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Kishu Tripathi ¹, T. Siva Kumar ²

Affiliations
1 Institute of Pharmaceutical Sciences & Research Centre, Bhagwant University, Ajmer, Rajasthan, IN
2 Nandha College of Pharmacy, Tamil Nadu, IN

Abstract

Cholic acid, a natural biodetergent has been reported to exhibited antibacterial, antiviral⁵antifungal, antimalarial , antitubercular, anticancer, spermicidal , antiallergic etc.

Keywords

Cholic Acid, Antimicrobial Activity.

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Kishu Tripathi ¹, T. Siva Kumar ²

Affiliations
1 Surya College of Pharmacy, Lucknow, IN
2 Nandha College of Pharmacy, Tamil Nadu, IN

Abstract

Music is a combination of rhythmical, harmonic and melodic sounds, and many peoples, throughout history,have believed in its medicinal effects. Don Campbell more poetically puts it: 'Music helps plants grow, drives our neighbors to distraction, lulls children to sleep and marches men to war.'

Keywords

Music, Human Diseases.

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Kishu Tripathi ¹

Affiliations
1 Surya College of Pharmacy, Lucknow, IN

Abstract

Herbs like St. John's Wort, Kava Kava, Rhodiola, Siberian ginseng, Ginkgo, Liquorice, Chamomile, Borage, Black cohosh, Flaxseed, Hop, Lavender, Scutilaria ateriflora, Passion Flower, Rosemary, Lemon balm etc are used to treat depression.

Keywords

Depression, St. John's Wort, Kava Kava, Rhodiola, Siberian Ginseng.

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Shom Prakash Kushwaha ¹, Sunil Kumar Rawat ¹, Pavan Kumar ¹, Abhishek ¹, Kishu Tripathi ¹

Affiliations
1 Sagar Institute of Technology and Management, Department of Pharmacy, 6th Km. Stone, Faizabad Road, Barabanki, Uttar Pradesh, 225001, IN

Abstract

Diabetes mellitus is associated with impaired glucose metabolism that leads to an increase in blood glucose levels and free radicals production. Unfortunately none of the present drugs used in management of metabolic disorders are unimpeachable. Sulfonylureas result in hypoglycemia, Metformin increases the risk of lactic acidosis while Acarbose causes flatulence and bloating. Fracture risk is known to increase due to Pioglitazone and Rosiglitazone. Glitazones ameliorate endothelial dysfunction in patients with diabetes, lowers reactive oxygen species. The therapeutic attestation for 2,4-thiazolidinedione as antidiabetic, antioxidant agents has pointed toward its biodynamic nature. Limiting glucose lowering efficacy (20 % maximum decrease in fasting plasma glucose at the maximum recommended dose) and side effect profile (chiefly weight and fluid retention) confines the use of currently available thiazolidinediones. Therefore, novel thiazolidinediones compounds with superior glucose lowering efficacy and address to the components of metabolic syndrome (free radicals) are needed to be investigated.

Keywords

Diabetes Mellitus, 2,4-Thiazolidinedione, Free Radicals.

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Shom Prakash Kushwaha ¹, Pavan Kumar ¹, Sunil Kumar Rawat ¹, Abhishek ¹, Poonam Parashar ¹, Altaf Hussain ¹, Priyanka Singh ¹, Shikha Srivastava ¹, Kishu Tripathi ¹

Affiliations
1 Sagar Institute of Technology and Management, Department of Pharmacy, 6th Km. Stone, Faizabad Road, Barabanki, Uttar Pradesh, 225001, IN

Abstract

Health promotion is knacks of assisting people to enhance their motivation to strive for optimal health and supporting them in altering their lifestyle to move toward a state of finest health. Lifestyle transformation can be assisted through an amalgamation of experiences that enhance awareness. In India health alertness among the mass is been propagated from side to side through several media such as television, radio, newspaper, health camp, holdings. Often a question arises: Are people aware about general health issues such as family planning, vaccination? The general opinion was assembled from people and signaled that a large section of people was aware about family planning, vaccination, care for pediatric patient, care for women during pregnancy and safe delivery, balanced diet (for lactating mothers, infant and children) and various health programs organized by government/non-government organization to the people. On the other hand, people were not sure about their awareness regarding disease in the locality and care of old age patients and thus these restraining features need consideration and reflection in deeds.

Keywords

Family Planning, Vaccination, Care for Geriatric Patient, Health Awareness.

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Kishu Tripathi ¹, T. Siva Kumar ²

Affiliations
1 Institute of Pharmaceutical Sciences and Research Center, Bhagwant University, Ajmer, Rajasthan, IN
2 Nandha College of Pharmacy, Tamil Nadu, IN

Abstract

Vincristine is a vinca alkaloid obtained from Catharanthus and is a potent mitotic inhibitor.

Keywords

Vincristine, Mitotic Inhibitor.

