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Padmalatha, K.
- Analytical UV Spectroscopic Method Development and Validation for the Estimation of Mycophenolate Mofetil
Abstract Views :363 |
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Authors
Affiliations
1 Department of Pharmaceutical Analysis and Quality Assurance. Vijaya Institute of Pharmaceutical Sciences for Women. NH-5, Enikepadu. Vijayawada - 521 108, IN
1 Department of Pharmaceutical Analysis and Quality Assurance. Vijaya Institute of Pharmaceutical Sciences for Women. NH-5, Enikepadu. Vijayawada - 521 108, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 5, No 4 (2015), Pagination: 209-213Abstract
A simple, precise, accurate UV-spectroscopic method was developed and validated for the determination of Mycophenolate Mofetil in bulk and dosage form using solvents like methanol for dissolving the drug and acetate buffer of pH-3.5 for dilutions. At the λmax of 250nm, it was proved linear in the range 10- 50 μg/ml, and exhibit good correlation coefficient (R2 =0.995) and excellent mean recovery (99.990-100.014). The developed method was validated for accuracy, precision, robustness, ruggedness according to ICH guidelines. All these parameters showed adaptability of the method for the quality control analysis of Mycophenolate Mofetil in bulk and in marketed formulation.Keywords
Mycophenolate Mofetil, UV-Spectroscopy, Acetate Buffer, Validation.
- Synthesis, Characterization and Evaluation of Starch Acetate as Rate Controlling Matrix for Controlled Release of Aceclofenac
Abstract Views :153 |
PDF Views:3
Authors
Affiliations
1 Department of Pharmaceutics, Vijaya Institute of Pharmaceutical Sciences for Women, Enikepadu, Vijayawada–521108, IN
2 Department of Pharmacology, Vijaya Institute of Pharmaceutical Sciences for Women, Enikepadu, Vijayawada–521108, IN
1 Department of Pharmaceutics, Vijaya Institute of Pharmaceutical Sciences for Women, Enikepadu, Vijayawada–521108, IN
2 Department of Pharmacology, Vijaya Institute of Pharmaceutical Sciences for Women, Enikepadu, Vijayawada–521108, IN
Source
Research Journal of Pharmacy and Technology, Vol 10, No 1 (2017), Pagination: 121-130Abstract
The objective of the present study is to develop Aceclofenac control release matrix tablet formulations by wet granulation method employing starch citrate, a new modified starch. Starch acetate prepared by reacting potato starch with acetic anhydride in the presence of sodium hydroxide at elevated temperatures was insoluble in water and has poor swelling and gelling property when heated in water. The degree of substitution (DS) of starch acetate was found to be 1.60 and high DS develop hydrophobicity are insoluble acetone and chloroform. In the micromeritic evaluation, the angle of repose and compressibility index values revealed the excellent flow characteristic of starch acetate prepared. All the physical properties studied indicated that starch acetate is a promising pharmaceutical excipient in tablets. Aceclofenac, a widely prescribed anti inflammatory analgesic drug belongs to BCS class II and exhibit variable oral bioavailability due to its poor solubility and dissolution rate. Matrix tablets of Aceclofenac (100 mg) prepared employing starch acetate as matrix former in different proportions gave slow and controlled release more than 12 hr. Aceclofenac release was diffusion controlled and dependent on percentage of starch acetate. As the polymer concentration was increased, release rate was decreased. Good linear relationship was observed between percent polymer and release rate (K0). Thus drug release from the matrix tablets could be controlled by varying the proportion of drug: polymer in the matrix.Keywords
Starch Acetate, Anti Inflammatory, Matrix Tablets, Controlled Release and Non-Fickian Diffusion.- Hydrotropy: A Promising Tool for Solubility Enhancement
Abstract Views :68 |
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Authors
Affiliations
1 Department of Pharmaceutics, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, IN
2 Department of Pharmacology, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, IN
