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Patil, Manojkumar
- Zero order and Area Under Curve Spectrophotometric Methods for Determination of Riboflavin in Pharmaceutical Formulation
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Authors
Affiliations
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 6, No 1 (2016), Pagination: 35-40Abstract
Simple, fast and reliable spectrophotometric methods were developed for determination of Riboflavin in bulk and pharmaceutical dosage forms. The solutions of standard and the sample were prepared in Methanol. The quantitative determination of the drug was carried out using the zero order derivative values measured at 445 nm and the area under the curve method values measured at 420-473nm (n=2). Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of Riboflavin using 5-25μg/ml (r²=0.999 and r²=0.999) for zero order and area under the curve spectrophotometric method. All the proposed methods have been extensively validated as per ICH guidelines. There was no significant difference between the performance of the proposed methods regarding the mean values and standard deviations. Developed spectrophotometric methods in this study are simple, accurate, precise and sensitive to assay of Riboflavin in tablets.Keywords
Riboflavin, UV Visible Spectrophotometry, AUC, Method Validation, Zero Order Method.
- Estimation of Levocetirizine in Bulk and Formulation by Second Order Derivative Area under Curve UV-Spectrophotometric Methods
Abstract Views :278 |
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Authors
Affiliations
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur MS, IN
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur MS, IN
Source
Asian Journal of Pharmaceutical Research, Vol 5, No 3 (2015), Pagination: 145-150Abstract
Simple, fast and reliable spectrophotometric methods were developed for determination of Levocetirizine in bulk and pharmaceutical dosage forms. The solutions of standard and the sample were prepared in Methanol. The quantitative determination of the drug was carried out using the second order Derivative Area under Curve method values measured at 247-255nm. Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of Levocetirizine using 5-25μg/ml (r²=0.999) for second order Derivative Area under Curve spectrophotometric method. The proposed methods have been extensively validated as per ICH guidelines. There was no significant difference between the performance of the proposed methods regarding the mean values and standard deviations. The developed methods were successfully applied to estimate the amount of Levocetirizine in pharmaceutical formulations.Keywords
Levocetirizine, Second Order Derivative, Area under Curve (AUC), Precision, Accuracy.- Simultaneous UV Spectrophotometric Methods for Estimation of Cefixime Trihydrate and Ofloxacin in Bulk and Tablet Dosage Form
Abstract Views :273 |
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Authors
Audumbar Mali
1,
Santosh Jadhav
1,
Rahul Gorad
2,
Aamer Quazi
2,
Ritesh Bathe
1,
Manojkumar Patil
1,
Ashpak Tamboli
3
Affiliations
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
2 Department of Pharmaceutics, ASPM’S K. T. Patil College of Pharmacy, Osmanabad-413501, Maharashtra, IN
3 Department of Pharmaceutical Chemistry, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
2 Department of Pharmaceutics, ASPM’S K. T. Patil College of Pharmacy, Osmanabad-413501, Maharashtra, IN
3 Department of Pharmaceutical Chemistry, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
Source
Asian Journal of Pharmaceutical Research, Vol 6, No 2 (2016), Pagination: 100-106Abstract
Simple, precise, economical, fast and reliable two UV methods have been developed for the simultaneous estimation of Cefixime Trihydrate and Ofloxacin in bulk and pharmaceutical dosage form. Method A is Absorbance maxima method, which is based on measurement of absorption at maximum wavelength of 287 nm and 296 nm for Cefixime Trihydrate and Ofloxacin respectively. Method B is area under curve (AUC), in the wavelength range of 265-301 nm for Cefixime Trihydrate and277-320nm for Ofloxacin. Linearity for detector response was observed in the concentration range of 5-25 μg/ml for Cefixime Trihydrate and 5-25 μg/ml for Ofloxacin. The accuracy of the methods was assessed by recovery studies and was found to be 98.83% and 100.12% for Cefixime Trihydrate and 102.71 % and 99.01 % Ofloxacin by using method A and B respectively. The developed method was validated with respect to linearity, accuracy (recovery), precision and specificity. The results were validated statistically as per ICH Q2 R1guideline and were found to be satisfactory. The proposed methods were successfully applied for the determination of for Cefixime Trihydrate and Ofloxacin in commercial pharmaceutical dosage form.Keywords
