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Premakumari, K. B.
- Comparative Antimicrobial Studies of Methanolic Extract of Muntingia calabura, Basella alba and Basella rubra Leaves
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Authors
Affiliations
1 Dayananda Sagar College of Pharmacy, Kumaraswamy Lay Out, Bangalore, IN
1 Dayananda Sagar College of Pharmacy, Kumaraswamy Lay Out, Bangalore, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 2, No 3 (2010), Pagination: 246-248Abstract
In vitro antimicrobial activity of methanolic extract of Muntingia calabura, Basella alba and Basella rubra leaves was investigated. The extracts exhibited marked antimicrobial activity against gram positive and gram negative bacteria and fungi. Muntingia calabura showed higher inhibitory effect against the pathogens like Staphylococcus aureus, Bacillus subtilis, Escherichia coli. Basella rubra showed mild inhibitory activity against Staphylococcus aureus, Basella alba showed good inhibitory activity against Aspergillus niger. A Comparative study shows maximum antimicrobial activity in Muntingia calabura extract.Keywords
Muntingia calabura, Basella alba and Basella rubra and Antimicrobial Activity.
- Simultaneous Estimation of Paracetamol and Zaltoprofen in Pharmaceutical Dosage Form by HPTLC
Abstract Views :196 |
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Dayananda Sagar University, Bengaluru, IN
2 Lotus Labs, Vasanth Nagar, Bengaluru, IN
1 Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Dayananda Sagar University, Bengaluru, IN
2 Lotus Labs, Vasanth Nagar, Bengaluru, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 5 (2019), Pagination: 2075-2078Abstract
Objective: A method for HPTLC was developed and validated for simultaneous estimation of Paracetamol and Zaltoprofen in a pharmaceutical dosage form. Methods: The Chromatographic separation was achieved on TLC aluminum plates precoated with silica gel G60 F254 as the stationary phase. The mobile phase consisted of Hexane: Chloroform: Methanol in the ratio of 3.5:5.5:1v/v/v. Results: The method was found to be linear in the concentration range of 0.8-4μg/spot for PCM and 0.2-1 μg/spot for ZLT and the correlation coefficient were found to be 0.996 for PCM and 0.998 for ZLT. The %RSD value obtained for intraday precision were 0.237 and 0.377 and for inter-day precision were 0.259 and 0.766 respectively, the low % RSD indicates that proposed method is precise as per ICH guidelines. The accuracy of the method was determined and the mean recovery of PCM was 99.73-100.15% and ZLT was 99.57-100.18%. LOD and LOQ values were found to be 0.034 μg/spot and 0.105 μg/spot for PCM, 0.006μg/spot and 0.018 μg/spot for ZLT. Conclusion: The method reported is accurate, precise, specific, robust and linear for the estimation of Paracetamol and Zaltoprofen in Pharmaceutical dosage form.Keywords
Paracetamol, Zaltoprofen, HPTLC, Chromatography, HPTLC.References
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