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Journal of Natural Remedies

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2022
2023

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Kakadiya, Jagdish

An Evidence-Based Review of Anti‐Obesity and Weight Lowering Effects of Zingiber officinale Roscoe and Terminalia chebula Retz

Abstract Views :97 | PDF Views:69

Authors

Jagdish Kakadiya ¹, Saloni Soni ¹, Sachin Sharma ², Sunil Shastri ², M. K. Mohan Maruga Raja ³

Affiliations
1 Department of Pharmacology, Parul Institute of Pharmacy and Research, Parul University, Vadodara – 391760, Gujarat, IN
2 Department of Pharmaceutical Chemistry, Parul Institute of Pharmacy and Research, Parul University, Vadodara – 391760, Gujarat, IN
3 Department of Pharmacognosy, Parul Institute of Pharmacy and Research, Parul University, Vadodara – 391760, Gujarat, IN

Source

Journal of Natural Remedies, Vol 22, No 4 (2022), Pagination: 517-527

Abstract

Since time immemorial, the Indian medical system, particularly Ayurveda and Siddha, has prioritised prevention and health over symptoms and drugs. Siddha, an Indian system of medicine, originated in ancient Thamilakam (currently Tamil Nadu, India). The combination of Inji (Zingiber officinale Roscoe), Sukku (Zingiber officinale Roscoe) and Kadukkai (Terminalia chebula Retz) as herbal therapy with numerous chemical constituents can be considered a better pharmacological approach than consuming individual ingredients and/or chemical constituents. This review is an attempt to summarize the evidence related to the anti-obesity and weight-lowering effects of ginger and T. chebula. The overall view shows an anti-hyperlipidemic effect of Zingiber officinale and Terminalia chebula.

Keywords

Black Myrobalan, Ginger, Inji, Kadukkai, Siddha, Sukku

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An Updated Review on Medicinal Plants with Hepato-protective Activity

Abstract Views :253 | PDF Views:67

Authors

Yash Janve ¹, Jagdish Kakadiya ¹, Mohan Raja ¹

Affiliations
1 Department of Pharmacology, Parul Institute of Pharmacy and Research, Parul University, Vadodara - 391110, Gujarat, IN

Source

Journal of Natural Remedies, Vol 23, No 1 (2023), Pagination: 47-55

Abstract

Many precious medicines from traditional medicinal plants can be produced using a phototherapeutic approach to modern drug research. Finding pure phytochemicals that can be used as medicines requires time and money. The treatment of liver problems involves the use of numerous herbs and polyherbal mixtures. However, the treatments are ineffective in the majority of severe instances. Even though many of these plants and mixtures were subjected to experimental evaluations, the research was frequently insufficient and uncompleted. It was found that the therapeutic effects were evaluated in animals with subclinical liver damage brought on by a few substances. Antioxidants included in common foods can offer this kind of defence against liver damage brought on by hazardous substances’ oxidative processes. Therefore, hepato-protective natural products such as Phyllanthus amarus, Silybum marianum, Solanum nigrum, Tephrosia purpurea, Eclipta alba, Cichorium intybus, Phyllanthus Niruri, Centella asiatica, Capparis spinosa, Terminalia arjuna, Cassia occidentalis, Fumaria parviflora, Embelia ribes, Boerhaavia diffusa, Tamarix gallica, Achillea millefolium, Terminalia chebula, Ocimum sanctum, Glycyrrhiza glabra, Foeniculum vulgare, Garcinia mangostana, Acacia Catechu, Pergularia daemia, Annona squamosa, Flacourtia indica. The goal of the current review is to gather information on promising phytochemicals from medicinal plants that have been evaluated in hepatotoxicity models utilising cutting-edge scientific methods.

Keywords

ALP, ALT, Anti-oxidant, AST, Liver Disease.

Full Text

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Alleviating Potential of Zingiber officinale and Cow Urine Distillate Co-administered with Levetiracetam in Epileptic Rats: A Pharmacokinetic and Pharmacodynamics Approach

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Authors

Nilay Solanki ¹, Harshal Patel ¹, Milap Patel ¹, Yamini Patel ¹, Preetu Shukla ², Jagdish Kakadiya ², Rajesh Maheshwari ³, Priyal Chauhan ¹

Affiliations
1 Department of Pharmacology, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, CHARUSAT-Campus, Changa – 388421, Gujarat, IN
2 Department of Pharmacology, Parul Institute of Pharmacy and Research, Parul University, Vadodara – 391350, Gujarat, IN
3 Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara – 391760, Gujarat, IN

Source

Journal of Natural Remedies, Vol 23, No 2 (2023), Pagination: 677-685

Abstract

Background: Epilepsy is a severe neurological condition that affects all ages of people. Complex pathways involved in pathogenesis make it complicated to treat; selected antiepileptic drug options are available for Epilepsy. There is a need for an hour to develop novel treatment approaches for epilepsy with lesser side effects. This research aimed to evaluate the alleviating role of bio-enhancers co-administered with levetiracetam for pilocarpine-induced epilepsy. Methodology: Pilocarpine (250 mg/kg) was used to develop epilepsy in rats. Levetiracetam (LEV) (140 mg/kg) was administered with Zingiber officinale Extract (ZOE) (15 mg/kg and 30 mg/kg) and Cow Urine Distillate (CUD) (1.5 ml/kg and 3 ml/kg). HPLC was used to evaluate drug concentration in blood. Serum nitrate, catalase, CRP, calcium level and calcium level of the brain, behavioural markers in rats were assessed and compared with the Leviteracetam group only. Result and Discussion: The present study showed that combining ZOE and CUD with levetiracetam was advantageous through substantial reduction (p < 0.05) in serum nitrate, CRP and increased catalase (p < 0.05), while reduced serum calcium compared to LEV alone. Combination of ZOE and CUD with levetiracetam treatment also reduced seizure behaviour and duration in rats. The bioavailability of LEV in plasma and brain was increased when epileptic rats were treated with LEV plus ZOE and CUD compared to disease control. Conclusion: Utilization of Zingiber officinale and CUD in combination with LEV was proven therapeutically effective in the epileptic model and used to lower the dose of LEV along with reducing seizure behaviour and time with the potential for the treatment of epilepsy.

Keywords

Catalase and Nitrate, Cow Urine Distillate, Epilepsy, Levetiracetam, Zingiber officinale Extract.

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References

Available from: https://www.who.int/news-room/fact-sheets/detail/epilepsy

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Kakadiya, Jagdish

An Evidence-Based Review of Anti‐Obesity and Weight Lowering Effects of Zingiber officinale Roscoe and Terminalia chebula Retz

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An Updated Review on Medicinal Plants with Hepato-protective Activity

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Alleviating Potential of Zingiber officinale and Cow Urine Distillate Co-administered with Levetiracetam in Epileptic Rats: A Pharmacokinetic and Pharmacodynamics Approach

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