Informatics Publishing Limited

Naiya Devgan ¹, Meenakshi Barsaul ², Rashmi Sindhwani ², Smiti Nanda ², Manish Devgan ³

Affiliations
1 General Hospital, Rohtak, Haryana, IN
2 PGIMS, Rohtak, Haryana, IN
3 SDM College of Pharmacy, Kaithal, Haryana, IN

Abstract

The aim of this study was to compare the effectiveness, safety and possible adverse effects of terbutaline and nifedipine in prolonging pregnancy beyond 48 hrs. A randomized controlled trial was conducted with 60 pregnant women admitted with preterm labor, randomized into two groups, which were given terbutaline (30 patients) and nifedipine (30 patients) respectively. Bivariate and multivariate analysis, using regression, were used to analyze the data. No statistically significant difference was found between the two groups in terms of prolongation of gestation to 48 hrs. Both the drugs significantly prolonged the pregnancy (P < 0.001), however there was no statistically significant (P > 0.05) difference in the tocolytic efficacy (mean absolute prolongation of gestation) and birth outcomes between the two groups. The maximum number of patients in both groups (47 % in group A and 70 % in group B) delivered between 34.1 to 37 weeks. However, side effects were significantly more common in the terbutaline group (P < 0.02), especially maternal tachycardia, transient hypotension and chest pain. In the terbutaline group, 14.8 % neonates required mechanical ventilation while 11.1 % suffered intra ventricular hemorrhage. Terbutaline and nifedipine appeared to be equally effective in their tocolytic action. However, nifedipine did have the advantage of the ease of administration. It also had significantly less side effects.

Keywords

Terbutaline, Nifedipine, Preterm Labor and Tocolysis

Full Text

     

Manish Devgan ¹

Affiliations
1 R.P. Educational Trust Group of Institutions, Bastara, Karnal-132001, Haryana, IN

Abstract

Minichromosome maintenance proteins (MCM2-7) form the important part of the DNA replication initiation system. The MCM proteins contribute to restricting the initiation of DNA replication to once per cycle. A heteromeric complex is formed by binding of these six proteins with each other. The aim of this work was to prepare the homologous model of MCM5 protein and perform the docking studies. In this work, a theoretical model of MCM5 protein was generated using the concepts of homology modeling and loop modeling. The resulting model was validated by Procheck with Ramachandran plot analysis. The ligands generated with the help of Drug bank and ZINC data base were docked against MCM5 protein using DockThor portal. The study revealed that the compound acetonyl-cycloheptylcyclohexyl- BLAHtrione (ZINC15861168) has the maximum probability to bind with MCM5. Thus, the usage of this compound can lead to inhibition of the protein MCM5 which will act as a blockade in the formation of heteromeric complex of MCM2-7 proteins thereby assisting in the treatment of multiple myeloma and other cancer cells.

Keywords

Minichromosome Maintenance Proteins, Molecular Modeling, Homology Modeling, Loop Modeling, Molecular Docking.

Full Text

     

Kamal Arora ¹, Ish Grover ², Amit Chandna ¹, Manish Devgan ²

Affiliations
1 Doon Valley Institute of Pharmacy and Medicine, Karnal, Haryana, IN
2 RPIIT Technical and Medical Campus, Karnal, Haryana, IN

Abstract

Fast Dissolving Tablet instead of dissolving or disintegrating in water is expected to dissolve or disintegrate in oral cavity without drinking water. Super disintegrates are added to a drug formulation to facilitate the break-up or disintegration of tablet or capsule content into smaller particles that can dissolve more rapidly than in the absence of disintegrates In the present study, the effects of a natural superdisintegrants Plantago ovata, Hibiscus rosa sinensis and synthetic superdisintegrants like sodium starch glycolate (SSG), Crosspovidone and Croscarmellose sodium (Ac-di-sol) were compared in the formulations of fast dissolving tablets (FDT). FDTs of Cefixime were prepared by direct compression method and were evaluated for weight variation, hardness, thickness, disintegration time, wetting time, water absorption ratio, In vitro dispersion, friability and dissolution. Among all the super disintegrates, Plantago ovata showed the highest swelling index and natural super disintegrates like husk of Plantago ovata showed better disintegrating property than the most widely used synthetic super disintegrates like AC-di-Sol, C.P and SSG in the formulations.

Keywords

Disintegration, Superdisintegrants, Fast Dissolving Tablets, Swelling Index.

Full Text

     

Shashi Pal Bharti ¹, Hitesh Kumar ¹, Bharat Parashar ¹, Sandeep Deswal ², Nitika Chahar ², Manish Devgan ²

Affiliations
1 Department of Pharmacy, Manav Bharti University, Solan, Himachal Pradesh, IN
2 Chemistry Research Lab., R.P. Educational Trust Group of Institutions, Bastara, Karnal, Haryana, IN

Abstract

The anthelmintic activity of ethanol and aqueous extract of Abies pindrow was studied against earthworm Eisenia foetida (redworm). The ethanolic and aqueous extract was prepared by hot and cold respectively. Albendazole was used as the standard drug. The anthelmintic activity was carried out to study the effect of plant extract on adult earthworm Eisenia foetida (redworm), and noted down the paralysis time (Vermifuse), and death time (Vermicidal). It was found that both ethanolic and aqueous extract of bark of Abies pindrow found to have significant action against adult earthworm Eisenia foetida (redworm) at the dose of 25 mg/ml or more; which may be due to the presence of glycosides, carbohydrates, tannins and saponins in the extract. Thus it can be concluded that the bark of Abies pindrow can be used as anthelmintic agent.

Keywords

Abies pindrow, Eisenia foetida and Anthelmintic.

Full Text