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Parmesh Kumar Dwivedi ¹, Kishu Tripathi ², Mamta Mishra ³, Suprabhat Ray ¹

Affiliations
1 Amity Institute of Pharmacy, Amity University, Uttar Pradesh, Lucknow Campus, Lucknow, IN
2 Institute of Pharmaceutical Sciences and Research Center, Bhagwant University, Ajmer, Rajasthan, IN
3 State Public Analytical Laboratory (FDA), Lucknow, IN

Abstract

Leishmaniasis is a disease caused by number of protozoa in the genus leishmania,is a complex of diseases caused by 17 species of the protozoan parasite Leishmania and transmitted by~30 species of phlebotomine sandflies. Current treatment strategies and problems associated with it are given.

Keywords

Leishmaniasis, Antileishmanial.

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Kishu Tripathi ¹, T. Siva Kumar ²

Affiliations
1 Institute of Pharmaceutical Sciences and Research, Bhagwant University, Ajmer, IN
2 Nandha College of Pharmacy, Erode, Tamil Nadu, IN

Abstract

Bacopa also called as Brahmi is used in anxiety and depression, epilepsy, bronchitis and asthama, gastrointestinal disorders, cardiovascular effects, hyperthyroidism, protection from drug toxicity, Cancer, antioxidant activity, hepatoprotective activity, attention-deficit disorder, revitalizing intellectual functions in children, reduction of pain.

Keywords

Brahmi, Bacopa.

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Kishu Tripathi ¹, T. Siva Kumar ²

Affiliations
1 Institute of Pharmaceutical Sciences and Research Center, Bhagwant University, Ajmer, Rajasthan, IN
2 Nandha College of Pharmacy, Erode, Tamil Nadu, IN

Abstract

Bacopa also called as Brahmi is used in anxiety and depression, epilepsy, bronchitis and asthama, gastrointestinal disorders, cardiovascular effects, hyperthyroidism, protection from drug toxicity, Cancer, antioxidant activity, hepatoprotective activity, attention-deficit disorder, revitalizing intellectual functions in children, reduction of pain.

Keywords

Brahmi, Bacopa.

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Kishu Tripathi ¹

Affiliations
1 Surya College of Pharmacy, Lucknow, IN

Abstract

Curcumin is the the principal active phytochemical component in turmeric exhibit number of pharmacological actions like anti-inflammatory, antidiabetic, antibacterial, antifungal, antiprotozoal, antiviral, etc activities.

Keywords

Curcumin, Anti-Inflammatory, Antidiabetic, Antibacterial.

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Kishu Tripathi ¹

Affiliations
1 Surya College of Pharmacy, Lucknow, IN

Abstract

Curcumin is the the principal active phytochemical component in turmeric exhibit number of pharmacological actions like anti-inflammatory, antidiabetic, antibacterial, antifungal, antiprotozoal, antiviral, etc activities.

Keywords

Curcumin, Anti-Inflammatory, Antidiabetic, Antibacterial.

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Kishu Tripathi ¹

Affiliations
1 Surya College of Pharmacy, Lucknow, U.P., IN

Abstract

Omega 3 Fatty Acids ,Ginkgo biloba ,Turmeric ,Salvia miltiorrhiza, Rosemary, Withania somnifera, Vinpocetine, Centellaasiatica(GotuKola), Citicoline,Phosphatidyl Serine (PS),DMAE etc are used as memory enhancer.

Keywords

Memory Enhancer, Noortropic.

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Kishu Tripathi ¹

Affiliations
1 Surya College of Pharmacy, Lucknow, U.P., IN

Abstract

Obesity is one of the major health concerns which give an open invitation for six of the most terrible diseases known to man - diabetes, atherosclerosis, cardiovascular problems, paralysis, gangrene and heart attacks, therefore, herbs like Garcinia, Guggul, Kelp, Siberian ginseng, Green tea etc are used.

Keywords

Obesity, Herbs for Obesity.

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Parmesh Kumar Dwivedi ¹, Kishu Tripathi ², Mamta Mishra ³

Affiliations
1 Amity University, Lucknow, IN
2 Surya College of Pharmacy, Lucknow, IN
3 State Public Analytical Laboratory(FDA), Lucknow, IN

Abstract

Aminopyrimidine and its derivatives have a great biological importance. In last decades a number of compounds have been synthesized having aminopyrimidine moiety either fused with other ring system or its derivatives. These synthesized compounds show a lot of biological activity like anticancer, antimicrobial, antimalarial, antiviral and various other biological activities having importance in the treatment of diseases. Many reviews on pyrimidine are available but there is no collective information about aminopyrimidines for recent years. The purpose of present review is to provide exhaustive information about the aminopyrimidine as new target of drug synthesis.

Keywords

Aminopyrimidine.

