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Pawar, Manoj
- Study of Serum Alkaline Phosphatase Levels among Psoriasis Patients and Comparative Group in Tertiary Care Institute
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PDF Views:115
Authors
Affiliations
1 Department of Dermatology, Dr. Vasantrao Pawar Medical College Hospital & RC, Nashik – 422003, Maharashtra, IN
1 Department of Dermatology, Dr. Vasantrao Pawar Medical College Hospital & RC, Nashik – 422003, Maharashtra, IN
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MVP Journal of Medical Sciences, Vol 5, No 2 (2018), Pagination: 211-215Abstract
Background: Psoriasis is a chronic relapsing autoimmune skin disease of unknown etiology, characterised by complex alterations in epidermal growth and differentiation. Oxidative stress is a known risk factor for exacerbation of psoriasis. Serum alkaline phosphatase level is a marker of oxidative stress in body. Aims and Objectives: To study and compare serum alkaline phosphatase levels in cases of psoriasis. Materials and Methods: Serum Alkaline Phosphatase levels were evaluated in 100 cases of psoriasis and controls. Results: There was no statistically significant difference between serum alkaline phosphatase levels among cases and controls. Conclusion: Serum alkaline phosphatase levels, as a marker of oxidative stress is not significantly raised in cases of psoriasis.Keywords
Alkaline Phosphatase, Oxidative Stress, Psoriasis.Full Text
References
- Nickoloff BJ, Nestle FO. Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities, J. Clin. Invest. 2004; 113:1664−75.
- Dogra S, Yadav S. Psoriasis in India: Prevalence and pattern, Indian J. Dermatol. Venerol. Leprol. 2010; 76:595−601.
- Bedi TR. Clinical profile of psoriasis in North India, Indian J. Dermatol. Venereol. Leprol. 1995; 61:202−5.
- Kaur I, Handa S, Kumar B. Natural history of psoriasis: A study from the Indian subcontinent, J. Dermatol. 1997; 24:230−4.
- Malligarjunan H, Gnanaraj P, Subramanian S, Elango T, Dayalan H. Clinical efficacy of propylthiouracil and its influence on prolactin in psoriatic patients, Clin. Biochem. 2011 Oct; 44(14-15):1209−13. Epub. 2011 Jul 28. https://doi.org/10.1016/j.clinbiochem.2011.07.009.
- Smith AE, Kassab JY, Rowland Payne CME, Beur WE. Bimodality in age of onset of psoriasis in both patients and relatives, Dermatology. 1993; 186:181−86.
- Pavithran K, Karunakaran M, Aparna P, Raghunatha S. PsoariasisIn: Valia RG, Valia AR. EDS. Disorders of keratinization. IADVL textbook of dermatology. Third edition. Volume 1, reprint. Bhalani publishing house; 2012. 30, p. 1021−56.
- Gudjonsson JE, Elder JT. Psoriasis. In: Goldsmith LA, Katz SI, Gilchrest, Paller AS, Leffell DJ, Wolff K. Eds. Fitzpatrick Dermatology in General Medicine. Eighth edition. Volume I; 2008. 18, p. 197−231.
- Griffiths CEM, Barker JNWN. Psoriasis In: Tony B, Stephen B, Neil C, Christopher G. editors. Rook textbook of dermatology, Eighth edition. Volume 1, Wiley-Blackwell; 2010. 20, p. 1−20.
- Peter Cm, Kerkhof vd, Nestle FO. Psoriasis In: Bolognia JL, Jorizzo JL, Schaffer JV, Eds. Dermatology, Third edition. Elsevier; 2008. p. 135−56.
- Smith CH, Anstey AV, Barker JN et al. British Association of Dermatologists guidelines for use of biological intervention in psoriasis, Br J Dermatol. 2005; 153:486−97.
- David H. Vroon, Zafar Israili. Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd Edition.
- Oxidative Medicine and Cellular Longevity. 2016 (2016). Article ID 8490643, p. 7.
- Bhatnagar M, Bapna A, Khare A K. Serum proteins, trace metals and phosphatases in psoriasis, Indian J. DermatolVenereol. Leprol. 1994; 60:18−2
- Franck H, Ittel T. Serum osteocalcin levels in patients with psoriatic arthritis: An extended report, Rheumatol Int. 2000; 19(5):161−4
- Nestle FO et al. Skin immune sentinels in health and disease, Nat. Rev. Immunol. 2009; 9(10):679−91.
