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Saravanan, J.
- Synthesis, Characterization and Antimicrobial Activity of Some Schiff Bases of 2-amino-4-(4-chlorophenyl)–n-(3-furan-2-ylmethyl carboxamido) thiophenes
Abstract Views :318 |
PDF Views:5
Authors
Affiliations
1 Department of Pharmaceutical Chemistry, PES College of Pharmacy, Bangalore-50, Karnataka, IN
1 Department of Pharmaceutical Chemistry, PES College of Pharmacy, Bangalore-50, Karnataka, IN
Source
Asian Journal of Research in Chemistry, Vol 6, No 1 (2013), Pagination: 24-28Abstract
2-amino-4-(4-chlorophenyl)-N-(3-furan-2-ylmethyl carboxamido) thiophenes was synthesized using versatile Gewald reaction .First step is preparation of furfuryl cyanoacetamide which was carried out by condensation of furfuryl amine and ethyl cyano acetate which was then reacted with p-chloro acetophenone, sulphur, diethyl amine to give 2-amino-4-(4- chlorophenyl)-N-(3-furan-2-yl methyl carboxamido) thiophene (SM-4) later the compound was treated with twelve different substituted aryl aldehydes to yield twelve new Schiff bases(SM 4a-4l). The compounds were characterized IR, 1H NMR and mass spectral data and screened for antimicrobial activity.Keywords
Synthesis, Thiophenes, Schiff Bases, Spectral Analysis, Antimicrobial Activity
References
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- Lina Li,Lei Chang, Stephane P.R, Francois L, Marc L, Rene B, Yuqing Wu. Synthesis and evaluation of benzo[b]thiophene derivatives as inhibitors of alkaline phosphatise. Bioorg. Med. Chem. 2009; 3:7290-7300.
- Isloor AM, Kalluraya B, Pai KS. Synthesis, characterization and biological activities of some new benzo[b]thiophene derivatives. Eur J Med Chem 2010;45:825–30.
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- Bhattacharjee S, Sarvanan J, Mohan S,Arora M. Synthesis, Charaterization and CNS depressant activity of some schiff bases of 2-amino-4-(4-chlorophenyl) thiophene-3 carboxamide. Asian J of Res Chem.2011;4(10):1562-65.
- Barry A L, Antimicrobial susceptibility test, principle and practices (Illus lea and fehinger, Philedepephia USA) 1976, pp 93-108.
- Synthesis, Characterization and CNS Depressant Activity of Some New Mannich Bases Derivatives
Abstract Views :265 |
PDF Views:2
Authors
Affiliations
1 Department of Pharmaceutical Chemistry, PES College of Pharmacy, Bangalore-50, Karnataka, IN
1 Department of Pharmaceutical Chemistry, PES College of Pharmacy, Bangalore-50, Karnataka, IN
Source
Asian Journal of Research in Chemistry, Vol 6, No 3 (2013), Pagination: 244-247Abstract
The novel 2-amino-3-carbethoxy-4- phenyl thiophene was synthesized by using a acetophenone and ethyl cyano acetate and the parent compound was reacted with chloroacetic acid and glacial acetic acid, the chloro compound was then substituted with different substituted primary and secondary amines to obtain a series of title compounds [SBJa 1-8]. All the new title compounds were characterized by spectral data and were screened for CNS depressant activity. In conclusion, it can be inferred that the electron donating groups on the phenyl ring at R of the title compounds influenced the CNS depressant activityKeywords
Synthesis, Thiophene, Manich Base, Characterization, CNS Depressant ActivityReferences
- Isloor AM, Kalluraya B, Pai KS. 2010; Synthesis, characterization and biological activities of some new benzo[b]thiophene derivatives. Eur J Med Chem.; 45:825–30
- Pinto E, Queiroz MJRP, Vale-Silva LA, Oliveira JF, Begouin A, Begouin JM, et al. 2008; Antifungal activity of synthetic di(hetero)arylamines based on the benzo[ b ]thiophene moiety. Bioorg Med Chem.; 16:8172–7
- Issa M.I Fakhr, Mohamed A.A. Radwan,Seham EI-Batran, Omar M.E, Abd El-Salam, Siham M.El-Shenawy. 2009; Synthesis and pharmacological evaluation of 2-substituted benzo[b]thiophenes as anti-inflamatory and analgesic agents. Eur J Med Chem. 44:1718-1725
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- S.I. Graham, K.I. Shepard,P.S. Anderson,J.J. Baldwin, D.B. Best, M.E. Christy,M.B. Freedman, P. Gautheron, C.N. Habecker, 1989; J. Med. Chem.32 ,2548-2554.
- Andrey E.S, Valeria A.G, Lyubov G.D, Yuri N.L, Yuri B.S, Leonid V.K, 2009; Synthesis and Cytotoxic properties of 4,11- bis(aminoethyl)amino]anthra-[2,3-b]thiophene-5,10-diones,novel analogues of antitumor anthacene-9,10-diones. Bioorg Med Chem.; 1861-1869
- Lina Li, Lei Chang, Stephane P.R, Francois L, Marc L, Rene B, Yuqing Wu. 2009; Synthesis and evaluation of benzo[b]thiophene derivatives as inhibitors of alkaline phosphatise. Bioorg Med Chem.; 7290-7300.
