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- Ayanam Vasavi
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Sowjanya, M.
- Polymers used in the Designing of Controlled Drug Delivery System
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Authors
Affiliations
1 Department of Pharmaceutics, Seven Hills College of Pharmacy, Tirupati-517561, A.P., IN
1 Department of Pharmaceutics, Seven Hills College of Pharmacy, Tirupati-517561, A.P., IN
Source
Research Journal of Pharmacy and Technology, Vol 10, No 3 (2017), Pagination: 903-912Abstract
Polymers are becoming very important in the drug delivery field. To control the drug release rate from the formulation, polymers are being used as the main tool. Polymers can be used as taste masking agents, to enhance stability of drug and to modify drug release characteristics. Biodegradable materials are used in medicine and other areas. In recent years there has been increase in use of biodegradable polymers. Biodegradable polymers are of two classes; synthetic and natural polymers. Natural polymers offer few advantages than synthetic polymers. Although polymers are used extensively as pharmaceutical packaging, this review is concerned with the use of polymers in the formulation of various dosage forms.Keywords
Polymers, Drug Delivery System, Controlled Drug Delivery, Biodegradable Polymers, Drug Release Mechanism.
- Evaluation of Anti-bacterial and Anti-inflammatory Activities of Ethanolic Extract of Hibiscus hirtus Linn. Leaves
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Authors
Affiliations
1 Department of Chemistry, A.K.R.G. College of Pharmacy, Nallajerla, Andhra Pradesh, IN
2 Dept. of Pharmacology, Brilliant Group of Institutions, Abdullapaur, R.R. Dist., Hyderabad, Telangana, IN
3 Department of Analysis, A.K.R.G. College of Pharmacy, Nallajerla, Andhra Pradesh, IN
4 Vijaya Teja Degree College, Addanki, Andhra Pradesh, IN
1 Department of Chemistry, A.K.R.G. College of Pharmacy, Nallajerla, Andhra Pradesh, IN
2 Dept. of Pharmacology, Brilliant Group of Institutions, Abdullapaur, R.R. Dist., Hyderabad, Telangana, IN
3 Department of Analysis, A.K.R.G. College of Pharmacy, Nallajerla, Andhra Pradesh, IN
4 Vijaya Teja Degree College, Addanki, Andhra Pradesh, IN
Source
Asian Journal of Pharmaceutical Research, Vol 12, No 1 (2022), Pagination: 5 - 10Abstract
The current investigation is started to find the antibacterial and anti-inflammatory activities of the sub shrub Hibiscus hirtus L. The leaves of this conventional shrub were found to possess' different activities which incorporate antibacterial and hostile to helminthic effects. Thus we made an endeavor to perform extraction utilizing ethanol as solvent and soxhlation as a strategy for extraction. The leaves were priorly researched for their pharmacognostic, phytochemical and physical parameters. The antibacterial action of the ethanolic leaf extract was conveyed at various concentrations on strains of gram positive and gram-negative bacteria, for example, Staphylococcus aureus and Escherechia coli individually by utilizing cup and plate technique. The outcomes were outfitted as the zone of inbition acquired around every grouping of the concentrate and were compared with those of standard antibiotic utilized in the analysis, amoxycillin. Anti-inflammatory activity of Hibiscus hirtus L was studied and compared with standard drug, ibuprofen. Ethanollic concentrate of leaves (2.5- 15 mg/ml) and ibuprofen (2.5-15 mg/ml) were utilized to measure the paw edema by plethysmometer and compared with control groups. Hibiscus hirtus L showed critical decrease of paw edema in the chosen model of inflammation for example formalin prompted chronic model of inflammation. Ethanollic concentrate of the plant leaves showed anti- microbial and anti-inflammatory impacts.