- Sheikh G, Masood Q, Majeed S, Hassan I. Comparison of levels of serum copper, zinc, albumin, globulin and alkaline phosphatase in psoriatic patients and controls: A hospital based case control study, Indian Dermatol. Online J. 2015 Mar-Apr; 6(2):81−3. https://doi.org/10.4103/2229-5178.153006.
- Enerback C, Martinsson T, Inerot A, Wahlstrom J, Enlund F, Yhr M, Swanbeck G. Evidence that HLA-cw6 determines early onset of psoriasis, obtained using sequence-specific primers (PCR-SSP), Acta. Dermatovenerologica. 1997; 77(4):273−76.
- Cohen A D, Gilutz H, Henkin Y, Zahger D, Shapiro J, Bonneh D Y, Vardy D A. Psoriasis and the Metabolic Syndrome. ActaDermVenereol 2007; 87: 506–509. https://doi.org/10.2340/00015555-0297.
- Madanagobalane S, Anandan S. Prevalence of metabolic syndrome in south Indian patients with psoriasis vulgar is and the relation between disease severity and metabolic syndrome: A hospital-based case-control study, Indian J. Dermatol. 2012; 57:353−7.
- Golov KG, Varshavskiĭ VA, OkunevDIu, Neverov NI, Shestakova MV, Proskurneva FP. Urinary enzymes in the assessment of the early stage of kidney involvement in psoriasis and diabetes mellitus, Ter. Arkh. 1995; 67(10):80−1 (Russian).
- McMillan EM, Rowe D. Plasma zinc in psoriasis: relation to surface area involvement, Br. J. Dermatol. 1983 Mar; 108(3):301−05. PubMed PMID: 6830695.
- A Clinical and Histopathological Correlation among Leprosy Patients (in this Post Elimination Era) Attending Tertiary Referral Centre
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PDF Views:134
Authors
Affiliations
1 PG Resident, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik - 422003, Maharashtra, IN
2 Associate Professor, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik - 422003, Maharashtra, IN
3 Professor and Head, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik - 422003, Maharashtra, IN
4 Senior Resident, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Institute of Medical Sciences and Research, Nashik – 422003, Maharashtra, IN
1 PG Resident, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik - 422003, Maharashtra, IN
2 Associate Professor, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik - 422003, Maharashtra, IN
3 Professor and Head, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik - 422003, Maharashtra, IN
4 Senior Resident, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Institute of Medical Sciences and Research, Nashik – 422003, Maharashtra, IN
Source
MVP Journal of Medical Sciences, Vol 6, No 2 (2019), Pagination: 103-108Abstract
Background: Leprosy is caused by Mycobacterium leprae, which chiefly affect skin and peripheral nerves. Leprosy expresses itself in different clinicopathological forms depending upon underlying immunity of the host. Histopathology is considered gold standard for accurate diagnosis especially in early disease, however, clinicopathological correlation is a must for appropriate diagnosis and classification of disease that will in-turn affect the treatment and overall prognosis of the patient. The present study of clinicohistopathological correlation among leprosy patients in this post elimination era was undertaken. Aims and Objectives: To study the clinical and histopathological correlation among leprosy patients. Materials and Methods: Present study consists of 54 patients of newly diagnosed leprosy cases at Department of Dermatology, Venerology and Leprology from November 2016 to October 2018. Skin punch biopsy and slit skin smear taken from patients. Histopathological examination by staining with H&E and Fite-Faraco stain for tissue AFB and Ziehl-Neelsen staining of SSS for presence of AFB. Results: In this study, 35 cases (64.81%) showed clinicohistopathological concordance and 19 cases (35.19 %) were discordant according to Ridley-Jopling spectrum. Conclusion: Histology should be performed in all suspected patients of leprosy if feasible, for exact allocation of the patient across the spectrum for accurate treatment and to identify the vulnerable patients in borderline spectrum as they are prone for reactions, neuritis and thus deformities and it also aids in achieving terminal goal of leprosy elimination.Keywords
Clinicohistopathological Concordance, Leprosy, Ridley-Jopling Classification.Full Text
References
- Tan SY, Graham C. Armauer Hansen (1841-1912): Discoverer of the cause of leprosy. Singapore Med J. 2008; 49(7): 520–21.
