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Khaleel, Mohamed
- Evaluation of Adaptogenic Activity of Moringa Oleifera Lam
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Authors
Affiliations
1 M.M.U. College of Pharmacy, K. K. Doddi, Dist-Ramanagara-571511, Karnataka, IN
1 M.M.U. College of Pharmacy, K. K. Doddi, Dist-Ramanagara-571511, Karnataka, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 2, No 3 (2010), Pagination: 243-247Abstract
Moringa oleifera Lam. (Moringaceae) is an medicinal plant used in the treatment of many clinical conditions in India. Its adaptogenic activity have been investigated in this study using albino mice and rats. The ethanolic extract of Moringa oleifera leaves was prepared and subjected to preliminary qualitative phytochemical screening. Glycosides, phytosterols, tannins and amino acids were found to be present. Acute toxicity studies were carried out in albino mice. The ethanolic extract did not show the lethal effect upto the doses of 2000mg/kg body weight with no signs of abnormalities or any mortality observed for 14 days period under observation after single dose of drug administration. The parameters studied were swimming endurance, cold-restraint induced ulcer, and effect of coldrestraint stress on adrenocortical activity and weights of organs like liver, spleen, adrenal glands. Geriforte was used as a standard adaptogenic drug, which is a commercial preparation of Himalaya Drugs Company. The results indicate that pretreatment with ethanolic extract of leaves of Moringa oleifera exhibited significant adaptogenic activity at the tested doses of 200 mg/kg and 400 mg/kg body weight. On the basis of results, it was concluded that Moringa oleifera possess adptogenic activity.Keywords
Adaptogenic, Cold-Restraint Stress, Moringa oleifera, Swimming Endurance.
References
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- Transdermal Drug Delivery System of Salbutamol Sulphate:Formulation and Evaluation
Abstract Views :376 |
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Authors
Affiliations
1 Dept. of Pharmaceutics, M.M.U College of Pharmacy, K. K. Doddi, Dist- Ramanagara- 571511, Karnataka, IN
2 Department of Pharmaceutical Chemistry, M.M.U College of Pharmacy, K. K. Doddi, Dist. Ramanagara- 571511, Karnataka, IN
1 Dept. of Pharmaceutics, M.M.U College of Pharmacy, K. K. Doddi, Dist- Ramanagara- 571511, Karnataka, IN
2 Department of Pharmaceutical Chemistry, M.M.U College of Pharmacy, K. K. Doddi, Dist. Ramanagara- 571511, Karnataka, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 1 (2010), Pagination: 56-61Abstract
Salbutamol Sulphate (SS) is a selective 2 adrenergic receptor agonist having oral bioavailability of 50%. The transdermal films of SS were formulated using solvent casting technique. Solutions containing polymers i.e. Hydroxy Propyl Methyl Cellulose (HPMC) and Ethyl Cellulose (EC) at different concentrations (1%, 1.5%, 2%, 2.5%, and 3%) were prepared. These solutions were then used to prepare films. Prepared films were then evaluated for their different physicochemical parameters like physical appearance, weight variation, thickness, drug content, folding endurance, tensile strength, percent elongation and finally in vitro release study across rat abdominal skin. Between the two polymers used results revealed that the films prepared by using 2% HPMC with 30% propylene glycol(PG) was very flexible with high folding endurance and uniform drug content, further release study showed 88.68% release across the rat abdominal skin for 24 hours.
Keywords
Salbutamol, Asthma, Bronchitis.- Development of a New, Simple, Sensitive and Cost-Effective Method for Estimation of Atenolol in Formulation and Bulk
Abstract Views :420 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutical Chemistry. M.M.U College of Pharmacy, K. K. Doddi, Dist. Ramanagara- 571511, Karnataka, IN
2 Department of Pharmaceutical Chemistry, M.M.U College of Pharmacy, K, K, Doddi, Dist. Ramanagara- 571511, Karnataka, IN
1 Department of Pharmaceutical Chemistry. M.M.U College of Pharmacy, K. K. Doddi, Dist. Ramanagara- 571511, Karnataka, IN
2 Department of Pharmaceutical Chemistry, M.M.U College of Pharmacy, K, K, Doddi, Dist. Ramanagara- 571511, Karnataka, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 1 (2010), Pagination: 72-76Abstract
Atenolol is selective 1- adrenergic receptor blocking agent with insignificant partial agonist activity and weak membrane stabilizing properties. Atenolol is official in Indian Pharmacopoeia (IP) and British Pharmacopoeia (BP) and the official method for its assay is by nonaqueous titration. Literature survey revealed non-aqueous titration used for the assay of pure drug and in formulations, High Performance Liquid Chromatography (HPLC) and Gas Liquid Chromatography (GLC) methods for the determination of this drug from serum&urine and Colorimetric and Spectrophotometric methods to estimate this drug in its formulations. But the titrimetric method suffers from various drawbacks and is not satisfactory for pharmaceutical products. This prompted us to develop a newer, simple and cost-effective method for estimation of Atenolol in formulation and bulk. This method is based upon the reaction of Atenolol with dinitrofluorobenzene in acetone in presence of borax and dioxane to develop a yellow colour which is then determined spectrophotometrically at 389 nm (λ max of the complex formed). A series of dilutions containing atenolol 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34 μg /ml were prepared among which linearity showed at the range of 2-24 μg/ml. Calibration plot was obtained by using above dilutions. By using the calibration plot the amount of atenolol present in tablet formulation and bulk was found out and the results were satisfactory and encouraging.
Keywords
Atenolol, Spectrophotometric Determination,λ Max, Calibration Curve.- Estimation and Validation of Bilastine in Pharmaceutical Dosage Form and in Bulk Drug by Spectrophotometric Method
Abstract Views :246 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutical Chemistry, M.M.U College of Pharmacy, Ramanagar - 562159 Karnataka, India ., IN
2 Department of Pharmaceutical Chemistry, M.M.U College of Pharmacy, Ramanagar - 562159 Karnataka, India., IN
1 Department of Pharmaceutical Chemistry, M.M.U College of Pharmacy, Ramanagar - 562159 Karnataka, India ., IN
2 Department of Pharmaceutical Chemistry, M.M.U College of Pharmacy, Ramanagar - 562159 Karnataka, India., IN
Source
Asian Journal of Research in Chemistry, Vol 15, No 4 (2022), Pagination: 279 - 283Abstract
A simple, sensitive, accurate, rapid and economical Spectrophotometric method was developed for estimation and validation of Bilastine in pure drug and tablet dosage form. The absorbance was measured at 226.2nm using Methanol as solvent system. It obeyed Beer’s law at the concentration range of 2-12µg/ml with coefficient of correlation (r2) of 0.9993. Limit of detection (LOD) was found to be 1.224µg/ml and Limit of quantitation (LOQ) was found to be 4.088µg/ml. The proposed analytical method was validated according to ICH guidelines, yielded good results concerning range, linearity, precision, accuracy, robustness and ruggedness.Keywords
Bilastine, Antihistamine, Spectrophotometry, Methanol, method validation.References
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