Refine your search
Collections
Co-Authors
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Arshad, Md
- Role of Interleukin-I Super Family in Progression of Osteoarthritis
Abstract Views :224 |
PDF Views:129
Authors
Amit Kumar
1,
Md Arshad
2,
Ajai Singh
3,
Asif Jafri
4,
Sabir Ali
5,
Manish Yadav
5,
Suchit Swaroop
1
Affiliations
1 Experimental and Public Health Laboratory, Department of Zoology, University of Lucknow, Lucknow – 226007, IN
2 Molecular Endocrinology Lab, Department of Zoology, University of Lucknow, Lucknow-226007, IN
3 Department of Orthopaedics, King George Medical University, Lucknow – 226003, IN
4 Molecular Endocrinology Lab, Department of Zoology, University of Lucknow, Lucknow – 226007, IN
5 Department of Orthopedics, King George Medical University, Lucknow – 226003, IN
1 Experimental and Public Health Laboratory, Department of Zoology, University of Lucknow, Lucknow – 226007, IN
2 Molecular Endocrinology Lab, Department of Zoology, University of Lucknow, Lucknow-226007, IN
3 Department of Orthopaedics, King George Medical University, Lucknow – 226003, IN
4 Molecular Endocrinology Lab, Department of Zoology, University of Lucknow, Lucknow – 226007, IN
5 Department of Orthopedics, King George Medical University, Lucknow – 226003, IN
Source
Journal of Ecophysiology and Occupational Health, Vol 17, No 1-2 (2017), Pagination: 9-16Abstract
Osteoarthritis (OA) is considered as multifactorial disorder characterized by erosion of articular cartilage, tightening of joint space, subchondral bone remodelling and internal synovial inflammation. OA reduces joint function progressively as a person gets older. The most important group of the cytokines or chemokines are pre-dominantly involving in the early progression of the disease includes IL-1, IL-6, IL-18 and TNF-a, etc. IL-1 family of cytokines are known to be strongest stimulus for progressive synthesis of Matrix Metallo Proteinases (MMPs). Large number of immune cells, chondrocytes and endothelial cells potentially secrete IL-1 with diverse effect on number of diseases. This review highlights the association of IL-1 family cytokine in OA.Keywords
Cytokine, IL-1 Family, Mode of Action, Osteoarthritis.Full Text
- Association of Cytokine TNF-α in Development of Osteoarthritis: A Comprehensive Study
Abstract Views :242 |
PDF Views:119
Authors
Affiliations
1 Department of Zoology, Experimental and Public Health Laboratory, University of Lucknow, Lucknow − 226007, IN
2 Department of Zoology, Molecular Endocrinology Lab, University of Lucknow, Lucknow − 226007, IN
3 Department of Orthopaedics, King George Medical University, Lucknow − 226003, IN
1 Department of Zoology, Experimental and Public Health Laboratory, University of Lucknow, Lucknow − 226007, IN
2 Department of Zoology, Molecular Endocrinology Lab, University of Lucknow, Lucknow − 226007, IN
3 Department of Orthopaedics, King George Medical University, Lucknow − 226003, IN
Source
Journal of Ecophysiology and Occupational Health, Vol 18, No 3-4 (2018), Pagination: 117-121Abstract
Osteo-Arthritis (OA) is a disease of joints affecting the normal functions of joint and causes physical disability. Many factors are responsible for development of osteoarthritis including over age, obesity, gender, drug abuse, over load on joints and genetic factors. OA causes health problems and impairs the quality of life with increased economic burden across the world. Apart from the pro-inflammatory role of cytokine Interleukin-1 (IL-1) in osteoarthritis, Tumor necrosis factor-alpha (TNF-α) is also involved in the progression of osteoarthritis. Members of TNF family are secreted from lymphocytes and natural killer cells but in OA patients it is also secreted from chondrocyte cells to influence the catabolic processes in Extra Cellular Matrix (ECM) by inducing the activity of matrix metaloproteinases (MMPs). In promoter region, most of the Single nucleotide polymorphisms (SNPs) of TNF-α located on -863, -857, -308, and -238. These SNPs are involved in various diseases including OA, rheumatoid Arthritis, systemic lupus erythematosus etc. Significance association of SNP -G308A of the TNF-α gene in OA has been observed in various studies. Aim of this mini review is to conclude the fundamental roles of TNF-α cytokine in patients with OA.Keywords
Cytokine, Gene Variants, Osteoarthritis, Pathophysiology, TNF-α.Full Text
References
- Kumar A, Arshad M, Singh A, Jafri A, Ali S, Yadav M, Swaroop S. Role of Interleukin-1 Super Family in Progression of Osteoarthritis, Journal of Ecophysiology and Occupational Health. 2017; 17:9−16.
