Informatics Publishing Limited

Monika Gaba ¹, Punam Gaba ¹, Sarbjot Singh ², Neelima Dhingra ³

Affiliations
1 Department of Pharmaceutical Sciences, ASBASJSM College of Pharmacy, Bela, Ropar, Punjab, IN
2 Drug Discovery Research, Panacea Biotech Pvt. Ltd., Mohali, Punjab, IN
3 University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, IN

Abstract

Leukocyte function associated antigen-1 (LFA-1, CD11a/CD18, αLβ₂) is a cell surface adhesion protein expressed on leukocytes. Interaction of LFA-1 with its counter receptor intercellular adhesion molecule-1 (ICAM-1) promotes the migration of leukocytes to the site of inflammation and is responsible for a variety of cell adhesion events required for normal and pathological functions of the immune system. Thus, the LFA-1/ICAM-1 interaction is thought to play a role in the pathogenesis of inflammatory and auto-immune disease conditions such as psoriasis, multiple sclerosis, asthma, rheumatoid arthritis, inflammatory bowel disease and transplant rejection. LFA-1/ICAM-1 interaction inhibitors have been extensively studied as a therapeutic target for clinically important diseases; leading to the development of therapeutic antibodies, peptides, peptidomimetics, allosteric and competitive inhibitors. However, despite of promising preclinical results, the outcome of clinical trials with LFA-1/ICAM-1 interaction inhibitors has been inconsistent and met with limited clinical success. This article gives a brief account of rationale and efficacy of different LFA-1/ICAM-1interaction inhibitors as promising therapeutic strategy for surmounting inflammatory disorders.

Keywords

Inflammation, LFA-1, ICAM-1, Leukocytes, Therapeutic Strategy.

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Gurleen Kaur ¹, Srishti Gautam ¹, Poonam Arora ¹, Neelima Dhingra ²

Affiliations
1 Chitkara College of Pharmacy, Chitkara University, Rajpura, Patiala -140401, Punjab,, IN
2 University Institute of Pharmaceutical Sciences, Panjab University -160014, Chandigarh,, IN

Abstract

Antioxidant activity encompasses protection against cellular wear and tear by interfering in the formation of free radicals. The majority of the diseases are linked to oxidative stress generated due to these free radicals. It makes the basis for plants containing secondary metabolites showing antioxidant activity as the potential source for development of newer formulations showing action against diseases like infections, cancers and other degenerative diseases. The present study involves the study of methanolic extracts of three medicinal herbs cannabis (Cannabis sativa.), wheatgrass (Triticum aestivum) and carrot (Dascus carota L.) commonly available in Indian cultivation. The antioxidant potential of the combination of these extracts was also studied. The combinations showed a synergistic antioxidant activity suggesting that potential of natural plant extracts against any disease can be increased when used in combinations.

Keywords

Antioxidant, Synergistic, Plant extract, Wheat grass, Cannabis, Carrot, Phytochemical.

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