Informatics Publishing Limited

L. Galate ¹, N. Khan ¹, R. Seth ¹, J. S. Shastri ¹

Affiliations
1 Dept. of Microbiology, TNMC & BYL Nair Ch. Hosp., Mumbai Central, Mumbai-400008, IN

Abstract

Tuberculosis (TB) is a major health problem in India and extrapulmonary tuberculosis (EPTB) comprises 20% of all cases of TB. EPTB is more common in HIV positive individuals and immunocompromised patients. In immunocompetent adults it has been observed that EPTB constitutes 15%-20% of all cases of tuberculosis. The emergence of strains of Mycobacterium tuberculosis that are resistant to antimycobacterial agents although not a new problem has recently received increased attention owing largely to outbreaks of drug resistant tuberculosis in HIV infected people. The true global magnitude of drug resistant tuberculosis is not well described. Here we report a case of streptomycin monoresistant mediastinal tuberculosis in a 29 year old Medical student. We wish to report this case because of rarity of streptomycin monoresistant in a case of extrapulmonary tuberculosis in an immunocompetent medical student.

Keywords

Streptomycin monoresistant, Extrapulmonary Tuberculosis.

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R. Set ¹, S. Zadbuke ¹, N. Khan ¹, J. Shastri ¹

Affiliations
1 Topiwala National Medical College, Mumbai, IN

Abstract

Extrapulmonary manifestation of tuberculosis is prevalent in 10-34% of non HIV cases while it occurs in 50-70% of patients co-infected with HIV. Very limited data is available for drug resistance in extrapulmonary tuberculosis (EPTB). This was a prospective, observational study to assess the prevalence of multidrug resistant tuberculosis (MDRTB) from 90 clinically suspected cases of EPTB at a tertiary care centre in Mumbai. In the present study, M. tuberculosis was found in 18.88% of EPTB patients of which 47.05% were MDRTB. Maximum culture positivity (40%) was found in lymph node aspirates. High drug resistance to M. tuberculosis warrants periodic assessment of the trends of drug resistance to anti tuberculosis agents.

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