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Vinod, K. R.
- Vector Control Activity Studies on the Leaf of Zyziphus mauritiana
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Authors
Affiliations
1 Dept. of Pharmacognosy, Nalanda College of Pharmacy, Nalgonda AP, IN
2 Nalanda College of Pharmacy, Nalgonda, A.P., IN
1 Dept. of Pharmacognosy, Nalanda College of Pharmacy, Nalgonda AP, IN
2 Nalanda College of Pharmacy, Nalgonda, A.P., IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 2, No 1 (2010), Pagination: 71-74Abstract
The present study was undertaken to evaluate anthelmintic and larvicidal activity of crude ethanolic leaf extract of Zyziphus mauritiana belonging to family Rhamnaceae. Through the preliminary chemical tests it was found that the plant is rich in flavonoids, phenols, steroids and tannins. Pheretima posthuma was used as the test worms. Various concentrations of ethanolic extracts were tested in the anthelmintic screening, which involved determination of time of paralysis (P) and time of death (D) of the worms. Piperazine citrate was included as standard reference and distilled water as control. In the case of larvicidal activity the study was conducted on Culex quniquefasicatus species of mosquito larvae and the rate of larval mortality was calculated. The results indicated that the crude ethanolic extract significantly demonstrated paralysis and also caused death of the helminth especially at higher concentration of 50 mg/ml, as compared to standard reference piperazine citrate. Similarly very optimistic results were observed for Culex quniquefasicatus species of mosquito larvae and LC50 value was calculated as 54.9658.Keywords
Antihelmintic, Larvicidal, Zyziphus mauritiana, Pheretima Posthuma, Culex quniquefasicatus.
References
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- Factorial Designing for Pharmaceutical Product and Process Development
Abstract Views :293 |
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Authors
K. R. Vinod
1,
S. Sandhya
2
Affiliations
1 Dept. of Pharmaceutics, Nalanda College of Pharmacy, Nalgonda– 508001, Anshra Pradesh, IN
2 Nalanda College of Pharmacy, Nalgonda-508001, Anshra Pradesh, IN
1 Dept. of Pharmaceutics, Nalanda College of Pharmacy, Nalgonda– 508001, Anshra Pradesh, IN
2 Nalanda College of Pharmacy, Nalgonda-508001, Anshra Pradesh, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 3, No 5 (2011), Pagination: 199-202Abstract
The conventional experimental designs are not adequately contributing robustness of the experiment. Quality by design is an essential tool for time and cost effectiveness. Common design is factorial design. Factorial designing is more flexible and gives more knowledge about process and product and several software are also available. This manuscript gives the reader an in depth information of factorial experimental design, its theoretical background and how to implement this statistical tool in the real practical research.Keywords
Total Quality Management, Quality by Design, Interaction, Factorial Design.- A Comprehensive Review on GLP
Abstract Views :395 |
PDF Views:0
Authors
Affiliations
1 Dept. of Pharmaceutics, Nalanda College of Pharmacy, Nalgonda 508001, A.P., IN
1 Dept. of Pharmaceutics, Nalanda College of Pharmacy, Nalgonda 508001, A.P., IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 3, No 4 (2011), Pagination: 117-122Abstract
This article gives staff and students to get an overall idea about GLP which is included in pharma curriculum. Separate QC procedures must be identified for raw materials, API, finished products and packaging and labelling. Safety instructions which can be implemented in the lab also is furnished. In addition to this, the duties and responsibilities of the lab in charge, lab attender and lab assistant of Institutions is differentiated.Keywords
GLP, ISO, Triple Role Concept.- Evaluation of Anti Bacterial and Anti Platelet Activity of Ethanolic Leaf Extract of Physalis angulata
Abstract Views :238 |
PDF Views:0
Authors
Affiliations
1 Nalanda College of Pharmacy, Nalgonda, A.P, IN
2 Department of Pharmacognosy, Nalanda College of Pharmacy, Cherlapally, Nalgonda-508001 Andhra Pradesh, IN
3 ASN Pharmacy College, Tenali, A.P, IN
1 Nalanda College of Pharmacy, Nalgonda, A.P, IN
2 Department of Pharmacognosy, Nalanda College of Pharmacy, Cherlapally, Nalgonda-508001 Andhra Pradesh, IN
3 ASN Pharmacy College, Tenali, A.P, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 2, No 1 (2010), Pagination: 67-69Abstract
There has always been a closed association between plants and human beings through ancient time and till date. Physalis angulata is an annual herb indigenous to many parts of the tropics, including the Amazon. It can be found on most continents in the tropics, including Africa, Asia, and the Americas. It grows up to 1 m high, bears small, cream-colored flowers, and produces small, light yellowish-orange, edible fruit sometimes referred to as Cutleaf Groundcherry. It is a popular medicine used due to its anti inflammatory effects, anti tumor effects, immunomodulatory effects etc. The present study is to evaluate the anti bacterial and anti platelet activity of the ethanolic leaf extract of Physalis angulata. From the phytochemical screening it was found that the plant is mainly constituted with phenols, steroids and flavonoids .The anti bacterial activity was performed by well diffusion method on various concentrations of the extract. Gentamycin was used as the standard and ethanol as the control. In the antiplatelet activity study, the platelet was induced using adenosine di phosphate. Nephlometer was used to observe the aggregation. It was observed that the ethanolic leaf extract showed pronounced anti platelet activity. But the anti bacterial activity was found to be false positive.