- Galil SMA, Ezzeldin N, Fawzy F, El-Boshy M. The SingleNucleotide Polymorphism (SNP) of tumor necrosis factor α− 308G/A gene is associated with early-onset primary knee osteoarthritis in an Egyptian female population, Clinical Rheumatology. 2017; 36:2525−30. https://doi.org/10.1007/s10067-017-3727-1. PMid: 28695434.
- Aoki Y, Ohtori S, Ino H, Douya H, Ozawa T, Saito T, Takahashi K. Disc inflammation potentially promotes axonal regeneration of dorsal ischolar_main ganglion neurons innervating lumbar intervertebral disc in rats, Spine. 2004; 29:2621−26. https://doi.org/10.1097/01.brs.0000146051.11574.b4. PMid:15564910.
- Ji B, Shi J, Cheng X, Zhou J, Zhou Q, Cao C, Pang J. Association analysis of two candidate polymorphisms in the tumour necrosis factor-α gene with osteoarthritis in a Chinese population, International Orthopaedics. 2013; 37:2061−63. https://doi.org/10.1007/s00264-013-1931-4. PMid: 23748461, PMCid: PMC3779584.
- Bodmer JL, Schneider P, Tschopp J. The molecular architecture of the TNF superfamily, Trends in Biochemical Sciences. 2002; 27:19−26. https://doi.org/10.1016/S0968-0004(01)01995-8.
- Varfolomeev E, Goncharov T, Fedorova AV, Dynek JN, Zobel K, Deshayes K, Vucic D. c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor α (TNFα)-induced NF-κB activation, Journal of Biological Chemistry. 2008; 283:24295−99. https:// doi.org/10.1074/jbc.C800128200. PMid: 18621737, PMCid: PMC3259840.
- Farahat MN, Yanni G, Poston R, Panayi GS. Cytokine expression in syno-vial membranes of patients with rheumatoid arthritis and osteoarthritis, Annals of the Rheu-Matic Diseases. 1993; 52:870. https://doi.org/10.1136/ard.52.12.870.
- Fernandes JC, Martel‐Pelletier J, Pelletier JP. The role of cytokines in os-teoarthritis pathophysiology, Biorheology. 2002; 39:237−46. PMid: 12082286.
- Guerne PA, Carson DA, Lotz M. IL-6 production by human articular chon-drocytes.Modulation of its synthesis by cytokines, growth factors, and hormones in vitro, The Journal of Immunology. 1990; 144:499−505. PMid: 2104896.
- Joos H, Wildner A, Hogrefe C, Reichel H, Brenner RE. Interleukin-1 beta and tumor necrosis factor alpha inhibit migration activity of chondrogenic progenitor cells from non-fibrillated osteoarthritic cartilage, Arthritis Research and Therapy. 2013; 15:R119. https://doi.org/10.1186/ar4299. PMid: 24034344, PMCid: PMC3978440.
- Idriss HT, Naismith JH. TNFα and the TNF receptor superfamily: Struc-ture‐function relationship (s)”, Microscopy Research and Technique. 2000; 50:184−95. https://doi.org/10.1002/10970029(20000801)50:3<184::AID-JEMT2>3.0.CO;2-H.
- Hajeer AH, Hutchinson IV. TNF‐α gene polymorphism: Clinical and bio-logical implications, Microscopy Research and Technique. 2000; 50:216−28. https://doi.org/10.1002/10970029(20000801)50:3<216::AID-JEMT5>3.0.CO;2-Q.
