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Rao, K. N. V.
- Alpha-Glucosidase Inhibitory Activities of Wrightia tinctoria Roxb and Schrebera swietenoides Roxb Bark Extract
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Authors
Affiliations
1 Fathima Institute of Pharmacy, Ramarajupalli, Kadapa, Andhra Pradesh, IN
2 Department of Pharmacognosy, Nalanda College of Pharmacy, Nalgonda, Andhra Pradesh, IN
3 Nalanda College of Pharmacy, Nalgonda, Andhra Pradesh, IN
1 Fathima Institute of Pharmacy, Ramarajupalli, Kadapa, Andhra Pradesh, IN
2 Department of Pharmacognosy, Nalanda College of Pharmacy, Nalgonda, Andhra Pradesh, IN
3 Nalanda College of Pharmacy, Nalgonda, Andhra Pradesh, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 3, No 1 (2011), Pagination: 22-24Abstract
Alpha glucosidase inhibitory activities of Wrightia tinctoria Roxb and Schrebera swietenoides Roxb ethanol extracts were investigated individually. Wrightia tinctoria Roxb and Schrebera swietenoides Roxb bark extract showed in-vitro inhibitory activity of intestinal alpha glucosidase enzyme maltase. Analysis of data confirms that alpha glucosidase inhibition activity was the maximum at 1500mcg/ml of Wrightia tinctoria Roxb bark and 2000mcg/ml of Schrebera swietenoides Roxb bark. The purpose of study was to know whether Wrightia tinctoria Roxb bark and Schrebera swietenoides Roxb bark extract could reduce intestinal absorption of monosaccharides by inhibiting disaccharide hydrolysis. These results suggest that the Wrightia tinctoria Roxb bark extract and Schrebera swietenoides Roxb bark has little potent alpha glucosidase inhibitory activity individually and would be effective in suppression of elevation in blood glucose.Keywords
Wrightia tinctoria Roxb, Schrebera swietenoides Roxb, Maltase, Acarbose.
References
- Puls, W., U. Keup, H. P. Krause et al., Glucosidase Inhibition. A new approach to the treatment of diabetes, obesity, and hyperlipoproteinaemia. Naturwissen-schaften, 1977, 64: 536 537.
- Ratner, L. Glucosidase inhibitors for treatment of HIV-1 infection. AIDS Res. Hum. Retroviruses, 1992, 8(2): 165-173.
- Nisioka,T., Watanabe.J.,Kawabata, J.,and Niki,R., Isolation and activity of N-coumaroyl tyramine an glucosidase inhibitor in welsh onion (Allium Fistulosum). Biosci. Biotechnol. Biochem, 1997, 61 ,1138-1141.
- Toda,H.,Kawabata,J.,andKasuariT., Alpha-glucosidase Inhibitors From Clove(Syzgium Armactum). Biosci.Biotechnol.Biochem, 2000, 64, 294-298.
- Honda, M and Hara,V., Inhibition of rat small intestinal sucrase and glucosidase activities by tea polyphenols. Biosci. Biotechnol. Biochem, 1993, 57,123-124.
- Del Prato, S. Post-prandial hyperglycaemia-the necessity for better control,Int J Clin Pract Suppl. 2000, 112, 3S-8S.
- Nadkarni K. M. Indian Materia Medica, Vol.I (Bombay: Popular Prakashan), 1976, 1296.
- C. P. Khare, Indian Medicinal Plants- An illustrated dictionary, spinger publications, pg.589.
- Yuste, P.; Longstaff, M.; McCorquodale, C. The effect of proanthocyanidin-rich hulls and proanthocyanidin extracts from bean (Vicia faba L.) hulls on nutrient digestibility and digestive enzyme activities in young chicks. Br. J. Nutr. 1992, 67, 57-65.
- Longstaff, M.; McNab, J.M. The inhibitory effects of hull polysaccharides and tannins of field beans (Vicia faba L.) on the digestion of amino acids, starch and lipid and on digestive enzyme activities in young chicks. Br. J. Nutr. 1991, 65, 199-216.
- Kuk.-Kook Lee, J.-J.Cho, J. Park and J. D. Choi Anti-elastase and anti-hyaluronidase of phenolic substance from Areca catechu as a new anti-ageing agent. International Journal of Cosmetic Science. 2001, 23(6): 341-346.
- Kobayashi, Y.; Suzuki, M.; Hideo, S.; Arai, S.; Yukihiko, H.;Suzuki, K.; Miyamoto, Y.; Shimizu, M. Green tea polyphenols inhibit the sodium-dependent glucose transporter of intestinal epithelial cells by a competitive mechanism. J. Agric. Food Chem 2000, 48:5618-5623.
