Informatics Publishing Limited

K. Malhotra ¹, S. Aslam ¹, P. D. Gupta ²

Affiliations
1 Department of Pharmacology, Maharishi Markendeshwer Institute of Medical Sciences & Research Mullana, Haryana 133207, IN
2 Maharishi Markendeshwer Institute of Medical Sciences & Research Mullana, Haryana 133207, IN

Abstract

Background:Cardiovascular disease (CVD) is the most common contributor of morbidity and mortality in underdeveloped and developing countries and places a huge burden on the society in terms of health care resources and loss of productivity. Statins are the most popular hypolipidemic drug used to treat hyperlipidemia which is generally administered daily.

Objectives: The study was conducted to compare the percent change of LDL-C, TC, TG and HDL and compare the safety of Rosuvastatin in patients of dyslipidemia.

Material and Methods: Sixty patients were randomly divided into two groups: once daily group and Alternate day group of rosuvastatin 10mg for six weeks. The lipid profile was compared from the baseline and at end of six weeks.

Results: Baseline characters of both the groups were well balanced. LDL-C was reduced by 23.8 % in once-daily group and 26.05 % in alternate-day group, respectively. Changes were also recorded for the other lipid parameters (TC, TG, HDL). Such changes were found to be of no significant difference when compared between the two groups (p>0.05 NS.

Conclusion: Alternate day therapy is as effective as the once -daily dosing with rosuvastatin in Indian population in improving the lipid parameters in dyslipidemic patients.

Keywords

Rosuvastatin, Dyslipidemia, Alternate Day Regime, Daily Regime, Lipid Profile.

Full Text

   

T. Aggarwal ¹, A. Malhotra ², K. Mardi ², S. Puri ², K. Malhotra ³, S. Goyal ²

Affiliations
1 Department of Surgery, Indira Gandhi Medical College, Shimla (H.P.), Pin: 171001, IN
2 Indira Gandhi Medical College, Shimla, IN
3 Department of Surgery, Indira Gandhi Medical College, Shimla, IN

Abstract

Carcinoid tumours are low grade malignant neuroendocrine tumours found mainly in small intestine, lungs. However primary carcinoid tumour is not normally present in the kidneys, this being an extremely rare renal malignant neoplasm with less than 100 cases reported so far, with majority of cases being associated with horse shoe kidneys. We describe a 39 years old male who presented with complaint of pain abdomen in left lumbar region, with solid renal mass detected on Computed Tomography. We treated the patient with radical nephrectomy. Pathological examination revealed tumor cells arranged in trabeculae, anastomosing cords, nests with peripheral palisading, and in cribriform pattern. The 'tumor cells showed round to oval nuclei, stippled nuclear chromatin, inconspicuous nucleoli, indistinct cell borders and scant cytoplasm, findings consistent with carcinoid tumour. IHC was positive for synaptophysin, chromogranin, and Panck. The patient has been kept on follow up to look for any local recurrence or systemic metastasis.

Keywords

Carcinoid, Kidney, Neuro-Endocrine Tumor, Synaptophysin.

Full Text