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Sahu, Jyoti
- Effects of Methanolic Extracts of Quisqualis indica (Aerial Parts) on Passive Smoking Induced Hyperlipidemia in Rats
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Authors
Affiliations
1 T.I.T. College of Pharmacy, Department of Pharmacology, Anand Nagar, Bhopal, Madhya Pradesh, IN
1 T.I.T. College of Pharmacy, Department of Pharmacology, Anand Nagar, Bhopal, Madhya Pradesh, IN
Source
Asian Journal of Pharmacy and Technology, Vol 3, No 1 (2013), Pagination: 26-29Abstract
In the present study the hypolipidemic activity of methanolic extracts of aerial parts of Quisqualis indica (QI) including flowers on passive smoking (PS) induced hyperlipidemia in rats had been evaluated. Hyperlipidemia was induced by passive smoking in a closed chamber having 1 burning ciggrette inside it. The hypolipidemic activity was analysed by reading the blood serum level in UV at 505 nm after treated with reagent present in auto span diagnostic kit. Dose of Methanolic extracts of QI had been prepared by using distilled water i.e. 200 mg/kg p.o. Methanolic extracts of QI significantly reduce the harmful lipid layer in blood serum at varying concentration and dose dependent manner which shows that the plant carries the hypolipidemic properties. It reduces the LDL, VLDL, cholesterol, triglyceride and raise HDL level in blood serum upto certain extent which was may be due to the inhibition of lipid peroxidation as the plants contain some active ingredients acting as antioxidants. Our result shows that the plants extracts recover the disorders in lipid metabolism noted in hyperlipidemic state.Keywords
Hypolipidemic, Hypocholesterolemic, Passive smoking (PS), Hyperlipidemia, Quisqualis indica, Coronary heart disease
References
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- Hepatoprotective Effect of Ethanolic and Hydro Alcoholic Leaf Extract of Madhuca indica in Carbon Tetra Chloride Intoxicated Rat
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Authors
Affiliations
1 T.I.T. College of Pharmacy, Department of Pharmacology, Anand Nagar, Bhopal. M.P., IN
2 Rajiv Gandhi College, Bhopal, IN
1 T.I.T. College of Pharmacy, Department of Pharmacology, Anand Nagar, Bhopal. M.P., IN
2 Rajiv Gandhi College, Bhopal, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 4, No 5 (2012), Pagination: 311-314Abstract
The liver is a vital organ present in vertebrates and some other animals. It has a wide range of functions, including detoxification, protein synthesis, and production of biochemical necessary for digestion. This organ plays a major role in metabolism and has a number of functions in the body including glycogen synthesis, hormone production, and detoxification. Excess consumption of N.S.A.I.D. and alcohol causes the liver disease. Madhuca indica that is also known as mahua in different parts of the country belonging to the family Sapotaceae is having several medicinal properties. The leaves of Mahua tree contain saponin, an alkaloid, and glucoside. Sapogenin and other basic acid are found in the seeds. Various Photochemical studies on Mahua include characterization of Sapogenin, triterpenoids, steroids, saponin, flavonoids and glycosides. Madhuca indica has several pharmacological activity, and potential to provide health to the society. It is used as Anti diabetic, antiulcer, hepato protective, anti pyretic, anti fertility, analgesic, anti oxidant, swelling, inflammation, piles, emetic, dermatological, laxative, tonic, anti burn, anti earth worm, wound healing headache and many more problems. The ethanolic extract of Madhuca indica at 200 mg/kg and 400 mg/kg produce significant hepatoprotective effect against paracetamol induced hepatotoxicity. Different parameters such as physical, Histopathological and biochemical studies like ALT, SGOT, SGPT, bilirubin test had been included in the study which provides the satisfactory data to conclude the hepatoprotective effects of Madhuca indica.Keywords
Madhuca indica, Mahua, Hepatoprotective, CCl4, Liver Disease.References
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