Refine your search
Collections
Co-Authors
Journals
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Shah, Nehal
- Empty and Filled Bottle Inspection System
Abstract Views :187 |
PDF Views:1
Authors
Affiliations
1 Department of Electronics and Communication Engineering, Sarvajanik College of Engineering and Technology, IN
1 Department of Electronics and Communication Engineering, Sarvajanik College of Engineering and Technology, IN
Source
ICTACT Journal on Image and Video Processing, Vol 6, No 2 (2015), Pagination: 1122-1126Abstract
Automated Visual Inspection System (AVIS) have a strong ability for quality control in manufacturing industries by inspecting products automatically instead of manual inspections. This paper gives methods for bottle inspection in manufacturing industries. The paper describes mechanism for the defect detection, top and bottom detection, cap placement and fill level inspection. For empty bottle inspection the image is processed by contrast enhancement and then circular Hough transform is used. The location and radius of top and bottom of bottle is analyzed. After filling the bottle with liquid and placing the cap, edge detection method is used which is followed by horizontal line detection to identify whether fill level and cap closure is appropriate or not. Presented bottle inspection system works with 100% accuracy in proper illumination condition.- Forced Degradation Studies of Olmesartan Medoxomil and Characterization of Its Major Degradation Products by LC-MS/MS, NMR, IR and TLC
Abstract Views :246 |
PDF Views:2
Authors
Affiliations
1 Department of Quality Assurance, Shree Dhanvantry Pharmacy College, Kim, Surat, Gujarat, IN
2 Dharmaj Degree of Pharmacy, Dharmaj, Anand, Gujarat, IN
1 Department of Quality Assurance, Shree Dhanvantry Pharmacy College, Kim, Surat, Gujarat, IN
2 Dharmaj Degree of Pharmacy, Dharmaj, Anand, Gujarat, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 5, No 3 (2015), Pagination: 119-125Abstract
The proposed study describes an isocratic reversed phase HPLC method for investigation of degradation products of Olmesartan medoxomil API under different stress conditions (acid hydrolysis degradation). Separation of Olmesartan medoxomil and its degradation products was achieved on symmetry C18 (150 mm × 4.6 mm, 5 μ) column using a Acetonitrile: 0.02 M Na2HPO4(45:55 v/v) mobile phase and pH 7 adjusted with ortho phosphoric acid. Isocratic elution mode at a flow rate of 1.0 ml/min at Room temperature with a load of 20μl Injection volume. The detection was carried out at 240 nm followed by Base hydrolysis Structures of the degradation products were studied using a Triple Quadrapole Mass Spectrometer. A separate gradient LCMS method was developed for this purpose Depending on the degradation type, possible chemical reactions were predicted and supported by fragmentation data obtained from LC-MS/NMR. One major products were obtained in solid form using Rotavap and were then analyzed by NMR, IR and TLC to confirm their structural details.Keywords
Olmesartan Medoxomil, Forced Degradation Studies, Degradation Products, LC, LCMS,NMR, IR and TLC.- Development and Validation of Stability Indicating High Performance Liquid Chromatographic Method for Olmesartan Medoxomil and Indapamide in Tablet
Abstract Views :211 |
PDF Views:0
Authors
Affiliations
1 Department of Quality Assurance, Shree Dhanvantry Pharmacy College, Kim, Surat, Gujarat, IN
2 Dharmaj Degree of Pharmacy, Dharmaj, Anand, Gujarat, IN
1 Department of Quality Assurance, Shree Dhanvantry Pharmacy College, Kim, Surat, Gujarat, IN
2 Dharmaj Degree of Pharmacy, Dharmaj, Anand, Gujarat, IN
Source
Asian Journal of Pharmaceutical Research, Vol 5, No 1 (2015), Pagination: 15-23Abstract
