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Hoque, Mohibul
- Formulation and Evaluation of Fast Dissolving Tablets of Doxazosin Mesylate
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Authors
Affiliations
1 Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmaceutics, Karavali College of Pharmacy, Mangalore, IN
3 Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore, IN
4 Department of Pharmacology, Karavali College of Pharmacy, Mangalore, IN
1 Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmaceutics, Karavali College of Pharmacy, Mangalore, IN
3 Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore, IN
4 Department of Pharmacology, Karavali College of Pharmacy, Mangalore, IN
Source
Asian Journal of Pharmaceutical Research, Vol 6, No 3 (2016), Pagination: 131-146Abstract
The objective of this research was to formulate fast dissolving tablets of Doxazosin mesylate that disintegrate in the oral cavity upon contact with saliva and there by improve therapeutic efficacy. Doxazosin mesylate is used for the treatment of the signs and symptoms of benign Prostatic Hyperplasia. Fast dissolving tablets of Doxazosin mesylate were prepared by direct compression method using superdisintegrant addition method, by using sublimation method and effervescent method. Thirty two formulations were prepared and evaluated for hardness, thickness, friability, weight variation, drug content, in vitro disintegration time, in vitro dispersion time, wetting time, water absorption ratio and in vitro dissolution studies.
FTIR and DSC studies revealed that there was no chemical interaction between the drug and the excipients. Formulation S8 was found to be the best on the basis of wetting time, in vitro disintegration time and in vitro drug release. The formulation S8 containing camphor (8%) as subliming agent was found to be the optimized combinations. Stability studies were carried out at 25°C±2°C/60%±5% RH and 40°C±2°C/75%±5% RH for formulation S8 for 60 days. The results of stability studies indicated no significant changes with respect to physicochemical properties, in vitro disintegration time, wetting time and in vitro drug release.
Keywords
Fast Dissolving Tablets, Doxazosinmesylate, Superdisintegrant, Directcompression, Sodium Starch Glycollate, Camphor, Citric Acid.
- Formulation and Evaluation of Montelukast Sodium Fast Dissolving Tablets
Abstract Views :262 |
PDF Views:1
Authors
Affiliations
1 Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmaceutics, Karavali College of Pharmacy, Mangalore, IN
3 Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore, IN
4 Department of Pharmacology, Karavali College of Pharmacy, Mangalore, IN
1 Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmaceutics, Karavali College of Pharmacy, Mangalore, IN
3 Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore, IN
4 Department of Pharmacology, Karavali College of Pharmacy, Mangalore, IN
Source
Asian Journal of Pharmaceutical Research, Vol 6, No 3 (2016), Pagination: 159-169Abstract
Montelukast sodium is an anti-asthmatic, mainly prevents leukotriene mediated effect associated with asthma. Mouth dissolving tablets of montelukast sodium was prepared by direct compression method using superdisintegrants such as croscarmellose sodium, crospovidone and sodium starch glycolate.
Mouth dissolving tablets (MDTs) disintegrates or dissolves rapidly without water within few seconds in the mouth due to the action of superdisintegrants or maximizing pore structure in the formulation. The tablets were prepared using various diluents like MCC, Lactose and superdisintegrants namely Crosscarmellose sodium, Crosspovidone and Sodium starch glycollate in different concentrations. Pre-compression parameters such as angle of repose, bulk density, tapped density, compressibility index, Hausner's ratio were carried out to study the flow properties of powder to achieve uniformity of tablet weight and the values were within permissible limits.The prepared tablets were evaluated for hardness, thickness, weight variation, friability, % drug content, wetting time, water absorption ratio, in vitro disintegration time, in vitro dispersion time and in vitro drug release.The formulation M12 and L12 was found to be the best on the basis of wetting time, in vitro disintegration time and in vitro drug release. Stability studies were carried out at 25°C±2°C/60%±5% RH and 40°C±2°C/75%±5% RH for a period of 60 days for the selected formulations. The formulation M12 and L12 containing Crospovidone (8%) as superdisintegrant and microcrystalline cellulose and lactose as diluents was respectively found to be the optimized combination.