Cefixime Trihydrate, Ofloxacin, Simultaneous Estimation, Accuracy, Absorbance Maxima Method, Area under Curve.- An Updated Review on Current Situation of Corona Virus Disease
Abstract Views :150 |
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Authors
Affiliations
1 Department of Quality Assurance, Sahyadri College of Pharmacy, Methwade, Sangola - 413307, Solapur, Maharashtra, IN
2 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola - 413307, Solapur, Maharashtra, IN
3 Internal Medicine SAIL Hospital, Durgapur - 713216, West Bengal, IN
1 Department of Quality Assurance, Sahyadri College of Pharmacy, Methwade, Sangola - 413307, Solapur, Maharashtra, IN
2 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola - 413307, Solapur, Maharashtra, IN
3 Internal Medicine SAIL Hospital, Durgapur - 713216, West Bengal, IN
Source
Asian Journal of Pharmacy and Technology, Vol 12, No 2 (2022), Pagination: 167-175Abstract
COVID-19 is currently regarded as a lethal disease. COVID-19 has exaggerated over 2.5 million citizen’s universal, consequential into more than 170,000 confirmed cases deaths Very recently a novel corona virus, SARS-CoV-2, was identified because of causal cause of an outbreak of viral pneumonia centered around Wuhan, Hubei, China in Dec 2019, now called as COVID-19. The corona disease infection 2019 (Covid-19) (2019- nCoV) pandemic is an international public health emergency with major social and economic disruptions and devastating health consequences. COVID-19 is also known as a pandemic. COVID-19 has infected over 2.5 million people around the world, resulting in over 170,000 deaths. The rapid development of vaccines is imperative. Corona viruses are a group of related RNA viruses that cause diseases in mammals and birds. It triggers breathing zones that can vary from moderate to fatal in humans and birds more than a few issues to ordinary frosty (so as to can also be affected via different pathogens, mostly rhinoviruses) are mild, while more deadly strains be able to reason SARS, MERS, and COVID-19 in humans. Thousands of illnesses and deaths have occurred as a result of the disease. In fact, none exact cure remains available for the disorder yet this demands that even the condition should not expand. Notable Isolation of sick people, adequate ventilation, hand washing, and the utilization of PPE Kit are also preventive measures. As a result, this paper covers all aspects of COVID-19, including epidemiology, transmission, clinical characteristics, diagnosis, treatment, and prevention.
Keywords
Covid-19, SARS, Pandemic, MERS, Corona Virus, Viral PneumoniaReferences
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- In-vitro, In-vivo Evaluation of Floating Tablets of Clarithromycin
Abstract Views :151 |
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Authors
Affiliations
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
2 Department of Quality Assurance, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
2 Department of Quality Assurance, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
Source
Asian Journal of Pharmacy and Technology, Vol 12, No 3 (2022), Pagination: 225-231Abstract
The main purpose of this research work was to design and process optimization of oral floating drug delivery system of Clarithromycin floating tablets by using the hydrophilic polymer Hydroxylpropyl methyl cellulose and gas generating agent sodium bicarbonate and citric acid. A 32 randomized full factorial design was used to study. In this design 2 factors were evaluated, each at 3 levels and experimental trials were performed at all 9 possible combinations. The independent and dependent variables are selected for optimization study. The radio-labelled floating tablets were prepared by adding barium sulphate in the optimized formulations for in- vivo radiographic study. The Results of multiple regression analysis indicated that both factors X1 and X2 significantly affected on the dependent parameters. The formulation was optimized on the basis of floating ability and in-vitro drug release. It should be concluded that as the time increases, the swelling index was increased, because weight gain by tablet was increased proportionally with rate of hydration. In-vivo radiographic studies of the optimized formulations were performed using New Zeal Albino rabbits by X-ray imaging technique. The in-vivo X-ray imaging and radiographic studies clearly indicated that the prepared optimized floating tablets were retained in the rabbit stomach over a prolonged period of time and had good in-vivo performance. Radiological evidences suggest that the formulated floating tablets of antibiotics were well floated more than 6 h in rabbit stomach.Keywords
In-vivo Radiographic Studies, In-vivo Performance, New Zeal Albino Rabbits, Clarithromycin Floating TabletsReferences
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