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Kumaresn, K.
- Study on Teratogenic Effects of Bhavana Panjankula Thailam, Castor oil, Ricin Using Chick Embryo as a Model System
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1 Department of Biochemistry, Vysya College, Salem-103, IN
1 Department of Biochemistry, Vysya College, Salem-103, IN
Source
Asian Journal of Pharmaceutical Research, Vol 5, No 2 (2015), Pagination: 67-77Abstract
Teratogenicity is the ability to cause developmental abnormaltiies in foetus. Substances with teratogenicity effects can damage the DNA of a developing foetus. They may cause abnormal development of a limb malformation of an organ and the effects for the developing foetus can vary depending on the teratogen. Chicken eggs are used as a model system to test teratogenic effect of drug. The present study carried out, Bhavana panjankula thailam is one of the Siddha drug indicated for karuppachudu (a type of pitha disorder affecting uterus), urinary tract infections, dry skin and constipation. In this study five concentrations of drug Bhavana panjankula thailam were injected into the chicken embryos. The castor oil, Ricin also injected to chick embryos at same concentrations. Lithium is used as a positive control in the same concentrations which affects limb deformities of the organ. 1:1 ratio of lithium and drug were injected into the embryo for scrutinize the effect of drug. At the 12th day of incubation the eggs were dissected out and detect the malformation in the embryo. The results suggested that the lowest concentrations of drug treated embryo have no malformation and highest concentrations of drug treated embryo have malformed like heart and other organs are distorted. The DNA was isolated from embryos of chick and run in agarose gel electrophoresis to confirm the DNA damage.Keywords
Teratogenicity, Bhavana Panjankula Thailam, Castor Oil, and Ricin, Chick Embryo, DNA Damage.- Effect of Zinc Oxide Nanoparticles on Artemia salina
Abstract Views :236 |
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Authors
Affiliations
1 Department of Biochemistry, Vysya College, Salem-103, IN
2 Department of Biotechnology, Vysya College, Salem-103, IN
1 Department of Biochemistry, Vysya College, Salem-103, IN
2 Department of Biotechnology, Vysya College, Salem-103, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 7, No 2 (2015), Pagination: 103-110Abstract
The present study revealed the toxic effect of Zinc oxide nanoparticles (ZnO NPs) in Artemia salina and evaluated the mortality rate, morphological variations, Swimming speed velocity and chemical analysis in Artemia salina cysts. The ZnO NPs was synthesised by thermochemical method and it was characterized by using UV spectrum, XRD and FT-IR. Nanoparticles were spherical in nature and with size range of 30-40 nm. Artemia cysts were purchased from store, processed, and hatched in salt water. Artemia salina was treated using ZnO nanoparticles of various concentrations (mg/ml) and LC50 value (0.4 mg/ml) and mortality rate (24 and 48 hours) was evaluated. Aggregation of ZnO NPs in the gut region of salina was studied using phase contrast microscope. Behavioural responses (swimming speed velocity) in A. salina exposed to ZnO NPs for 48 hr were evaluated. This study showed that as the concentration of ZnO NPs increased, the mortality rate and aggregation of NPs in gut region were increased in salina, whereas the swimming speed velocity in A. salina decreased. Thus this study revealed that the low concentrations of ZnO NPs have no toxic effect on Artemia salina.Keywords
Zinc Oxide, Nanoparticles and Artemia salina.- Toxicity Effect of Copper Oxide Nanoparticles on Artemia salina
Abstract Views :272 |
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Authors
Affiliations
1 Department of Biochemistry, Vysya College, Salem-103, IN
2 Department of Biotechnology, Vysya College, Salem-103, IN
1 Department of Biochemistry, Vysya College, Salem-103, IN
2 Department of Biotechnology, Vysya College, Salem-103, IN