Refine your search
Collections
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
P, Laxmi Prasanna
- Formulation Development and Evaluation of a Novel Emulsion Composition Embracing Aspirin and Glycerol in the Treatment of Ischemic Stroke
Abstract Views :135 |
PDF Views:0
Authors
Koteswari Poluri
1,
Swetha Tippani
1,
Laxmi Prasanna P
1,
Swapna Saha
1,
Akshitha D
1,
Sana Saneela
1
Affiliations
1 Department of Pharmaceutics, Smt. Sarojini Ramulamma College of Pharmacy, Palamuru University, Mahabubnagar - 509001 Telangana,, IN
1 Department of Pharmaceutics, Smt. Sarojini Ramulamma College of Pharmacy, Palamuru University, Mahabubnagar - 509001 Telangana,, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 12, No 03 (2022), Pagination: 177-182Abstract
An ischemic stroke occurs when the blood supply to part of the brain is interrupted or reduced, preventing brain tissue from getting oxygen and nutrients. Brain cells begin to die in minutes. Ischemic stroke can be treated by using Antiplatelet drug such as aspirin as an immediate treatment which may prevent blood clots and improve recovery after stroke. Glycerol is also used as it decreases the edema in ischemic stroke. The aim of the present investigation is to develop a novel formulation of oil in Glycerol emulsion comprising aspirin in the treatment of ischemic stroke and in vitro evaluation. The oil in glycerol emulsion was prepared by high shear homogenization and prepared emulsions were evaluated for particle size, drug content, in vitro drug release and stability. Based on log P values of aspirin, olive oil is selected as oil phase and tween 80 was used as emulsifying agent. Total 10 formulations F1to F10 were prepared and among these, in F1-F6 phase separation was observed within 24 hrs whereas F8 to F10 were stable for one week and later creaming was observed and it is re-dispersible. The particle size was determined by optical microscopy and the average particle size for F8, F9 and F10 were 6.04, 3.38 and 7.8 μm respectively. Drug content was determined as 68±3.95%,108±5.816%, 103±4.61% respectively in compositions F8, F9 and F10. Rate of drug release followed first order kinetics and an immediate burst release effect was observed within 15 minutes. It is concluded that olive oil and glycerol emulsions containing aspirin is prepared successfully and evaluated. It is a promising formulation approach for co administration of aspirin and glycerol in the treatment of ischemic stroke. The formulations were physically and chemically stable. In vivo application of this formulation will be done in suitable animal models in future.Keywords
Ischemic stroke, Glycerol, High shear homogenization, Aspirin, Stability.
References
- Banerjee TK, Das SK. Epidemiology of s 1 troke in India. Neurology Asia 2006; 11: 1 – 4.
- Wasay M, Khatri IA, Kaul S. Stroke in South Asian Count 22 ries. Nature Reviews Neurology 2014; 10:135-143. doi:10.1038/nrneurol.2014.13.
- Sacco RL, Kasner SE, Broderick JP, Caplan LR, Connors JJ, Culebras A et al. An Updated Definition of Stroke for the 21st Century: A Statement for Healthcare Professionals from theAmerican Heart Association/American Stroke Association. Stroke. 2013;44:2064-2089; doi:10.1161/STR. 0b013e318296aeca.
- Meretoja A, Keshtkaran M, Saver JL, Tatlisumak T, Parsons MW, Kaste M, et al. Stroke thrombolysis: save a minute, save a day. Stroke 2014; 45: 1053-1058.
- ISA: Consensus statement. Recommendations for the early management of acute ischemic stroke: A consensus statement for health care professionals from the Indian stroke association.
- Sandip S, C and Swapnil DP. Simultaneous equation method for aspirin and omeprazole (Yosprala) tablet by using UV-Spectroscopy. Asian Journal Research in Pharmaceutical Sciences 202; 10:69-72.
- Pawar PY, Ankita RB, SOnu RL and Amrutha AB. Simultaneous estimation of atorvastatin calcium and aspirin in pure and capsule dosageform by using UV Spectrophotometric method. Der Pharma chemical 2013; 5:98-103.
- Sahoo CK, Satyanarayana K, Ramana DV and Panda KC. Formulation and evaluation of controlled release tablets of aspirin. Asian Journal of Pharmacy and Technology 2017; 7:229-233.
- Prajakta MP, Omprasad SN, Mangesh B, Somnath B and Dheeraj R. Extraction of pectin from lemon peel and its use as a natural binder in aspirin tablet. Asian Journal of Pharmacy and Technology 2012; 2:115-118.
- Vyshnavi K, Bhashetty M, Swain N, Venkatasway M and Ramesh A. Evaluation of prepared aspirin modified release tablets with polymer isolated from fresh mosambi leaves. Research Journal of Pharmaceutical Dosageforms and Technology 2017; 9: 45-47.
- Pawan Singh, Prevesh Kumar and Neelkant Prasad. Formulation and evaluation of aspirin tablets by using different lubricants in combination for better kinetic drug release study by PCP. Research Journal of Pharmacy and Technology 2017; 10:2934-2938.
- Jiyauddin Khan, Siti N, Ram KS et al. Development and evaluation of topical emulgel of aspirin using different polymeric bases. Research Journal of Pharmacy and Technology 2020; 12:6300-6304.
- Dhara P, Nimisha P, Anjali P, Jayvadan P, Antia P and Manish P. Microemulsion as a novel carrier for vaginal delivery – A review. Research Journal of Pharmacy and Technology 2012; 5:877-882.
- Ashish D, Asmita J and Shirishkumar K. Formulation development and in-vitro evaluation of self micro–emulsifying drug delivery systems (SMEDDS) of antiretroviral. Research Journal of Pharmacy and Technology 2012; 5, 1347-1351.
- Deepika Rani, Vaishali Sharma, Pinki singh and Ranjit Singh. Glycerosomes: A Novel vesicular drug delivery system. Research Journal of Pharmacy and Technology 2022; 15:921-6.