Informatics Publishing Limited

Vasantha Kumar ¹, C. M. Ramesha ², V. Sharanraj ³, Sadashiva M ⁴, Kavya K ⁵

Affiliations
1 Department of Mechanical Engineering, Bearys Institute of Technology, Visvesvaraya Technological University,Mangalore, Karnataka, India., IN
2 Department of Mechanical Engineering, MSRIT, Visvesvaraya Technological University, Bengaluru, Karnataka, India., IN
3 Department of Mechanical Engineering (W&SM), Sri Jayachamarajendra (Govt.) Polytechnic, Bengaluru, Karnataka,India., IN
4 Department of Mechanical Engineering, PES College of Engineering, Visvesvaraya Technological University, Mandya,Karnataka, India., IN
5 Department of Zoology, St. Joseph’s University, Bengaluru, Karnataka, India., IN

Abstract

This research article intended to study and comparison of cytotoxicity effects of Magnesium AZ31 and PEEK 450G biomaterials. L-929 mouse fibroblast cell line was used to measure cytotoxicity effect of Magnesium AZ31 and PEEK 450G biomaterials by extraction method. Biocompatibility in-vitro cytotoxicity test was performed on L-929 mouse fibroblast cell line for Magnesium AZ31 and PEEK 450G samples. In extraction process, leachates take out from the test samples were used for measurements of cytotoxicity. Since there was reactivity and the reactivity grade was greater than ‘2’ in Magnesium AZ31 biomaterial, test sample was measured as non-toxic, where as in PEEK 450G biomaterial there was no reactivity, no reduction in cell growth and no cell lysis, the grade was zero, and test sample was measured as non-toxic. Hence PEEK 450G biomaterial reveals an outstanding cytotoxicity behaviour than Magnesium AZ31. This is an added advantage for cardiovascular stent implant applications.

Keywords

Cytotoxicity, Biomaterials, Peek 450G, In-Vitro, Biocompatibility, Cardiovascular Stent Implant.

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