Refine your search
Collections
Co-Authors
Journals
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Sudhakar, Muvvala
- Problems and Proceedings to Antiretroviral Therapy for the Treatment of AIDS
Abstract Views :214 |
PDF Views:137
Authors
Affiliations
1 Department of Pharmaceutics, Osmania University College of Technology, Osmania University, Hyderabad, Telangana, IN
2 Mekelle Institute of Technology, Mekelle University, Mekelle, ET
3 Department of Pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda, Secunderabad, Telangana, IN
1 Department of Pharmaceutics, Osmania University College of Technology, Osmania University, Hyderabad, Telangana, IN
2 Mekelle Institute of Technology, Mekelle University, Mekelle, ET
3 Department of Pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda, Secunderabad, Telangana, IN
Source
SMU Medical Journal, Vol 3, No 1 (2016), Pagination: 240-254Abstract
Long term use of antiretroviral therapy suppresses HIV infection in real. But due to mutation there is chance of drug resistance, drug toxicity, drug penetration, adherence to therapy, viral replication in cellular reservoirs and augmentation of host immune responses. Viral replication causes the accumulation of drug resistance, mutations, increase in viral loads and disease progression. The optimization of antiviral therapy by the understanding of the pathogenesis of drug resistant HIV-1 is essential. In the present review outlines various problems to HIV therapy and discussions about the success of antiviral therapy.Keywords
Replication, Drug Resistance, Antiviral Therapy, Progression.Full Text
- Development and Evaluation of Controlled Release Formulation of Zidovudine Based on Microporous Osmotic Tablet Technology Using Fructose as Osmogen
Abstract Views :193 |
PDF Views:3
Authors
Affiliations
1 Pharmaceutics Department, University College of Technology, Osmania University, Hyderabad, Telangana-500007, IN
2 Mekelle Institute of Technology, Mekelle University, Mekelle, ET
3 Department of pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda, Secunderabad, Telangana-500014, IN
4 Department of pharmacognosy, Princeton College of Pharmacy, Korremula, Ghatkesar, R.R. District, Telangana-500088, IN
1 Pharmaceutics Department, University College of Technology, Osmania University, Hyderabad, Telangana-500007, IN
2 Mekelle Institute of Technology, Mekelle University, Mekelle, ET
3 Department of pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda, Secunderabad, Telangana-500014, IN
4 Department of pharmacognosy, Princeton College of Pharmacy, Korremula, Ghatkesar, R.R. District, Telangana-500088, IN
Source
Research Journal of Pharmacy and Technology, Vol 10, No 5 (2017), Pagination: 1459-1470Abstract
The present work was aimed to develop and evaluate controlled porosity osmotic pump (CPOP) tablets of an anti HIV drug zidovudine to provide a uniform concentration of drug at absorption site. The formulations were prepared by wet granulation method using drug, various excipients, controlled release polymer hydroxylpropylmethyl cellulose(HPMCE5M LV) and osmogen (Fructose).The CPOP tablets consist of an osmotic core coated with a micro porous membrane made up of cellulose acetate(CA) which is incorporated with sorbitol as porogen. Prior to compression the prepared granules were evaluated for pre compression parameters such as angle of repose, bulk density, tapped density, Carr's index and Hausner's ratio. After compression the prepared granules were evaluated for thickness, coat thickness, hardness, weight variation, friability, drug content, diameter, in vitro drug release study and scanning electron microscopy (SEM) study. The release kinetics for different formulations were analyzed using zero order model equation, first order model equation, Higuchi model equation, Korsmeyer Peppas model equation and Hixson-Crowell equation. The optimized formulation of drug release was independent of pH, agitation intensity, but dependent on the osmotic pressure of the release media. Based on the in vitro dissolution profile optimized formulation ZF4 exhibited Fickian transport mechanism with a drug release of 97.83% in 16 hrs. FTIR and DSC study revealed that there was no interaction between drug and excipients. Formulations subjected to stability testing (at 40±2°C/75±5% RH) as per ICH guidelines for three months indicated stability with no significant changes in thickness, hardness, weight variation, friability drug content and dissolution profiles.Keywords
CPOP, Zidovudine, Cellulose Acetate, SEM, DSC.
