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Shrivastava, Meena
- Role of Ascorbic Acid Supplementation on Prevention of Olanzapine Induced Metabolic Side Effects in Schizophrenic Patients
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Authors
Affiliations
1 Department of Pharmacology. Smt. Kashibai Navale Medical College & Hosp. Narhe Campus, Dhayari Phata, Pune-411041, IN
2 Department of Pharmacology Indira Gandhi Govt. Medical College, Nagpur, IN
3 Department of Psychiatry Indira Gandhi Govt. Medical College, Nagpur, IN
1 Department of Pharmacology. Smt. Kashibai Navale Medical College & Hosp. Narhe Campus, Dhayari Phata, Pune-411041, IN
2 Department of Pharmacology Indira Gandhi Govt. Medical College, Nagpur, IN
3 Department of Psychiatry Indira Gandhi Govt. Medical College, Nagpur, IN
Source
Indian Journal of Public Health Research & Development, Vol 2, No 1 (2011), Pagination: 12-16Abstract
Schizophrenia is one of the most debilitating disorders with devastating effects on its victims and their families. Atypical antipsychotics (AAPs) because of their superior efficacy, reduced side effects,&better compliance, have rapidly become the mainstay of treatment. However, these AAPs have unique side effect profile like weight gain, hyperglycemia, and hyperlipidemia. Although preliminary data suggest benefit of vitamin C in improving the lipid and glucose dysregulation, whether vitamin C as an antioxidant has any effect on improving drug induced metabolic derangements has not been clarified yet. Therefore, this prospective clinical trial has been carried out to determine the impact of vitamin C as an antioxidant in modifying these parameters in schizophrenic patients. Among 30 newly diagnosed DSM-IV patients of schizophrenia enrolled, mean body weight, BMI, blood sugar, and lipid profile were significantly increased from baseline to 6 and 12 weeks after treatment with olanzapine(p <0.001). However, there were no statistically significant differences in these parameters between patients who received only olanzapine and those who received both olanzapine and vitamin C. Thus, vitamin C as an antioxidant does not modify the metabolic side effect profile of olanzapine.Keywords
Schizophrenia, Olanzapine, Vitamin C, Blood Sugar, Lipid Profile
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- The Psychomotor Effects of Levocetirizine - a Second Generation Antihistamine in Healthy Volunteers
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Authors
Affiliations
1 Pharmacology Rajiv Gandhi Institute of Medical Sciences (RIMS) Adilabad A.P., IN
2 Pharmacology Rajiv Gandhi Institute of Medical Sciences (RIMS) Adilabad, A.P., IN
3 Pharmacology Wasantrao Naik Medical College Yeotmal, M.S., IN
4 Pharmacology Indira Gandhi Government Medical College Nagpur, M.S., IN
1 Pharmacology Rajiv Gandhi Institute of Medical Sciences (RIMS) Adilabad A.P., IN
2 Pharmacology Rajiv Gandhi Institute of Medical Sciences (RIMS) Adilabad, A.P., IN
3 Pharmacology Wasantrao Naik Medical College Yeotmal, M.S., IN
4 Pharmacology Indira Gandhi Government Medical College Nagpur, M.S., IN
Source
Indian Journal of Public Health Research & Development, Vol 2, No 1 (2011), Pagination: 44-47Abstract
Background
Levocetirizine, a new second generation antihistamine which is claimed to be non-sedative in western studies is an R-enantiomer of cetirizine. In Indian context there is little literature available about its impact on psychomotor performance. That's why present study was planned to exclude the possibility of adverse effect of levocetirizine on psychomotor performance in Indian conditions.
Materials and methods
In this double blind, placebo controlled, cross over study, 24 healthy volunteers performed various objective and subjective psychometric test after single dose of levocetirizine 5 mg, chlorpheniramine 4 mg or placebo at 0hrs, 2hrs and 4 hrs intervals. The test battery included was - six digit cancellation test, digit symbol substitution test, arithmetic ability, critical flicker fusion, serial verbal learning, hand steadiness test and three different visual analogue scales.
Results
In the present study levocetirizine was statistically similar with chlorpheniramine on six digit cancellation test (p value <0.05), however it did not impair any other psychomotor performance test and was similar to placebo. Chlorpheniramine impaired performance significantly on all the objective and subjective psychomotor test at both time intervals.
Conclusion
It can be concluded that levocetirizine in 5mg dose is free from the negative effects of the previous generation of antihistamines and do not impair psychomotor performance in Indian conditions also.
Keywords
Levocetirizine, Six Digit Cancellation Test, Psychomotor PerformanceReferences
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