- Han L, Song JH, Yoon JH, Park YG, Lee SW, Choi YJ, ... Park WS. TNF-α and TNF-β Polymorphisms are Associated with Susceptibility to Osteoarthri-tis in a Korean Population, Korean Journal of Pathology. 2012; 46:30. https://doi.org/10.4132/KoreanJPathol.2012.46.1.30. PMid: 23109975, PMCid: PMC3479703.
- Campbell J, Ciesielski CJ, Hunt AE, Horwood NJ, Beech JT, Hayes LA, ... Foxwell BM. A novel mechanism for TNF-α regulation by p38 MAPK: In-volvement of NF-κB with implications for therapy in rheumatoid arthritis, The Journal of Immunology. 2004; 173:6928−37. https://doi.org/10.4049/jimmunol.173.11.6928. PMid: 15557189.
- Xue J, Wang J, Liu Q, Luo A. Tumor necrosis factor-α induces ADAMTS-4 expression in human osteoarthritis chondrocytes, Molecular Medicine Reports. 2013; 8:1755−60. https://doi.org/10.3892/mmr.2013.1729. PMid: 24126638.
- Marcu BK, Otero M, Olivotto E, Maria Borzi R, Goldring BM. NF-κB sig-naling: Multiple angles to target OA, Current Drug Targets. 2010; 11:599−613. https://doi.org/10.2174/138945010791011938. PMid: 20199390, PMCid: PMC3076145
- Kalichman L, Hernández-Molina G. Hand osteoarthritis: An epidemiological perspective, In Seminars in Arthritis and Rheumatism. 2010; 39:465−76. https://doi.org/10.1016/j.semarthrit.2009.03.001. PMid: 19482338.
- Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP, Fahmi H. Role of proinflammatory cytokines in the pathophysiology of osteoarthritis, Nature Reviews Rheu-matology. 2011; 7:33. https://doi.org/10.1038/nrrheum.2010.196. PMid: 21119608.
- Kou S, Wu Y. Meta-analysis of tumor necrosis factor alpha308 polymorphism and knee osteoarthritis risk, BMC Musculoskeletal Disorders. 2014; 15:373. https://doi.org/10.1186/1471-2474-15-373. PMid: 25398219, PMCid: PMC4289255.
- Krasnokutsky S, Attur M, Palmer G, Samuels J, Abramson SB. Current concepts in the pathogenesis of osteoarthritis, Osteoarthritis and Cartilage. 2008; 16:S1−S3. https://doi.org/10.1016/j.joca.2008.06.025. PMid: 18723377.
- O’Donnell MA, Legarda-Addison D, Skountzos P, Yeh WC, Ting AT. Ubiquitination of RIP1 regulates an NF-κB-independent cell-death switch in TNF signal-ing, Current Biology. 2007; 17:418−24. https://doi.org/10.1016/j.cub.2007.01.027. PMid: 17306544, PMCid: PMC1868513.
- Grell M, Douni E, Wajant H, Löhden M, Clauss M, Maxeiner B, ... Scheurich P. The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor, Cell. 1995; 83:793−802. https://doi.org/10.1016/0092-8674(95)90192-2.
- Lopez-Armada MJ, Carames B, Martin MA, Cillero-Pastor B, Lires-Dean M, Fuentes-Boquete I, ... Blanco FJ. Mitochondrial activity is modulated by TNFα and IL-1β in normal human chondrocyte cells, Osteoarthritis and Cartilage. 2006;14:1011−22. https://doi.org/10.1016/j.joca.2006.03.008. PMid: 16679036.
- Rodríguez M, Cabal-Hierro L, Carcedo MT, Iglesias JM, Artime N, Darnay BG, Lazo PS. NF-κB signal triggering and termination by tumor necrosis factor re-ceptor 2, Journal of Biological Chemistry. 2011; 286:22814−24. https://doi.org/10.1074/jbc.M111.225631. PMid: 21558270, PMCid: PMC3123049.
- Steenvoorden MMC, Bank RA, Ronday HK, Toes REM, Huizinga TWJ, DeGischolar_main J. Fibroblast-like synoviocyte-chondrocyte interaction in cartilage degra-dation, Clinical and Experimental Rheumatology. 2007; 25:239. PMid: 17543148.
