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Jyothi, K.
- Acetaminophen-induced Hepato- and Nephrotoxicity and Amelioration by Silymarin and Terminalia chebula in Rats
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Authors
Affiliations
1 Department of Pharmacology and Toxicology, College of Veterinary Science, Hyderabad - 500030, Andhra Pradesh, IN
1 Department of Pharmacology and Toxicology, College of Veterinary Science, Hyderabad - 500030, Andhra Pradesh, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 17, No 2 (2010), Pagination: 64-66Abstract
Experimental study was conducted to evaluate the hepato- and renoprotective effect of silymarin and Terminalia chebula against experimentally-induced acetaminophen (APAP) toxicity in rats. Oral administration of APAP @ 500 mg/kg for 1 to 3 days to all the four groups (six rats in each) resulted in significant elevation of serum triglycerides, total cholesterol, blood urea nitrogen, serum creatinine, and aspartate transaminase activity. Posttreatment with silymarin @ 25 mg/kg and T. chebula 125 mg/kg in groups 2 and 3 and their combination to group 4 from day 4 to 14 has significantly reversed the alterations of above said markers and offered better protection. The results of the study enunciated that silymarin and T. chebula exhibit good hepato- and nephro-protection against APAP toxicity.Keywords
Acetaminophen, hepatotoxicity, nephrotoxicity, silymarin, Terminalia chebula- Interaction Study on Garlic and Atorvastatin with Reference to Nephrotoxicity in Dyslipidaemic Rats
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Authors
Affiliations
1 Department of Pharmacology and Toxicology, College of Veterinary Science, Hyderabad, Andhra Pradesh - 521 102, IN
2 NTR College of Veterinary Science, Gannavaram, Krishna Dt., Andhra Pradesh - 521 102, IN
1 Department of Pharmacology and Toxicology, College of Veterinary Science, Hyderabad, Andhra Pradesh - 521 102, IN
2 NTR College of Veterinary Science, Gannavaram, Krishna Dt., Andhra Pradesh - 521 102, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 17, No 2 (2010), Pagination: 90-93Abstract
A total of 56 male Sprague dawley rats of uniform weight and age were randomly divided into seven groups consisting of eight rats in each group. Groups 1, 2, and 3 served as plain control, dyslipidaemic control (DL), and atorvastatin control, respectively. Groups 4, 5, 6, and 7 received 1, 0.5, 0.25, and 0.75% fresh garlic w/w in feed, respectively in addition to the high-fat and high-cholesterol diet and administered with atorvastatin orally for 12 weeks at the rate of 10, 5, 7.5, and 2.5 mg/kg b.wt., respectively. Plasma creatinine was estimated at 4-week intervals, whereas histopathology, electron microscopy, and estimation of TBARS concentration in kidney were conducted at the end of experiment. The TBARS concentration in DL was significantly (P<0.05) increased when compared with groups 1, 3, 6, and 7. On histopathological examination, kidney sections of group 3 had mild degenerative changes in the tubules with fatty change in few tubules, while groups 4 and 5 exhibited mild-tomoderate degenerative and fatty changes in tubules with inter tubular hemorrhages. The electron microscopy of group 2 showed hypertrophy of Bowman’s capsule, while that of group 4 showed secretary deposits in the cytoplasm. The interaction studies on kidney indicated that high dose of atorvastatin + garlic has negative safety profile when compared with groups having low dose of statin and high dose of garlic.Keywords
Atorvastatin, garlic, kidney- Sero-biochemical Studies in Sheep Fed with Bt Cotton Plants
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Authors
B. Anilkumar
1,
A. Gopala Reddy
1,
B. Kalakumar
1,
M. Usha Rani
1,
Y. Anjaneyulu
2,
T. Raghunandan
3,
Y. Ramana Reddy
4,
K. Jyothi
1,
K. S. Gopi
1
Affiliations
1 Departments of Pharmacology and Toxicology, College of Veterinary Science, Hyderabad, Andhra Pradesh, IN
2 Veterinary Pathology, College of Veterinary Science, Hyderabad, Andhra Pradesh, IN
3 Livestock Research Institute, College of Veterinary Science, Hyderabad, Andhra Pradesh, IN
4 Department of Animal Nutrition, College of Veterinary Science, Hyderabad, Andhra Pradesh, IN
1 Departments of Pharmacology and Toxicology, College of Veterinary Science, Hyderabad, Andhra Pradesh, IN
2 Veterinary Pathology, College of Veterinary Science, Hyderabad, Andhra Pradesh, IN
3 Livestock Research Institute, College of Veterinary Science, Hyderabad, Andhra Pradesh, IN
4 Department of Animal Nutrition, College of Veterinary Science, Hyderabad, Andhra Pradesh, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 17, No 2 (2010), Pagination: 99-101Abstract
An experimental study was conducted to evaluate the toxicological effects, if any, due to feeding of Bt (Bacillus thuringiensis) cotton plants to sheep. A total of 32 sheep of one year of age belonging to Deccani breed were randomly divided into four groups, consisting of eight sheep in each group. Group 1 was maintained on basal diet (concentrate feed at the rate of 300 g + green fodder at the rate of 3 kg/sheep/day), group 2 on non-Bt cotton plant at the rate of 1.5 kg + green fodder at the rate of 1.5 kg + concentrate feed at the rate of 300 g/ sheep/day, group 3 on Bt cotton plants (50%) at the rate of 1.5 kg + green fodder at the rate of 1.5 + concentrate feed at the rate of 300 g/sheep/day, and group 4 on Bt cotton plants ad libitum + concentrate feed at the rate of 300 g/sheep/day. All the groups of sheep were maintained for three months and various hemato-biochemical parameters were studied at monthly intervals. The activity of aspartate transaminase, gamma glutamyltransferase, and creatine kinase in sera samples, and the concentration of blood urea nitrogen and creatinine did not differ significantly among different groups at different time intervals. The histological examination of liver and kidney did not reveal any significant changes in Bt and non-Bt cotton-fed groups. In conclusion, the results of the present investigation enunciated that feeding of genetically modified (Bt) cotton plants to sheep was without detrimental effects in the biological system of sheep.Keywords
Bt cotton, sero-biochemistry, sheep- A study on free radical-induced renal toxicity due to cyclophosphamide and its amelioration with N-acetyl cysteine
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