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Parmesh Kumar Dwivedi ¹, Kishu Tripathi ², Mamta Mishra ³

Affiliations
1 Amity University, Lucknow, IN
2 Surya College of Pharmacy, Lucknow, IN
3 State Public Analytical Laboratory (FDA), Lucknow, IN

Abstract

Aminopyrimidine and its derivatives have a great biological importance. In last decades a number of compounds have been synthesized having aminopyrimidine moiety either fused with other ring system or its derivatives. These synthesized compounds show a lot of biological activity like anticancer, antimicrobial, antimalarial, antiviral and various other biological activities having importance in the treatment of diseases. Many reviews on pyrimidine are available but there is no collective information about aminopyrimidines for recent years. The purpose of present review is to provide exhaustive information about the aminopyrimidine as new target of drug synthesis.

Keywords

Aminopyrimidine.

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Kishu Tripathi ¹

Affiliations
1 Surya College of Pharmacy, Lucknow (UP), IN

Abstract

Garlic, Allium sativum is among the oldest of all cultivated plants. It has been used as a medicinal agent for thousands of years. It is a remarkable plant, which has multiple beneficial effects such as antimicrobial, antithrombotic, hypolipidemic, antiarthritic, hypoglycemic and antitumoractivity, hypocholesterolaemic, antioxidant, pesticidal, antidepressant, neuroprotective, artery and heart protector, hair re-growth inducer, immune booster etc.

Keywords

Garlic, Allium sativum.

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Kishu Tripathi ¹

Affiliations
1 Surya College of Pharmacy, Lucknow (UP), IN

Abstract

Herbal abortifacients are among the oldest herbal medicines, found in every indigenous pharmacopeia including Black Cohosh, Blue Cohosh, Gossypium, Primrose (Oenotherahookeri), Parsley (Petroselinum crispum), Penny Royal (Mentha Pulegium), Pineapple, Tansy (Tanacetum vulgare), Daucus carota, Vitamin C etc.

Keywords

Herbal Abortifacients, Black Cohosh, Blue Cohosh, Penny Royal.

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Kishu Tripathi ¹

Affiliations
1 Surya College of Pharmacy, Lucknow, IN

Abstract

Garlic [Allium sativum] is among the oldest of all cultivated plants. It has been used as a medicinal agent for thousands of years. It is a remarkable plant, which has multiple beneficial effects such as antimicrobial, antithrombotic, hypolipidemic, antiarthritic, hypoglycemic and antitumor activity etc.

Keywords

Garlic, Allium.

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Kishu Tripathi ¹

Affiliations
1 Surya College of Pharmacy, Lucknow, IN

Abstract

Metallopharmaceuticals used as anticancer agents, metal-mediated antibiotics, antibacterials, antivirals, antiparasitics, antiarthritics, andradiosensitizing agents appear in therapeutic medicinal inorganic chemistry.

Keywords

Metallopharmaceuticals, Metallodrugs.

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Alka Verma ¹, Bhupesh Verma ¹, Sunil Kumar Prajapati ², Kishu Tripathi ³

Affiliations
1 Saroj Institute of Technology and Management, Lucknow (UP), IN
2 Department of Pharmacy, Bundelkhand University, Jhansi (UP), IN
3 Surya College of Pharmacy, Lucknow (UP), IN

Abstract

The development of prodrugs promises to be very effective method for treatment of diseases in future. This approach has several advantages over conventional drug administration. Prodrugs design to maximize the amount of an active drug reaching its target through changing the physicochemical, biopharmaceutical or pharmacokinetic properties of drugs. It also includes characteristics development and classification, effect of prodrug on solubility, permeability and targeted challenge.

Keywords

Prodrug, Delivery System.

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Kishu Tripathi ¹, Shobha Kulshreshtha ²

Affiliations
1 Surya College of Pharmacy, Lucknow, IN
2 Department of Pharmacology, SN Medical College, Agra, IN

Abstract

Inhibiting 11HSD2;mediate cortisol-dependent nuclear translocation and transcriptional activation of MR and are responsible at least for a part of the sodium retention and potassium excretion observed in patients with biliary obstruction;dose-dependent scratching of the injected site with the forepaws and hindpaws. Up to 100 μg of sodium deoxycholic acid, deoxycholic acid induced intestinal secretion in part by lowering mucosal permeability; DCA decreased adhesion of HCA-7 cells to the substratum and induced dephosphorylation of FAK at Tyrosine-576/577 (Tyr-576/577) and Tyr-925; inhibition of Clostridium botulinum, hyperproliferation of colonic crypt cells with an expansion of the proliferative zone,which is regarded as a biomarker of increased cancer risk; significantly increase tyrosine phosphorylation of catenin, induce urokinase-type plasminogen activator, uPAR, and cyclin D1 expression and enhance colon cancer cell proliferation and invasiveness ,major impact on apoptotic mechanisms in colonic cells and this may be contributing to its effect as a tumor promoter.

Keywords

Deoxycholic Acid.

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