- Munoz-Valle JF, Oregón-Romero E, Rangel-Villalobos H, Martínez-Bonilla GE, Casta-eda-Saucedo E, Salgado-Goytia L, ...Parra-Rojas I. High expression of TNF alpha is associated with− 308 and− 238 TNF alpha polymorphisms in knee osteoarthri-tis, Clinical and Experimental Medicine. 2014; 14:61−67. https://doi.org/10.1007/s10238-012-0216-3. PMid: 23108479.
- Nakajima M, Takahashi A, Kou I, Rodriguez-Fontenla C, GomezReino JJ, Furuichi T, ... Kubo M. New sequence variants in HLA class II/III region associated with susceptibility to knee osteoarthritis identified by genome-wide association study, PloS One. 2010; 5:e9723. https://doi.org/10.1371/journal.pone.0009723. PMid: 20305777, PMCid: PMC28411.
- Micheau O, Tschopp J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes, Cell. 2003; 114:181−90. https://doi.org/10.1016/S0092-8674(03)00521-X.
- Verma P, Dalal K. ADAMTS‐4 and ADAMTS‐5: Key enzymes in osteoarthri-tis, Journal of Cellular Biochemistry. 2011; 112:3507−14. https://doi.org/10.1002/jcb.23298. PMid: 21815191.
- Thomas DP, King B, Stephens T, Dingle JT. In vivo studies of cartilage regeneration after damage induced by catabolin/interleukin-1, Annals of the Rheumatic Dis-eases. 1991; 50:75−80. https://doi.org/10.1136/ard.50.2.75.
- Hämäläinen S, Solovieva S, Vehmas T, Leino-Arjas P, Hirvonen A. Variations in the TNFα gene and their interactions with the IL4R and IL10 genes in relation to hand osteoarthritis, BMC Musculoskeletal Disorders. 2014; 15:311. https://doi.org/10.1186/1471-2474-15-311. PMid: 25252624, PMCid: PMC4181701.
- Schäfers M, Marziniak M, Sorkin LS, Yaksh TL, Sommer C. Cyclooxy-genase inhibition in nerve-injury-and TNFinduced hyperalgesia in the rat, Experimental Neurology. 2004; 185:160−68. https://doi.org/10.1016/j.expneurol.2003.09.015. PMid: 14697327
- Shi, D., Zheng, Q., Chen, D., Zhu, L., Qin, A., Fan, J., ...&Xu, J. (2010) “Association of sin-gle-nucleotide polymorphisms in HLA class II/III region with knee osteoarthri-tis”, Osteoarthritis and cartilage, 18, 1454-1457. https://doi.org/10.1016/j.joca.2010.07.009. PMid: 20691797.
- Sommer C, Kress M. Recent findings on how proinflammatory cytokines cause pain: peripheral mechanisms in inflammatory and neuropathic hyperalgesia, Neuroscience Letters. 2004; 361:184−87. https://doi.org/10.1016/j.neulet.2003.12.007. PMid: 15135924.
- Haas TL, Emmerich CH, Gerlach B, Schmukle AC, Cordier SM, Rieser E, ... Koschny R. Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction, Molecular Cell. 2009; 36:831−44. https://doi.org/10.1016/j.molcel.2009.10.013. PMid:20005846.
- Wilson AG, Symons JA, McDowell TL, McDevitt HO, Duff GW. Ef-fects of a polymorphism in the human tumor necrosis factor α promoter on transcriptional activation, Proceedings of the National Academy of Sciences. 1997; 94:3195−99. https://doi.org/10.1073/pnas.94.7.3195.
- Yoshihara Y, Nakamura H, Obata KI, Yamada H, Hayakawa T, Fujikawa K, Okada Y. Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids from patients with rheumatoid arthritis or osteoarthritis, Annals of the Rheu-Matic Diseases. 2000; 59:455−61. https://doi.org/10.1136/ard.59.6.455. PMCid:PMC1753174.
- Zhou Z, Connell MC, MacEwan DJ. TNFR1-induced NF-κB, but not ERK, p38MAPK or JNK activation, mediates TNF-induced ICAM-1 and VCAM-1 expression on endothelial cells, Cellular Signalling. 2007; 19:1238−48. https://doi.org/10.1016/j.cellsig.2006.12.013. PMid: 17292586.
