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Alagar Raja, M.
- Spectrophotometric (Vierodt's) Method for Simultaneous Estimation of Eperisone Hydrochloride and Diclofenac Sodium in Rapisone-D SR Capsules
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Authors
Affiliations
1 Department of Pharmaceutical Analysis and Quality Assurance, Nalanda College of Pharmacy, Cherlapally, Nalgonda, Andhra Pradesh, IN
2 School of Pharmacy, Taylors University, Subang Jaya, MY
1 Department of Pharmaceutical Analysis and Quality Assurance, Nalanda College of Pharmacy, Cherlapally, Nalgonda, Andhra Pradesh, IN
2 School of Pharmacy, Taylors University, Subang Jaya, MY
Source
Asian Journal of Research in Chemistry, Vol 6, No 7 (2013), Pagination: 683-686Abstract
The present method describes simple, sensitive, rapid, accurate, precise and economical Spectrophotometric method for the simultaneous determination of Diclofenac Sodium and Eperisone Hydrochloride in bulk and capsule dosage form. The method is based on the Vierodts Method (simultaneous estimation)for analysis of both the drugs using distilled water as solvent. Diclofenac sodium (DIC) has absorbance maxima at 277 nm and Eperisone hydrochloride (EPE) has absorbance maxima at 255 nm in distilled water. The linearity was obtained in the concentration range of 2- 12 μg/mL and 3-18 μg/mL for Diclofenac Sodium and Eperisone Hydrochloride, respectively. The concentrations of these drugs were determined by using vierodts equations. The mean % recovery (w/w%) was 99.3 and 100.3% for Diclofenac Sodium and Eperisone Hydrochloride, respectively. The proposed method was found to be simple and sensitive for the routine quality control application of dosage form of Diclofenac Sodium and Eperisone Hydrochloride. The results of analysis have been validated statistically according to ICH guidelines.Keywords
Diclofenac Sodium, Eperisone Hydrochloride, Recovery, Vierodts Method, RAPISONE D SR capsules, Validation, ICH
References
- Japanese Pharmacopoeia, 15th edition, Society of Japanese Pharmacopeia 2006: 618
- http://www.chemspider.com/eperisone.drugprofile
- Indian Pharmacopoeia, Vol. II, The Controller Publication, Govt. of India, New Delhi 2010: 1199.
- British Pharmacopoeia, Vol. I, The British Pharmacopoeia Commission, London 2010: 672.
- Skoog, A.D. and West M.D., Principles of instrumental analysis, Saunders golden, Japan, 3rd ed., 1985, 212-213.
- A.H.Beckett,J.B. Stenlake , Practical Pharmaceutical Chemistry, CBS Publishers and distributors, 1997; 4(2), 275-337.
- The International Conference on Harmonization, Q2 (R1), Validation of Analytical Procedure, Text and Methodology, 2005.
- Michael E, Schartz IS, Krull. Analytical method development and Validation. 2004, 25-46.
- The International Conference on Harmonization, Q2 (R1), Validation of Analytical Procedure, Text and Methodology, 2005.
- Ding L, Wang X, Yang Z, and Chen Y The use of HPLC/MS, GC/MS, NMR, UV and IR to Identify Degredation product of eperisone hydrochloride in the the tablets, J of pharm and Bio Anal, 2008, 46: 282-287.