1 Department of Pharmaceutics, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, IN
2 Department of Pharmacology, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, IN
Source
Asian Journal of Pharmacy and Technology, Vol 12, No 2 (2022), Pagination: 146-150Abstract
Solubility is one of the key parameters to attain desired concentration of drug in systemic circulation to show pharmacological response. Various methods are engaged to augment the aqueous solubility of poorly water-soluble drugs and hydrotropic solubilisation is one of them. Hydrotropy is defined as a solubilization process whereby addition of a large amount of second solutes results in an increase in the aqueous solubility of another solute and chemicals which are used in the hydrotropy are called hydrotropes like sodium benzoate, sodium citrate, urea, niacinamide etc. Based on advantages like the high selectivity, independent of pH and cheap, easy availability makes this technique more prevailing than other solubilisation methods. Mixed hydrotropy is a solubilisation technique to augment the water solubility of poorly water soluble drugs by the way of different ratio of blends of hydrotropic agents which gives synergistic augmentation effect. The purpose of this review article is to illustrate the need for solubility, hydrotropic solubilisation, mechanism of action of hydrotrope, classification of hydrotropes, advantages and mixed hydrotropic technique of solubilisation for improving the solubility which in turn helps to attain absorption and improved bioavailability.Keywords
Hydrotropy, Hydrotropes, Solubility, Mixed Hydrotropy, SolubilisationReferences
- Kapadiya Nidhi, Singhvi Indrajeet, Mehta Khushboo, Karwani Gauri, Dhrubo Jyoti Sen. Hydrotropy: A promising tool for solubility enhancement: A Review. International Journal of Drug Development & Research 2011; 3(2): 26 – 33.
- V. Sampath Kumar, C. Raja, C. Jayakumar. A review on solubility enhancement using hydrotropic phenomena. International Journal of Pharmacy and Pharmaceutical Sciences 2014; 6(6): 1 – 7.
- R. K. Maheshwari and Y. Jagwani. Mixed Hydrotropy: Novel Science of solubility Enhancement. Indian Journal of Pharmaceutical Sciences 2011; 73(2): 179 – 183.
- Md. Ali Sajid, Vicky Choudhary. Solubility Enhancement Methods with importance of hydrotropy. Journal of Drug Delivery and Therapeutics 2012; 2(6): 96 – 101.
- Vividha Dhapte, Piyush Mehta. Advances in hydrotropic solutions: An updated review. St. Petersburg Polytechnical University Journal: Physics and Mathematics 2015; 1: 424 – 435.
- Varun Raj Vemula, Venkateshwarlu Lagishetty, Srikanth Lingala. Solubility Enhancement Techniques. International Journal of Pharmaceutical Sciences Review and Research 2010; 5(1): 41 – 51.
- Satish Polshettiwar, Snehal Shivaji Khorate. Mixed Hydrotropy: A rising tool for solubility enhancement of transdermal drug delivery and cosmeceutical applications. Indo American Journal of Pharmaceutical Research 2016; 6 (10): 6680 – 6690.
- K. Girishpai, S. Divya, M. Reddy, L. Kumar, V. Krishna. Solubility enhancement of norfloxacin by hydrotropy technique. International Journal of Pharmacy and Pharmaceutical Sciences 2014; 6 (8): 395 – 397.
- C. Jayakumar, A. Morais, N. Arunodhaya, N. Gandhi. Solubility enhancement of theophylline drug using different solubilisation techniques. International Journal of Pharmaceutical and Clinical Science 2012; 2(1): 7 – 10.
- Mangesh R. Patil, Saurabh B. Ganorkar, Amod S. Patil, Atul A. Shirkhedkar and Sanjay J. Surana. Hydrotropic Solubilization in Pharmaceutical Analysis: Origin, Evolution, Cumulative Trend and Precise Applications. Critical Reviews in Analytical Chemistry 2021; 51(3): 278 - 288.
- Jyoti Joshi, Nidhi Nainwal Sharma, Vikas Anand Saharan. A review on hydrotropy: A potential approach for the solubility enhancement of poorly soluble drug. Asian Journal of Pharmaceutical and Clinical Research 2019; 12(10): 19 – 26.
- Avital Beig, David Lindley, Jonathan M. Miller, Riad Agbaria1 and Arik Dahan. Hydrotropic Solubilization of Lipophilic Drugs for Oral Delivery: The Effects of Urea and Nicotinamide on Carbamazepine Solubility–Permeability Interplay. Frontiers in Pharmacology 2016; 7: Article 379.