An approach of forced degradation study was successfully applied for the development of a stability-indicating high performance liquid chromatographic method for simultaneous determination of Olmesartan medoxomil and Indapamide in a formulation in the presence of its degradation products. In the present study a simple, accurate and precise reverse phase liquid chromatographic method has been developed and validated for simultaneous estimation of Olmesartan medoxomil and Indapamide in tablet dosage form. Developed Method was achieved on symmetry C18 (150 mm × 4.6 mm, 5 μ) column using a Acetonitrile: 0.02 M Na2HPO4 (45:55 v/v) mobile phase and pH 7 adjusted with ortho phosphoric acid. Isocratic elution mode at a flow rate of 1.0 ml/min at Room temperature with a load of 20μl Injection volume. The detection was carried out at 240 nm. The linearity of the proposed method was investigated in the range of 50-250 microg/mL (r2 = 0.998) for Olmesartan medoxomil and 10-50 microg/mL (r2 = 0.998) for Indapamide. The retention time of Olmesartan medoxomil and Indapamide were found to be around 4.79 min and 7.59 min respectively. The drug substances were subjected to stress conditions of acid hydrolysis, base hydrolysis, Oxidative, photolytic and thermal. The developed RP-HPLC method was validated with respect to linearity, accuracy, precision, robustness, LOD and LOQ.Keywords
Olmesartan Medoxomil, Indapamide, Hypertension, Stability Study.- Development and Validation of Stability Indicating High Performance Liquid Chromatographic Method for Indapamide
Abstract Views :186 |
PDF Views:0
Authors
Affiliations
1 Department of Quality Assurance, Shree Dhanvantary Pharmacy College, Kim, Surat, Gujarat, IN
2 Dharmaj Degree of Pharmacy, Dharmaj, Anand, Gujarat, IN
1 Department of Quality Assurance, Shree Dhanvantary Pharmacy College, Kim, Surat, Gujarat, IN
2 Dharmaj Degree of Pharmacy, Dharmaj, Anand, Gujarat, IN
Source
Asian Journal of Pharmacy and Technology, Vol 5, No 3 (2015), Pagination: 158-164Abstract
An approach of forced degradation study was successfully applied for the development of a stability-indicating high performance liquid chromatographic method for Indapamide in the presence of its degradation products. In the present study a simple, accurate and precise reverse phase liquid chromatographic method has been developed of Olmesartan Indapamide in bulk. Developed Method was achieved on symmetry C18 (150 mm × 4.6 mm, 5 μ) column using a Acetonitrile: 0.02 M Na2HPO4(45:55 v/v) mobile phase and pH 7 adjusted with ortho phosphoric acid. Isocratic elution mode at a flow rate of 1.0 ml/min at Room temperature with a load of 20μl Injection volume. The detection was carried out at 240 nm. The linearity of the proposed method was investigated in the range of 10-50 microg/mL (r2 = 0.998) for Indapamide. The retention time of Indapamide was found to be around 4.79 min and 7.59 min respectively. The drug substances were subjected to stress conditions of acid hydrolysis, base hydrolysis, Oxidative, photolytic and thermal. The developed RP-HPLC method was validated with respect to linearity, accuracy, precision, robustness, LOD and LOQ.Keywords
Indapamide, Hypertension, Stability Study.- Development and Validation of Stability Indicating High Performance Liquid Chromatographic Method for Olmesartan Medoxomil and Indapamide in Tablet Dosage Form
Abstract Views :191 |
PDF Views:0
Authors
Affiliations
1 Department of Quality Assurance, Shree Dhanvantry Pharmacy College, Kim, Surat, Gujarat, IN
2 Dharmaj Degree of Pharmacy, Dharmaj, Anand, Gujarat, IN
1 Department of Quality Assurance, Shree Dhanvantry Pharmacy College, Kim, Surat, Gujarat, IN
2 Dharmaj Degree of Pharmacy, Dharmaj, Anand, Gujarat, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 5, No 2 (2015), Pagination: 1-12Abstract
An approach of forced degradation study was successfully applied for the development of a stability-indicating high performance liquid chromatographic method for simultaneous determination of Olmesartan medoxomil and Indapamide in a formulation in the presence of its degradation products. In the present study a simple, accurate and precise reverse phase liquid chromatographic method has been developed and validated for simultaneous estimation of Olmesartan medoxomil and Indapamide in tablet dosage form. Developed Method was achieved on symmetry C18 (150 mm × 4.6 mm, 5 μ) column using a Acetonitrile: 0.02 M Na2HPO4(45:55 v/v) mobile phase and pH 7 adjusted with ortho phosphoric acid. Isocratic elution mode at a flow rate of 1.0 ml/min at Room temperature with a load of 20μl Injection volume. The detection was carried out at 240 nm. The linearity of the proposed method was investigated in the range of 50-250 microg/mL (r2 = 0.998) for Olmesartan medoxomil and 10-50 microg/mL (r2 = 0.998) for Indapamide. The retention time of Olmesartan medoxomil and Indapamide were found to be around 4.79 min and 7.59 min respectively. The drug substances were subjected to stress conditions of acid hydrolysis, base hydrolysis, Oxidative, photolytic and thermal. The developed RP-HPLC method was validated with respect to linearity, accuracy, precision, robustness, LOD and LOQ.Keywords