- Synthetic Modulation Including Structure Establishment, Antiproliferative Activity of Some p-Aryl Substituted (Z)-2-Cyanoethylideneacetohydrazides, and their Structure Activity Relationship
Abstract Views :229 |
PDF Views:81
Authors
Deepak Chowrasia
1,
Nisha Sharma
1,
Ajay Kumar
1,
Md Arshad
2,
Sahabjada Siddiqui
2,
Asif Jafri
2,
Juhi Rahis
2
Affiliations
1 University Institute of Pharmacy, Chhatrapati Shahu ji Maharaj (CSJM) University, Kalyanpur, Kanpur 208 024, IN
2 Department of Zoology, Lucknow University, Lucknow 226 007, IN
1 University Institute of Pharmacy, Chhatrapati Shahu ji Maharaj (CSJM) University, Kalyanpur, Kanpur 208 024, IN
2 Department of Zoology, Lucknow University, Lucknow 226 007, IN
Source
Current Science, Vol 115, No 12 (2018), Pagination: 2287-2290Abstract
A series of p-substituted aryl-2-cyanoethylideneacetohydrazides derivatives (2a-j) were successfully synthesized in the laboratory (yield 60–80%). The synthesized compounds were screened for their antiproliferative activity against MCF-7 (estrogen dependent human breast cancer cell line), SaOS-2 (osteosarcoma cell line), and K562 (myeloid leukemia cell line) by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide) reduction assay. They showed moderate to mild antiproliferative activity, (2j) being the most potent in the series with an IC50 55, 64 and 35 μM against MCF-7, SaOS-2 and K562 cell lines, depict p-nitro as a better antiproliferative substituent comparatively. We have also tested the hypothesis – ‘Electron withdrawing phenomenon affects antiproliferative activity’.Keywords
Cancer, Cyanoacetohydrazide, Electron Withdrawing Ring Substituent, MTT Assay.Full Text
References
- http://www.who.int/cancer
- Filippova, M. et al., The small splice variant of HPV1 reduces tumor formation in cervical carcinoma xenografts, Virology, 2014, 450, 153–164.
- Murray, R. K., Granner, D. K., Mayes, P. A. and Rhodwell, V. W., Cancer, Cancer genes, and Growth Factor, Harper’s Biochemistry; Appleton and Lange; 1996, 24th edn.
- Park, J. H., El-Gamal, M. I., Lee, Y. S. and Oh, C. H., New imidazo[ 2,1-b]thiazole derivatives: synthesis, in vitro anticancer evaluation, and in silico studies. Eur. J. Med. Chem., 2011, 46, 5769– 5777.
- Banimustafa, M., Kheirollahi, A., Safavi, M., Ardestani, S. K., Aryapour, H., Foroumadi, A. and Emami, S., Synthesis and biological evaluation of 3-(trimethoxyphenyl)-2(3H)-thiazole thiones as combretastatin analogs. Eur. J. Med. Chem., 2013, 70, 692–702.
- Chavva, K. et al., Synthesis and biological evaluation of novel alkyl amide functionalized trifluoromethyl substituted pyrazolo[3,4b]pyridine derivatives as potential anticancer agents. Bioorg. Med. Chem. Lett., 2013, 23, 5893–5895.
- Liu, H. et al., Synthesis, preliminary structure – activity relationships, and in vitro biological evaluation of 6-aryl-3-aminothieno[ 2,3-b]pyridine derivatives as potential anti-inflammatory agents. Bioorg. Med. Chem. Lett., 2013, 23, 2349–2352.
- Pandey, J., Pal, R., Dwivedi, A. and Hajela, K., Synthesis of some new diaryl and triaryl hydrazone derivatives as possible estrogen receptor modulators. Arzneimittelforschung, 2002, 52, 39–44.
- Abadi, A. H., Eissa, A. A. H. and Hassan, G. S., Synthesis of novel 1,3,4-trisubstituted pyrazole derivatives and their evaluation as antitumor and antiangiogenic agents. Chem. Pharm. Bull., 2003, 51, 838–844.