- Browne SG. The history of leprosy. 2nd ed. In: Leprosy, Hastings RC, ed. New York: Churchill Livingstone; 1994.1–14.
- Panday AN, Tailor HJ. Clinocohistopathological correlation of leprosy. Ind J. Dermatol Venerol. Leprol. 2008; 74: 174–76. https://doi.org/10.4103/0378-6323.39723.
- Sengupta U. Leprosy: Immunology. In: Valia RG and Valia AR. IADVL Textbook and Atlas of Dermatology, 2nd edn. Mumbai. Bhalani Publishing House. 2001: 1573.
- Ridley DS, Jopling WH. Classification of leprosy according to immunity: a five group system. Int. J. Lep. 1996; 34(3): 255–77.
- Jopling WH, Mcdougall AC. Diagnostic Tests, In: Hand book of leprosy, 5th edn. CBS. 1999.60.
- Nayak SV, Shivarudrappa AS, Nagarajapa AH, Ahmed SM. Role of modified rapid AFB method in Histopathological sections of Hansen’s disease. Ind. J. Dermatol Venereol Leprol. 2003; 69: 173–74.
- Lucus SB, Ridley DS. Use of histopathology in leprosy diagnosis and research. Lep Rev. 1989; 60: 257–62. https://doi.org/10.5935/0305-7518.19890031.
- Ridley DS, Charles SK. The pathology of leprosy, In: Leprosy (Hastings). Churchill Livingstone. 1985.111.
- Ridley DS, Jopling WH. A classification for research purposes. Lepr Rev 1962; 33: 119–28. https://doi.org/10.5935/0305-7518.19620014.
- Scollard MD. Classification of leprosy: a full colour spectrum, or black and white? Int J Lepr Other Mycobact Dis. 2004; 72 (2) 166–168. https://doi.org/10.1489/1544-581X(2004)072<0166:COLAFC>2.0.CO;2.
- Gupte MD, Manickam P. Leprosy: Epidemiology. 3rd ed. In: IADVL Textbook of Dermatology, Valia RG, Valia AR, eds. Mumbai: Bhalani Publishers; 2008. 1994–2004.
- Charles K Job, Joyce Ponnaiya.Laboratory diagnosis. 1st ed. In: IAL Textbook of Leprosy, Hemanta Kumar Kar, Bhushan Kumar. New Delhi: Jaypee Publishers; 2010; 177–187.
- www.nlep.nic.in (National leprosy elimination programme website).
- Noordeen SK. The epidemiology of leprosy. 2nd ed. In: Leprosy, Hastings RC. New York: Churchill Livingstone; 1994; 15–30.
- Nitesh Mohan, Nitish Mishra, Int J Med Res Health Sci. 2013; 2(4): 887–892. https://doi.org/10.5958/j.2319-5886.2.4.142.
- Ankur Kumar, S. R. Negi, Kusum Vaishnav, A study of Clinicohistopathological correlation of leprosy in a tertiary care hospital in western district of Rajasthan. Journal of Research in Medical and Dental Science. 2014; 2(3): 43–48. https://doi.org/10.5455/jrmds.20142310.
- Bijjaragi S,V Kulkarni , KK Suresh , KR Chatura , P Kumar, Correlation of clinical and histopathological classification of Leprosy in post elimination era, Indian J Lepr. 2012; 84: 271–275.
- Nadia S, Jindal R, Ahmad S, Rawat SDS, Selvi Thamarai N, Harsh Meena, clinico pathological correlation of leprosy: a 4 years retrospective study from a tertiary referral centre in North India. Int J Med Res Health Sci. 2015; 4(2): 350–354. https://doi.org/10.5958/2319-5886.2015.00065.X.
- K L Shobha, C J Prakash, Clinico-Histopathological Study of Leprosy. International Int. J. Sci. Study. 2015; 3(1): 94–98.
- Mathur MC, Ghimire RBK, Shrestha P, Kedia SK. Clinicohistopathological Correlation in Leprosy. Kathmandu Univ Med J. 2011; 36(4): 248–51. https://doi.org/10.3126/kumj.v9i4.6338.
