antiprotozoal activity of chloro-quinoline based chalcones. Eur. J. Med. Chem., 2011, 46(5), 1897–1905.
- Kotra, V., Ganapathy, S. and Adapa, S. R., Synthesis of new quinolinylchalcones as anticancer and anti-inflammatory agents. Indian J. Chem., 2010, 49(B), 1109–1116.
- Rizvi, S. U. F., Siddiqui, H. L., Johns, M., Detorio, M. and Schinazi, R. F., Anti-HIV-1 and cytotoxicity studies of piperidylthienylchalcones and their 2-pyrazoline derivatives. Med. Chem. Res., 2012, 21(11), 3741–3749.
- Ahmad, M. S., Sahabjada, Jafri, A., Ahmad, S., Afzal, M. and Arshad, M., Induction of apoptosis and antiproliferative activity of naringenin in human epidermoid carcinoma cell through ROS generation and cell cyle arrest. PLoS ONE, 2014, 9(10), e110003; doi:10.1371/journal.pone.0098409.
- Kaleem, S., Siddiqui, S., Hussain, A., Arshad, M., Akhtar, J., Rizvi, A. and Siddiqui, H. H., Eupalitin induces apoptosis in prostate carcinoma cells through ROS generation and increase of caspase3 activity. Cell Biol. Intern., 2016, 40(2), 196–203.
- Thiamine an Unexplored, Ecologically Hormonizable, Nontoxic Catalyst for Benzoylation
Abstract Views :218 |
PDF Views:71
Authors
Affiliations
1 University Institute of Pharmacy, Chhatrapati Shahu ji Maharaj University, Kalyanpur, Kanpur 208 024, IN
1 University Institute of Pharmacy, Chhatrapati Shahu ji Maharaj University, Kalyanpur, Kanpur 208 024, IN
Source
Current Science, Vol 115, No 11 (2018), Pagination: 2130-2133Abstract
Numerous catalysts have been evaluated to assist benzoylation since its origin (1883), each having their own pros and cons with respect to synthetic environment. However, the one (thiamine) we report here is superior as well as multidimensionally advantageous with reference to non-hygroscopic characteristic, stability at room temperature and reaction conditions, uninflammable, non-volatile, easy to handle, non-corrosive, environmentally harmonizable, biodegradable, recyclable and non-toxic. Our result denies the traditional concept of ‘Inorganic alkaline assistance’ for benzoylation. The percentage yield of benzoylated product obtained by thiamine assisted method was found to be comparable with traditional methods. Furthermore non-catalyst assisted benzoylation in neat water was also studied and the results coincide with traditional as well as thiamine-assisted method reported here with some limitations.Keywords
Benzoylation, Catalyst, Clean Water, Thiamine.Full Text
References
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- Synthetic Modulation Including Structure Establishment, Antiproliferative Activity of Some p-Aryl Substituted (Z)-2-Cyanoethylideneacetohydrazides, and their Structure Activity Relationship
Abstract Views :229 |
PDF Views:81
Authors
Deepak Chowrasia
1,
Nisha Sharma
1,
Ajay Kumar
1,
Md Arshad
2,
Sahabjada Siddiqui
2,
Asif Jafri
2,
Juhi Rahis
2
Affiliations
1 University Institute of Pharmacy, Chhatrapati Shahu ji Maharaj (CSJM) University, Kalyanpur, Kanpur 208 024, IN
2 Department of Zoology, Lucknow University, Lucknow 226 007, IN
1 University Institute of Pharmacy, Chhatrapati Shahu ji Maharaj (CSJM) University, Kalyanpur, Kanpur 208 024, IN
2 Department of Zoology, Lucknow University, Lucknow 226 007, IN
Source
Current Science, Vol 115, No 12 (2018), Pagination: 2287-2290Abstract
A series of p-substituted aryl-2-cyanoethylideneacetohydrazides derivatives (2a-j) were successfully synthesized in the laboratory (yield 60–80%). The synthesized compounds were screened for their antiproliferative activity against MCF-7 (estrogen dependent human breast cancer cell line), SaOS-2 (osteosarcoma cell line), and K562 (myeloid leukemia cell line) by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide) reduction assay. They showed moderate to mild antiproliferative activity, (2j) being the most potent in the series with an IC50 55, 64 and 35 μM against MCF-7, SaOS-2 and K562 cell lines, depict p-nitro as a better antiproliferative substituent comparatively. We have also tested the hypothesis – ‘Electron withdrawing phenomenon affects antiproliferative activity’.Keywords
Cancer, Cyanoacetohydrazide, Electron Withdrawing Ring Substituent, MTT Assay.Full Text
References
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- Pharmacognostic and Physicochemical Studies of Garcinia lanceifolia Roxb. Var. Oxyphylla
Abstract Views :158 |
PDF Views:0
Authors