- Controlled Porosity Osmotic Pump Tablets of Zidovudine and Lamivudine Combination:Optimization and Characterization
Abstract Views :168 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutics, University College of Technology, Osmania University, Hyderabad, Telangana-500007., IN
2 Mekelle Institute of Technology, Mekelle University, Mekelle, ET
3 Department of Pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda, Secunderabad, Telangana-500014., IN
1 Department of Pharmaceutics, University College of Technology, Osmania University, Hyderabad, Telangana-500007., IN
2 Mekelle Institute of Technology, Mekelle University, Mekelle, ET
3 Department of Pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda, Secunderabad, Telangana-500014., IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 9, No 3 (2017), Pagination: 114-122Abstract
The present study was undertaken to develop controlled porosity osmotic pump tablets of zidovudine-lamivudine combination. The tablets were prepared by wet granulation method using HPMC E5LV, and osmogen was prinicipal ingredients a dose of 300mg zidovudine-150 mg lamivudine twice daily. The coating solution of core tablets were prepared by using cellulose acetate, poly ethylene glycol of different grades, sorbitol and acetone to quantity sufficient for different batches. The prepared tablets were evaluated for pre-compression parameters, post compression parameters, in vitro drug release study and scanning electron microscopy study. Among developed formulations CS4 batch show 96.31% drug release in 8 h for zidovudine and 97.83% for lamivudine in 8 h. The in vitro release kinetics were analyzed for different batches by different pharmacokinetic models such as zero order, first order, Higuchi, Korsmeyer Peppas and Hixon-Crowell model. The result of optimized formulation was independent of the pH and agitation intensity. Short term stability study (at 40±2ºC / 75±5% RH for three months) on the best formulation indicated that there were no significant changes in thickness, friability, weight variation, drug content and in vitro drug release.Keywords
AIDS, Wet Granulation, In Vitro Drug Release, Stability Study.References
- Barre Sinoussi F, Chermann JC, Rey F et al. “Isolation of a T lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome(AIDS)”, Science, 220:868-871,1983.
- UNAIDS, Review of data from People Living with HIV Stigma Index surveys conducted in more than 65 countries, 2016.
- Sahoo CK, Sahoo NK, Rao SRM, Sudhakar M. (2017) A Review on Prevention and Treatment of Aids. Pharm Pharmacol Int J 5(1): 00108.
- Michael J. Mugavero, Charles B. Hicks, HIV resistance and the effectiveness of combination antiretroviral treatment. Drug Discovery Today: Therapeutic strategies 2004; 1(4):529-535.
- Sahoo CK, Rao SRM, Sudhakar M and Sahoo NK. Advances in osmotic drug delivery system. J of Chemical and Pharmaceutical Research. 2015; 7:252-273.
- Verma RK, Krishna DM, Garg S. Formulation aspects in the development of osmotically controlled oral drug delivery systems. J control release; 2000; 79:7-27.
- Jadav MM, Teraiya SR, Patel KN, Patel BA, Patel PA. Formulation and Evaluation of Oral Controlled Porosity Osmotic Pump Tablet of Zaltoprofen International Journal for Pharmaceutical Research ScholarsV-1, I-2, 2012,254-267.
- Edavalath S, Shivanand K, Prakasam K, Rao BP, Divakar G. Formulation development and optimization of controlled Porosity osmotic pump tablets of diclofenac sodium.Int.J.Pharm.Pharm.Sci.2011;3(1):80-87.
- Sahoo CK, Sahoo NK, Rao SRM, Sudhakar M, Satyanarayana K.A review on controlled porosity osmotic pump tablets and its evaluation Bulletin of Faculty of Pharmacy, Cairo University 2015;53 (2):195-205.
- Anju CL, Palanichamy S, Rajesh M, Ramasubramaniyan P, Solairaj P. Formulation and evaluation of osmotic drug delivery system of ibuprofen. Ars Pharm.2014;55(4):44-51.
- Sahoo CK, Rao SRM, Sudhakar M. Evaluation of controlled porosity osmotic pump tablets: a review Research J. Pharm. and Tech. 2015; 8(12):119-125.
- Sahoo CK, Rao SRM, Sudhakar M and Kokkula S. The kinetic modeling of drug dissolution for drug delivery systems: an overview. Der Pharmacia Lettre 2015;7(9):186-194.
- Costa P, Lobo JMS. Modelling and comparison of dissolution profiles, European J of Pharmaceutical Sciences,2001;13:123-133.
- Banerjee A, Verma PRP, Gore S. Controlled porosity solubility modulated osmotic pump tablets of Gliclazide. AAPS Pharm Sci Tech 2015;16(3):554-568.
- Khan ZA, Tripathi R, Misha B. Design and evaluation of enteric coated microporous osmotic pump tablet(ECMOPT) of quetiapine fumarate for the treatment of psychosis. Acta Poloniae –Drug Research 2012;69(6):1125-1136.
- Kumaravelrajan R, Narayanan N, Suba V. Development and evaluation of controlled porosity osmotic pump for Nifedipine and Metoprolol combination. Lipids in Health and Disease.2011;10:51.
- Kanagale P, Lohay BB, Misra A, Davadra P, Kini R. Formulation and Optimization of Porous Osmotic Pump based Controlled Release System of Oxybutynin. AAPS Pharm SciTech. 2007;8(3):E1-E7.
- Syed MS, Lahoti S, Syed AA. Controlled porosity osmotic tablet of atenolol: in vitro and in vivo evaluation, Marmara Pharmaceutical Journal,2016;20:325-332.
