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Sundarapandian, M.
- Spectrophotometric Method for Estimation of Quetiapine Fumarate in Bulk and Dosage Form
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, K.M. College of Pharmacy, Uthangudi, Madurai-107, IN
2 Department of Pharmaceutical Analysis, K.M. College of Pharmacy, Uthangudi, Madurai-107, IN
1 Department of Pharmaceutical Chemistry, K.M. College of Pharmacy, Uthangudi, Madurai-107, IN
2 Department of Pharmaceutical Analysis, K.M. College of Pharmacy, Uthangudi, Madurai-107, IN
Source
Asian Journal of Research in Chemistry, Vol 2, No 4 (2009), Pagination: 452-453Abstract
A simple, precise and accurate spectrophotometric method has been developed for the determination of Quetiapine fumarate in bulk drug and pharmaceutical dosage form. Standard stock solution was prepared in distilled water and further dilution was carried out with distilled water. The λmax of Quetiapine fumarate was found to be 290 nm. The A (1%,1 cm) value of Quetiapine fumarate was found to be 186.22±3.11. Calibration graph was linear over the range of 5-25 μg/ml. The correlation coefficient (r) was found to be 0.9997. The limit of detection (LOD) and limit of Quantification (LOQ) was found to be 0.41 μg/ml and 1.25 μg/ml respectively of Quetiapine fumarate. The result of estimation in marketed tablet formulations were found to be 100.64±0.18 and 101.32±0.35. The proposed method was applied successfully for the determination of Quetiapine fumarate in tablets with average recovery of 102±1.14 and 98.8±1.10. The method was then validated statistically as per ICH guidelines, which yielded good results concerning range, linearity, precision and accuracy.Keywords
Quetiapine Fumarate, Spectrophotometry.- Spectrophotometric Determination of Meloxicam in Bulk Drug and Pharmaceutical Formulations
Abstract Views :172 |
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Authors
Affiliations
1 Department of Pharmaceutical Analysis, K.M. College of Pharmacy, Uthangudi, Madurai-625107, IN
2 Department of Pharmaceutical Chemistry, K.M. College of Pharmacy, Uthangudi, Madurai-625107, IN
1 Department of Pharmaceutical Analysis, K.M. College of Pharmacy, Uthangudi, Madurai-625107, IN
2 Department of Pharmaceutical Chemistry, K.M. College of Pharmacy, Uthangudi, Madurai-625107, IN