Keywords
Hibiscus hirtus L, Anti-inflammatory, Antimicrobial activity, ExtractionReferences
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- Formulation and Evaluation of Sustained Release Stavudine Microspheres by Ionotropic Gelation Method
Abstract Views :71 |
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Authors
Affiliations
1 Department of Pharmaceutics, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh, IN
2 Department of Pharmaceutical Analysis, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh, IN
3 Department of Chemistry, Vijaya Teja Degree College, Addanki - 523201, Andhra Pradesh, IN
1 Department of Pharmaceutics, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh, IN
2 Department of Pharmaceutical Analysis, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh, IN
3 Department of Chemistry, Vijaya Teja Degree College, Addanki - 523201, Andhra Pradesh, IN
Source
Asian Journal of Pharmacy and Technology, Vol 12, No 2 (2022), Pagination: 119-124Abstract
As a novel drug delivery system, microspheres improve the efficacy of a drug, increase the time of action, lower the number of times in which a dosage form needs to be administered, and to increase patient compliance. Oral administration side effects such as gastric irritation are lessened through the use of microspheres. Ionotropic gelation was used to create HPMC K15M, Guar gum, and Carbopol 934 microspheres with different concentrations of Carbopol 934 polymer. Cross-linking was accomplished with the use of calcium chloride. In order to conduct a systematic evaluation of all the preparations, we performed various tests: morphology, FTIR, DSC, entrapment efficiency, size, microsphere size, and in-vitro drug release. The discrete, free-flowing, and spherical particles of prepared Stavudine microspheres were found. In compliance with standards, the mean particle size was in the range of 72.64 to 95.22 percent. In vitro drug release studies were performed in phosphate buffer solution with a pH of 6.8. As the concentration of sodium alginate and calcium chloride increased, the percentage of drug release was reduced. In the case of F9 formulation, which contained Stavudine, the decreased drug release rate was obtained via carbopol 934(1:3), sodium alginate, and calcium chloride. Conclusively, the present study shows that Stavudine microsphere preparation and formulation F9 are successful. Stavudine microspheres must be prepared in order to preserve an effective drug concentration in serum for a long time, while reducing gastrointestinal irritation.Keywords
Microspheres, Controlled Release, Stavudine, In-vitro StudiesReferences
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- Design, Formulation and Evaluation of Fexofenadine HCl Immediate Release Tablets by Solid Dispersion Method using Solvent Evaporation Technique
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Authors
Affiliations
1 Department of Pharmaceutics, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh, IN
2 Department of Pharmaceutical Analysis, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh, IN
3 Department of Chemistry, Vijaya Teja Degree College, Addanki, Andhra Pradesh, IN
1 Department of Pharmaceutics, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh, IN
2 Department of Pharmaceutical Analysis, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh, IN
3 Department of Chemistry, Vijaya Teja Degree College, Addanki, Andhra Pradesh, IN
Source
Asian Journal of Pharmacy and Technology, Vol 12, No 4 (2022), Pagination: 290-298Abstract
Currently, this study focuses on developing immediate-release Fexofenadine hydrochloride tablets. The Fexofenadine HCl tablets have super disintegrants that help to accelerate dissolution and bioavailability. Sodium lauryl sulphate, microcrystalline cellulose as filler, crospovidone, and sodium starch glycolate were used to make the tablets using a direct compression method (2-8 percent). Pre and post compressional parameters were used in the preparation of the tablets. The In-vitro disintegration study shows that as concentration of sodium starch glycolate is increased, there is an increase in the amount of time it takes for the solution to disintegrate, but at the same time, there is a decrease in the amount of time it takes for the solution to disintegrate when the crospovidone level is increased. When combined with the crospovidone tablet formulation, the test found that the resulting tablets broke down in approximately 3 to 6 minutes, with enough force to release the fragments but not to harm the friability of the product. It was found that Fexofenadine hydrochloride tablet, a fast-acting form of treatment for allergic rhinitis, could be formulated in an immediate-release form.Keywords
Allergic Rhinitis, Crospovidone, Croscarmellose SodiumReferences
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- S. Kumara Swamy, G. Arun, Bethi Srinivas, Agaiah Goud B. Effect of Various Super Disintegrants on the Drug Release Profile of Orally Disintegrating Tablets. Asian J. Pharm. Tech. 2016; 6(2): 99-105.
