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Daxina, K. L.
- Spectrophotometric Methods for Simultaneous Estimation of Meclizine Hydrochloride and Caffeine in their Combined Tablet Dosage Form
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Authors
Affiliations
1 Department of Quality Assurance, Maliba Pharmacy College, Bardoli-Mahuva Road, Tarsadi, Dist. Surat, 394 350, Gujarat, IN
1 Department of Quality Assurance, Maliba Pharmacy College, Bardoli-Mahuva Road, Tarsadi, Dist. Surat, 394 350, Gujarat, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 8 (2011), Pagination: 1249-1253Abstract
Two simple spectrophotometric methods have been developed for simultaneous estimation of meclizine hydrochloride and caffeine from tablet dosage form. Method I i s a n absorbance correction method in which absorbance is measured at two wavelengths, 288 nm at which meclizine hydrochloride has no absorbance and 236 nm at which both the drugs have considerable absorbance. Method II i s simultaneous equation method which involves two wave lengths , 236 nm (for measurement of meclizine hydrochloride) and 273 nm (for measurement of caffeine). Both the methods were found linear between the range of 4-20 μg/ml for caffeine and 5-25 μg/ml for meclizine hydrochloride. The accuracy and precision were determined and found to comply with ICH guidelines. Both the methods showed good reproducibility and recovery with % RSD in the desired range. The methods were found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis of meclizine hydrochloride and caffeine in their combined tablet dosage form.Keywords
Meclizine Hydrochloride, Caffeine, Absorbance Correction Method, Simultaneous Equation Method.- Simultaneous Estimation of Cefixime and Ofloxacin by Derivative Spectroscopy Method
Abstract Views :185 |
PDF Views:1
Authors
Affiliations
1 Department of Quality Assurance, Maliba Pharmacy College, Bardoli-Mahuva Road, Tarsadi, Dist, Surat, 394 350, Gujarat, IN
1 Department of Quality Assurance, Maliba Pharmacy College, Bardoli-Mahuva Road, Tarsadi, Dist, Surat, 394 350, Gujarat, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 3 (2011), Pagination: 415-418Abstract
Accurate, precise, rapid and economical method was developed for the estimation of Cefixime and Ofloxacin in tablet dosage form. The first order derivative spectroscopy wavelengths selected for quantitation were 312. 0 nm for Cefixime (zero cross for Ofloxacin) and 358. 2 nm for Ofloxacin (zero cross for Cefixime). In this method linearity for detector response was observed in the concentration range of 5-40 μg/ml for both Cefixime and Ofloxacin. The proposed method was successfully applied for the simultaneous determination of both drugs in commercial tablet preparation. The results of the analysis have been validated statistically and by recovery studies.