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Gautam, Manish
- Ayurveda Rasayana in Prophylaxis of Covid-19
Abstract Views :270 |
PDF Views:66
Authors
Bhushan Patwardhan
1,
Preeti Chavan-Gautam
2,
Manish Gautam
3,
Girish Tillu
2,
Arvind Chopra
4,
Sunil Gairola
3,
Suresh Jadhav
3
Affiliations
1 AYUSH Centre of Excellence, Centre for Complementary and Integrative Health, Interdisciplinary School of Health Sciences, Savitribai Phule Pune Univer-sity, Pune 411 007, IN
2 AYUSH Centre of Excellence, Centre for Complementary and Integrative Health, Interdisciplinary School of Health Sciences, Savitribai Phule Pune University, Pune 411 007, IN
3 Serum Institute of India Ltd, Pune 411 028, IN
4 Centre for Rheumatic Diseases, Pune 411 001, IN
1 AYUSH Centre of Excellence, Centre for Complementary and Integrative Health, Interdisciplinary School of Health Sciences, Savitribai Phule Pune Univer-sity, Pune 411 007, IN
2 AYUSH Centre of Excellence, Centre for Complementary and Integrative Health, Interdisciplinary School of Health Sciences, Savitribai Phule Pune University, Pune 411 007, IN
3 Serum Institute of India Ltd, Pune 411 028, IN
4 Centre for Rheumatic Diseases, Pune 411 001, IN
Source
Current Science, Vol 118, No 8 (2020), Pagination: 1158-1160Abstract
Respiratory viral infections such as SARS-CoV-2 affect immune homeostasis by altering the immune regulatory network leading to decreased responsiveness, changes in lymphocyte sub-populations and decreased macrophage function1 . Clinically, the immune response induced by SARS-CoV-2 infection occurs in two phases: the first immune defence-based protective phase and the second inflammation-driven damaging phase2 . The first immune defence-based protective phase is characterized by recruitment of antibody-secreting cells, follicular helper T-cells, activated CD4 and CD8 T-cells and immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies that bind to SARS-CoV-2 (ref.3). The second phase leads to uncontrolled cytokine release causing cytokine release syndrome (CRS), or ‘cytokine storm’ characterized by increased IL-2, IL-7, granulocyte colony stimulating factor, IFN-gamma and TNF-alpha4 . CRS damages tissues of the lungs, kidney and heart leading to rapid multiorgan failure. The deaths from COVID-19 are due to massive alveolar damage leading to acute respiratory distress syndrome (ARDS) that culminates in respiratory failure. Restoration of Th1/Th-2 cytokine balance is one of the mechanisms of establishing immune homeostasis5,6 .References
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- Amelioration of Streptozotocin Induced Cytotoxicity by Mimosa pudica Root Extract - A Proteomic Based In-Vitro Study
Abstract Views :109 |
PDF Views:0
Authors
Pallavi S. Jamadagni
1,
Sharad D. Pawar
1,
Shrirang Jamadagni
1,
Shridhar Chougule
1,
Manish Wanjari
1,
Manish Gautam
2,
Sudesh Gaidhani
3,
Arun Gurav
1,
N. Shrikanth
3
Affiliations
1 Regional Ayurveda Research Institute, Central Council for Research in Ayurvedic Sciences, Ministry of AYUSH, Gandhi Bhavan Road, Kothrud, Pune - 411038, Maharashtra, IN
2 Assam Down Town University, Panikhaiti, Guwahati - 781026, Assam, IN
3 Central Council for Research in Ayurvedic Sciences, Ministry of AYUSH, 61-65, Institutional Area, Opposite Janakpuri D Block, New Delhi - 110058, IN
1 Regional Ayurveda Research Institute, Central Council for Research in Ayurvedic Sciences, Ministry of AYUSH, Gandhi Bhavan Road, Kothrud, Pune - 411038, Maharashtra, IN
2 Assam Down Town University, Panikhaiti, Guwahati - 781026, Assam, IN
3 Central Council for Research in Ayurvedic Sciences, Ministry of AYUSH, 61-65, Institutional Area, Opposite Janakpuri D Block, New Delhi - 110058, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 29, No 4 (2022), Pagination: 447-454Abstract
The in-vitrocytotoxicity was studied in a pancreatic cell line (RIN5F) using streptozotocin-induced cellular damage. The Cytotoxic dose of aqueous and hydro-alcoholic extracts of Mimosa pudica root powder before and after streptozotocin treatment was studied and protein expression was explored. Both the extracts were subjected to metabolite analysis by LCMS. Mimosa pudica root powder extracts prevented Streptozotocin-induced cellular damage. Proteomics studies indicated both aqueous and hydro-alcoholic extracts of Mimosa pudica regulate proteins related to insulin secretion, glucose uptake, and insulin resistance with marked changes in proteins involved in insulin secretion. The study first time reports cytotoxicity of Mimosa pudica in RIN5F cells and explores protein expression after Mimosa pudica treatment. It was also observed that the abundance of Mimosine is more in Hydro-alcoholic extracts as compared to aqueous extracts.Keywords
LC-MS, Mimosa pudica, Proteomics, RIN5F.References
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