- Formulation Techniques for Designing of Osmotic Controlled Drug Delivery Systems:A Review
Abstract Views :217 |
PDF Views:0
Authors
Chinmaya Keshari Sahoo
1,
Surepalli Rammohan Rao
2,
Muvvala Sudhakar
3,
D. Venkata Ramana
4,
Kanhu Charan Panda
5
Affiliations
1 Department of Pharmaceutics, University College of Technology, Osmania University, Hyderabad, Telangana-500007., IN
2 Mekelle Institute of Technology, Mekelle University, Mekelle, ET
3 Department of Pharmaceutics, Malla Reddy College of Pharmacy (Affiliated to Osmania University), Maisammaguda, Secunderabad, Telangana-500014, IN
4 Department of Pharmaceutical Technology, Netaji Institute of Pharmaceutical Sciences, Toopranpet, Yadadri Bhongir, Telangana – 508252, IN
5 Department of Pharmaceutics, Anwarul Uloom College of Pharmacy, Newmallepally, Hyderabad, Telangana, IN
1 Department of Pharmaceutics, University College of Technology, Osmania University, Hyderabad, Telangana-500007., IN
2 Mekelle Institute of Technology, Mekelle University, Mekelle, ET
3 Department of Pharmaceutics, Malla Reddy College of Pharmacy (Affiliated to Osmania University), Maisammaguda, Secunderabad, Telangana-500014, IN
4 Department of Pharmaceutical Technology, Netaji Institute of Pharmaceutical Sciences, Toopranpet, Yadadri Bhongir, Telangana – 508252, IN
5 Department of Pharmaceutics, Anwarul Uloom College of Pharmacy, Newmallepally, Hyderabad, Telangana, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 9, No 4 (2017), Pagination: 147-157Abstract
Osmotic drug delivery system (ODDS) provides the drug dose and dosing interval in optimized manner to maintain drug concentration within therapeutic window thus ensuring efficacy and minimizing toxic effects. The objective of ODDS is to release pharmacologically active ingredients in a predetermined, predictable and reproducible manner to systemic circulation. ODDS delivers a drug to large extent is independent of the physiological factors of the gastrointestinal tract, pH. Hence it can be utilized for systemic as well as targeted delivery of drugs. The release of drugs from osmotic system controls the drug release by controlling various formulation factors such as solubility, osmotic pressure of the core components, size of the delivery orifice and nature of the rate controlling membrane. The design of osmotic system is achieved by optimizing formulation and processing factors to deliver drugs in preprogrammed rate and controlled manner. In present study is an update on osmosis, different types of osmotic systems, components of ODDS, key parameter sand some patents.Keywords
Osmotic Drug Delivery System, Osmosis, Osmotic Pressure.References
- Parmar NS, Vyas SK, Vaya N. Osmotic Pump A Novel Drug Delivery System. In: Jain NK, Editors. Advances in controlled and novel drug delivery systems. New Delhi: CBS Publishers and distributors;2004,p.18-37.
- Li X and Jasti BR. Osmotic controlled drug delivery systems, In: Designof controlled release of drug delivery systems, McGraw Hill, 2006; p.203-229.
- Verma RK, Garg S. Current status of drug delivery technologies and future directions. Pharma Technol On line(http://www.pharmaportal.com) 2001;25:1-14.
- Malaterre V, Ogorka J, Loggia N, Gunny R. Oral osmotically driven systems:30 years of development and clinical use Eur. J. Pharm. Biopharm. 2009;73:311-323.
- Madhavi BB, Nath AR, Banji D. Ramalingam R, Madhu MN and Kumar DS. Osmotic drug delivery system :a review. Pharmakine 2009;2:5-14.
- Kaushal AM and Garg S: An update on osmotic drug delivery patents. Pharm. Tech.,2003, 27, 38-44
- Verma RK, Arora S, Garg S. Osmotic pumps in drug delivery Critical Review in Therapeutic Drug Carrier Systems 2004;21(6):477-520.
- Singh K, Walia MK, Agarwal G, Harikumar SL. Osmotic pump drug delivery system: a novel approach Journal of Drug Delivery and Therapeutics 2013;3(5):156-162.
- Grattoni A, Merlo M, Ferrari M. Osmotic pressure beyond concentration restrictions J. Phys. Chem. B 2007;111:11770-11775.
- Herrlich S, Spieth S, Messner S, Zengerle. Osmotic micropumps for drug delivery. Advanced Drug Delivery Reviews.2012;64:1617-1627.
- Theeuwes F. Elementary osmotic pump J.Pharm.Sci.1975;64:1987-1991.
- Verma RK, Krishna DM and Garg S. Formulation aspects in the development of osmotically controlled oral drug delivery systems. J Control Release 2002;79:7-27.
- Rose S, Nelson J.A Continuous long term injector Aust.J.Exp.Biol.Med.Sci.1955;33:415-421.
- Higuchi T and Leeper HM. Improved osmotic dispenser employing magnesium sulfate and magnesium chloride.US Patent3760804 ;1973.
- Theeuwes F, Higuchi T, Inventors; Alza corporation, Palo Alto, CA, Assignee. Osmotic dispensing device for releasing beneficial agent.US Patent;1974,3845770.
- ALZET Osmotic pumps http://www.alzet.com/research_applications.
