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Habeeb, Mohammad
- Development Characterization and Molecular Simulation Studies Of Metoclopramide Hcl and Tramadol Hcl Bilayer Tablets
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Authors
Mohammad Habeeb
1,
K. L. Deepthi
2,
M. Vijaya Vara Prasad
3,
N. Irfan
3,
Shaik Liakhat Ali
4,
K. Navyaja
5
Affiliations
1 Department of Pharmaceutics, Crescent School of Pharmacy, B.S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai,, IN
2 Department of Pharmaceutics, Raghu college of Pharmacy, Visakhapatnam, AndhraPradesh,, IN
3 Department of Pharmaceutical Chemistry, Crescent School of Pharmacy, B.S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai, Tamilnadu,, IN
4 Department of Pharmacology, Vignan Pharmacy college, Vadlamudi,Guntur, Andhra Pradesh., IN
5 Department of Pharmacognosy, Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam, Tirupati, Andhra Pradesh,, IN
1 Department of Pharmaceutics, Crescent School of Pharmacy, B.S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai,, IN
2 Department of Pharmaceutics, Raghu college of Pharmacy, Visakhapatnam, AndhraPradesh,, IN
3 Department of Pharmaceutical Chemistry, Crescent School of Pharmacy, B.S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai, Tamilnadu,, IN
4 Department of Pharmacology, Vignan Pharmacy college, Vadlamudi,Guntur, Andhra Pradesh., IN
5 Department of Pharmacognosy, Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam, Tirupati, Andhra Pradesh,, IN
Source
Research Journal of Pharmacy and Technology, Vol 15, No 2 (2022), Pagination: 529-534Abstract
This work mainly aimed to develop bilayer tablets of drug Metoclopramide HCl and Tramadol HCl with the aid of various polymers such as Guar gum, HPMC, Na CMC and Xanthan gum, either alone or in mixtures. Tablets were ready by instant unleash direct compression and sustained release wet granulation methodology and assessed for numerous physical parameters. The drug unleashes studies were performed exploitation USP equipment sort exploitation zero. 1N HCl and pH scale 6.8 phosphate buffers as dissolution medium. Drug unleash was quicker from Metoclopramide layer and tramadol combination with HPMC, Na CMC, Guargum with Xanthan gum it continuous drug unleash efficiently. The fitting the dissolution approach, initial order, Hixson Crowell and Higuchi, Korsmeyer-Peppas equations were used to analyze the speed and unleash mechanism of Tramadol HCl. Results showed that zero-order unleash Mechanism was followed by F1-F10 formulations. The plots (Higuchi) for all the designs remained rectilinear representing the drug unleash by diffusion controlled. Hixon-Crowell root model showed high r2 price proportion because of hydrophobicity of the gel layer erosion. The discharge configuration, consequences of the in-vitro dissolution information stood fitted to the Korsmeyer-Peppas equation that illustrates the delivery mechanism directs the non fickian transport it confers with a combination of each diffusion and erosion rate delivery. The results concluded that the formulation F10 will improve patient compliance in pain and gastro esophageal reflex and also provides higher wellness management.Keywords
Metoclopramide, Tramadol HCl, Metoclopramide HCl, Bilayer, Molecular simulation.References
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- Investigation of Wrightia Tinctoria Extract Activity on Alopecia Using In-silco And In-vivo Studies
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh,, IN
2 Department of Pharmaceutical Chemistry, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh,, IN
3 Department of Pharmaceutics, Crescent School of Pharmacy, B.S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai, Tamilnadu,, IN
1 Department of Pharmaceutical Chemistry, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh,, IN
2 Department of Pharmaceutical Chemistry, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh,, IN
3 Department of Pharmaceutics, Crescent School of Pharmacy, B.S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai, Tamilnadu,, IN
Source
Research Journal of Pharmacy and Technology, Vol 15, No 2 (2022), Pagination: 643-649Abstract
There are many drugs for alopecia such as minoxidil, glucocorticoids, sulfasalazine, nitric oxide, and vitamin D3. Hair loss is also known as alopecia, or baldness commonly refers to hair loss from either a portion of a head or body. Fresh Leaves, and bark from twigs of Wrightia tinctoria were taken and used for extraction. A phytochemical assessment was continued to carry out on W.tinctoria extract and the presence of aromatic hydrogen and aromatic protons was demonstrated by spectral characterization. Insilco studies were done. Compounds 1and6 shown more docking values than the minoxidil and Swiss ADME confirmed that the compounds can enter the blood-brain barrier and not the substrates of PgP carriers. In vivo evaluation of alopecia activity using albino male, Wistar rats were done by comparing it with standard drug involves the evaluation of in vivo hair development activities of W.tinctoria extract. It also involves histopathological studies which include the action of hair growth at anagen and telogen phases on 15th and 30th day. The study indicates that the material elements of W.tinctoria which include Quercetin and Indirubin playing a critical role in hair promoting activity.Keywords
Wrightia tinctoria, Alopecia, Coconut oil, Minoxidil, Anagen phase, Telogen phase.References
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