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- In-Vitro Screening Of Anti-Microbial, Anti-Fungal And Anti-Oxidant Activities Of Ethanolic Leaf Extract Of Anthocephalus cadamba
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Authors
Nalla Priyanka
1,
M. Srikanth
2,
Raveendra Babu
3,
M. Sowjanya
4,
V . Ramya Sri
1,
M. Vasanthi
1,
K. Sri Lakshmi Bhargavi
1,
Y. Tirupathaiah
1,
K. Mohana Sri Vasavi
1,
N. Raviteja
1
Affiliations
1 Department of Pharmaceutical Chemistry, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh, IN
2 Department of Pharmacognosy, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh, IN
3 Department of Pharmaceutical Analysis, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh, IN
4 Department of Chemistry, Vijaya Teja Degree College, Addanki - 523201, Andhra Pradesh, IN
1 Department of Pharmaceutical Chemistry, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh, IN
2 Department of Pharmacognosy, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh, IN
3 Department of Pharmaceutical Analysis, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh, IN
4 Department of Chemistry, Vijaya Teja Degree College, Addanki - 523201, Andhra Pradesh, IN
Source
Asian Journal of Pharmaceutical Research, Vol 12, No 4 (2022), Pagination: 275 - 280Abstract
Anthocephalus cadamba, Rubiaceae, is a medicinal herb of great importance for traditional applications against several disease kinds. Because of the range of compounds, the genus Anthocephalus is regarded as one of the most significant genus utilised in many medical systems. The plant was chemically investigated for its phytoconstituents in the current analysis, Anthocephalus cadamba. The results for steroids, flavanoids, tannins and glycosides were shown to be positive. Bacterial species, such as Staphylococcus aureus, Bacillus subtiliis and Escherichia coli, have been moderately actively monopolised. Antifungal activity at doses of 100mg/ml, 300mg/ml with fungal organisms, was observed in the ethanol leaves extract. Plant ethanol extract had a substantial impact on the hydrogen peroxide radical activity of scavenging and less effects than the standard of nitric oxide radical activity.
Keywords
Anthocephalus cadamba, Scavenging activity, Anti microbial activity, Gram + VeReferences
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- Synthesis, characterization, anti-inflammatory and anti-oxidant activities of novel 2, 4-di substituted 1, 5- benzodiazepine derivatives
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh., IN
2 Department of Chemistry, Vijaya Teja Degree College, Addanki-523201, Andhra Pradesh ., IN
3 Department of Pharmaceutics, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh ., IN
4 Department of Pharmaceutics, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh., IN
5 Department of Pharmaceutical Analysis, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh., IN
1 Department of Pharmaceutical Chemistry, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh., IN
2 Department of Chemistry, Vijaya Teja Degree College, Addanki-523201, Andhra Pradesh ., IN
3 Department of Pharmaceutics, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh ., IN
4 Department of Pharmaceutics, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh., IN
5 Department of Pharmaceutical Analysis, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh., IN
Source
Asian Journal of Research in Chemistry, Vol 15, No 2 (2022), Pagination: 109 - 114Abstract
The study's goal is to synthesis novel benzodiazepine analogues, some of which are chalcones. The elemental analysis, infrared, and 1H nuclear magnetic resonance examinations examined the structures of the newly produced substances. To test for anti-inflammatory and anti-oxidant properties, all substances bearing a descriptor were evaluated. Here, 1,5-(disubstituted phenyl)-2,4-pentadien-1-one derivatives are created from scratch using a new process. By condensing cinnamaldehyde with different aromatic ketones in the presence of 10% NaOH as a base, 1,5-(disubstituted phenyl)-2,4-pentadien-1-one was produced. 2-(substituted phenyl)-3- styryl-2,3-dihydro-1H-benzodiazepine derivatives were synthesised from 1,5-(disubstituted phenyl)-2,4- pentadien-1-one on cyclization with o-phenylene diamine in the presence of NaOH as base. Carrageenan and formalin-induced rat paw edoema technique was used to evaluate the antioxidant and anti-inflammatory activities of the final synthesised benzodiazepine derivatives. Compared to the usual ascorbic acid and diclofenac sodium, the compounds displayed significant anti-inflammatory effect. This means that nitro, chloro, fluoro, and bromo included electron withdrawing groups, which caused an increase in anti-inflammatory action. Most of the produced drugs had strong anti-inflammatory efficacy .Keywords
Chalcones, 1,5-benzodiazepines, Anti-inflammatory activity, Anti-oxidant activity.References
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