- K N Shivaswamy, A L Shyamprasad , T K Sumathy , C Ranganathan , Vidushi Agarwal .Clinico histopathological correlation in leprosy, Dermatol. Online J. 2012; 18 (9): 1–2.
- Giridhar M, Arora G, Lajpal K, Singh Chahal K.Clinicohistopathological concordance in leprosy - a clinical, histopathological and bacteriological study of 100 cases Indian. J. Lepr. 2012; 84(3): 217–225.
- Manandhar U, Adhikari RC, Sayami G: Clinico-Histopathological Correlation of Skin Biopsies in Leprosy. Journal of Pathology of Nepal. 2013; 3: 452–8. https://doi.org/10.3126/jpn.v3i6.8992.
- Bhatia AS, Katoch Kiran, Narayanan RB, Ramu Gopal, Mukherjee Ashok, Lavania RK: Clinical and Histopathological Correlation in the Classification of Leprosy. Int. J. Lepr. 1993; 61(3): 433–438.
- An Observational Study of Dermatological Manifestations in Patients of Chronic Renal Failure Undergoing Hemodialysis
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PDF Views:106
Authors
Affiliations
1 PG Resident, Department of Dermatology, Venereology and Leprology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik – 422002, Maharashtra, IN
2 Associate Professor, Department of Dermatology, Venereology and Leprology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik – 422003, Maharashtra, IN
3 Professor and Head, Department of Dermatology, Venereology and Leprology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik – 422003, Maharashtra, IN
4 Senior Resident, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Institute of Medical Sciences and Research, Nashik – 422003, Maharashtra, IN
1 PG Resident, Department of Dermatology, Venereology and Leprology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik – 422002, Maharashtra, IN
2 Associate Professor, Department of Dermatology, Venereology and Leprology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik – 422003, Maharashtra, IN
3 Professor and Head, Department of Dermatology, Venereology and Leprology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik – 422003, Maharashtra, IN
4 Senior Resident, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Institute of Medical Sciences and Research, Nashik – 422003, Maharashtra, IN
Source
MVP Journal of Medical Sciences, Vol 6, No 2 (2019), Pagination: 120–125Abstract
Background: Chronic Renal Failure (CRF) patients develop myriad of cutaneous findings. Novel cutaneous changes are being described since the introduction of hemodialysis, which prolongs the life expectancy, and thus more time for the skin changes to develop. Aims & Objectives: We aimed to evaluate the prevalence of dermatologic manifestations among the patients suffering from Chronic Renal Failure (CRF) who are on hemodialysis. Methods: 93 patients with CRF receiving hemodialysis were evaluated for skin, hair and nail changes. Results: All the enrolled patients experienced some skin problem. The most prevalent cutaneous manifestation was xerosis (54.8%), followed by pallor (21.5%), pruritus (19.35%) and dyspigmentation (18.3%). Other dermatologic manifestations included Kyrle’s disease (5.4%); fungal (5.4%), bacterial (6.5%) and viral (3.2%) infections and purpura (9.7%). Recorded nail changes were half and half nail (21%), koilonychia (39.78%), onychomycosis (1.08%), onychorrhexis (6.45%), splinter hemorrhages (1.08%), and Beau’s lines (2%). Hair changes included sparse hair (18.28%), and brittle and lustreless hair (11.83%). Oral cavity manifestations were enlarged tongue with teeth indentations (23.65%). Conclusions: CRF is associated with multiple skin, hair and nail manifestationsKeywords
Dyspigmentation, Koilonychia, Onychomycosis, Pruritus, Xerosis.Full Text
References
- Udaykumar P, Balasubramanian S, Ramalingam KS, Lakshmi C, Srinivas CR, Mathew AC. Cutaneous manifestations in patients with chronic renal failure on hemodialysis. Indian J Dermatol Venereol and Lepr. 2006; 72:119–25. https://doi.org/10.4103/0378-6323.25636 PMid:16707817
- Hegab D, Mourad B, Okasha K, Rizk S. Prospective study on prevalence of dermatological changes in patients under hemodialysis in hemodialysis units in Tanta University hospitals, Egypt. Clinical, Cosmetic and Investigational Dermatology. 2014 Nov; 313–17. https://doi.org/10.2147/CCID.S70842 PMid:25419152 PMCid:PMC4235205
- Thomas R, Kanso A, Sedor JR. Chronic kidney disease and its complications. Prim Care. 2008; 35(2):329–44. https://doi.org/10.1016/j.pop.2008.01.008 PMid:18486718 PMCid:PMC2474786
- Sorour N, Saudi W, Elmasry A, Sanad E. Prevalence of cutaneous manifestations in chronic renal failure patients on regular hemodialysis: A hospital–based study. Egyptian Journal of Dermatology and Venerology. 2014; 34(1):27 https://doi.org/10.4103/1110-6530.137278
- Chanda GM, Chintagunta SR, Arakkal G. Dermatological manifestations in chronic renal failure patients with and without hemodialysis: A study at a tertiary care centre. J NTR Univ Health Sci. 2017; 6:8–14
- Singh G, Verma AK, Singh G, Singh SJ. Cutaneous changes in chronicrenal failure. Indian J Dermatol Venereol and Leprol. 1992; 58:320–22.