- Asmat Majeed, Syed Naiem Raza and Nisar Ahmad Khan. Hydrotrophy: Novel solubility enhancement technique: a review. International Journal of Pharmaceutical Sciences and Research 2019; 10(3): 1025-1036.
- K. Venkata Gopaiah. Hydrotropic technique: a promising method to enhance aqueous solubility of nimesulide and to reduce difficulties in bioavailability. Asian Journal of Pharmaceutics 2018; 12(4): 2951 -2960.
- Alka N Choudhary and Suhasini Nayal. A review: Hydrotropy a solubility enhancing technique. The Pharma Innovation Journal 2019; 8(4): 1149-1153.
- Sneha Jagtap, Chandrakant Magdum, Dhanraj Jadge, Rajesh Jagtap. Solubility Enhancement Technique: A Review. Journal of Pharmaceutical Sciences and Research 2018; 10(9): 2205-2211.
- Sikarra Deepshikha, Shukla Vaibhav, Kharia Ankit Anand. Review Article Techniques for Solubility Enhancement of Poorly Soluble Drugs: An Overview. Journal of Medical Pharmaceutical and Allied Sciences 2012; 01: 18-38.
- Priyanka Arjaria. Hydrotropic Solubilization. International Journal of Pharmaceutical and Psychopharmacological Research 2013; 3(1):17-23.
- Deepak Ghogare, Sheetal Patil. Hydrotropic Solubilization: Tool for Eco-Friendly Analysis, International Journal of Pharmacy and Pharmaceutical Research 2018; 11(3): 300-322.
- Rajawardhan Reddy. A Review on Hydrotropy. Journal of Pharma Research. 2013; 2(4): 5-6.
- Prakash Khadka, Jieun RO. Pharmaceutical Particle Technologies: An Approach to Improve Drug Solubility, Dissolution and Bioavailability. Asian Journal of Pharmaceutical Sciences 2014; 9: 304-316.
- Keshav Jindal. Reviewon Solubility: A Mandatory Tool for Pharmaceuticals. International Research Journal of Pharmacy 2017; 8(11): 11-15.
- Kadam SV, Shinkar DM, Saudagar RB. Review on Solubility Techniques. International Journal of Pharmacy and Biological Sciences 2013; 1: 462-475.
- Badwan AA, El-Khordagui LK, Saleh AM. The Solubility of Benzodiazepines In Sodium Salicylate Solutions And A Proposed Mechanism For Hydrotropic Solubilisation. Int. J Pharm. 1983; 13: 67 - 74.
- Avinash Dhobale V, Gunesh Dhembre N. Solubility Enhancement Techniques A Review, IAJPS 2018; 05(04): 2798-2810.
- Sandeep Kumar, Pritam Singh. Various Techniques for Solubility Enhancement: An Overview. The Pharma Innovation Journal 2016; 5(1): 23-28.
- A Review on Transdermal Drug Delivery System
Abstract Views :55 |
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Authors
Affiliations
1 Department of Pharmaceutics, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, IN
2 Department of Pharmacology, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, IN
1 Department of Pharmaceutics, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, IN
2 Department of Pharmacology, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, IN
Source
Asian Journal of Pharmacy and Technology, Vol 12, No 2 (2022), Pagination: 159-166Abstract
Nowadays about 74% of drugs are taken orally and are found not to be as effective as required. To improve such characters transdermal drug delivery system was emerged. Drug delivery through the skin to attain a systemic effect of a drug is commonly known as transdermal drug delivery and differs from traditional topical drug delivery. Transdermal drug delivery systems (TDDS) are dosage forms involves drug transport to viable epidermal and or dermal tissues of the skin for local therapeutic effect while a very major fraction of drug is transported into the systemic blood circulation. The adhesive of the transdermal drug delivery system is critical to the safety, efficacy and quality of the product. Topical administration of therapeutic agents offers many advantages over conventional oral and invasive methods of drug delivery. Several important advantages of transdermal drug delivery are limitation of hepatic first pass metabolism, enhancement of therapeutic efficiency and maintenance of steady plasma level of the drug. This review article provides an overview of advantages and disadvantages, factors affecting transdermal drug delivery, components and types of transdermal drug delivery, methods of preparation and methods of evaluation.Keywords
TDDS, Topical Drug Delivery, Systemic Blood Circulation, SkinReferences
- Ashvini S. Kadam, Mukesh P. Ratnaparkhi, Shilpa P. Chaudhary. Transdermal drug delivery: An overview. International Journal of Research and Development in Pharmacy and Life Sciences 2014; 3(4): 1042 – 1053.