- Wright JC, Johnoson RM and Yum SI. Duros Osmotic Pharmaceutical Systems for Parenteral and Site Directed Therapy. Drug. Deliv. Technol 2003;3:3-11
- Prajapati HM, Prajapati ST, Patel CN.A review on recent innovation in osmotically controlled drug delivery system. Int. J of Pharma. Research and Bioscience 2012;1(3):158-194.
- Mishra B, Makesh BK and Sankar C.Oral push pull osmotic pumps of pentazocine hydrochloride development and evaluation. Ind. J Pharm Sci.,2006;68(1):85-87.
- Srenivasa B, Kumar NR, Murthy KVR. Development and in vitro evaluation of osmotically controlled oral drug delivery system. Easstern Pharmacist 2001;22.
- Zentner GM, Rork GS, Himmelstein KJ. The controlled porosity osmotic pump. J Control Release 1985;1(4):269-282.
- Padma priya S, Ravichandram V, Suba V.A review on osmotic drug delivery system. Int. J of Research in Pharmaceutical and Biomedical Sciences 2013;4(3):810-821.
- Dong L ,Wong P and Espinal S. loros hardcap: A new osmotic delivery system for controlled release of liquid formulations: In :Proceedings of the International Symposium on controlled release of biomedical materials, San Dieego;2001.
- Sareen R, Jain N and Kumar D. An insight to osmotic drug delivery. Curr Drug Deliv. 2012;9(3):285-96.
- Theewes F, Wong PSL, Burkoth TL, Fox DA and Bicek PR. Colonic drug absorption and metabolism. Marcel Decker, New York;1993,pp137-158.
- Lee HB, Liu L, Ku J, Khang G, Lee B and Rhee JM. Nifedipine controlled delivery sandwiched osmotic tablet system ,J Control Release 2000;68:145-156.
- Liu L and Wang X. Solubility modulated monolithic osmotic pump tablet for atenolol delivery. Eur J Pharm Biopharm 2008;68(2):298-302.
- Thakor RS, Majmudar FD, Patel JK and Rajput GC. Osmotic drug delivery systems current scenario. Journal of Pharmacy Research 2010;34:771-775.
- Schultz P, Kleinebudde P.A new multiparticulate delayed release system Part I Dissolution properties and release mechanism. J Control Release 1997;47:181-189.
- Ramdan MA, Tawashi R. The effect of hydrodynamic conditions and delivery orifice size on the rate of drug release from elementary osmotic pump system. Drug Dev Ind Pharm 1987;13(2):235-248.
- Arora S, Ali J, Ahuja A, Baboota S and Qureshi J. Pulsatile drug delivery systems an approach for controlled drug delivery. Ind. J.Pharm.Sci.2006;68(3):295-300.
- Godbillion JH, Gerardin A, Richard J, Leroy D, Moppert J. Osmotically controlled delivery of metoprolol in man in vivo performance of oros system with different duration of drug release.Br.J.Clin.Pharma.1985;19:69S-76S.
- Kumar L, Shivani, Kumar A, Parashar D, Bhadra S. Asymmetric membrane capsule(AMC):an useful osmotic drug delivery system Int J. Pharm Pharm Sci.2012;4(2):54-59.
- Swanson DR, Barclay BR, Wong PSL et.al. Nifedipine gastrointestinal therapeutic system.Am.J.Med.1987;83(6B):3-9.
- Thombre AG, DeNoto AR, Gibbes DG. Delivery of glipizide from asymmetric membrane capsules using encapsulated excipients. J. Cont. Rel. 1999;60:333-341.
- Bauer K, Kaik G, Kaik B. Osmotic release oral drug delivery system of metoprolol in hypertensive asthmatic patients, Pharmacodynamic effects on beta 2-adrenergic receptors. Hypertension 1994;24:339-346.
- Vyas SP, Khar RK. Controlled drug delivery:concept and advances. Vallabh prakashan,NewDelhi;2001,477-501.
- Khavare NB, Dasankoppa SF, Najundaswamy NG.A review on key parameters and components in designing of osmotic controlled oral drug delivery systems. Indian J of Novel Drug Delivery 2010;2(4):122-131.
- Jerzewski Rand Chien Y. Osmotic drug delivery, In:Treatise on controlled drug delivery:Fundamentals, optimization, Application. Marcel Dekker;1992,225-253.
- Verma RK, Mishra B, Garg S. Osmotically controlled oral drug delivery. Drug Dev Ind Pharm 2000;26:695-708.
- Patel H, Patel U, Kadikar H, Bhimani B, Daslaniya D, Patel G. Areview on osmotic drug delivery system. Int. Res J of Pharm 2012;3(4):89-94.
- Mahalaxmi R, Phanidhar, Sastri, Ravikumar, Atin Kalra, Pritam Kanagale and Narkhede. Enhancement of Dissolution of Glipizide from controlled porosity osmotic pump using wicking agents and a solubilizing agent. Int. J. Pharm Tech Res.2009;1(3):705-711.
- Guo J. An investigation into formation of plasticizer channels in plasticized polymer films. Drug Dev.Ind.Pharm.1994;20:1883-1893.