Keywords
Fast Dissolving Tablets, Superdisintegrants, Diluents, Mouth Dissolving Tablets, Montelukast Sodium, Asthama.- Design and Evaluation of Transdermal Patches Containing Risperidone
Abstract Views :208 |
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Authors
Affiliations
1 Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmaceutics, Karavali College of Pharmacy, Mangalore, IN
3 Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore, IN
4 Department of Pharmacology, Karavali College of Pharmacy, Mangalore, IN
1 Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmaceutics, Karavali College of Pharmacy, Mangalore, IN
3 Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore, IN
4 Department of Pharmacology, Karavali College of Pharmacy, Mangalore, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 6, No 4 (2016), Pagination: 208-222Abstract
Transdermal drug delivery systems are also known as patches, containing dispersed or dissolved drug with plasticizers, polymers, etc. are intended to deliver a therapeutically effective amount of drug across the skin. In the present work, Transdermal drug delivery of Risperidone were formulated in different concentration (10%, 20% and 30% ) of glycerine and polyethylene glycol 400 as plasticizer and a blend of two in different concentrations of polymers (PVPK30,HPMC,PVA and Eudragit RS 100) were formulated by solvent casting method. Drug polymer interaction study was carried out using FTIR and DSC studies. In this study the results indicates, as increase in the concentration of glycerine and Polyethylene glycol increases the diffusion rate of Risperidone patches. The physico-chemical parameters like weight variation, thickness, folding endurance. Percentage Flatness and Water vapour transmission of the Risperidone patches were evaluated. All the physico chemical parameters were found to be satisfactory. Risperidone patches formulated by using 30% glycerine 30% PEG400shows enhanced rate of diffusion than the patches prepared with 10% and 20% glycerine10% and 20% PEG400 respectively. Risperidone patches formulated with 20% glycerine 20% PEG400 had enhanced rate than the patches prepared with 10%glycerine/10% PEG400 respectively. Among polymers, combination of HPMC and Eudragit had enhanced diffusion rate than the combination of HPMC and PVPK30 in all formulations formulated by using glycerine as plasticizer. The polymers, combination of PVPK30 and Eudragit had enhanced diffusion rate than the combination of PVPK30 and PVA in all formulations formulated by using PEG400 as plasticizer. The Risperidone transdermal patches shows greater diffusion rate when formulated with higher concentration of plasticizer hence the30% of glycerine and PEG 400 had shown a values higher than 20 and 10 % glycerine and PEG 400. The kinetic study and mechanism for the diffusion of Risperidone transdermal patches obeys higuchi, peppas model. The correlation coefficient (R2) values were greater, indicating from the analysis of diffusion data as per above models. The T50 and T80 values for Risperidone patches formulated with glycerine andPEG400 are exhibited good results. The SEM films indicating uniform distribution of the drug with polymers and plasticizers.Keywords
Transdermal Drug Delivery, Diffusion Rate, Eudragit, Risperidone, Plasticizer, HPMC.- Studies on Memory Enhancing Property of Bravobol-A Polyherbal Formulation in Experimentally Induced Alzheimers Disease in Experimental Animals
Abstract Views :184 |
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Authors
Affiliations
1 Department of Pharmacology, Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore, IN
1 Department of Pharmacology, Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 5, No 2 (2015), Pagination: 1-8Abstract
In recent decades, it has become one of the principal pillars of a branch of science called cognitive neuroscience, an interdisciplinary link between cognitive and neuroscience. The objective of this to investigate the neuropsychological effect of a polyherbal formulation Bravobol on learning and memory processes in mice by elevated plus maze and Morris water maze model. Bravobol contains Evolvulus alsinoids (Shankhpushpi), Bacopa monnieri (Brahmi), Withania somnifera (Ashwagandha), Celastrus paniculatus (Malkangani) and Abhrak bhasma. Its effect (250, 500, and 750 mg/kg, p.o.) was tested on learning and memory processes. Activity of Bravobol on acquisition and retention was studied using elevated plus maze model (EPM) and spatial memory using Morris water maze model (MWM) in mice. The results were compared with the vehicle-treated group. Administration of Bravobol (250, 500 and 750 mg/kg, p.o) showed significant reduction in transfer latency in EPM and escape latency in MWM as compared to the control group. Bravobol may act as a memory enhancer formulation and may also be useful as a supportive adjuvant in the treatment of Alzheimers disease.Keywords
Polyherbal Formulation, Elevated Pluz Maze, Moriss Water Maze.- Studies on Memory Enhancing Property of Sumenta-A Polymherbal Formulation in Experimentally Induced Alzhiemers Disease in Experimental Animals
Abstract Views :234 |
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Authors
Affiliations
1 Department of Pharmacology, Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore, IN
1 Department of Pharmacology, Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 7, No 2 (2015), Pagination: 61-67Abstract