- J. Ashok Kumar, Nikhila Pullakandam, S. Lakshmana Prabu, V. Gopal. Transdermal drug delivery system: An overview. International Journal of Pharmaceutical Sciences Review and Research 2010; 3(2): 49 – 54.
- Latheeshjlal.L, P. Phanitejaswini, Y. Soujanya, U. Swapna, V. Sarika, G. Moulika. Transdermal drug delivery systems: An overview. International Journal of Pharm Tech Research 2011; 3(4): 2140 – 2148.
- Richa Sachan, Meenakshi Bajpai. Transdermal drug delivery system: A review. International Journal of Research and Development in Pharmacy and Life Sciences 2013; 3(1): 748 – 765.
- Dipen Patel, Sunita A. Chaudhary, Bhavesh Parmar, Nikunj Bhura. Transdermal drug delivery system: A review. The Pharma Journal 2012; 1(4): 65 – 75.
- H. Michael Wolff. Future of Transdermal drug delivery systems. American Pharmaceutical Review 2014; 3(2): 1 – 6.
- Shalu Rani, Kamal Saroha, Navneet Syan, Pooja Mathur. Transdermal patches a successful tool in Transdermal drug delivery system: An overview. Pelagia Research Library 2011; 2(5): 17 – 29.
- Mark R. Prausnitz and Robert Langer. Transdermal drug delivery. Nat Biotechnol. 2008; 26 (11): 1261 – 1268.
- Ahlam Zaid Alkilani, Maeliosa T. C. Mc Crudden and Ryan F. Donnelly. Transdermal drug delivery: Innovative Pharmaceutical Developments based on disruption of the barrier properties of the stratum corneum. Pharmaceutics 2015; 7: 438 – 470.
- Anna M. Wokovich. Suneela Prodduturi, William H. Doub. Ajaz S. Hussain, Lucinda F. Buhse. Transdermal drug delivery system adhesion as a critical safety, efficacy and quality attribute. European Journal of Pharmaceutics and Biopharmaceutics 2006; 64 (1): 1 - 8.
- Berner B and John V.A. Pharmacokinetic characterization of Transdermal delivery systems. Jour. Clinical pharmacokinetics 1994; 26 (2): 121 - 34.
- Jalwal P, Jangra A, Dhaiya L, Sangwan Y, Saroha R. A review on transdermal patches. Pharm Res. J. 2010; 3: 139 - 149.
- Bhowmik D, Chiranjib, Chandira M, Jayakar B, Sampath KP. Recent advances in transdermal drug delivery system. Int. J Pharm Tech Res. 2010; 2(1):68 - 77.
- Kumar A, Pullankandam N, Prabhu SL, Gopal V. Transdermal drug delivery system: an overview. Int. J Pharm Sci. Review Res. 2010; 3(2):49 - 54.
- Divya A, Rao MK, Gnanprakash K, Sowjanya A, Vidyasagar N, Gobinath M. A review on current scenario of transdermal drug delivery system. Int. J Res. Pharm Sci. 2012; 3(4):494 - 502.
- Rani S, Saroha K, Syan N, Mathur P. Transdermal patches a successful tool in transdermal drug delivery system. Plegia Res. Lib. 2011; 2(5): 17 - 29.
- Patel D, Chaudhary SA, Parmar B, Bhura N. Transdermal drug delivery system: a review. The Pharm Innovation. 2012; 1(4): 66-75.
- Ramteke KH, Dhole SN, Patil SV. Transdermal drug delivery system: a review. J Advanced Sci. Res. 2012;3(1):22-35.
- Yadav V. Transdermal drug delivery system: review. Int. J Pharm Sci. Res. 2012; 3(2): 376-382.