- Sultan MM, Mansour HH, Wahby IM, Houdery AS. Cutaneous manifestations in Egyptian Patients with Chronic Renal Failure on regular hemodialysis. J Egypt Women Dermatol Soc. 2010; 7:49–55.
- Hajheydari Z, Makhlough. Cutaneous and mucosal manifestations in patients on maintenance hemodialysis: A study of 101 patients in Sari, Iran. Iranian Journal of Kidney diseases. 2008; 2:86–90.
- Falodun O, Ogunbiyi A, Salako B,George AK. Skin changes in patients with Chronic Renal Failure. Saudi J Kidney Dis Transpl. 2011; 22(2):268272
- Kolla PK, Desai M, Pathapati RM, Valli BM, Pentyala S, Reddy GM, et al. Cutaneous manifestations in patients with Chronic Kidney Disease on maintenance Hemodialysis. ISRN Dermatology. 2012:1–4. https://doi.org/10.5402/2012/679619 PMid:22830039 PMCid:PMC3398619
- Khanna D, Singal A, Kalra OP. Comparison of cutaneous manifestations in chronic kidney disease with or without dialysis. Postgrad Med J 2010; 86:641–4. https://doi.org/10.1136/pgmj.2009.095745 PMid:21037238
- Study of Skin Diseases in Incumbent Prison Inmates
Abstract Views :301 |
PDF Views:144
Authors
Affiliations
1 Former PG Resident, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College and Hospital & Research Centre, Adgaon, Nashik – 422003, Maharashtra, IN
2 Professor and Head, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik - 422003, Maharashtra, IN
3 Assistant Professor, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik – 422003, Maharashtra, IN
4 Senior Resident, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik – 422003, Maharashtra, IN
1 Former PG Resident, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College and Hospital & Research Centre, Adgaon, Nashik – 422003, Maharashtra, IN
2 Professor and Head, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik - 422003, Maharashtra, IN
3 Assistant Professor, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik – 422003, Maharashtra, IN
4 Senior Resident, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik – 422003, Maharashtra, IN
Source
MVP Journal of Medical Sciences, Vol 7, No 2 (2020), Pagination: 277-281Abstract
Introduction: Dermatological diseases in prison is still an under-researched field and the importance of identifying and treating them promptly has recently been recognized. Skin diseases are common among prisoners especially those from developing countries due to the substandard living conditions such as overcrowding with hot and humid environment. Aims and Objectives: Our study aimed to estimate the occurrence of various dermatological diseases among prison inmates. Materials and Methods: A descriptive cohort study of inmates at Nashik Central Jail, Maharashtra was done for a duration of 6 months between February to July 2018. Results: Out of 3609 inmates, 532 inmates (461 males and 71 females) aged 23–62 years were suffering from various skin diseases. Most common skin disease were infectious dermatoses (72.18%, n=384). Amongst infections, fungal contributed to maximum cases (85.93%, n=330) of cases followed by bacterial infection (13.84%, n=53). Infestations were second most common skin disease (20.86%, n=111). Rest were less 7% of cases. Conclusion: Prison inmates are prone to develop various skin infections and infestations due to poor standard of living. They are often neglected & may pose a danger of spreading skin infections among other prison inmates & in the community eventually. Appropriate and adequate health policies can prevent skin disease in prison.Keywords
Eczema, Papulosquamous, Infection, Infestation, Prison, Skin DiseasesFull Text
References
- Kuruvila M, Shaikh M, Kumar P. Pattern of dermatoses among inmates of district prison- Mangalore, Indian J Dermatol Venereol Leprol. 2002; 68:16–18.