Alzheimer is an irreversible, progressive brain disorder related to changes in nerve cells that result in the death of brain cells. The present work is focused on generating scientific data on the nootropic activity of Sumenta, in Alzheimer's induced experimental animals like mice and rats. The objective of the proposed study was to investigate the therapeutic potential of poly herbal formulation Sumenta on Alzheimer's in different animal models. Like Locomotors activity, Hebb's- William maze. Evaluation of nootropic activity was done by using 3 doses of PHFS (250, 500 and 750 mg/kg) in vivo models. Locomotors function test, Hebb's- William maze Hebb's William maze was used for studying learning, memory and reasoning in animals. The clever the rat, the more quickly it is able to make use of past experience and therefore more quickly it learns its way out in the maze. In the present study, we evaluated the effects of SUMENTA on learning, memory and reasoning model using the Hebb's William maze in mice. Drug treated animal group in Hebb's William maze showed transfer latency decrease compared to control. PHFS did not shown any significant changes in locomotors function, its suggested that it has no sedative action. The present study on nootropic activity with PHFS has shown significant nootropic Activity in different animal models.Keywords
Polyherbal Formulation, Locomotion Activity, Hebb's- William Maze, TL.- Antihyperlipidemic Activity in Aqueous Leaf Extract of Ciceracida in Wistar Albino Rats
Abstract Views :161 |
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Authors
Mohibul Hoque
1,
S. Satish
2
Affiliations
1 JJT University, Jhunjhunu, Rajasthan, IN
2 Department of Pharmaceutical Science, JJT University, Jhunjhunu, Rajasthan, IN
1 JJT University, Jhunjhunu, Rajasthan, IN
2 Department of Pharmaceutical Science, JJT University, Jhunjhunu, Rajasthan, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 9, No 3 (2017), Pagination: 142-146Abstract
Hyperlipidemia is a major cause of Atherosclerosis and the atherosclerosis-associated condition such as coronary heart disease ischemic cerebrovascular disease and peripheral vascular disease. The present study was carried out to investigate antihyperlipidemic properties of aqueous leaf extract of ciceracida (ALEC) against hyperlipidemia induced by high fat diet (HFD) in wistar albino rats. Wistar albino rats were divided in 6 groups of 6 rats in each. Group I received normal diet. Group II received high fat diet. Group III received a high fat diet supplemented with simvastatin 4mg/kg. Group IV received high fat diet supplemented with aqueous leaves extract of ciceracida 100 mg/kg. Group V received a high fat diet supplemented with aqueous leaves extract of ciceracida 250 mg/kg and Group VI received a high fat diet supplemented with aqueous leaves extract of ciceracida 500mg/kg for 30 days. At the end of the experiments on the 30th, day blood samples was collected 4 h after the last dose of administration using light ether anesthesia. Blood samples were collected separately from retro orbital sinus puncture into sterilized dry centrifugation tubes. Blood serum was analysed for its hypolipidemic activity. Serum analysis showed decrease cholesterol, triglyceride, low density lipoprotein, very low density lipoprotein, atherogenic index, body weight, food intake and an increase cholesterol excretion and serum high density lipoprotein content was observed in the group III, IV, V and VI rats as compared to the group II rats, and there is no histopatholological alteration in rat aorta was seen. Thus it could be concluded that ALEC is potent antihyperlipidemic activity.Keywords
Ciceracida Leaf, Lipoprotein, Hyperlipidemic Diet, Obesity.References
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- Antidiabetic Activity in Aqueous Leaf Extract of Ciceracida Linn in Alloxan Induced Diabetes Rats Model
Abstract Views :174 |
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Authors
Mohibul Hoque
1,
S. Satish
2
Affiliations
1 JJT University, Jhunjhunu, Rajasthan, IN
2 Department of Pharmaceutical Science, JJT University, Jhunjhunu, Rajasthan, IN
1 JJT University, Jhunjhunu, Rajasthan, IN
2 Department of Pharmaceutical Science, JJT University, Jhunjhunu, Rajasthan, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 9, No 3 (2017), Pagination: 152-156Abstract
Diabetes mellitus is the most common endocrine disorder that impairs glucose homeostatis resulting in severe diabetic complication including retinopathy nephropathy, angiopathy, neuropathy due to perturbation in utilization of glucose. The present study was focused on antidiabetic effect of aqueous leaf extract of ciceracida (ALEC) in alloxan induced diabetic rats using Glibenclimide as a standard. The aqueous leaves extract of ciceracida administered at a dose of 100 mg/kg, 250 mg/kg and 500 mg/kg orally to the diabetic rats for 10 days in acute treatment group, whereas sub acute treatment for 30 days administration was done. In acute treatment group blood glucose level investigation was carried out on 4th, 7th and 10th day similarly in sub acute study animals were tested for blood glucose level on 14th, 21th and 30th day. Both acute and sub acute treatment groups shown reduction in elevated blood glucose level but sub acute treatment groups shown noticeable significant reduction in blood glucose level as compared with the control group. The study concluded that ALEC can be a new clinical significant choice in the treatment of diabetes.Keywords
Ciceracida Leaf, Diabetes, Alloxon, Glibenclamide.References
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- Trease GE, Evans MC. Text book of Pharmacognosy, London, Bailiare Tindall 2003;12:193-336.
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