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Mondal, Maitrayee
- Jussiaea repens as a Herbal Cotraceptive-A Mating Study in Male Rats
Abstract Views :1366 |
PDF Views:3
Authors
Subhasis Ghoshal
1,
Arnab Das
2,
Kajari Bhattacharya
2,
Maitrayee Mondal
2,
Indrani Chakraborty
3,
Nimai Masanta
4,
Nirmal Pradhan
2
Affiliations
1 Dept. of Physiology, Presidency University, Kolkata, West Bengal, IN
2 P. G. Dept. of Physiology, Hooghly Mohsin College, Chinsurah, Hooghly, West Bengal, IN
3 Dept. of Physiology, Krishnanagar Govt. College, Nadia, West Bengal, IN
4 Dept. of Physiology, Jhargram Raj College, Paschim Medinipur, West Bengal, IN
1 Dept. of Physiology, Presidency University, Kolkata, West Bengal, IN
2 P. G. Dept. of Physiology, Hooghly Mohsin College, Chinsurah, Hooghly, West Bengal, IN
3 Dept. of Physiology, Krishnanagar Govt. College, Nadia, West Bengal, IN
4 Dept. of Physiology, Jhargram Raj College, Paschim Medinipur, West Bengal, IN
Source
Journal of Environment and Sociobiology, Vol 12, No Sp Iss (2015), Pagination: 20-20Abstract
Jussiaea repens (locally called Kesardam) is a medicinal herb in different countries in the world. It grows in wetlands and is also used as vegetables and animal-forage. In Papua New Guinea leaves and stems of this plant are considered as contraceptive in preventing pregnancy. But suitable studies of this plant on male reproduction are yet not available. The present study was designed to investigate the anti-gonadal property of J. repens in male rats through mating studies. The aqueous extract of J. Repens at oral dose of 200 mg/kg b.wt/day for 28 days caused no signifcant change in b.wt but weight of testis and cauda epididymis, sperm motility, total sperm count from cauda epididymis, sperm viability and normal sperms were signifcantly reduced implantation site where in control it was 100% fertility and 10.7 implantation sites. In recovery group, 87.5% fertility and 9.8 implantation sites were observed per rat. This is near to normal. Withdrawal of drug for successive 28 days caused marked recovery in testicular and epididymal weight, sperm motility, count, viability and morphology possibly due to inhibition of spermatogenesis and steroidogenesis. The reversal studies caused recovery of reproductive parameters towards normal revealing the nontoxicity. So the present study may confrm the anti-fertility effect of J. repens. Therefore, it may be used as herbal male contraceptive.- Jussiaea repens as a Herbal Cotraceptive - A Mating Study in Male Rats
Abstract Views :551 |
PDF Views:1
Authors
Subhasis Ghoshal
1,
Arnab Das
2,
Kajari Bhattacharya
2,
Maitrayee Mondal
2,
Indrani Chakraborty
3,
Nimai Masanta
4,
Nirmal Pradhan
2
Affiliations
1 Department of Physiology, Presidency University, Kolkata, West Bengal, IN
2 Post Graduate Dept. of Physiology, Hooghly Mohsin College, Chinsurah, Hooghly, West Bengal, IN
3 Department of Physiology, Krishnanagar Govt. College, Nadia, West Bengal, IN
4 Department of Physiology, Jhargram Raj College, Paschim Medinipur, West Bengal, IN
1 Department of Physiology, Presidency University, Kolkata, West Bengal, IN
2 Post Graduate Dept. of Physiology, Hooghly Mohsin College, Chinsurah, Hooghly, West Bengal, IN
3 Department of Physiology, Krishnanagar Govt. College, Nadia, West Bengal, IN
4 Department of Physiology, Jhargram Raj College, Paschim Medinipur, West Bengal, IN
Source
Journal of Environment and Sociobiology, Vol 12, No 1 (2015), Pagination: 123-131Abstract
Wetland plant, Jussiaea repens (locally called Keshardam) is a medicinal herb in different countries in the world. It is also used as vegetables and animal-forage. In Papua New Guinea, the leaves and stems of the plant are considered as contraceptive in preventing pregnancy. But no suitable studies on antifertility effect of J. repens in males are yet available. The present study was designed to investigate the anti-gonadal property of J. repens in male rats through mating studies. The aqueous extract of J. repens at oral dose of 200 mg/kg b.wt/day for 28 days caused no significant change in body weight but weight of testis and cauda epididymis, sperm motility, total sperm count from cauda epididymis, sperm viability and normal sperms were signifi cantly reduced in treated group. The mating studies with treated group showed 25% fertility having '0' implantation site whereas in control it was 100% fertility and 10.7 implantation sites. In recovery group, 87.5% fertility and 9.8 implantation sites were observed per rat, which is near to normal. Withdrawal of drug for successive 28 days caused marked recovery in testicular and epididymal weight, sperm motility, count, viability and morphology possibly due to inhibition of spermatogenesis and steroidogenesis. The reversal studies caused recovery of reproductive parameters towards normal revealing the nontoxicity. So the present study may confi rm the anti-fertility effect of J. repens. Therefore, it may be used as herbal male contraceptive.Keywords
Jussiaea repens, Medicinal Herb, Antigonadal, Herbal Male Contraceptive, Male Reproduction.References
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