- Kelbert M, Bechard SR. Evaluation of cellulose latex as coating material for controlled release products. Drug Dev. Ind Pharm 1992;18:519-538.
- Dong LC, Espinal S, Wong PSL. Inventors Alza corporation Mountain View CA Assignee. Dosage form comprising liquid formulation .US Patent 6174547.Jan16;2001.
- Theeuwes F, Saunders RJ, Mefford WS. Process for forming outlet passageways in pills using a laser US Patent 4088864,May 9,1978.
- Chen C, Lee D, Xie J. Controlled release formulation for water insoluble drugs in which a passageway is formed in situ.US patent 5736159 April 7,1998.
- Ayer AD, Balkie HH. Method and apparatus for forming a hole in a drug dispensing device.US Patent 5071607 Dec10,1991.
- Haslam JL. Rork GS. Controlled porosity osmotic pump.US4880631 Patent Nov 14,1989.
- Rudine EM, Burnside BA, Flanner HH, Wassink SE, Couch RA, Pinkett JE. drug delivery system US patent 6,110,498 Aug.29,2000.
- Zentner GM, McClelland, Sutton SC. Controlled porosity solubility and resin modulated osmotic drug delivery systems for release of diltiazem hydrochloride J Control. Release 1991;16:237-244.
- Khanna SC. Therapeutic system for sparingly soluble active ingredients US patent 4,992,278,Feb.12.1991.
- Theewes F. Osmotic dispenser with gas generating means.US patent 4,036,228 July 19,1977.
- Okimoto K, Miyake M, Ohnishi N, Rajewski RA, Stella VJ, Irie T, Uekama K. Design and evaluation of an osmotic pump tablet for prednisolone a poorly water soluble drug using (SBE)-7m- ᵝ-CD.Pharm.Res.1998;15:1562-1568.
- Theeuwes F, Swanson DR, Guittard G, Ayer A, Khanna S. Osmotic delivery systems for the beta-adrenoceptor antagonists metoprolol and oxprenolol :design and evaluation of systems for once-daily administration Br. J. Clin. Pharmacol. 1985;19:69S76S.
- Thombre AG, DeNoto AR, Gibbs DC. Delivery of glipizide from asymmetric membrane capsules using encapsulated excipients J. Control. Release. 1999;60:333-341.
- Koparkar AD, Shah SB. Oral osmotic system for slightly soluble active agents US patent 5,284,662,Feb.8,1994
- McClelland, Sutton SC, Engle K, Zentner GM. The solubility modulated osmotic pump In vitro/in vivo release of diltiazem hydrochloride Pharm.Res.1991;8:88-92.
- Curatolo WJ. Dispensing devices powered by lyotropic liquid crystals US patent 5,108,756 April28,1992.
- Ghosh Tanmoy, Ghosh Amitav. Drug delivery through osmotic systems an overview. J. of Applied Pharmaceutical science 2011;01(2):38-49.
- Keraliya AR, Patel C, Patel P, Keraliya V, Soni GT, Patel CR and Patel MM. Osmotic drug delivery system as a part of modified release dosage form. Int. Scholarly Research Network 2012;2012:1-9.
- Theeuwes F. Microporous semipermeable laminated osmotic system, Alza corporation.1981;US Patent no4256108
- Ayer AD, Theeuwes F. Osmotic system for dispensing drugs, Alza corporation.1981;US Patent no4285987.
- Zentner GM, Rork GS, Himmnelstein KJ. Controlled porosity osmotic pump, Merck and Co.1986; EP Patent no. 0169105.
- Athayde AL, Faste RA, Horres Jr. CR, Low TP. Controlled release osmotic pump, Recordati corporation, US Patent no.5672167.
- Haslam JL, Rork GS. Controlled porosity osmotic enalpril pump, Merck and Co.Inc.1994;WO Patent no.1994001093.
- Haslam JL, Rork GS. Controlled porosity osmotic pump, Merck and Co.Inc.1992;EP Patent no.0309051.
- Haslam JL, Rork GS. Controlled porosity osmotic pump, Merck and Co.Inc.1991;CA Patent no.1320885.
- Debusi LA, Ruddy SB, Storey DE. Osmotic controlled release drug delivery device, Merck and Co.Inc.2001;WO Patent no.2001032149.
- Hood LE, Ishikawa MY, Jung EKY, Langer R, Clarence T, Wood TLL, Wood VYH. Osmotic pump with remotely controlled pressure generation The Invention Science Fund Lic.2012,US Patent no.8109923.
- Mccelland GA, Zentner GM. Solubility modulated drug delivery system Merck and Co.Inc.1990;US Patent no.4946686.
- Theeuwes F. Osmotic device having micro porous reservoir, Alza corporation 1976;US Patent no.3977404.
- Patel NK, Mehta TA.A review on oral osmotically driven systems Int. J Pharm Pharm Sci2013; 5(3):1005-1013.