Prakash Chandra Gupta
1,
Ashish Kar
2,
Nisha Sharma
1,
Nikunj Sethi
1,
Prashant Pandey
1,
Dipankar Saharia
2,
Naba Kumar Goswami
2
Affiliations
1 University Institute of Pharmacy, Chhatrapati Shahu Ji Maharaj University, Kanpur-208024, Uttar Pradesh, IN
2 The Energy and Resources Institute (TERI), Northeastern Regional Centre, Guwahati-781036 Assam, IN
1 University Institute of Pharmacy, Chhatrapati Shahu Ji Maharaj University, Kanpur-208024, Uttar Pradesh, IN
2 The Energy and Resources Institute (TERI), Northeastern Regional Centre, Guwahati-781036 Assam, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 2 (2019), Pagination: 706-710Abstract
Garcinia lanceifolia Roxb. var. Oxyphylla (Planch. & Triana) Laness (Clusiaceae), is a small and tropical evergreen plant commonly known as “Rupahi-thekera” (Assamese). It is an important and endemic medicinal plant of Assam which has been used by various ethnic communities of North-East India to treat various disorders like dysentery, dyspepsia and jaundice. The plant is considered to be containing much medicinal value and is also eaten raw or made into pickles by the local people. However, detailed scientific information is not available to identify the plant material, in order to ascertain its quality and purity. Therefore the study of morpho-anatomical characters and physicochemical analysis of G. lanceifolia was undertaken to establish the pharmacognostic and phytochemical details about the plant. Macro and microscopical studies of leaf showed the presence of simple leaf, lanceolate in shape, acuminate apex and paracytic type of stomata. Bowl shaped arrangement of xylem in leaf, crescent form vascular tissue in petiole and well developed phloem in the form of ring in stem are some of the diagnostic features noted from anatomical study of the plant. Powder microscopy revealed the presence of fibers, spiral and pitted vessels. HPTLC finger printing of plant tried with solvent system chloroform and methanol (8:2) confirmed the presence of 09 spots with different Rf value under UV light 366λ.The fluorescent analysis under day light and UV light by treatment with different chemical reagents showed different colour. Phytochemical evaluation revealed the presence of glycoside, triterpenoids, saponins, tannins and flavonoids.Keywords
Garcinia lanceifolia, Pharmacognosy, Microscopy, Physicochemical, HPTLC.
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- Screening and Molecular Identification of Hypercellulase and Xylanase-Producing Microorganisms for Bioethanol Production
Abstract Views :209 |
PDF Views:83
Authors
Affiliations
1 Microbiology Laboratory, Department of Basic Sciences, Dr Y. S. Parmar University of Horticulture and Forestry, Nauni–Solan 173 230, IN
1 Microbiology Laboratory, Department of Basic Sciences, Dr Y. S. Parmar University of Horticulture and Forestry, Nauni–Solan 173 230, IN
Source
Current Science, Vol 120, No 5 (2021), Pagination: 841-849Abstract
The present study projects the baseline work for bioconversion of pine needles to second generation biofuel, which deals mainly with screening, molecular identification and optimization of process parameters for cellulase and xylanase production. In total, 89 hydrolytic enzymes producing isolates were isolated from the soils and ten potential enzyme producers (seven for cellulase and three for xylanase) were subjected to secondary screening by inducing physical and chemical mutation. The wild and mutant strains of hypercellulase producers N12 and Kd1 were identified as Bacillus stratosphericus N12 and Bacillus altitudinis Kd1 using 16S rRNA technique. The fungal isolates RF1 and F2 were identified on the basis of 5.8 rRNA ITS technique and identified as Rhizopus oryzae, RF1 and Rhizopus delemar, F2 respectively. The mutant strains B. stratosphericus N12 (M) and B. altitudinis Kd1 (M) are highly stable till 10 generations. Cellulase activity increased from 3.230 to 5.983 IU, i.e. 85.23% increase in cellulase activity was achieved. Xylanase production increased from 51.32 to 95.25 IU with 85.60% increase in production. Solid-state fermentation was also performed by potential fungal strains, i.e. R. delemar F2 and R. oryzae RF1 using pine needles as the substrate.Keywords
Bioethanol, Cellulase, Solid-state Fermentation, Submerged Fermentation, Xylanase.Full Text
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