- Sharma RK, Keleb E, Mosa EB, Aljahwi AAZ. Transdermal drug delivery system- design and evaluation. Int. J Advances Pharm Sci. 2010; 1: 201 - 211.
- Sandhu P, Bilandi A, Kataria S, Middha A. Transdermal drug delivery system (patches), applications in present scenario. Int. J Res. Pharm Chem. 2011; 1(4): 1139 - 1151.
- Singh MC, Naik AS, Sawant SD. Transdermal drug delivery system with major emphasis on transdermal patches: a review. J Pharm Res. 2010; 3(10): 2537 - 2543.
- Yadav B, Sharma B, Saroha K. Transdermal patches: a discrete dosage form. Int. J Current Pharm Res. 2011; 3(3): 98 - 108.
- Gupta IK, Chokshi MM. Transdermal drug delivery system: an overview. Asian J Pharm Sci. Clinical Res. 2011; 1(1): 25 - 43.
- Jatav VS, Saggu JS, Jat RK, Sharma AK, Singh RP. Recent advances in development of transdermal patches. Pharmacophore Int. Res. J. 2011; 2(6): 287 - 297.
- Arunachalam A, Karthikeyan M, Kumar DV, Pratap M, Sethuraman S, Kumar SA. Transdermal drug delivery system: review. Current Pharm Res. 2010; 1(1): 70 - 81.
- Wokovich AM, Prodduturi S, Doub WH, Hussain AS, Buhse LF. Transdermal drug delivery system (TDDS) adhesion as a critical safety, efficacy and quality attribute. Eup. J Pharm BioPharm. 2006; 64: 1 - 8.
- Dhiman S, Thakur GS, Rehni AK. Transdermal patches: a recent approach to new drug delivery system. Int. J Pharmacy Pharm Sci. 2011; 3(5): 26 - 34.
- Lende LK, Grampurohit ND, Gaikwad DD, Gadhave MV, Jadhav SL. Transdermal patches: a review. Int. J Pharm Res. Dev. 2011; 4(3): 96 - 103.
- Sakalle P, Dwivedi S, Dwivedi A. Design, evaluation, parameters and marketed products of transdermal patches: a review. J Pharm Res. 2010; 3(2): 235 - 240.
- Sachan B, Bajpai M. Transdermal drug delivery system: A review. Int. J Res. Dev. Pharm and life Sci. 2013; 3(1): 748 - 765.
- Bathe R, Kapoor R. Transdermal drug delivery system: formulation, development and evaluation - An overview. J Biomedical and Advance Res 2015; 6(01): 1 - 10.
- Mali AD, Bathe R, Patil M. An updated review on transdermal drug delivery systems. Int. J advances Sci. Res. 2015; 1(06): 244 - 254.
- Gaikwad AK. Transdermal drug delivery system: Formulation aspects and evaluation. Comprehensive J Pharm Sci. 2013; 1(1): 1 - 10.
- Shingade GM, Aamer Q, Sabale PM, Grampurohit ND, Gadhave MV, Jadhav SL, Gaikwad D. Review on: Recent Trends on Transdermal Drug Delivery System. J Drug Delivery Therapeutics 2012; 2(1): 66 - 75.
- Fast Dissolving Tablets: A Review
Abstract Views :70 |
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Authors
Affiliations
1 Department of Pharmaceutics, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, IN
1 Department of Pharmaceutics, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, IN
Source
Asian Journal of Pharmacy and Technology, Vol 12, No 2 (2022), Pagination: 183-189Abstract
In the pharmaceutical Industry oral route is considered as the safest and convenient route. Fast dissolving tablets (FDTs) are solid dosage forms containing drugs that disintegrate in the oral cavity within less than 1 minute leaving an easy to swallow residue. These dosage forms include superdisintegrants which impart quick disintegration with existence of saliva and can be swallowed without difficulty. Fast dissolving tablets are the very good preference for the paediatric as well as geriatric patients. To improve the bioavailability of many drugs, fast dissolving drug delivery systems are used widely. Sophisticated technologies used for manufacturing fast dissolving tablets are by direct compression method, freeze drying method, sublimation method, mass extrusion and cotton candy process. Taste is the vital factor since these tablets disintegrate directly in the mouth. FDTs are evaluated by various parameters such as hardness test, friability test, water absorption ratio, wetting time, disintegration test and dissolution test. These tablets are also well-known as mouth dissolving tablets and orodispersible tablets. This review article will emphasize on ideal properties, challenges, advantages, disadvantages, conventional techniques, patented technologies and evaluation of orodispersible tablets.Keywords
Sophisticated Technologies, SuperdisintegrantsReferences
- Dharashive V.M, Kapse V.N. Yelam. Orodispersible Tablet. International Journal of Current Research, 2017; 9(11): 61478 – 61482.
