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Zachariah, Jimson
- Protective role of Borreria hispida against Galactosamine Induced Diabetic Cataract
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Authors
M. Sumithra
1,
Shatabdi Choudhury
1,
L. S. Dhivya
1,
M. Nithiyanand
1,
Jimson Zachariah
1,
Sharmila
1
Affiliations
1 Dept of Pharmacology, SRM College of Pharmacy, Kasttankulathur, Kancheepuram District, Tamilnadu, IN
1 Dept of Pharmacology, SRM College of Pharmacy, Kasttankulathur, Kancheepuram District, Tamilnadu, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 3 (2019), Pagination: 1235-1238Abstract
Cataract is the major cause of blindness all over the world, nearly 42% of visual impairment occurs due to diabetic associated complications in the eye. Borreria hispida, belonging to Rubiaceae family was used to treat eye infections by folklore system of medicine in India. This study was aimed to create scientific evidence for the anti-cataract activity of hydroalcoholic leaf extract of Borreria hispida (HAEBH) in diabetes induced cataract using goat lens. Cataract was induced using galactosamine in goat eyes lens. In this study, isolated goat lenses were suspended in bovine serum albumin. Totally sixteen lenses were selected, each group containing four lenses - normal control (distilled water treated lens), galactosamine treated lens, 1mg/ml of the hydroalcoholic extract of Borreria hispida leaves extract treated lens (HAEBH) and finally 1mg/ml of standard drug atropine treated lens. The opacification of lens were monitored in all the sixteen lenses. Among these, the anticataract activity of Borreria hispida was strengthened by the reduction in the deposition of proteins which is involved in the opacification of lens compared to galactosamine treated lens. The extract shown effective anticataract effect similar to that of standard group. The hydroalcoholic extract of Borreria hispida possess anticataract activity may be due to inhibition of Aldose Reductase enzyme involved in the polyol pathway which has a prime role in developing diabetes induced cataract. Further studies has to be carried out to isolate the prominent biomolecule responsible to control diabetes associated cataract.Keywords
Borreria hispida, Galactosamine, Aldose Reductase, Polyol Pathway.
References
- D.K. Patel, S.K. Prasad, R Kumar, S Hemalatha . Asia Pac J Trop Disease, (2011); 323-9.
- Deepak G Langade, G Rao, RC Girme, PS Patki, PM Bulakh In vitro prevention by ACE inhibitors of cataract induced by glucose. Indian J of Pharmacol. 2006 :8(2): 107-110
- Eye Diseases Prevalence Research Group Prevalence of cataract and pseudophakia/aphakia among adults in the United States. Arch Ophthalmol. (2004;)122:487–494.
- GV Sampath Kumar, VVL Sri Vidya, Ch. Sandhya. Hepatoprotective Activity of Borreria hispida Roots Against Carbon Tetrachloride induced hepatotoxicity in Albino Wister Rats. Int J of Bio and Pharm Res (2013); 4(12) 1277-1282
- R Dhevi, V. Elango. Invitro Antioxidant activity and HPTLC Fringer printing of seeds of Spermacoce hispida linn. IJPPR (2015); 7-3-23a, 7-3-23b, 7-3-23c.
- K Chandrashekhar, Vinayak Meti., Shishir Mishra. Pharmacological Activities of Spermacoce hispidalinn: A review, IJRAP 4(1), Jan- Feb 2013.
- Farnsworth NR 1988. Screening plants for new medicines. In: Biodiversity, EO Wilson and FM Peter (eds), National Aca Press, Washington D.C., pp. 83—97.
- A G Chandorkar , M V Albal, PM Bulakh , MP Muley . Lens Organ Culture. Indian Journal of Ophthalmology,1981: 29(3): PP 151-152
- Lowry, A. Rosebrough, A. Farr , R. Randall J Biol Chem, 1951; 193:265 13. Srikanth Merugu , B Veeresh , Deepa Rekulapally . T Swetha. Study Of In Vitro Anticataract Activity Of Tamarindus indica Linn On Isolated Goat Lenses. Int Jl of Pharm (2012); 2(4) 758-763.
- Srikanth Merugu, B. Veeresh , Deepa Rekulapally . T Swetha. Study Of In Vitro Anticataract Activity of Tamarindus indica Linn On Isolated Goat Lenses. Int J of Phar 1951; 193:265 13.
- Lowry OH, Rosebrough NJ, Farr LA, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265–275.
- P. Thenmozhi., T.V. Poonguzhali., B. Janarthanam. Phytochemical Screening And Antioxidant Activity Of Borreria hispida L.- An anticancer plant. Int J of Modern Trends in Eng and Res: 2016:3(2): PP
- Khan SS, Chaghtai SA, Oommachan M. Medicinal plants of Rubiaceae of Bhopal - An Ethnobotanical study. J Scient Res (Bhopal) 1984; 6:37–9.
- Purushothaman KK, Kalyani K. Isolation of isorhamnetin from Borreria hispida Linn. J Res Indian Med Yoga Homeop. 1979; 14:131–2.
- Kaviarasan K, Kalaiarasi P, Pugalendi V. Antioxidant efficacy of flavonoid-rich fraction from Spermacoce hispida in hyperlipidemic rats. J Appl Biomed. 2008;6: 165–76.
- J. H. Kinoshita. A thirty year journey in the polyol pathway, Exp. Eye Res. 50 (1990); 567–573.