Informatics Publishing Limited

N. V. Krishna Prasad ¹, M. S. S. R. K. N. Sarma ¹, K. S. R. Murthy ², K. S. D. L. K. Prasad ³, N. Madhavi ⁴

Affiliations
1 Department of Physics, G.S.T, GITAM University, Bangalore, Karnataka, IN
2 Department of Physics, G.I.T, GITAM University, Visakhapatnam, AP, IN
3 Department of Physics, VITS College (Eng), Visakhapatnam, AP, IN
4 Department of Statistics, Govt. Degree College, Rajhamundry, AP, IN

Abstract

Bangalore is the third most populous cities of India with a total population of over 11.5 million. This city has witnessed a huge growth in its population between years 2001 (5.1 million)   to 2016(11.5 million). Bangalore lies approximately at a height of 3000 ft. above sea level and positioned at 12.96⁰N, 77.56⁰E latitude and longitude. Because of its elevation it enjoys cool climatic conditions yearlong when compared to other stations in India. However huge increase in population enhances urbanization which leads to severe anthropogenic activity in this station. Keeping this in view an attempt was made to study the incoming solar ultraviolet radiation for the period 2006-2015 and its impact if any on this station. It is observed that the UV Index at Bangalore has a minimum value of 9.15 and a maximum value of 13.4 for this decade 2006-2015. This indicates that the city is receiving maximum ultraviolet radiation with high to very high risk. Keeping this in view measures need to be taken for safeguarding the people of Bangalore from ultraviolet radiation. 

Keywords

Total Ozone Content, UV-Index, TEMIS, OMI.

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V. Jhansipriya Marabathuni ¹, M. Bhavani ¹, M. Lavanya ¹, K. Padmaja ¹, N. Madhavi ¹, P. Babu ¹, Ch. M. M. Prasada Rao ²

Affiliations
1 Department of Pharmaceutics, Bellamkonda Institute of Technology and Sciences, Podili, IN
2 Department of Pharm. Chemistry, QIS College of Pharmacy, Ongole, IN

Abstract

Carbamazepine is an anticonvulsant. It works by decreasing nerve impulses that cause seizures and pain. Carbamazepine is used to treat seizures and nerve pain such as trigeminal neuralgia and diabetic neuropathy. Carbamazepine is also used to treat bipolar disorder. Due to sudden onset of attack, it is necessary to formulate antiepileptics into such a delivery system, which provide immediate relief. Hence, the present investigation was undertaken with a view to develop mouth-dissolving tablets of Carbamazepine, which offers a new range of product having desired characteristics and intended benefits. In this study, the mouth dissolving tablets were prepared using two different technologies, direct compression method and solid dispersion technology. Tablets produced by direct compression method contain crospovidone as a super disintegrant and sorbitol as a sweetener. Solid dispersions of Carbamazepine with polyvinylpyrrolidone K-30 and polyethylene glycol 6000 in different weight ratios were prepared with a view to increase its water solubility. Carbamazepine solid dispersions with polyvinylpyrrolidone K-30 in 1:2 ratios of drug: carrier showed maximum drug release and hence, compressed along with other excipients into mouth dissolving tablet. The results compared for both the technologies showed that the Carbamazepine tablets prepared using solid dispersion technology was found to have good technological properties and satisfying and reproducible drug dissolution profiles. Moreover, the drug release was found to be comparable to the marketed dispersible tablet.

Keywords

Carbamazepine, Mouth Dissolving Tablets, PVP K30, PEG 6000, Solid Dispersions, FT-IR, Dissolution Rate.

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T. Sravanthi ¹, N. Madhavi ¹

Affiliations
1 PG Department of Chemistry, JKC College, Guntur, Andhra Pradesh, IN

Abstract

A stability indicating ultra pressure liquid chromatographic method was developed and validated for the simultaneous estimation of Epalrestat and Pregabalin in bulk and tablet dosage form. The study was performed using HSS column (100mm x 2.1 mm, 1.8), with a mobile phase consisting of 0.1% o-phosphoric acid buffer (55% v/v) and acetonitrile (45%v/v) at a flow rate of 0.3ml/min.The detection was carried at 210 nm using PDA detector and the retention times were found to be 1.704 and 1.084 min for Epalrestat and Pregabalin respectively. The method was found to be linear in the concentration range of 37.5–225 μg/ml for Epalrestat and Pregabalin with r²= 0.999.These drugs were subjected to stress conditions such as acidic, basic, peroxide, thermal and photo degradation. The method was validated according to ICH guidelines.

Keywords

Epalrestat, Pregabalin, UPLC, Degradation, ICH.

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