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Goyal, Kamya

A Concise Review on Synthesis, Anti-inflammatory and Antioxidant Activities of Chalcone

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Authors

Dheeraj Singh ¹, Vishal Kaundal ¹, Neha Aggarwal ¹, Shammy Jindal ², Amar Deep Ankalgi ¹, Kamya Goyal ¹

Affiliations
1 Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog, H.P., IN
2 Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, H.P., IN

Source

Asian Journal of Pharmaceutical Research, Vol 12, No 1 (2022), Pagination: 37 - 44

Abstract

Chalcones and their derivatives have been an area of great interest in recent years. Numbers of research publications have been published and chalcones continue to show promising effect for new drug investigations. Chalcone is an advantageous species with medicinal importance as it is consisting of highly reactive ketoethylenic system –CO–CH=CH– which belongs to flavonoids. Chalcones (1, 3-Diphenyl-2-propen-1-one) consists of a three carbon α, β-unsaturated carbonyl system and two or more aromatic rings and acts as precursors for the biosynthesis of flavonoids in plants. However, synthesis in laboratory of broad range of chalcones has also been reported. In chalcone and its derivatives, a highly reactive α, β-unsaturated carbonyl system is the major reason for their pharmacological potencies. Chalcones and their derivatives are known to show a wide range of pharmacological potencies such as anti-inflammatory, antioxidant, antileishmanial, antifungal, anticancer, antibacterial, antiulcer, antiprotozoal, antitumor, antimalarial, antidiabetic, anthelmintic, insecticidal, antigout, antihistaminic, antiviral, antimycobacterial etc. Chalcones can be prepared by Claisen– Schmidt’s condensation, Aldol condensation, Heck’s reaction, Suzuki’s reaction, Ultrasound method of synthesis, Solvent free synthesis of chalcones, One pot synthesis, Sonogashira Isomerization coupling reaction etc. The purpose of the present review is to focus on the various methods of preparation of chalcones and derivatives and their anti-inflammatory and antioxidant potencies.

Keywords

Chalcone, Claisen–Schmidt condensation, Aldol condensation, anti-inflammatory, antioxidant

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References

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Recent Updates on Psoriasis: A Review

Abstract Views :66 | PDF Views:0

Authors

Tejasavi Mahajan ¹, Navdeep Singh ¹, Kamya Goyal ², Shammy Jindal ¹, Vinay Pandit ¹, M.S. Ashawat ¹

Affiliations
1 Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog Jawalaji Dist - Kangra (H.P.), IN
2 Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog Jawalaji Dist - Kangra (H.P.), IN

Source

Asian Journal of Pharmaceutical Research, Vol 12, No 1 (2022), Pagination: 76 - 83

Abstract

In the past 15 years, breakthroughs in the understanding towards the pathogenesis of psoriasis have been translated into highly and targeted effective therapies which provides fundamental insights into the pathogenesis of chronic inflammatory diseases. In this article we understand the mechanisms involved in the initiation and development of psoriasis, as well as the therapeutic options that arises from the dissection of the inflammatory psoriatic pathways. The whole discussion begins by addressing the inflammatory pathways and key cell types which initiating and perpetuating the psoriatic inflammation. Also, we discuss the role of genetics, associated epigenetic mechanisms, and the interaction of the skin flora in the pathophysiology of psoriasis. So, we the purpose of our study is to understand psoriasis comprehensively, and this review is well-established to explain the therapies, and other novel targeted drugs that are mostly used in the effective treatment of psoriasis.

Keywords

Psoriasis, Types, Pathogenesis, Epidemiology, Pharmacotherapy

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A Laconic Review on Chalcones: Synthesis, Antimicrobial and Antioxidant activities

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Authors

Vishal Kaundal ¹, Dheeraj Singh ¹, Vipasha ², Arti Devi ³, Shammy Jindal ⁴, Amar Deep Ankalgi ⁵, Kamya Goyal ⁵

Affiliations
1 1Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog, H.P., India, IN
2 Department of Pharmacology, Maharaja Ranjit Singh Punjab Technical University, Bathinda, Punjab, India., IN
3 Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog, H.P., India, IN
4 Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, H.P., India, IN
5 Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog, H.P., India., IN

Source

Asian Journal of Research in Pharmaceutical Sciences, Vol 12, No 1 (2022), Pagination: 21-28

Abstract

Chalcones and their derivatives have been an area of great interest for several researchers in recent years. Several number of research publications have been published and chalcones continue to show promising effect for novel drug investigations. Chalcone is an advantaged moiety with therapeutic importance as it comprises of receptive ketoethylenic moiety – CO–CH=CH– having a place with flavonoids. Chalcones (1, 3-Diphenyl-prop-2-en-1-one) consists of a three carbon α, β-unsaturated carbonyl system and two or more aromatic rings and acts as precursors for the biosynthesis of flavonoids in plants. The presence of a highly reactive α, β-unsaturated carbonyl system in chalcone and its derivatives is the justification for its pharmacological potencies. However, synthesis in laboratory of broad range of chalcones has also been reported. Chalcones show a wide range of pharmacological impacts like anthelmintic, antileishmanial, antifungal, antimalarial, antioxidant, antiviral, antibacterial, antiulcer, antimycobacterial, insecticidal, antigout, antihistaminic, antiprotozoal, insecticidal, anticancer, antidiabetic, anti-inflammatory, analgesic etc. Chalcones can be synthesized through Claisen–Schmidt's condensation, Heck's reaction, Aldol condensation reaction, Suzuki's reaction, from cinnamic acid, Sonogashira Isomerization Coupling reaction, Microwave assisted synthesis etc. The purpose of the present review is to centralize the various and widely employed methods of synthesis of chalcone and their various derivatives and their antimicrobial and antioxidant activities.

