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Ilango, K.
- Synthesis and Antimicrobial Screening of some Mannich Bases of Isatin
Abstract Views :183 |
PDF Views:74
Authors
Affiliations
1 Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM University, Kattankulathur - 603 203, Kancheepuram District, Tamil Nadu, IN
1 Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM University, Kattankulathur - 603 203, Kancheepuram District, Tamil Nadu, IN
Source
Journal of Pharmaceutical Research, Vol 8, No 2 (2009), Pagination: 93-95Abstract
A series of Mannich bases have been synthesized by treating thiourea, isatin with formaldehyde and different aromatic primary and secondary amines. The structures of compounds were established based on IR, 1H NMR and Mass spectral data. The title compounds were screened for antibacterial and antifungal activities. The compounds S4, S6 and S10 with 1-benztriazolyl, 1-diethylamino and 1-dimethylamino substituted derivatives exhibited significant antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Klebesiella pneumonia, whereas the compounds S4, S6 and S10 with 1-benztriazolyl, 1-piperazinyl and 1-dimethylamino substituted derivatives exhibited better antifungal activity against Aspergillus niger.Keywords
Mannich Base, Isatin, Antimicrobial.- Free Radical Scavenging Activity of Leaves of Memecylon edule Roxb
Abstract Views :173 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmacognosy, SRM College of Pharmacy, SRM University, Kattankulathur- 603203, Tamil Nadu, IN
2 SRM College of Pharmacy, SRM University, Kattankulathur-603203, Tamil Nadu, IN
1 Department of Pharmacognosy, SRM College of Pharmacy, SRM University, Kattankulathur- 603203, Tamil Nadu, IN
2 SRM College of Pharmacy, SRM University, Kattankulathur-603203, Tamil Nadu, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 1, No 2 (2009), Pagination: 109-112Abstract
Free radical scavenging potential of leaves of Memecylon edule. Roxb was studied using superoxide radical scavenging effect, hydroxyl radical scavenging effect, lipid peroxide assay, nitric oxide scavenging effect. The content of superoxide radicals was studied by NBT reduction method, hydroxyl radical by Deoxy-ribose degradation method, lipid peroxide level by estimating the thiobarbituric acid releasing substances (TBARS) and the nitric oxide radical by Griess method. The ethanolic and aqueous leaf extracts were used for the study with reference to the ascorbic acid as standard drug. It was found that the aqueous extract showed significant free radical scavenging potential compared to the ethanolic extract. The IC50 for aqueous extract was found to be 502.9μg/ml, 493.78μg/ml, 469.6μg/ml and 227.8 μg/ml for superoxide radical scavenging effect, hydroxyl radical scavenging effect, lipid peroxide assay and nitric oxide scavenging effect respectively. The extracts studied can provide efficient antioxidant protection by complementary mechanisms, such as free radical scavenging and metal ions reduction with the non polar extracts.Keywords
Memecylon edule, Superoxide Radical Scavenging Effect, Hydroxyl Radical Scavenging Effect, Lipid Peroxide Assay, Nitric Oxide Scavenging Effect.- New Records of Rove Beetles (Coleoptera:Staphylinidae:Paederinae) from Mizoram, India
Abstract Views :224 |
PDF Views:105
Authors
Affiliations
1 Zoological Survey of India, M-Block, New Alipore, Kolkata-700 053, IN
1 Zoological Survey of India, M-Block, New Alipore, Kolkata-700 053, IN
Source
Records of the Zoological Survey of India - A Journal of Indian Zoology, Vol 116, No 3 (2016), Pagination: 233-240Abstract
In the family Staphylinidae under subfamily Paederinae all the 21 species of rove beetles belonging to 10 genera distributed in different districts are recorded for the first time from Mizoram. It is clear that further study of this group from the study area would explore more interesting species.- Synthesis and Biological Screening of Novel Aminoalkyl Substituted Azaphenothiazine
Abstract Views :171 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM University, Kattankulathur-603203, IN
1 Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM University, Kattankulathur-603203, IN