- Nirav Uchadadiya, Falgun Mehta, Pinak Sanchaniya, “Development and validation of derivative spectrophotometric method for simultaneous estimation of Eperisone hydrochloride and Paracetamol in combined tablet dosage form”,Novus Int J of Chem, 2012, Vol. 1, No. 1, 33-40
- Priyanka Patel, Dhara Patel, Hardik Modi, Falguni Patel, Hardiksinh Baria, Sanjay Patel“development and validation of RP-HPLC methods for simultaneous estimation of eperisone hydrochloride and lornoxicam in bulk and their synthetic mixture” Inventi Rapid: Pharm Analysis and Quality Assurance , Vol. 2013 ,724
- MR Sengar, SV Gandhi , UP Patil, VS Rajmane “Simultaneous Determination of Diclofenac Sodium and Thiocolchicoside in Fixed Dose Combination by Spectrophotometry” Asian J of Pharm and Cli Res , Vol.3 Issue 2, April-June 2010 ,pg.no.86-9
- Chakraborty Mithun , Ray Chaudhury Dipanjan, Basu Arindam, Das Debabrata and Chakraborty Susanto, “Simultaneous Determination of Paracetamol, Chlorzoxazone and Diclofenac Sodium in Tablet Dosage form by HPLC”, Int J Of Pharm Innovations, Volume 2, Issue 2, pg.no.34-40
- D. S. Patel, A. D. Captain, P. P. Prajapati, H. G. Shah, “Development and Validation of HPTLC Method for Simultaneous Determination of Tolperisone Hydrochloride and Diclofenac Sodium in Combined Dosage Form” Int J of PharmTechand Res,Vol.5, No.1, pp 147-154
- J.Umang Patel, Patel Paresh.U,Patelo Sejal K “Spectrophotometric method for simultaneous estimation of eperisone hydrochloride and diclofenac sodium in synthetic mixture”, Int Res J of pharmacy ,2012,vol.3(9)pg.no.203-206
- RP-HPLC Method Development and Validation for Estimation of Sofosbuvir in Pure and Tablet Dosage Form
Abstract Views :276 |
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Authors
Affiliations
1 Nalanda College of Pharmacy, Charlapally, Nalgonda, Telangana, IN
1 Nalanda College of Pharmacy, Charlapally, Nalgonda, Telangana, IN
Source
Asian Journal of Pharmacy and Technology, Vol 7, No 3 (2017), Pagination: 153-156Abstract
A rapid and precise Reverse Phase High Performance Liquid Chromatographic method has been developed for the validation of Sofosbuvir, in its pure form as well as in tablet dosage form. Chromatography was carried out on a Hypersil C18 (4.6×150mm, 5μ) column using a mixture of Methanol (100% v/v) as the mobile phase at a flow rate of 1.0 mL/min, the detection was carried out at 265 nm. The retention time of the Sofosbuvir was 3.515 ±0.02min. The method produce linear responses in the concentration range of 20-100μg/mL of Sofosbuvir. The method precision for the determination of assay was below 2.0% RSD. The method is useful in the quality control of bulk and pharmaceutical formulations.Keywords
Sofosbuvir, RP-HPLC, Validation, Tablet Dosage Forms.References
- Andrea Weston and Phyllisr.Brown, HPLC Principle and Practice ,1st edition Academic press, (1997), PP 24-37.
- Yuri Kazakevich and Rosario Lobrutto, HPLC for Pharmaceutical Scientists, 1stedition, Wiley Interscience A JohnWiley & Sons, Inc., Publicat ion, (2007), PP 15-23.
- Chromatography, (online). URL:http://en.wikipedia.org/wiki/Chromatography.
- Meyer V.R. Practical High-Performance Liquid Chromatography, 4th Edn. England, John Wiley & Sons Ltd, (2004), PP 7-8.
- Sahajwalla CG a new drug development, vol 141, Marcel Dekker Inc., New York, (2004), PP 421–426.
- Introduction to Column. (Online),URL:http://amitpatel745.topcities.com/index_files/study/column care.
- Detectors used in HPLC (online )URL:http://wiki.answers.com/Q/What_detectors_are_used_in_HPLC
- Detectors (online) ,URL:http://hplc.chem.shu.edu/NEW/HPLC_Book/Detectors.
- Detectors (online) ,URL:http://www.dionex.com/enus/webdocs/64842-31644-02_PDA-100.
- Detectors (online),URL:http://www.ncbi.nlm.nih.gov/pubmed/8867705
- Detectors (online),URL:http://www.chem.agilent.com/Library/applications/59643559.
- Draft ICH Guidelines on Validation of Analytical Procedures Definitions and terminology. Federal Register, vol 60. IFPMA, Switzerland, (1995), PP 1126.
- Code Q2B, Validation of Analytical Procedures; Methodology. ICH Harmonized Tripartite Guidelines, Geneva, Switzerland, (1996), PP 1- 8.