- Loomis, W. D. and J. Battaile.. Plant phenolics and the isolation of plant enzymes. Phytochemistry, 1966, 5:423.
- Supercritical Fluid Extraction (SFE)-An Overview
Abstract Views :422 |
PDF Views:6
Authors
Affiliations
1 Nalada College of Pharmacy, Charlapally, Hyderabad Road, Nalgonda-508001 Andhra Pradesh, IN
1 Nalada College of Pharmacy, Charlapally, Hyderabad Road, Nalgonda-508001 Andhra Pradesh, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 2, No 3 (2012), Pagination: 112-120Abstract
Among the different extraction techniques used at analytical and preparative scale, supercritical fluid extraction (SFE) is one of the most used separation technique, which mostly depends on critical temperature and pressure of supercritical fluid. This review covers the most recent developments of SFE indifferent fields (SFE applications), such as food science, natural products, by-product recovery, pharmaceutical and environmental sciences, during the period 2007-2009. The revision is focused on the most recent advances and applications in the different areas; among them, it is remarkable the strong impact of SFE to extract high value compounds from food and various natural products but also its increasing importance in areas such as heavy metals recovery, enantiomeric resolution or drug delivery systems.Keywords
Super Critical Fluid Extraction, Critical Temperature, Critical Pressure, Supercritical Fluid, Food Science, Natural Products.References
- Available at http://www.kerouac.pharm.uky.edu/asrg/wave/wavehp.html
- King JW, Grasa Y Aceites, 2002, 53,(8).
- Steytler D, Grandison A, Lewis M (Eds.). Separation Processes in the Food and Biotechnology Industries: Principles and Applications. Wood head Publishing Ltd, Abington, England, 1996.
- Zekovic. Z, Lepojevic. Z, Vujic. Dj. Chromatographia. 2000, 51,175.
- Stojanovic. G, Palic. R, Alagic. S, Zekovic. Z, Flavour Frog. J., 2000, 15,335.
- Brunner's, Food. H, England, 2005, 67, 21.
- Yanker. C.R, Smith. R.D, Charpentier. B.A and Sevenants. M.R., "In Supercritical Fluid Extraction and Chromatography: Techniques and Applications", ACS Symposium Series-366,Eds. American Chemical Society, Washington, DC, 1988,161.
- Yonker. C,R and Smith. R.D, Physical Chemistry, 1988,(92),23-74.
- Lee.M.L and Markides. K. E., Eds. Analytical Supercritical FIuid Chromatography and Extraction. Chromatography Conferences, Provo, UT, 1990, 577.
- Bidlingmeye BA. and Rogers LB. Sep. Science.7; 1972: 131.
- Peng D. and Robinson. D.B., AIChE. J. 1977,23, 137.
- Heidemann. R.A. and Khahl .A.H., AIChE. J. 1980,26, 769.
- Chueh P.L. and Prauanitz. J.M., AIChE. J. 1967,13, 1099 .
- Smith. R.D., Wright. B.W and KaIinoaki. H.T., Yoshioka. M., Parvez. S., Miyazaki. T."In Progress in HPLC", Eds. (VSP, Utrecht), 1989,4, 99.
- Available at http://www.zirchrom.com/
- Available at http://hplc.chem.vt.edu/
- McHugh. M.A and Krukonic. V.J. Butterworth-Heinmann, stonecham, MA, "Supercritical fluid extraction: principle and practices", Edition-2, 1994.
- Tanaka Y et al., J Oleo Sci 2004, 53, 417.
- J. C. Giddings, M. N. Myers, L. McLaren, and R. A. Keller, Fundamentals of column performance in SFC ,journal of chromatography A, 1968,162, 67.
- J. C. Giddings, M. N. Myers, and J. W. King, J. "Fundamentals of column performance in SFC", Journal of Chromatography A 1968, 7, 276.
- M. A. McHugh and V. J. Krukonis, "Supercritical Fluid Extraction-Principles and Practice", Butterworths, Boston, 1986, 238.
- E. H. Chimowitz and K. J. Pennisi, AlChE. J., 1986,32, 16-65.
- J. W. King, J. H. Johnson, and J. P. Friedrich, J. Agric. Food Chem., 1989, 37,95-1.
- K. D. Bartle, A. A. Clifford, S. B. Hawthorne, J. J. Lagenfeld, D. J. Miller, and R. Robinson, J. Supercrit. Fluids, 1990,3, 143
- K. P. Johnston, "New Directions in Supercritical Fluid Science and Technology,"in K. P. Johnston and J. M. L. Penninger, Eds., Supercritical Fluid Science and Technology, American Chemical Society, Washington, DC, 1989, 6.
