A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Guptha, N. S. R. C.
- A Study on Evaluation of Factors Contributing to Fatty Liver in Type 2 Diabetes Mellitus
Authors
1 Associate Professor Department of Medicine, GSL Medical College, NH-5, Lakshmipuram, Andhra Pradesh - 533294, IN
2 Department of Medicine, GSL Medical College, NH5, Lakshmi Puram, A.P, IN
3 Department of Pathology, Siddhartha Medical College, Vijayawada, A.P, IN
4 Anil Diabetes Care, Red Cross Lane, Khaleelwadi, Nizamabad, A.P, IN
Source
International Journal of Contemporary Medicine, Vol 2, No 1 (2014), Pagination: 177-181Abstract
Background: As type 2 diabetes patients are prone to develop fatty liver which can predispose them to cirrhosis, we tried to evaluate the factors that contribute to development of fatty liver in diabetes.
Material and Method: We enrolled 137 type 2 diabetes patients, took anthropometric measurements like BMI, waist circumfrence and waist hip ratio. We subjected them to investigations like ultrasonography (USG) of abdomen, liver function tests and fasting lipid profile. Based on USG abdomen, we classified these patients into FL+(fatty liver ) group and FL-(non fatty liver) group. We analysed various factors that correlate with the development of fatty liver.
Results: Out of 137 type 2 diabetes patients, fatty liver was seen in 48 cases (35%). Cirrhosis was found in 2 cases and hepattocellular carcinoma in 1 case. FL+ group has statically significant high mean total cholesterol, LDL and triglycerides than FL- group. Age, duration of diabetes, gender and HBA1C did not show any statistical correlaton with the development of fatty liver. Among anthropometric measurements, waist circumfrence and BMI in FL+ group is higher than in FLgroup and showed statically significant correlation. Liver function tests like S.Bilirubin, AST, ALT, ALP were much higher in FL+ group than in FL- group but none of them have shown any statistical significance.
Conclusion: Simple measurements like BMI, waist circumfrence and routine laboratory tests like total cholesterol, LDL and triglycerides can be used as prognostic indicators for the development of fatty liver in type 2 diabetes patients.
Keywords
Fatty liver, Diabetes
- Association of Micro and Macrovascular Complications with Fatty Liver in Patients with Type 2 Diabetes Mellitus
Authors
1 Medicine, GSL General Hospital, Rajahmundry, IN
2 Pathology, GSL General Hospital, Rajahmundry, IN
Source
International Journal of Medical and Dental Sciences, Vol 3, No 1 (2014), Pagination: 270-275Abstract
Background:Fatty liver is a fairly common entity seen in the diabetic population. Studies showed that liver adiposity is independently associated with Insulin Resistance and can substantially increase the risk of various micro and macrovascular complications of diabetes mellitus.
Aims: Identifying various micro and macrovascular complications and finding their association with fatty liver disease in type 2 diabetes patients.
Material and methods: 141 diabetic patients admitted in a tertiary care center over a two year period were screened for fatty liver by ultrasonography of the abdomen and were classified into FL (fatty Liver) group and NFL (non fatty liver) group. All patients were investigated for complications like nephropathy, neuropathy, retinopathy, cardiac and peripheral vascular disease. Statistical analysis was done to find the association of complications with fatty liver.
Results: out of 141 patients, 49 (35%) had fatty liver. Leading complication was neuropathy (31.2%), followed by nephropathy (11.3%), retinopathy (10.6%), cardiac disease (9.2%) and peripheral vascular disease (3.55). Between FL and NFL groups, Diabetic neuropathy (40.8% vs 23.9%) and cardiac disease (16.3% vs 5.4%) showed statical significance (p<0.05), while other complications were more or less equally prevalent in the two groups.
Conclusions: Fatty liver is seen in one third of diabetic patients. vascular complications like neuropathy and cardiac disease are more commonly seen in diabetic patients with fatty liver than those without fatty liver.
Keywords
Fatty Liver, Diabetes, Vascular Complications.Full Text
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