Informatics Publishing Limited

P. B. Pawar ¹, M. P. Wagh ², S. N. Bhandare ¹

Affiliations
1 Department of Pharmaceutics, P.R.E.S’s College of Pharmacy, Chincholi, Nashik-422101, Maharashtra, IN
2 Department of Pharmaceutics, N.D.M.V.P’s College of Pharmacy, Nashik-422002, Maharashtra, IN

Abstract

Hydroxyzine hydrochloride is histamine H1 antagonist, antipruritic and anxiolytic, sedative and hypnotic agent. It helps in suppression of histaminic edema, flare and pruritus, but it has poor patient compliance due to its bitterness. So its taste should be masked to formulate it in a palatable dosage form. So in the present work undertaken , an attempt was made to mask the taste of Hydroxyzine hydrochloride by complexation technique using Ion exchange resin (IER), Indion- 234 (Polyacrylic hydrogen with carboxylic functionality), and to formulate mouth dissolving tablet(MDT). The drug -IER complex (resinate) was evaluated for taste masking and characterized by DSC, IR. MDTs were formulated using resinate by direct compression method using solid drug: resin complex of Hydroxyzine HCl with indion-234 (equivalent to dose of drug, 1:3 ratios). Super disintegrating agents like Croscarmellose Sodium, sodium starch glycolate, crospovidone, L-HPC, Pregelatinised Starch and combination of sodium bicarbonate and citric acid (1.5:1). Formulations were coded as formulation F1, F2, F3, F4, F5 and F6 respectively. Tablets are evaluated for hardness, friability, Disintegration time, Thickness, weight variation and drug content and In vitro release study. The tablets disintegrated in vitro with in 10-50 sec. Cros povidone shows lesser disintegration time from all the formulation. The result showed that Hydroxyzine HCl was successfully taste masked and formulated into MDT as an alternative to conventional tablets.

Keywords

Mouth Dissolving Tablet, Hydroxyzine Hydrochloride, Indion-234, Taste Masking.

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S. T. Deshpande ¹, M. P. Wagh ²

Affiliations
1 SCSSS's Sitabai Thite College of Pharmacy, Shirur, Pune- 412210, IN
2 Department of Pharmaceutics, MVP’s College of Pharmacy, Nashik, IN

Abstract

Iontophoretic system deliver the drugs in the form of ions into the body by the use of electric current typically upto 0.5 mA/cm2. The technique is used for several decades clinically in delivering medication to surface tissues. However, its potential is recently being rediscovered for transdermal systemic delivery of ionic drugs including peptide/protein drugs which are normally difficult to administer except by parenteral route. This review describe the advantages, disadvantage and basic principle of iontophoresis with its electrochemistry. Various factors which affect transdermal absorption have also been reviewed. In the final section we summarizes the studies conducted recently using chemical enhancers and the list of drugs investigated in iontophoretic delivery system This article is focused to review old as well recent literature on the principle, Biomedical application and to provide reader a very comprehensive over view of the state of art of this potential in the new era pharmaceutical research.

Keywords

Iontophoresis, Electric Current, Transdermal,Iontophoretic Device, Chemical Enhancer, Skin.

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P. B. Pawar ¹, M. P. Wagh ², S. N. Hiremath ³, A. V. Baviskar ³, M. R. Akul ⁴

Affiliations
1 P.R.E.S’s College of Pharmacy, Chincholi, Nasik (M.S)-422102, IN
2 Department of Pharmaceutics, N.D.M.V.P.S’s College of Pharmacy, Nasik-422002 Maharashtra, IN
3 Department of Pharmaceutics, P.R.E.S’s College of Pharmacy, Chincholi, Nasik-422101, Maharashtra, IN
4 Reasearch and Development Cell, Glenmark Pharmaceuticals Ltd., Sinnar, Nasik, Maharashtra, IN

Abstract

Hydroxyzine hydrochloride is histamine H1 antagonist, antipruritic and anxiolytic, sedative and hypnotic agent. It helps in suppression of histaminic edema, flare and pruritus, but it has poor patient compliance due to its bitterness. So its taste should be masked to formulate it in a palatable dosage form. Hence an attempt was made to mask the taste of Hydroxyzine hydrochloride with strong and weak cation exchange resins. The complex formation of drug with different cation exchange resins was carried out to block the functional group responsible for causing bitter taste. DSC analysis, X-ray diffractometry, FTIR spectra and decomplexation studies give evidences of complex formation.Hydroxyzine hydrochloride shows good complexation and effective taste masking with strong cation exchanger like Tulsion-343, Tulsion-344 and weak cation exchanger like Indion-234. But Tulsion-343 and Tulsion-344 resins affect the drug release from complex at gastric pH due to their sustained release action. The complex for formulation was selected considering the results obtained from release of drug from complex at salivary pH as well as at gastric pH, sensory evaluation of complex. Accelerated stability studies (at 40°C ± 2°C /75% RH±5% RH) on the selected resinate indicate that there are no significant change in drug content and in vitro dissolution profile (p < 0.05).

Keywords

Hydroxyzine Hydrochloride, Taste Abatement, Ion Exchange Resins.

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M. P. Wagh ¹, M. H. Bele ², J. S. Patel ², A. Y. Pawar ²

Affiliations
1 NDMVPS’s College of Pharmacy, Department of Pharmaceutics, Shivajinagar, Gangapur Road, Nashik-422002, IN
2 NDMVPS’s College of Pharmacy, Department of Pharmaceutics, Shivajinagar, Gangapur Road, Nashik-422002, IN

Abstract

Solid dispersion technique is being used to enhance the dissolution rate of poorly water-soluble drugs and/or BCS class II drugs (Low solubility and High permeability). Conventionally, it can be prepared by two methods; melting and solvent evaporation. But these approaches are found to be having certain limitations regarding reproducibility, scale-up and stability of the drug. Various novel strategies have been tried for solid dispersion manufacturing such as lyophilization (freeze drying), melt agglomeration process, spray drying technology, use of surfactant, electrostatic spinning method, spray coating on sugar beads with a fluidized bed coating system, hot melt extrusion, direct capsule filling and super critical fluid technology. These technologies have been found to eliminate several drawbacks posed by the conventional methods of manufacturing of solid dispersions such as laborious preparation methods, reproducibility, scaling up of manufacturing processes, stability of drug, and vehicle. The paper highlights the potential applications and limitations of these novel approaches in solid dispersion manufacturing.

Keywords

Solid Dispersion, Surfactants, Supercritical Fluid Technology, Direct Capsule Filling.

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