- Burdick and Jackson Solvent Guide, 2nd ed. Burdick and Jackson Labs, Muskegon, MI., 1984.
- Eastman Org. Chem. Bull., , 1975, 47 , 1-12.
- J. A. Graham and L. B. Rodgers, J. Chromatogr. Sci, 1980, 18, 75.
- D. R. Gere, Analytical Chemistry, 54, 736.
- B. W. Wright and R. D. Smith, in C. M. White, Ed.,"Modern Supercritical Fluid Chromatography", Huethig, Heidelberg, Germany, 1988, 189.
- B. E. Ricther, D. J. Bornhop, J. T. Swanson, J. G. Wangsgaard, and M. R. Anderson, J. Chromutography Science, 1989,27, 303.
- Jackson W.P., Markides K.E., Lee M.L. J. "High ResolutionChromatogr. Chromatography Communication". 1986, 9, 213.
- W.R. Jian, S.B. Ming, J. Chuangchun College Trad. Chin. Med. 13; 1997, 46.
- S. Keszei, B. Simandi, E. Szekely, E. Fogassy, J. Sawinsky, S. Kemany, "Tetrahedron Asymmetry 10",1999,12,75.
- K. Wu, J. Li, W. Wang, D.A. Winstead, J., Pharmaceutical Science,2009,98,24-22.
- N. Fidalgo-Used, E. Blanco-Gonzalez, A. Sanz-Medel, Anal. Chim. Acta 590,2007, 1.
- A. Kawashima, S. Watanabe, R. Iwakiri, K. Honda, Chemosphere 75 788.
- Mukhopadhyay, M. 2000."Natural Extracts Using supercritical Carbon dioxide". CRC press. Boca Raton, FL. 2009,327.
- RP-HPLC Method Development and Validation for Estimation of Sofosbuvir in Pure and Tablet Dosage Form
Abstract Views :257 |
PDF Views:0
Authors
Affiliations
1 Nalanda College of Pharmacy, Charlapally, Nalgonda, Telangana, IN
1 Nalanda College of Pharmacy, Charlapally, Nalgonda, Telangana, IN
Source
Asian Journal of Pharmacy and Technology, Vol 7, No 3 (2017), Pagination: 153-156Abstract
A rapid and precise Reverse Phase High Performance Liquid Chromatographic method has been developed for the validation of Sofosbuvir, in its pure form as well as in tablet dosage form. Chromatography was carried out on a Hypersil C18 (4.6×150mm, 5μ) column using a mixture of Methanol (100% v/v) as the mobile phase at a flow rate of 1.0 mL/min, the detection was carried out at 265 nm. The retention time of the Sofosbuvir was 3.515 ±0.02min. The method produce linear responses in the concentration range of 20-100μg/mL of Sofosbuvir. The method precision for the determination of assay was below 2.0% RSD. The method is useful in the quality control of bulk and pharmaceutical formulations.Keywords
Sofosbuvir, RP-HPLC, Validation, Tablet Dosage Forms.References
- Andrea Weston and Phyllisr.Brown, HPLC Principle and Practice ,1st edition Academic press, (1997), PP 24-37.
- Yuri Kazakevich and Rosario Lobrutto, HPLC for Pharmaceutical Scientists, 1stedition, Wiley Interscience A JohnWiley & Sons, Inc., Publicat ion, (2007), PP 15-23.
- Chromatography, (online). URL:http://en.wikipedia.org/wiki/Chromatography.
- Meyer V.R. Practical High-Performance Liquid Chromatography, 4th Edn. England, John Wiley & Sons Ltd, (2004), PP 7-8.
- Sahajwalla CG a new drug development, vol 141, Marcel Dekker Inc., New York, (2004), PP 421–426.
- Introduction to Column. (Online),URL:http://amitpatel745.topcities.com/index_files/study/column care.
- Detectors used in HPLC (online )URL:http://wiki.answers.com/Q/What_detectors_are_used_in_HPLC
- Detectors (online) ,URL:http://hplc.chem.shu.edu/NEW/HPLC_Book/Detectors.
- Detectors (online) ,URL:http://www.dionex.com/enus/webdocs/64842-31644-02_PDA-100.
- Detectors (online),URL:http://www.ncbi.nlm.nih.gov/pubmed/8867705
- Detectors (online),URL:http://www.chem.agilent.com/Library/applications/59643559.
- Draft ICH Guidelines on Validation of Analytical Procedures Definitions and terminology. Federal Register, vol 60. IFPMA, Switzerland, (1995), PP 1126.
- Code Q2B, Validation of Analytical Procedures; Methodology. ICH Harmonized Tripartite Guidelines, Geneva, Switzerland, (1996), PP 1- 8.