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Panda, Nirupama
- A Review on Phytoconstituents and Metal Complexes for the Treatment of Tuberculosis
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Authors
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1 Dr. APJ Abdul Kalam Research Laboratory, Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur – 603203, Tamil Nadu, IN
1 Dr. APJ Abdul Kalam Research Laboratory, Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur – 603203, Tamil Nadu, IN
Source
Journal of Natural Remedies, Vol 23, No 1 (2023), Pagination: 1-12Abstract
Tuberculosis (TB) is an infectious lung disease. Tiny droplets discharged into the air during cough and sneezes by an individual can transmit the bacteria that cause tuberculosis from one person to another. More than one million people die each year as a result of the communicable disease tuberculosis. Anti-TB allopathic drugs have been administered to treat the disease’s symptoms; however, they can produce negative side effects such as hepatitis, hypersensitivity reactions, nausea, vomiting, etc. As a result of the toxicity and side effects of allopathic medicines, the use of herbal medicine is growing in popularity. Since ancient times, medicinal plants have been used to treat illnesses. Alkaloids, coumarins, flavonoids, polyphenols, terpenoids, quinines, and other secondary metabolites that have antibacterial activity are produced by plants and may be helpful in the treatment of tuberculosis. This review aims to explore the possible uses of medicinal herbs and metal complexes with antitubercular capabilities.Keywords
Iron Complex, Metal Complex, Terpenes, Tuberculosis.Full Text
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- Deuterium - A Natural Isotope to Combat Microbial Resistance
Abstract Views :160 |
PDF Views:74
Authors
Nirupama Panda
1,
S. K. Zakki Uddin
1,
G. V. Anjana
1,
P. Ramalingam
2,
Senthilkumar Palaniappan
3,
M. K. Mohan Maruga Raja
4,
M. K. Kathiravan
1
Affiliations
1 Dr APJ Abdul Kalam Research Laboratory, Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur – 603203, Tamil Nadu, IN
2 Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER) Hajipur District: Vaishali, Hajipur - 844102, Bihar, IN
3 Faculty of Pharmacy, Karpagam Academy of Higher Education, Pollachi Main Road, Eachanari Post, Coimbatore - 641021, Tamil Nadu, IN
4 Department of Pharmacognosy and Phytochemistry, Parul Institute of Pharmacy and Research, Parul University, Vadodara, Gujarat – 391760, IN
1 Dr APJ Abdul Kalam Research Laboratory, Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur – 603203, Tamil Nadu, IN
2 Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER) Hajipur District: Vaishali, Hajipur - 844102, Bihar, IN
3 Faculty of Pharmacy, Karpagam Academy of Higher Education, Pollachi Main Road, Eachanari Post, Coimbatore - 641021, Tamil Nadu, IN
4 Department of Pharmacognosy and Phytochemistry, Parul Institute of Pharmacy and Research, Parul University, Vadodara, Gujarat – 391760, IN
Source
Journal of Natural Remedies, Vol 23, No 2 (2023), Pagination: 295-305Abstract
Deuterated medicinal chemistry is an attempt to introduce deuterium into existing drug molecules through the replacement of hydrogen atoms (-H) with deuterium (-D). The process of deuteration is to reduce the rates of breaking the carbonhydrogen bond. If the carbon-hydrogen bond breaking is the rate-determining step in the biotransformation of the drug, the deuterated drug may show improved pharmacokinetic characteristics, such as a longer half-life, hence lowering the need for frequent dosing. In this review, we discuss the improvement in the drug’s pharmacokinetic profile with deuterium. Further, this Deuterium exchange chemistry can reduce toxicity and be safe for human use. Also, the drugs experimented with using deuterium are discussed as how deuterated chemistry can help fight antimicrobial resistance. Beyond all, still, the design and development of a successful deuterated drug with acceptable efficacy is hence a challenge. The translation of hypotheses from laboratory experiments to clinical application and further to real-time practice is unpredictable. Also, long-term drug stability and toxicity studies for individual drugs are to be studied which may vary from patient to patient.Keywords
Antimicrobial Resistance, Deuterium, Metronidazole, Pharmacokinetic PropertyFull Text
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