- Formulation and Optimization of Porous Osmotic Pump Based Controlled Release System of Ritonavir for the Treatment of HIV Infection
Abstract Views :454 |
PDF Views:2
Authors
Chinmaya Keshari Sahoo
1,
Surepalli Ram Mohan Rao
2,
Muvvala Sudhakar
3,
D. Venkata Ramana
4,
K. Satyanarayana
5
Affiliations
1 Department of Pharmaceutics, Faculty of Pharmacy, University College of Technology, Osmania University, Hyderabad, Telangana - 500007, IN
2 Mekelle Institute of Technology, Mekelle University, Mekelle, ET
3 Department of pharmaceutics, Malla Reddy College of Pharmacy (Affiliated to Osmania University), Maisammaguda, Secunderabad, Telangana - 500014, IN
4 Department of pharmaceutical Technology, Netaji Institute of Pharmaceutical Sciences, Toopranpet, Yadadri Bhongir, Telangana - 508252, IN
5 Department of Pharmacognosy, Princeton College of Pharmacy, Korremula, Ghatkesar, R.R. District, Telangana - 500088, IN
1 Department of Pharmaceutics, Faculty of Pharmacy, University College of Technology, Osmania University, Hyderabad, Telangana - 500007, IN
2 Mekelle Institute of Technology, Mekelle University, Mekelle, ET
3 Department of pharmaceutics, Malla Reddy College of Pharmacy (Affiliated to Osmania University), Maisammaguda, Secunderabad, Telangana - 500014, IN
4 Department of pharmaceutical Technology, Netaji Institute of Pharmaceutical Sciences, Toopranpet, Yadadri Bhongir, Telangana - 508252, IN
5 Department of Pharmacognosy, Princeton College of Pharmacy, Korremula, Ghatkesar, R.R. District, Telangana - 500088, IN
Source
Asian Journal of Pharmacy and Technology, Vol 8, No 1 (2018), Pagination: 13-22Abstract
The current research involves the development of controlled porosity osmotic pump (CPOP) tablets of ritonavir for the treatment of HIV infection. Core tablets were prepared by wet granulation method using hydroxyl propyl methyl cellulose (HPMCE5LV) polymer, mannitol as osmogen, MCC as diluents and other additives. The CPOP tablets were coated with cellulose acetate as wall forming material, poly ethylene glycol as flux regulating agent, and sorbitol acts as pore forming material in SPM. The prepared tablets were evaluated for FTIR, DSC, precompression parameters, post compression parameters, in vitro drug release study and scanning electron microscopy study. The optimized formulation RM5 showed 94.83% at the end of 14 hrs with zero order drug release. The difference factor (f1) and similarity factor (f2) for RM5 were observed 14.61 and 75.12 respectively. Optimized formulation did not show any significant change on the pH and agitation intensity, but it depends on osmotic pressure of dissolution media indicated that mechanism of drug release was due to osmotic pressure. SEM micrographs confirmed that no pores were found before dissolution and after dissolution had shown the porous nature of the membrane. Short term stability study at 40 ± 2 °C/75 ± 5% RH for three months on the RM5 formulation indicated that there was no significant change weight variation, %friability, drug content and in vitro drug release.Keywords
Ritonavir, Wet Granulation, CPOP, Difference Factor, In Vitro Drug Release, Stability Study.References
- Sahoo CK, Sahoo NK, Rao SRM, Sudhakar M. (2017) A Review on Prevention and Treatment of Aids. Pharm Pharmacol Int J 5(1): 00108.
- Aungst BJ, P-glycoprotein, secretory transport, and other barriers to the oral delivery of anti-HIV drugs, Adv Drug Del Rev 39, 105-116, 1999.
- Shafran SD et al. The effect of low-dose ritonavir monotherapy on fasting serum lipid concentrations. HIV Med 6: 421-425, 2005 4. Biswas M, Gupta RN, Parhi R, Sethi KK, Sahoo SK. Formulation and in vitro evaluation of gastroretentive floating drug delivery system of ritonavir, Turk. J. Pharm. Sci. 10(1), 69-86:2013.
- Sahoo CK, Rao SRM, Sudhakar M and Sahoo NK. Advances in osmotic drug delivery system. J of Chemical and Pharmaceutical Research. 2015; 7:252-273.
- Verma RK, Krishna DM, Garg S. Formulation aspects in the development of osmotically controlled oral drug delivery systems. J control release; 2000; 79:7-27.
- Robinson JR, Eriksen SP.Theoratical formulation of sustained dosage forms. J Pharm.Sci. 1966; 55:1254-63.
- Sahoo CK, Sahoo TK, Moharana AK, Panda KC. Formulation and optimization of porous osmotic pump based controlled release system of Residronate sodium for the treatment of postmenopausal osteoporosis, International Journal of Pharmaceutical Sciences Review and Research, 2012; 12(1):118-122.
- Jadav MM, Teraiya SR, Patel KN, Patel BA, Patel PA.Formulation and Evaluation of Oral Controlled Porosity Osmotic Pump Tablet of Zaltoprofen International Journal for Pharmaceutical Research Scholars V-1, I-2, 2012, 254-267.