- Guo W, Cronk R, Scherer E, Oommen R, Brogan J, Sarr M, Bartram J. A systematic scoping review of environmental health conditions in penal institutions, Int J Hyg Environ Health. 2019 Jun; 222(5):790–803. https://doi.org/10.1016/j. ijheh.2019.05.001. PMid:31078437
- Oninla OA, Onayemi O. Skin infections and infestations in prison inmates,Int J Dermatol. 2012 Jan17; 51(2):178– 81.https://doi.org/10.1111/j.1365-4632.2011.05016.x. PMid:22250627
- Oninla OA, Onayemi O, Olasode OA, et al. Pattern of dermatoses among inmates of Ilesha prison Nigeria, Niger Postgrad Med J. 2013; 20:174–80
- Bayle P, Cuzin L, Paul C, et al. Prisoners and skin diseases in Toulouse, France: Epidemiological analysis and evaluation of life impact, J Eur Acad Dermatol Venereol. 2009; 23:52–7. https://doi.org/10.1111/j.1468-3083.2008.02945.x. PMid:18702624
- Parajuli N, Jonkman Veenstra G, Jonkman M. Skin diseases in a Nepali prison, Journal of Chitwan Medical College. 2015 Jan 28;4(4). https://doi.org/10.3126/jcmc.v4i4.11968
- Kocaturk E, Kocaturk A, Kayala M. Prevalence of skin diseases in female prisoners in Turkey: Analysis of impact of prison conditions and psychological stress, Acta Dermatovenerol Croat. 2014; 22:26–31.
- Mannocci A, Di Thiene D, Semyonov L, et al. A cross-sectional study on dermatological diseases among male prisoners in southern Lazio, Italy, Int J Dermatol. 2014; 53:586– 592.https://doi.org/10.1111/j.1365-4632.2012.05762.x. PMid:24758231
- Coury C, Kelly B. Prison dermatology: Experience in the Texas Department of Criminal Justice dermatology clinic, J Correct Health Care. 2012; 18:308.https://doi. org/10.1177/1078345812456365. PMid:22899813
- Brauner GJ, Goodheart HP. Dermatologic care behind bars, J Am Acad Dermatol. 1988 May; 18:1066–73.https://doi. org/10.1016/S0190-9622(88)70107-3
- Rich JD, Chandler R, Williams BA, Dumont D, Wang EA, Taxman FS, et al. How health care reform can transform the health of criminal justice-involved individuals,Health Aff. 2014 Mar 1; 33(3):462–467.https://doi.org/10.1377/ hlthaff.2013.1133. PMid:24590946. PMCid:PMC4034754
- Unresponsive Alopecia Areata Treated Successfully with Liquid Nitrogen Cryotherapy: A Study of Five Patients
Abstract Views :297 |
PDF Views:89
Authors
Affiliations
1 Professor and Head, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik - 422003, Maharashtra, IN
2 Former PG Resident, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College and Hospital and Research Centre, Adgaon, Nashik – 422003, Maharashtra, IN
3 Assistant Professor, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik – 422003, Maharashtra, IN
4 Senior Resident, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik – 422003, Maharashtra, IN
1 Professor and Head, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik - 422003, Maharashtra, IN
2 Former PG Resident, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College and Hospital and Research Centre, Adgaon, Nashik – 422003, Maharashtra, IN
3 Assistant Professor, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik – 422003, Maharashtra, IN
4 Senior Resident, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik – 422003, Maharashtra, IN
Source
MVP Journal of Medical Sciences, Vol 7, No 2 (2020), Pagination: 288-294Abstract
