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A. Ankarao ¹, C. H. Babu Rao ², N. Devanna ³

Affiliations
1 Department of Pharmaceutics, Hindu College of Pharmacy, Guntur, IN
2 Department of Chemistry, Donbosco pg college of Pharmacy, Guntur, IN
3 Department of Chemistry, J.N.T.U College of Engineering, Anantapur, IN

Abstract

The purpose of this research work was to establish mucoadhesive buccal tablets of terbutaline sulphate in the forms of bilayered tablets. The tablets were prepared using Hydroxy propyl methyl cellulose (HPMC K4M) and sodium carboxymethylcellulose (SCMC) and Carbopol-934 (CP) as bioadhesive polymers to impart mucoadhesion and ethyl cellulose (EC) to act as an impermeable backing layer. Buccal tablets were evaluated by different parameters such as weight uniformity, content uniformity, thickness, hardness, surface pH, swelling index, ex vivo mucoadhesive strength, in vitro drug release, and in vitro drug permeation. The mechanism of drug release was found to be non-Fickian diffusion (value of n between 0.5 and 1.0) for both the buccal tablets. The present study concludes that mucoadhesive buccal tablets of terbutaline sulphate can be a good way to bypass the extensive hepatic first-pass metabolism and to improve the bioavailability of terbutaline sulphate.

Keywords

Bilayered Buccal Tablet, Buccal Delivery, Mucoadhesion,Terbutaline Sulphate.

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G. ChandraSekhar Reddy ¹, N. Devanna ¹, K. B. Chandrasekhar ²

Affiliations
1 Department of Chemistry, Govt. Polytechnic, Anantapur (A.P), IN
2 Department of Chemistry, JNTU, Anantapur (A.P), IS

Abstract

Ruthenium (III) forms a purple Coloured water soluble complex with Diacetyl Monoxime Isonicotinoylhydrazone (DMIH) reagent in acidic buffer P^H 4.5 with λ_max at 346 nm. The molar absorptivity and sandell's sensitivity are 1.4 X 10 ⁴ L mol^-1 cm^-1 and 0.0048 μg / cm² respectively. The Beer's law validity range is 0.505 to 6.06 μg / mL. Ruthenium (III) forms (M: L) 1:1 complex with DMIH and stability constant of the complex is 2.694 X 10⁶ .The derivative spectrophotometric determination of Ru (III) was carried out by measuring peak height method. The developed derivative spectrophotometric method was employed for the determination of Ruthenium (III) in synthetic samples of alloy and river water samples .The effect of various diverse ions was also studied.

Keywords

Diacetyl Monoxime Isonicotinoyl Hydrazone (DMIH, Derivative Spectrophotometry, Ruthenium (III).

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G. Chandra Sekhar Reddy ¹, N. Devanna ², K. B. Chandrasekhar ²

Affiliations
1 Senior Lecturer in Chemistry, Govt.Polytechnic, Anantapur (A.P), IN
2 Department of Chemistry, JNTU, Anantapur, IN

Abstract

Molybdenum (VI) forms a greenish Yellow Coloured water soluble complex with Diacetyl Monoxime Isonicotinoylhydrazone(DMIH) reagent in acidic buffer P^H 5.0 with λ_max at 346 nm. The molar absorptivity and sandell’s sensitivity are 1.93 X 10 4 L.mol ^-1.cm ^-1 and 0.00259067 μg / cm ² respectively. The Beer’s law validity range is 0.48 to 5.76 μg / ml. The optimum concentration range is 0.96 – 4.8 μg / ml. Molybdenum (VI) forms (M:L) 1:1 complex with DMIH and stability constant of the complex is 4.731 X 10⁶ .The derivative spectrophotometric determination of Mo(VI) was carried out by measuring peak height method. The developed derivative spectrophotometric method was employed for the determination of Molybdenum (VI) in synthetic samples of alloy samples. The effect of various diverse ions was also studied.

Keywords

Diacetyl Mmonoxime Isonicotinoylhydrozone(DMIH), Derivative Spectrophotometry, Molybdenum (VI).

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J. Mamatha ¹, N. Devanna ²

Affiliations
1 Department of Chemistry, G. Pullaiah College of Engineering and Technology, Kurnool – 518002, Andhra Pradesh, IN
2 Department of Chemistry, JNTUA College of Engineering, Anantapur – 515002, Andhra Pradesh, IN

Abstract

Objective: A novel RP-HPLC method has been developed for analysis of cidofovir in its available medicinal form. Method: Stationary phase was a sophisticated C-18 RP Column (250mm × 4.6mm). Mobile phase consisted of Ethylnitrile and 0.005M citric acid buffer (pH adjusted to 5.5) in 60:40 V/V ratio. Mobile phase flow rate was 1.0 ml per minute and Isocratic. UV detection wavelength was 260nm. Validation was carried according to ICH guidelines. Findings: The Retention time of both AP1 and the medicine was 3.88 minutes. Linearity was satisfied over the concentration range of 2 ppm to 10 ppm and r² value was 0.999. LOD and LOQ values were 0.067 ppm and 0.205 ppm respectively. Improvement: The Reported method was novel and all validation parameters met the criteria. Method can be used in quality control analysis.

Keywords

Method Development, Validation, RP - HPLC

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