- Sahoo CK, Sahoo NK, Rao SRM, Sudhakar M, Satyanarayana K. A review on controlled porosity osmotic pump tablets and its evaluation Bulletin of Faculty of Pharmacy, Cairo University 2015; 53 (2):195-205.
- Sahoo CK, Rao SRM, Sudhakar M.Evaluation of controlled porosity osmotic pump tablets: a review Research J. Pharm. and Tech. 2015; 8(12):119-125.
- Ranjit Prasad Swain, Nagamani Ragolu, Satyajit Panda. Formulation, In vitro Characterization and Stability Studies of fast Dispersing Tablets of Diclofenac Sodium. J App Pharm Sci, 2015; 5 (07): 094-102.
- Al-Achi A, Patel B. Formulation and optimization of potassium iodide tablets,Saudi Pharmaceutical Journal, 2015; 23:95-101.
- El-Bagory I, Barakat N, Ibrahim MA, El-Enazi F. Formulation and in vitro evaluation of theophylline matrix tablets prepared by direct compression: effect of polymer blends,Saudi Pharmaceutical Journal, 2012; 20: 229-238.
- Shanmugam S, Banthala RS, Ayyappan T, Sundaramoorthy K,Vetrichelvan T.Formulation and evaluation of sustained release matrix tablet of zidovudine using different polymers, Research J. of Pharmaceutical, Biological and Chemical Sciences 2011; 2(1): 576-589.
- Padmapriya S, Ravichandran V, Suba V. Development and evaluation of swellable elementary osmotic pump tablets of metoprolol succinate and ramipril. Glob J Pharmacol 2013; 7(2):179-86.
- Moore JW,Flanner HH., Mathematical comparison of curves with an emphasis on in vitro dissolution profiles. Pharm.Tech., 1996, 20, 64-74.
- Sahoo CK, Rao SRM, Sudhakar M and Kokkula S.The kinetic modeling of drug dissolution for drug delivery systems: an overview.Der Pharmacia Lettre 2015; 7(9):186-194.
- Costa P,Lobo JMS. Modelling and comparision of dissolution profiles, European J of Pharmaceutical Sciences, 2001; 13:123-133.
- Banerjee A,Verma PRP,Gore S.Controlled porosity solubility modulated osmotic pump tablets of Gliclazide. AAPS Pharm Sci Tech 2015; 16(3):554-568.
- Sahoo CK, Rao SRM, Sudhakar M, Bhanja S and Panda N. Development of controlled porosity osmotic pump of ritonavir design, optimization and characterization International Journal of Pharmaceutical Sciences Review and Research 2017; 47(1): 36-44.
- Khan ZA, Tripathi R, Mishra B. Design and evaluation of enteric coated microporous osmotic pump tablet (ECMOPT) of quetiapine fumarate for the treatment of psychosis.Acta Poloniae –Drug Research 2012; 69(6):1125-1136.
- Sahoo CK, Rao SRM, and Sudhakar M. Development and evaluation of controlled release formulation of lamivudine based on microporous osmotic tablet technology using fructose as osmogen Indonesian Journal of Pharmacy 2017; 28(3):168- 178.
- Kumaravelrajan R, Narayanan N, Suba V.Development and evaluation of controlled porosity osmotic pump for Nifedipine and Metoprolol combination. Lipids in Health and Disease. 2011; 10:51.
- Sahoo CK, Rao SRM, and Sudhakar M. Formulation and optimization of porous osmotic pump tablets based controlled release system of stavudine for the treatment of HIV infection. Current Trends of Pharmaceutical Biotech and Pharmacy 2017; 11(4): 358-370.
- Dasankoppa FS, Ningangowdar M, Sholapur H. Formulation and evaluation of controlled porosity osmotic pump for oral delivery of ketorolac. Journal of Basic and Clinical Pharmacy. 2013; 4(1):2-9.
- Sahoo CK, Rao SRM, and Sudhakar M. Formulation and Optimization of Controlled Porosity Osmotic Pump Tablets of Zidovudine using Mannitol as Osmogen for the Treatment of AIDS. International Journal of ChemTech Research 2017; 10(5): 216-235.
- Kanagale P, Lohray BB, Misra A, Davadra P, Kini R. Formulation and Optimization of Porous Osmotic Pump based Controlled Release System of Oxybutynin. AAPS Pharm Sci Tech. 2007; 8(3): E1-E7.
- Sahoo CK, Rao SRM, Sudhakar M., and Shashikala P. Formulation and Optimization of Controlled Porosity Osmotic Pump Tablets of Ritonavir, Journal of Chemical and Pharmaceutical Sciences 2017; 10(3): 1345-1352.
- Rani M, Mishra B. Comparative in vitro and in vivo evaluation of matrix,osmotic matrix and osmotic pump tablets for controlled delivery of diclofenac sodium.AAPS Pharm. Sci Tech. 2004; 5(4):17.
- Sahoo CK, Rao SRM, Sudhakar M. and Satyanarayana K. Development and Evaluation of Controlled Release Formulation of Zidovudine Based on Microporous Osmotic Tablet Technology Using Fructose as Osmogen. Research J. Pharm. and Tech. 2017; 10(5): 1459-1470.