- Ramakant Joshi, Navneet Garud and Wasim Akram. Fast Dissolving Tablets: A Review. International Journal of Pharmaceutical Sciences and Research, 2020; 11(4): 1562 - 1570.
- Dilip Kumar Gupta, Arpana Maurya and Dr. Munendra Mohan Varshney. Orodispersible tablets: An overview of formulation and technology. World journal of pharmacy and pharmaceutical sciences, 2020; 9(10): 1406 - 1418.
- Vishali T, Damodharan N. Orodispersible Tablets: A Review. Research J. Pharm. and Tech., 2020; 13(5): 2522 - 2529.
- Comoglu T, Dilek Ozyilmaz E. Orally disintegrating tablets and orally disintegrating mini tablets-novel dosage forms for pediatric use. Pharm Dev Technol., 2019; 24(7): 902 - 14.
- Sastry SV, Nyshadham JR, Fix JA. Recent technological advances in oral drug delivery - A review. Pharm Sci Technol Today, 2000; 3(4): 138 - 45.
- Kumar VD, Sharma I and Sharma V. A comprehensive review on fast dissolving tablet technology. Journal of Applied Pharmaceutical Science, 2011; 1: 50 - 58.
- Khanna K, Xavier G, Joshi SK, Patel A, Khanna S and Goel B. Fast dissolving tablets-A novel approach. International Journal of Pharmaceutical Research and Allied Sciences, 2016; 5: 311 - 22.
- Kaur V and Mehara N: A Review on: Importance of Superdisintegrants on Immediate Release Tablets. International Journal of Research and Scientific Innovation, 2016; 3: 39 - 43.
- Kenneth Roshan, H.S Keerthy. Orodispersible Tablets: A Compendious Review. Asian Journal of Pharmaceutical Research and Development, 2021; 9(3): 66 - 75.
- Hadyah Faleh Alotaibi, Samar Elsamagily, Gamal M. Mahrous, Mohsen A. Bayomi, Hanna Abdelmonem Mahmoud. Design of taste masked enteric orodispersible tablets of diclofenac sodium by applying fluid bed coating technology. Saudi Pharmaceutical Journal, 2019; 27: 354 – 362.
- Amol V. Patil, Dhanesh H. Sali, Satish S. Reddi, Nikhil S. Wargade, Santosh K. Mohapatra, Bharat V. Paygude. Recent trends and formulation technology of orodispersible tablets. Journal of Pharmacy Research, 2011; 4(3): 924 - 928.
- Rewar S, Singh C J, Bansal B K, Pareek R, Sharma A K. Oral dispersible tablets: An overview; Development, Technologies and Evaluation. International Journal of Research and Development, 2014; 3(6): 1223 – 1235.
- Ravi, Geeta Rajput, Amit Kumar. A review article on orodispersible tablet formulation. The Pharma Innovation, 2013; 2(2): 144 – 152.
- Suresh Bandari, Rajendra Kumar Mittapalli, Ramesh Gannu, Yamsani Madhusudan Rao. Orodispersible tablets: An overview. Asian Journal of Pharmaceutics, 2008; 2 – 11.
- Nikita K. Patel, Sahilhusen I. Jethara, Mukesh. S. Patel. A review on orodispersible tablets – As a Novel Formulation for Oral drug delivery systems. Journal of Pharmaceutical Science and Bioscientific Research, 2015; 5(3): 286 – 294.
- K. B. Deshpande, N. S. Ganesh. Orodispersible Tablets: An overview of formulation and technology. International Journal of Pharma and Bio Sciences, 2011; 2 (1): 726 – 734.
