Informatics Publishing Limited

Sumalatha Gindi ¹, Nagiat T. Hawisa ², Chandu Baburao ², Mukkanti Khagga ³

Affiliations
1 Hindu College Of Pharmacy, Amaravathi Road, Guntur-522002, Andhrapradesh, IN
2 College of Pharmacy, Al-Jabal Al-Gharbi University, Al- Zawia, LY
3 Centre for Pharmacy, JNT University, Hyderabad, Andhrapradesh, IN

Abstract

The present investigation explores the hepatoprotective activity of Ficus bengalensis leaf extract in albino rats. The dried leaves of Ficus bengalensis were extracted using ethanol and tested for hepatoprotective activity on albino rats intoxicated with rifampicin (50mg/kg p.o). liver weight, pentobarbitone sleeping time, biochemical parameters was studied. Ethanolic extract of Ficus bengalensis leaf lowered the elevated levels of SGOT, SGPT and serum bilirubin indicating promising anti hepatotoxic activity.

Keywords

Ficus Bengalensis, Rifampicin, Ethanoloic Extract and Hepatoprotective.

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Varun Dasari ¹, Bahlul Z. Awen ², Babu Rao Chandu ², Mukkanti Khagga ³

Affiliations
1 Hindu College of Pharmacy, Guntur-522002, Andhra Pradesh,, IN
2 College of Pharmacy, Al-Jabal Al-Gharbi University, Al- Zawia, LY
3 Centre for Pharmacy, JNT University, Hyderabad, IN

Abstract

GRDDSs helps in maintenance of constant therapeutic levels for prolonged periods and produce therapeutic efficacy and there by reduces the total dose of administration.GRDDSs are formulated as floating microparticles, tablets, pellets, capsules, etc among which the multiparticulate systems are more effective than the single unit dosage forms[1]. Assessment of dissolution study results revealed that formulations F7 (Stavudine: Gelucire 43/01- 1:1), F10 (Stavudine: Compritol 888 ATO - 1:1.5) and F19 (Stavudine: Lubritab - 1:2) had retarded the drug release in controlled manner upto 12 hours. The relative contributions of drug diffusion and matrix erosion to drug release were further confirmed by subjecting the dissolution data to Higuchi model and Erosion model. No prominent enthalpy changes was observed in the DSC thermograms of Stavudine+ Gelucire 43/01 physical mixtures and optimized formulations upon comparison with the peaks of drug and polymer alone. From the in vivo X-ray studies, conducted in the healthy human volunteers, it was found that the gastric residence time of the developed Stavudine multi unit granule system floating is dependent on the conditions of the stomach.

Keywords

Gastroretention, Buoyancy, Multi Unit, Melt Granulation.

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Varun Dasari ¹, Bahlul Z. Awen ², Babu Rao Chandu ², Mukkanti Khagga ³, Nagaraju Pappula ¹

Affiliations
1 Hindu College of Pharmacy, Guntur-522002, Andhra Pradesh, IN
2 College of Pharmacy, Al-Jabal Al-Gharbi University, Al-Zawia, LY
3 Centre for Pharmacy, JNT University, Hyderabad, Andhra Pradesh, IN

Abstract

A simple, sensitive and precise reverse phase high performance liquid chromatographic method has been developed for the simultaneous estimation of Ritonavir and Lopinavir in pharmaceutical dosage forms. The mobile phase consisted of Acetonitrile: buffer (0.05 M Potassium dihydrogen orthophosphate, P^H-3) in the ratio of 50:50 v/v delivered at a flow rate of 2.0 ml/min and wavelength of detection at 215 nm. The retention times of Ritonavir and Lopinavir were 10.253 min and 12.490 min respectively. The developed method was validated according to ICH guidelines. The proposed method can be used for determination of these drugs in combined dosage forms.

Keywords

Ritonavir, Lopinavir, RP-HPLC.

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