Olmesartan Medoxomil, Indapamide, Hypertension, Stability Study.- Unusual Localised Skin Reaction due to Ondansetron: Case Series
Abstract Views :361 |
PDF Views:321
Authors
Affiliations
1 Department of Pharmacology, Smt B. K. Shah Medical Institute and Research Centre, Sumandeep Vidyapeeth Deemed University, Piparia – 391760, Gujarat, IN
2 Department of Paediatric, GMERS Medical College, Gotri, Vadodara – 390021, Gujarat, IN
3 Department of Pharmacology, Nootan Medical College and Research Centre, Sankalchand Patel University, Visnagar – 384315, Gujarat, IN
4 Department of Physiology, Smt B.K Shah Medical Institute and Research Centre, Sumandeep Vidyapeeth Deemed University, Piparia – 391760, Gujarat, IN
1 Department of Pharmacology, Smt B. K. Shah Medical Institute and Research Centre, Sumandeep Vidyapeeth Deemed University, Piparia – 391760, Gujarat, IN
2 Department of Paediatric, GMERS Medical College, Gotri, Vadodara – 390021, Gujarat, IN
3 Department of Pharmacology, Nootan Medical College and Research Centre, Sankalchand Patel University, Visnagar – 384315, Gujarat, IN
4 Department of Physiology, Smt B.K Shah Medical Institute and Research Centre, Sumandeep Vidyapeeth Deemed University, Piparia – 391760, Gujarat, IN
Source
Asian Journal of Pharmaceutical Research and Health Care, Vol 13, No 3 (2021), Pagination: 275-277Abstract
Ondansetron is an antiemetic drug that belongs to 5-hydroxytryptamine (5-HT3) receptor antagonists group. It has been widely used to treat nausea and vomiting due to chemotherapy, post surgery or due to any other gastrointestinal problem with 5-HT3 receptors involvement. The typical adverse drug reactions of Ondansetron include headache, dizziness, constipation or diarrhoea. Here, we have observed the skin reaction around the site of injection following Ondansetron administration. Recognition of this hypersensitivity reaction may allow better preparedness of clinicians to manage this condition.
Keywords
Ondansetron, 5-HT3, Skin Reaction.References
- Varshney RK, Jain G. Localized urticaria with intravenous ondansetron: A case report with literature review. Acta Medica International 2014;1(1):39-40.
- Alame MM, Chamsy DJ, Zaraket H. Pityriasis rosea-like eruption associated with ondansetron use in pregnancy. Br J Clin Pharmacol. 2018;84(5):1077-1080. doi:10.1111/bcp.13560
- Mori-Vogt S, Blazer M. Palonosetron for the prevention of chemotherapyinduced nausea and vomiting. Expert Rev Anticancer Ther. 2013;13:919-36. doi: 10.1586/14737140.2013.814412. PubMed PMID: 23984894.
- Singhal AK, Kannan S, Gota VS. 5HT3 antagonists for prophylaxis of postoperative nausea and vomiting in breast surgery: a meta-analysis. J Postgrad Med. 2012;58:23-31. PubMed PMID: 22387645.
- Finn AL. Toxicity and side eff ects of ondansetron. Semin Oncol. 1992; 19(4): 53-60.
- Russell D,Kenny GNC. 5HT3 antagonists in postoperative nausea and vomiting. Br J Anaesth 1992; 69:63-68.
- Sharma A, Raina V. Generalised seizures following Ondansetron. Ann Oncol 2001; 12(1):131-2.
- Tolan MM, Fuhrman TM, Tsueda K, Lippmann SB: Perioperative extrapyramidal reactions associated with Ondansetron. Anesthesiology 1999; 90:340-1.
- Mehra KK, Gogtay NJ, Ainchwar R, Bichile LS. Hypersensitivity to intravenous ondansetron: a case report. J Med Case Rep. 2008;2:274. Published 2008 Aug 14. doi:10.1186/1752-1947-2-274
- Sharma A, Raina V: Generalised seizures following Ondansetron. Ann Oncol 2001, 12(1):131-132.
- Ondansetron: drug information - UpToDate [Internet]. Available at: https%3A%2F%2Fwww.uptodate.com%2Fcontents%2Fondansetron-drug information%3Fsource%3Dsearch_result%26amp%3Bsearch%3Dondansetron%26amp%3BselectedTitle% 3D1~132 (last accessed 3 July 2020).