- K. P. R Chowdary, K. Ravi Shankar and B. Suchitra. Recent Research on orodispersible tablets – A Review. International Research Journal of Pharmaceutical and Applied Sciences, 2014; 4(1): 64 – 73.
- Deepika Jain, Mishra Amul. A review – Formulation and Development of Orodispersible Tablet. International Journal of Pharmaceutical Erudition, 2014; 4(1): 21 – 38.
- Parijat Pandey, Mandeep Dahiya. Oral disintegrating tablets: A review. International Journal of Pharma Research and Review 2016; 5(1): 50 – 62.
- P. A. Hannan, J.A. Khan, A. Khan and S. Safiullah. Oral dispersible system: A new approach in drug delivery system. Indian Journal of Pharmaceutical Sciences, 2016; 78 (1): 2 – 7.
- Ashwin Shinde, Vishal Yadav, Vinay Gaikwad and Shree Dange. Fast disintegration drug delivery system: A review. International Journal of Pharmaceutical Sciences and Research, 2013; 4(7): 2548 – 2561.
- Mayuri R Patil, Nayan A Gujarathi, Bhushan R Rane. Formulation and Evaluation of mouth dissolving tablet: Review article. International Journal of Pharmaceutical Sciences, 2014; 5(2): 7 – 20.
- Abhay Asthana, Swati Aggarwal, Gayti Asthana. Oral dispersible tablets: Novel technology and development. International Journal of Pharmaceutical Sciences Review and Research, 2013; 20(1): 193 – 199.
- Panchal Dhavalkumar M, Tiwari Ajaykumar, Srivastava Priyam. A review on orodispersible tablets – A novel formulation for oral drug delivery system and its future prospective. Indo American Journal of Pharmaceutical Research, 2013; 3(5): 4149 – 4168.
- G. S. Bangale, G. J. Yadav, G. V. Shinde, B. Stephen Rathinaraj. New Generation of Orodispersible tablets: Recent advances and future prospects. International Journal of Pharmacy and Pharmaceutical Science Research, 2011; 1(2): 52 – 62.
- Ajit Kumar Yadav, Anamika Sharma, Shivangi Saxena and Arti Kesarwani. Mouth dissolving tablets: General overview and formulation aspects. Bulletin of Pharmaceutical Research, 2014; 4(1): 43 – 57.
- Rameesa C. K., Drisya M. K. Orodispersible tablet: A patient friendly dosage form. Bali Medical Journal, 2015; 4(1): 17 – 20.
- Satvinder Singh, Ujjwal Nautiyal, Ramandeep Singh, Sarabjot Kaur. Fast dissolving tablets – Future Aspects. International Journal of Pharmaceutical and Medical Research, 2015; 3(2): 216 – 231.
- Priyanka Nagar, Kusum Singh, Iti Chauhan, Madhu Verma, Mohd Yasir, Azad Khan, Rajat Sharma and Nandini Gupta. Orally disintegrating tablets: formulation, preparation techniques and evaluation. Journal of Applied Pharmaceutical Science, 2011; 1(4): 35 – 45.
- Optimization of Oxiconazole Topical Emulgel Formulation for the Treatment of Skin Infections
Abstract Views :69 |
PDF Views:0
Authors
B. Hemalatha
1,
T. Pavani Priya
1,
K. Manasa
1,
Ch. Greeshmika
1,
P. Kavya
1,
Shaik Sayeeda Sarah
1,
K. Padmalatha
2
Affiliations
1 Department of Pharmaceutics, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, IN
2 Department of Pharmacology, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, IN
1 Department of Pharmaceutics, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, IN
2 Department of Pharmacology, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, IN
Source
Asian Journal of Pharmacy and Technology, Vol 12, No 3 (2022), Pagination: 232-236Abstract
Emulgel is one of the promising topical drug delivery system for the delivery of hydrophobic drugs which overcome a variety of disadvantages of ointments and creams like greasiness as well as phase inversion. The aim of present work was to develop and evaluate Oxiconazole emulgel. Oxiconazole emulgel was prepared by using polymers like Carbopol 934 and HPMC K4M at different concentrations. Oxiconazole is a broad spectrum anti - fungal agent used in treat of various skin infections such as athlete’s foot, jock itch and ring worm. The prepared emulgels were evaluated in terms of physical appearance, measurement of pH, viscosity, spreadability, drug content and in vitro diffusion studies and skin irritation study. Formulation F1 containing carbapol 934 is considered as optimized formulation because it showed highest drug release i.e., 58.57% in 8 hrs.Keywords
Topical Drug Delivery, Emulgel, Oxiconazole, Carbapol 934, HPMC K4M, In Vitro Diffusion StudiesReferences
- A. S. Panwar, N. Upadhyay, M. Bairagi, S. Gujar, G.N. Darwhekar, D. K. Jain. Emulgel: A Review. Asian J Pharmacy and Life Sci 2011; 1(3): 333-343.
