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Nagpal, Manju
- Study of Anti-Inflammatory Potential of Ethanolic Fraction of Seeds of Ocimum basilicum Linn
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Authors
Affiliations
1 Rajendra Institute of Technology and Sciences, 4th mile stone, Hisar Road, Sirsa - 125055, IN
2 Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar (Haryana), IN
1 Rajendra Institute of Technology and Sciences, 4th mile stone, Hisar Road, Sirsa - 125055, IN
2 Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar (Haryana), IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 1, No 2 (2009), Pagination: 79-81Abstract
In the present study the ethanolic fraction of seeds of the plant Ocimum basilicum Linn. was taken and its anti-inflammatory potential was evaluated using carrageenan and formalin induced rat paw edema. The effect on chronic phase of inflammation was also studied using cotton pellet granuloma technique. The increase in paw thickness was measured using digital vernier caliper after 1,2,3 and 4 h of injection. Ethanolic fraction of the seeds of the plant at dose of 400 mg/Kg significantly inhibited acute phase of inflammation. The decrease in the weight of granuloma was also found by ethanolic fraction of the seeds at same dose. The study reveals that the ethanolic fraction of seeds of Ocimum basilicum Linn. possesses significant anti-inflammatory activity.Keywords
Anti-Inflammatory, Carrageenan, Formalin, Granuloma.
References
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- Gastroesophageal Reflux Disease: Pathophysiology and Treatments Available
Abstract Views :208 |
PDF Views:1
Authors
Affiliations
1 Rajendra Institute of Technology and Sciences, Sirsa Haryana, IN
2 Chitkara School of Pharmaceutical Sciences, Chitkara University, Barotiwala HP, IN
3 NCRD's Sterling Institute of Pharmacy, Navi Mumbai, IN
1 Rajendra Institute of Technology and Sciences, Sirsa Haryana, IN
2 Chitkara School of Pharmaceutical Sciences, Chitkara University, Barotiwala HP, IN
3 NCRD's Sterling Institute of Pharmacy, Navi Mumbai, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 2, No 2 (2010), Pagination: 160-164Abstract
Gastroesophageal reflux disease (GERD) is primarily a motility disorder. Escape of gastric contents into the esophagus occurs as a consequence of an incompetent gastroesophageal barrier. This barrier is weakened in the presence of an abnormally functioning Lower Esophageal Sphincter (LES). This review is focused on the epidemiology, pathophysiology and treatments of gastro-oesophageal reflux disease.Keywords
Reflux, Proton Pump Inhibitors, H2 Receptor Antagonists, Radiofrequency.References
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- Gastroretentive Drug Delivery Systems: A Promising Approach
Abstract Views :179 |
PDF Views:0
Authors
Yashomita Mehta
1,
Sunita Nirban
2,
Sunil Kumar
2,
Kuldeep Malodia
2,
Pankaj Rakha
3,
Manju Nagpal
2
Affiliations
1 Lord Shiva College of Pharmacy, Sirsa, IN
2 Lord Shiva College of Pharmacy, Sirsa, IN
3 Rajendra Institute of Technology and Sciences, 4th mile stone, Hisar Road, Sirsa, IN
1 Lord Shiva College of Pharmacy, Sirsa, IN
2 Lord Shiva College of Pharmacy, Sirsa, IN
3 Rajendra Institute of Technology and Sciences, 4th mile stone, Hisar Road, Sirsa, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 3, No 1 (2011), Pagination: 1-6Abstract
Controlled release drug delivery system (CRDDS) have been most extensively used to improve therapy of certain drugs, but several physiological difficulties faced with CRDDS is the inability to restrain and remain in the gastric region for several hours which limit the bioavailability of drug. Hence drug delivery systems with prolonged gastric residence time (GRT) are an approach to improve bioavailability of drugs, reduction in dose thereby leading to less side/toxic effects. Many approaches have been utilized in the development of gastric retention drug delivery systems (GRDDS) such as floating system, extended system, high density system, superporus system, bioadhesive system, and magnetic system etc. This review also summarizes the in vitro and in vivo studies to evaluate the performance and application of GRDDS. These systems are useful to several problems encountered during the development of a pharmaceutical dosage form.Keywords
Gastric Retention, Effervescent, Floating, Magnetic.- Comparison of Biorelevant and Compendial Dissolution Media and Prediction of In-vivo Plasma Profile of BCS Class II Drug
Abstract Views :221 |
PDF Views:0
Authors
Affiliations
1 Rajendra Institute of Tech. and Sciences, Sirsa, Haryana, IN
2 Rajendra Institute of Tech. and Sciences, Sirsa, Haryana, IN
3 NCRD’s Sterling Institute of Pharmacy, Navi Mumbai, IN
4 Glaxosmithcline Pvt. Ltd., Mumbai,, IN
1 Rajendra Institute of Tech. and Sciences, Sirsa, Haryana, IN
2 Rajendra Institute of Tech. and Sciences, Sirsa, Haryana, IN
3 NCRD’s Sterling Institute of Pharmacy, Navi Mumbai, IN
4 Glaxosmithcline Pvt. Ltd., Mumbai,, IN