Keywords

Chalcones, Antimicrobial activity, Antioxidant activity, Claisen–Schmidt condensation, Microwave assisted synthesis.

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Application of Nanocarrier in Drug development with special Emphasis on Liposomes: A Review

Abstract Views :76 | PDF Views:0

Authors

Anshul Sharma ¹, Keshav Dhiman ¹, Anshul Sharma ¹, Kamya Goyal ², Vinay Pandit ¹, M. S. Ashawat ¹, Shammy Jindal ¹

Source

Asian Journal of Pharmacy and Technology, Vol 12, No 4 (2022), Pagination: 320-328

Abstract

Liposomes are the nano-scale bilayer structure of phospholipid used as a carrier for a Large Variety of drugs. Both lipophilic and hydrophilic drugs can encapsulate into the liposome and delivered to the body. The purpose behind the preparation of liposomes is to reduce the side effects associated with systemic delivery of drugs as well as it also helps in the protection of biodegradable drugs and molecules such as protein and peptides from body enzymes and fluids. Other than these advantages liposome also have high skin permeation due to structural similarities with the stratum corneum and therefore can be used for the topical delivery of drugs. The various types of liposomes and their application in their marketed products are discussed below in the article.

Keywords

Liposome, Gene Therapy, Theranostic Applications

Full Text

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Application of Berberine on Skin Diseases: A Review

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Authors

Keshav Dhiman ¹, Anshul Sharma ¹, Anshul Sharma ¹, Kamya Goyal ², Vinay Pandit ¹, M. S. Ashawat ¹, Shammy Jindal ¹

Source

Research Journal of Pharmaceutical Dosage Form and Technology, Vol 14, No 4 (2022), Pagination: 304-308

Abstract

The plants containing berberine have been used for the treatment of skin diseases, inflammatory disorders, and reducing fevers, wound healing, digestive and respiratory diseases and in treatment of tumors. By taking the specific properties of the berberine, this review describes the method mentioned in the literature regarding the berberine extraction. Furthermore, many experimental and clinical studies suggest that berberine has several pharmacological activities such as antioxidative, cardioprotective, nephroprotective, and hepatoprotective effect. This review summarizes the information about botanical occurrence, traditional uses and pharmacological effects of berberine and berberine containing plants.

Keywords

Berberine, Skin Diseases, Psoriasis.

Full Text

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Fusidic Acid: A Therapeutic Review

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Authors

Anshul Sharma ¹, Keshav Dhiman ², Anshul Sharma ³, Kamya Goyal ⁴, Vinay Pandit ⁴, M.S. Ashawat ⁵, Shammy Jindal ¹

Affiliations
1 Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Jawalaji, Distt. Kangra (H.P.) India., IN
2 Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Jawalaji, Distt. Kangra (H.P.) India, IN
3 1Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Jawalaji, Distt. Kangra (H.P.) India, IN
4 Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog, Jawalaji, Distt. Kangra (H.P.) India., IN
5 Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Jawalaji, Distt. Kangra (H.P.) India ., IN

Source

Asian Journal of Research in Chemistry, Vol 15, No 5 (2022), Pagination: 372 - 380

Abstract

Fusidic acid (FA), derived from the fungus Fusidium coccineum, is an antimicrobial agent that inhibits bacterial protein synthesis by preventing EF-G translocation. This review will provide information regarding the properties of FA, as well as studies on its clinical efficacy in skin and soft-tissue infections (SSTIs). FA has been used for treatment of infection caused by gram- positive microorganism. FA cream or ointment are clinically effective and shown minimum adverse reaction when used in SSTIs two or three times regularly. The analytical methods which describe the presence of FA in biological samples and pharmaceutical formulations are reviewed in this article. High-performance liquid chromatography has been widely used analytical method in the analysis of FA, as it can reduce the cost as well as time of analysis. This review also includes the information regarding the randomised trials which investigates the clinical efficacy of fusidic acid in dermatology in comparative trials that were discovered.

Keywords

High-performance liquid chromatography, Gram- positive microorganism.

Full Text

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Goyal, Kamya

A Concise Review on Synthesis, Anti-inflammatory and Antioxidant Activities of Chalcone

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Recent Updates on Psoriasis: A Review

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A Laconic Review on Chalcones: Synthesis, Antimicrobial and Antioxidant activities

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Application of Nanocarrier in Drug development with special Emphasis on Liposomes: A Review

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Application of Berberine on Skin Diseases: A Review

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Fusidic Acid: A Therapeutic Review

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