- Syed MS, Lahoti S, Syed AA.Controlled porosity osmotic tablet of atenolol: in vitro and in vivo evaluation,Marmara Pharmaceutical Journal, 2016; 20:325-332.
- Sahoo CK, Rao SRM, and Sudhakar M. Formulation and evaluation of controlled porosity osmotic pump tablets for Zidovudine and Lamivudine combination using fructose as osmogen, Journal of Drug Delivery and Therapeutics. 2017; 7(4):41-50.
- Sanjay Bajaj, Dinesh Singla and Neha Sakhuja, Stability Testing of Pharmaceutical Products, Journal of Applied Pharmaceutical Science 02 (03); 2012: 129-138.
- Sahoo CK, Rao SRM, and Sudhakar M. Controlled Porosity Osmotic Pump Tablets of Zidovudine and Lamivudine Combination: Optimization and Characterization. Research Journal of Pharmaceutical Dosage Forms and Technology 2017; 9(3):114-122.
- Formulation and Evaluation of Mucoadhesive Buccal Tablets of Resperidone
Abstract Views :149 |
PDF Views:0
Authors
Affiliations
1 Malla Reddy College of Pharmacy, Department of Pharmaceutics, Maisammaguda, Dhulapally, Secunderabad - 500100 Affiliated by Osmania University, IN
1 Malla Reddy College of Pharmacy, Department of Pharmaceutics, Maisammaguda, Dhulapally, Secunderabad - 500100 Affiliated by Osmania University, IN
Source
Asian Journal of Pharmacy and Technology, Vol 12, No 1 (2022), Pagination: 13-19Abstract
The aim of present study was to formulation and evaluation of Mucoadhesive buccal tablets of Resperidone. Mucoadhesive buccal tablets of Resperidone were prepared by direct compression method using polymers such as Karaya gum, tamarind gum, carbopol, and Sodium carboxy methyl cellulose. The Buccal tablets were evaluated for various physical, drug content uniformity, in-vitro drug release and drug- excipient interactions (FT-IR). FT-IR spectroscopic studies indicated that there were no drug-excipient interactions. The formulation F9 (containing 30mg of Carbopol) were found to be best formulation, which showed maximum drug release within 8 h. These formulations have showed good bioadhesion strength (18 gm).Keywords
Risperidone, Mucoadhesive Buccal Tablets, Carbopol, Karaya Gum, and Sodium Carboxy Methyl CelluloseReferences
- Shojaei HA. Buccal mucosa as a route for systemic drug delivery: A Review. J Pharml Sci.1998; 1(1): 15-30.
- Mamatha Y et al. Buccal Drug delivery a Technical Approach, Journal of Drug Delivery Therapeutics. 2012; 2(2): 26-33.
- Mamatha y et al. Buccal Drug delivery a Technical Approach. Journal of Drug Delivery Therapeutics. 2012; 2(2): 26-33.
- Chinna Reddy P et al. A Review on Bioadhesive Buccal Drug Deliverysystems: Current Status of Formulation and Evaluation Methods. DARU. 2011; 19(6): 385-403.
- Jayanna BK, Devaraj TD, Roopa KP, Nagendrappa G, Kumar HR, Gowda N. Spectrophotometric estimation of risperidone in tablets. Indian J Pharm Sci. 2014; 76(5): 452-455.
- Thimmasetty J et al. Design and In vivo Evaluation of Carvedilol Buccal Mucoadhesive patch. Pak. J. Pharmsci. 2008; 21(3): 241-248.
- A Semalty et al. Formulation and Evaluation of Muco adhesive Buccal Films of Enalapril maleate. Indian Journal of Pharmaceutical Sciences. 2010; 72(5): 571-575.
- Milind et al. Formulation and Evaluation of Mucoadhesive Buccal Tablets Of Propranolol Prepared Using Natural Polymer. IJPSR. 2018; 9(7): 2905-2913.
- Burak Celik et.al. Risperidone mucoadhesive buccal tablets: formulation design, optimization and evaluation. Drug Des Devel Ther. 2017; (11), 3355-3365.
- Ikinci G, Capan Y, Senel S and Dalkara T. In vitro / in vivo studies on buccal bioadhesive tablet formulation of carbamazepine. Pharmazie. 2000; 55(10): 762 – 765.
- Ceschel GC, Maffei P, Lombardi BS and Ronchi C. Design and evaluation of buccal adhesive hydrocortisone acetate (HCA) tablets. Drug Deliv. 2001; 8(3): 161 - 171.
- Varshosaz J and Dehghan Z. Development and characterization of buccoadhesive nifedipine tablets. Eur J Pharm Biopharm. 2002; 54(2): 135 – 141
- Raghuraman S, Velrajan G, Jeyabalan B and Johnson BD. Design and evaluation of propranolol hydrochloride buccal films. Indian Journal of Pharmaceutical Sciences. 2002; 64(1): 32-35.