- Terzioğlu, N. and Gürsoy, A., Synthesis and anticancer evaluation of some new hydrazone derivatives of 2,6-dimethylimidazo[2,1b]-[1,3,4]thiadiazole-5-carbohydrazide. Eur. J. Med. Chem., 2003, 38, 781–786.
- Gürsoy, A. and Karali, N., Synthesis and primary cytotoxicity evaluation of 3-[[(3-phenyl-4(3H)-quinazolinone-2-yl)mercaptoacetyl] hydrazono]-1H-2-indolinones. Eur. J. Med. Chem., 2003, 38, 633–643.
- Savini, L., Chiasserini, L., Travagli, V., Pellerano, C., Novellino, E., Cosentino, S. and Pisano, M. B., New α-heterocyclichydrazones: evaluation of anticancer, anti-HIV and antimicrobial activity. Eur. J. Med. Chem.. 2004, 39, 113–122.
- Zhang, H., Drewe, J., Tseng, B., Kasibhatla, S. and Cai, S. X., Discovery and SAR of indole-2-carboxylic acid benzylidenehydrazides as a new series of potent apoptosis inducers using a cellbased HTS assay. Bioorg. Med. Chem., 2004, 12, 3649–3655.
- Demirbas, N., Karaoglu, S., Demirbas, A. and Sancak, K., Synthesis and antimicrobial activities of some new 1-(5-phenylamino[1,3,4]thiadiazol-2-yl)methyl-5-oxo-[1,2,4]triazole and 1-(4phenyl-5-thioxo-[1,2,4]triazol-3-yl)methyl-5-oxo-[1,2,4]triazole derivatives. Eur. J. Med. Chem., 2004, 39, 793–804.
- Cocco, M. T., Congiu, C., Lilliu, V. and Onnis, V., Synthesis and in vitro antitumoral activity of new hydrazinopyrimidine5-carbonitrile derivatives. Bioorg. Med. Chem., 2005, 14, 366– 372.
- Gürsoy, E. and Güzeldemirci-Ulusoy, N., Synthesis and primary cytotoxicity evaluation of new imidazo[2,1-b]thiazole derivatives. Eur. J. Med. Chem., 2007, 42, 320–326.
- Rahman, V. M., Mukhtar, S., Ansari, W. H. and Lemiere, G., Synthesis, stereochemistry and biological activity of some novel long alkyl chain substituted thiazolidin-4-ones and thiazan-4-one from 10-undecenoic acid hydrazide. Eur. J. Med. Chem., 2005, 40, 173– 184.
- Yapia, R., La Mara, M. P. and Massieu, G. H., Modifications of brain glutamate decarboxylase activity by pyridoxal phosphateglutamyl hydrazone. Biochem. Pharmacol., 1967, 16, 1211–1218.
- Sava, G., Perissin, L., Lassiani, L. and Zabucchi, G., Antiinflammatory action of hydrosoluble dimethyl-triazenes on the carrageen induced edema in guinea pigs. Chem. Biol. Interact., 1985, 53, 37–43.
- Xia, Y. L., Chuan-Dong, F., Zhao, B. X., Zhao, J., Shin, D. S. and Miaom, J. Y., Synthesis and structure activity relationships of novel 1-arylmethyl-3-aryl-1H-pyrazole-5-carbohydrazide hydrazone derivatives as potential agents A549 lung cancer cells. Eur. J. Med. Chem., 2008, 43, 2347–2353.
- Mohareb, R. F., Fleita, D. H. and Sakka, O. K., Novel synthesis of hydrazide-hydrazone derivatives and their utilization in the synthesis of coumarin, pyridine, thiazole and thiophene derivative with antitumor activity. Molecules, 2011, 16, 16–27.
- Bondock, S., Tarhoni, A. E. and Fadda, A. A., Utility of cyanoacetic acid hydrazide in heterocyclic synthesis; ARKIVOC, 2006, ix, 113–156.
- Chowrasia, D., Karthikeyan, C., Choure, L., Sahabjada, Gupta, G. and Arshad, M., Synthesis, characterization and anti-cancer activity of some fluorinated 3,6-diaryl-[1,2,4]triazolo[3,4-b][1,3,4] thiadiazoles. Arab. J. Chem., 2013 (in press).