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Patel, Madhabhai M.
- Techniques to Improve Bioavailability of Poorly Water Soluble Drugs-A review
Authors
1 Jodhpur National University, Jodhpur, IN
2 Kalol Institute of Pharmacy, Kalol-382721, Gujarat, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 3, No 5 (2011), Pagination: 183-192Abstract
The mark of a successful formulation depends on how efficiently it makes the drug available at the site of action. Therapeutic effectiveness of a drug depends upon the bioavailability and ultimately upon the solubility of drug molecules especially in oral formulation. Formulating an oral dosage form for a poorly water soluble drug is in itself a challenging task. A number of ways are used to improve solubility of drug by like salt formation, cosolvency, and addition of solublizing agent, micronization, solid dispersion and complexation and many more. Although these techniques have been used to increase dissolution rate of the drug, there are practical limitations with these techniques, the desired bioavailability enhancement may not always be achieved. In this review we have tried to discuss advanced techniques that have come up to solve these problems. Here in, novel technologies, such as sonocrystallisation, nanotechnologies such as nanosuspension, nanoemulsion, spray freezing in to liquid and some commercialized technologies such as nanocrystal, nanopure, nanoedge, biorise®, diffucaps® etc. which present novel methods of solubilisation, that may allow for greater opportunities to deliver poorly soluble drugs have been dealt in detail. These techniques may help a great in facing the challenges in formulating drugs with poor water solubility.
Keywords
Bioavailability, Techniques, Sonocrystallisation, Nanotechnology, Poor Water Solubility, Drug Delivery System.
- Stability Indicating HPLC Method for Simultaneous Determination of Repaglinide and Metformin Hydrochloride in Pharmaceutical Dosage Form
Authors
1 Kalol Institute of Pharmacy, B/H Old Janpath Hotel, National Highway, Kalol-382721, IN
2 Shree S. K. Patel College of Pharmaceutical Education and Research, Ganapat University, Kherva-382711, Gujarat, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 3 (2011), Pagination: 500-505Abstract
A simple, specific and accurate stability-indicating reversed phase high performance liquid chromatographic method was developed for the simultaneous determination of Repaglinide and Metformin hydrochloride. An isocratic RPHPLC was achieved on younglin HPLC system using Varian C18 (250 4.6 mm i.d, 5 m particle size) column with the mobile phase containing mixture of acetonitrile: 10mM ammonium acetate(pH 3.0, adjusted with phosphoric acid) (70 : 30, v/v). The flow rate was 1.0ml/min and the eluent was monitored at 230nm. The retention times of Repaglinide and Metformin hydrochloride were found to be 3.1 min and 5.58 min, respectively. Linearity was established for Repaglinide and Metformin hydrochloride in the range of 0.5-3 μg/ml and 200-1200 μg/ml, respectively. The percentage recoveries of Repaglinide and Metformin hydrochloride were found to be in the range of 99.87%±0.7 and 99.89%±0.15 respectively. Both the drugs were subjected to acid, alkali, oxidation, and dry heat degradation. The degradation studies indicated, Repaglinide and Metformin hydrochloride showed degradation in acid, alkaline, H2O2, and in dry heat condition. The degradation products of Repaglinide and Metformin hydrochloride were well resolved from the pure drug with significant differences in their retention time values. This method can be successfully employed for simultaneous quantitative analysis of Repaglinide and Metformin hydrochloride in bulk drugs and formulations.