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Vageesh, N. M.
- Formulation Development and In vitro Evaluation of Floating Tablets of Lafutidine by Employing Effervescent Technology
Abstract Views :248 |
PDF Views:7
Authors
Affiliations
1 St. Johns College of Pharmaceutical Sciences, Yerakota, Yemmiganur, Kurnool (Dist), Andhra Pradesh, IN
2 Department of Pharmaceutics, Osmania University, Hyderabad, IN
1 St. Johns College of Pharmaceutical Sciences, Yerakota, Yemmiganur, Kurnool (Dist), Andhra Pradesh, IN
2 Department of Pharmaceutics, Osmania University, Hyderabad, IN
Source
Asian Journal of Pharmaceutical Research, Vol 7, No 3 (2017), Pagination: 189-197Abstract
In the present research work gastro retentive floating matrix formulation of Lafutidine by using various polymers were developed. Initially analytical method development was done for the drug molecule. Absorption maxima was determined based on that calibration curve was developed by using different concentrations. Gas generating agent sodium bicarbonate concentration was optimized. Then the formulation was developed by using different concentrations of polymers Xanthan gum, guar gum and Sodium Alginate as polymeric substances. The formulation blend was subjected to various preformualation studies, flow properties and all the formulations were found to be good indicating that the powder blend has good flow properties. Among all the formulations Only Xanthan gum, Sodium Alginate highest concentrations (60 mg) retards the drug release upto 12 hours and the drug release 96. 25%, 95. 81% respectively. In this Xanthan gum releases the more drug release when compared to Sodium alginate. So F3 Formulation considered as optimized formulation. Optimised formulation F3 was kept for release kinetic studies. From the above graphs, it was evident that the formulation F3 was followed the Peppas release mechanism.Keywords
Lafutidine, Xanthan Gum, Guar Gum and Sodium Alginate, Floating Tablets.
- Preparation and In Vitro Charactersation of Fast Disintigrating Tablets of Cimetidine
Abstract Views :201 |
PDF Views:0
Authors
Affiliations
1 St.Johns College of Pharmaceutical Sciences, Yerakota, Yemmiganur , Kurnool (Dist) , Andhra Pradesh, IN
2 Department of Pharmaceutics, OU Ph.D Scholar, Osmania University, Hyderabad, IN
1 St.Johns College of Pharmaceutical Sciences, Yerakota, Yemmiganur , Kurnool (Dist) , Andhra Pradesh, IN
2 Department of Pharmaceutics, OU Ph.D Scholar, Osmania University, Hyderabad, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 7, No 3 (2017), Pagination: 141-148Abstract
The present study was carried out to develop Fast Disintegration Tablets of Cimetidine. Kollidon, Vivasol, Tulsion 330 powder were used as Super Disintegrants. The blend of all the formulations showed good flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations F7 formulation showed maximum % drug release i.e., 98.62% in 60 min hence it is considered as optimized formulation.Keywords
Cimetidine, Kollidon, Vivasol, Tulsion 330 and Fast Disintegration Tablets.References
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