Introduction: Alopecia Areata (AA) is one of the most common form of hair loss seen in dermatology. Treatment failures can occur with almost every conventional therapy, either singly or in combination. Aims and Objectives: To study the clinical profiles and management outcome of Liquid Nitrogen Cryotherapy (LNC) for the treatment of unresponsive cases of AA. Materials and Methods: A prospective study was conducted on five patients who showed no response to conventional topical treatment for six months. The subjects were enrolled in the study after written consent. Clinical photographs were recorded at each visit. Patients were given 3-5 sittings of LNC at 2 week intervals. Each session consisted of dual freeze thaw cycles of 15 seconds each, with a cryospray technique following application of topical anaesthetic cream. Suitable antibiotics and anti-inflammatory agents were prescribed post-operatively for five days. The clinical response was evaluated by using regrowth scale at 4th week and 8th week. Final end point evaluation of patient post 3 months after the last treatment session was done to observe sustained regrowth of hair. Results: Five patients were recruited, out of which three patients showed an excellent response, 1 each had a satisfactory response and a fair response respectively. Commonly seen adverse effects were slight pain, erythema, edema, erosion, crusting, dyspigmentation/hypopigmentation, which were transient and did not require withdrawal of treatment. Conclusion: Liquid Nitrogen Cryotherapy is a cheaper, easily available with transient adverse effects and can be worth trying in unresponsive Alopecia Areata.Keywords
Alopecia Areata(AA), Liquid Nitrogen Cryotherapy (LNC), UnresponsiveFull Text
References
- Ganjoo S, Thappa DM. Dermoscopic evaluation of therapeutic response to an intralesional corticosteroid in the treatment of Alopecia Areata. Indian J Dermatol Venereol Leprol. 2013; 79:408–17.PMid:23619446. https://doi.org/10.4103/0378-6323.110767.
- Seetharam KA. Alopecia Areata: An update. Indian J Dermatol Venereol Leprol. 2013; 79:563–75.PMid:23974575. https://doi.org/10.4103/0378-6323.116725.
- Zawar VP, Karad GM. Liquid nitrogencryotherapy in recalcitrant Alopecia Areata: A study of 11 patients. Int J Trichol. 2016; 8:15–20. PMid:27127370 PMCid:PMC4830166.https://doi.org/10.4103/0974-7753.179403.
- Schwartz RA, Janniger CK. Alopecia Areata. Cutis. 1997; 59:238–41.
- Sharma VK, Khandpur S. Guidelines for cryotherapy. Indian J Dermatol Venereol Leprol. 2009; 75:90–100. PMid:19439873. https://doi.org/10.4103/0378-6323.51238.
- Pimentel CB, Moraes AM, Cintra ML. Angiogenic effects of cryosurgery with liquid nitrogen on the normal skin of rats, through morphometric study. An Bras Dermatol. 2014; 89:410–3. PMid:24937813 PMCid:PMC4056697. https:// doi.org/10.1590/abd1806-4841.20142249.
- Christoph T, Müller-Rover S, Audring H, Tobin DJ, Hermes B, Cotsarelis G, et al. The human hair follicle immune system: Cellular composition and immune privilege. Br J Dermatol. 2000; 142:862–73.PMid:10809841. https://doi. org/10.1046/j.1365-2133.2000.03464.x.
- Tobin DJ. Characterization of hair follicle antigens targeted by the anti-hair follicle immune response. J Investig Dermatol Symp Proc. 2003; 8:176–81. PMid:14582669. https://doi.org/10.1046/j.1087-0024.2003.00805.x.
- Gita F, Mohammadreza R. Liquid Nitrogen Cryotherapy vs. betamethasone lotion in the management of Alopecia Areata. J Clin Med Res. 2013; 5:18–22. https://doi.org/10.5897/JCMR11.041.
- Hong SP, Jeon SY, Oh TH, Lee WS. Retrospective study of the effect of superficial cryotherapy on Alopecia Areata. Korean J Dermatol. 2006; 44:274–80.
- Radmanesh M, Azar Beig M. Cryotherapy as an alternative therapy for the treatment of recalcitrant Alopecia Areata. Iran J Dermatol. 2013; 16:49–52.
- Amirnia M, Mahmoudi SS, Karkon-Shayan F, Alikhah H, Piri R, Naghavi-Behzad M, et al. Comparative study of intralesional steroid injection and cryotherapy in Alopecia Areata. Niger Med J. 2015;56:249-52. PMid:26759508 PMCid:PMC4697211. https://doi.org/10.4103/0300-1652.165034.