- Bhatt P, Gnanaranjan G. Emulgel: A Novel Formulation Approach for Topical delivery of Hydrophobic Drugs. Int Res J Pharm. 2013; 4(2):12-16.
- Dalia Abd El- Rhman, Md El- Nabarawi and Doaa A. Helal. Pharmaceutical Studies on Fluconazole Topical Emulgel. Indian Streams Research Journal 2014; 4(5): 1-14.
- EI Laithy HM, EI Shaboury KM. The Development of Cutinalipogels and gel micro emulsion for topical administration of fluconazole. AAPS Pharm Sci Tech. 2002; 3(4):35-45.
- Haneefa KPM, Mohanta GP, Nayar C. Emulgel: An Advanced Review. Journal of Pharm Sci Res. 2013; 5(12):254-258.
- Jain A, Deveda P, Vyas N, Chuhan J, Khambete H, Jain S. Development of Antifungal Emulsion based gel for Topical fungal infection. Int J Pharm Res Dev 2011; 2(12).
- Joshi Baibhav, Singh Gurpreet and Saini Seema. Development and Characterization of Clarithromycin Emulgel for Topical Delivery. Int. Journal of Drug Development and Research 2012; 4(3): 310-323.
- Joshi Baibhav, Singh Gurpreet, Rana A.C, Saini Seema, SinglaVikas. Emulgel a comprehensive review on recent advances in topical delivery. IRJP 2011; 2(11), 66-70.
- Kuller R, Saini S, Seth N, Rana AC. Emulgel a surrogate approach for topical used hydrophobic drugs. Int J Pharm Bio Sci 2011; 1(3):117-128.
- Kumar L, Verma R. In vitro Evaluation of topical gel prepared using natural polymer. Int J Drug Delivery 2010; 2: 58-63.
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- An Overview on Nasal Drug Delivery System
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Authors
Affiliations
1 Department of Pharmaceutics, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, IN
2 Department of Pharmacology, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, IN
1 Department of Pharmaceutics, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, IN
2 Department of Pharmacology, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, IN
Source
Asian Journal of Pharmaceutical Research, Vol 12, No 3 (2022), Pagination: 249 - 258Abstract
Nasal drug delivery has got a great deal of attention as a convenient, reliable and potential method for the systemic administration of drugs. It is specially for those molecules which are ineffective orally and only effective if given by injection. The nasal route of drug delivery has advantages over the other alternative systems of non-invasive drug administration. Nasal route is advantageous for the drugs which are unstable on oral administration as they are much degraded in GIT or else metabolized by first pass effect in liver. Nasal route is alternative to parenteral therapy and as well helpful for long term therapy. Nasal mucosa is greatly vascularised as well as mainly permeable giving fast absorption and onset of action. Nasal route is non invasive, extensively used for the local treatment might also be used for systemic therapy as drug directly goes in systemic circulation. Nasal route gives excellent absorption of small molecules, than that of large molecules can be augmented by absorption promoters. The present review presents information pertaining to nasal drug delivery system such as advantages, limitations, anatomy of nose, mechanism of drug absorption, barriers to drug absorption, factors influencing nasal drug absorption, strategies to improve nasal absorption, excipients used in nasal formulations, nasal formulations and their evaluation.
Keywords
Nasal Drug Delivery System, systemic circulation, absorption promotersReferences
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