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S. M. Sarode ¹, M. A. Chaudhari ², M. K. Kale ², G. Vidyasagar ²

Affiliations
1 C/O M. B. Sarode, Shanti Nagar, Plot no.6, Yawal road, Bhusawal (M.S.), IN
2 K.Y.D.S.C.T's College of Pharmacy, Sakegaon (M.S.), IN

Abstract

A mixture of oil and surfactant (especially non-ionic) forms clear and transparent isotropic solution known as self-emulsifying system (SES). Lovastatin is HMG-CoA enzyme inhibitor. This enzyme is needed by the body to make cholesterol. Lovastatin causes cholesterol to be lost from LDL, but also reduces the concentration of circulating LDL (low density lipoprotein) particles. Animals studies demonstrated that lovastatin crosses the blood-brain and placental barriers. Elderly patients or those with renal insufficiency may have higher plasma concentrations of lovastatin after administration and may require a lower dose. SEDDS is prepared and filled in hard gelatin capsules. In vitro dissolution indicates that the release of lovastatin from SEDDS varied according to the type and ratio of the oil and surfactants. It was concluded that there was an increase in both the solubility and dissolution rate of drug in SEDDS form as compared to marketed tablet.

Keywords

SEDDS, Enzymes.

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S. M. Sarode ¹, G. Vidya Sagar ², M. K. Kale ³, P. K. Nimase ⁴, A. P. Kulkarni ³, S. D. Firke ³, B. M. Firke ³, P. D. Warke ³, M. A. Chaudhari ³

Affiliations
1 C/O M. B. Sarode, Shanti nagar, Plot no.6, Yawal Road, Bhusawal (M.S.), IN
2 Veerayatan Institute of Pharmacy, Bhuj, Gujrat, IN
3 K.Y.D.S.C.T’s College of Pharmacy, Sakegaon (M.S.), IN
4 Smt.S.S.Patil college of Pharmacy, Chopda (M.S.), IN

Abstract

The objective of this investigation was to develop an intra gastric floating drug delivery system of clarithromycin and also attempts were made to sustain the release of clarithromycin. Multiple-unit floating beads of clarithromycin were prepared from sodium alginate solution containing Hydroxypropylmethylcellulose (K100M) and sunflower oil by using emulsion-gelation method. These beads were evaluated for entrapment efficiency, drug loading, buoyancy and in vitro drug release. All formulations were the floating lag time below two minutes and shows total floating duration more than ten hours. It was observed that entrapment efficiency, drug loading and buoyancy was greater with formulation containing two percent sodium alginate solution and five percent calcium chloride solution along with 500mg HPMC and five ml sunflower oil (i.e.F14) and also the result of in-vitro dissolution studies reveals that the formulation F14 gave sustained release pattern of clarithromycin upto 12 hrs.

Keywords

Floating Alginate Beads, Emulsion Gelation, Clarithromycin, Controlled Release.

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M. A. Chaudhari ¹, S. M. Sarode ², Y. A. Chaudhari ³, G. Vidyasagar ², M. K. Kale ⁴

Affiliations
1 Gandhi Chowk, Savda, Dist-Jalgaon, IN
2 Veerayatan Institute of Pharmacy, Bhuj, Gujarat, IN
3 TVES’S Hon’ble L. M. C. College of Pharmacy, Faizpur, IN
4 Department of Pharmacology, K.Y.D.S.C.T’s College of Pharmacy, Sakegaon- 425201, IN

Abstract

Medicinal plants contribute in human health care system. Most of the plants utilized by village peoples as a folk medicine. Now we are turned in to medicinal plant analysis of active compounds and conservation aspect. In the present study we had select the four important medicinal plants in the Khandesh region. Such plants are widely used in this region for ayurvedic purpose by villagers and local herbal health masters. We have colleted four medicinally important medicinal plants such as Acalypha indica, Cassia auriculata, Eclipta alba and Phyllanthus niruri for antimicrobial studies. The experiment carried out in the selected medicinal plants leaves and ischolar_mains. The results are discussed with the available literature.

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