- M.A. Gouda, M.A.Berghot, Ghada E,Abd EI.G, A.m. Khalil. 2010; Synthesis and antimicrobial activities of some new thiazole and pyrazole derivatives based on 4,5,6,7-tetrahydrothiophene moiety. Eur J Med Chem.; 1-8
- Preliminary Pharmacognostical and Phytochemical Studies of Leaves of Hemigraphis colorata
Abstract Views :168 |
PDF Views:0
Authors
J. Saravanan
1,
W. R. Shariff
2,
H. Joshi Narasimhachar
2,
R. Varatharajan
2,
V. G. Joshi
3,
A. Karigar Asif
4
Affiliations
1 Sarada Vilas College of Pharmacy, Mysore- 570004, Karnataka, IN
2 Sarada Vilas College of Pharmacy, Krishnamurthypuram, Mysore-570004, Karnataka, IN
3 Marata Mandal College of Pharmacy, Belgaum, Karnataka, IN
4 Genba Sopanrao Moze College of Pharmacy, Pune, IN
1 Sarada Vilas College of Pharmacy, Mysore- 570004, Karnataka, IN
2 Sarada Vilas College of Pharmacy, Krishnamurthypuram, Mysore-570004, Karnataka, IN
3 Marata Mandal College of Pharmacy, Belgaum, Karnataka, IN
4 Genba Sopanrao Moze College of Pharmacy, Pune, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 2, No 1 (2010), Pagination: 15-17Abstract
The aim of this research was to develop the pharmacognostical parameters and phytochemical screening alongwith histological studies and quantitative microscopy of the leaf powder of Hemigraphis colorata.
The dried leaves of Hemigraphis colorata (Family: Acanthaceae) were subjected to standardization by following pharmacognostical and phytochemical screening methods. Methanolic extract was subjected to thin layer chromatography (TLC) to find out various phytoconstituents.
Microscopic study showed the presence of Cuticle, covering trichome, single layered thick walled epidermis, palisade cells, transfusion tissue, spongy cells, vascular bundle and chlorenchyma. Phytochemical screening reported the presence of alkaloids, tannins, proteins; steroids and sterols were present in Methanolic extract. TLC showed two different Rf values (0.86 and 0.36) with different nature of their residues.
Keywords
Phytochemical screening, TLC, Hemigraphis Colorata.- Synthesis, Characterization and CNS Depressant Activity of Some Schiff Bases of 2-Amino-4-(4-Chlorophenyl)Thiophene-3carboxamide
Abstract Views :148 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutical Chemistry, PES College of Pharmacy, Bangalore-50, Karnataka, IN
1 Department of Pharmaceutical Chemistry, PES College of Pharmacy, Bangalore-50, Karnataka, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 10 (2011), Pagination: 1562-1565Abstract
2-amino-4-(4-chlorophenyl)thiophene-3carboxamide was synthesized using versatile Gewald reaction conditions started with the preparation of acetamide, which was carried out by cold condensation of aniline and ethylcynoacetate, which was then reacted with p-chloro acetophenone, sulphur, diethyl amine to give 2-amino-4-(4- chlorophenyl)thiophene-3carboxamide. Later the compound was treated with twelve different substituted aryl aldehydes to yield twelve new Schiff bases (SBJ-Ia-l). The compounds were characterized by IR, 1H NMR and Mass spectral data and screened for CNS depressant activity.Keywords
Synthesis, Thiophenes, Schiff Bases, Spectral Analysis, CNS Depressant Activity.- Microwave Assisted Synthesis, Characterization and Antimicrobial Activity of Some Schiff Bases of 2-Amino (4-Chloro Phenyl) Thiazoles
Abstract Views :140 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutical Chemistry, PES College of Pharmacy, Bangalore-50, Karnataka, IN
1 Department of Pharmaceutical Chemistry, PES College of Pharmacy, Bangalore-50, Karnataka, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 3 (2010), Pagination: 751-754Abstract
2-amino (4-chloro phenyl)thiazoles were synthesized by brominating p-chloroaceto phenone to give p-chloro phenacyl bromide which was then reacted with thiourea in microwave synthesizer to give 2-amino (4-chloro phenyl) thiazoles(II). Later the compound II were treated with ten different substituted aryl aldehydes to yield ten new Schiff bases (III). The compounds were characterized by IR, 1H NMR and Mass spectral data. Investigation on the antimicrobial activity of these compounds was determined by cup plate method against bacteria and fungi. Among the compounds tested, five compounds exhibited significant antimicrobial activity.Keywords
Synthesis, Thiazoles, Schiff Bases, Antimicrobial Activity.- Evaluation of Neuroprotective Activity of Melissa officinalis in MPTP Model of Parkinson’s Disease in Mice
Abstract Views :191 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmacology, JSS College of Pharmacy (A constituent college of JSS Academy of Higher Education and Research), Ootacamund, The Nilgiris 643 001, IN
1 Department of Pharmacology, JSS College of Pharmacy (A constituent college of JSS Academy of Higher Education and Research), Ootacamund, The Nilgiris 643 001, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 5 (2019), Pagination: 2103-2108Abstract
The aim of the current study is to evaluate the neuroprotective effect of Melissa officinalis in MPTP model of Parkinson’s disease in mice. The whole plant material was extracted with n-hexane, chloroform, ethyl acetate and ethanol. All the above extracts were assayed for their antioxidant potential by In-vitro DPPH method. The antiparkinson’s activity of ethanolic extract of Melissa officinalis was evaluated by actophotometer and rotarod test. The levels of catalase and SOD were estimated in cortex, cerebellum, hippocampus and striatum. The activity of complex-I was also estimated. Among the four extracts, ethanolic extract showed highest antioxidant potential in DPPH method so it was decided to use ethanolic extract for in-vivo studies. The ethanolic extract of Melissa officinalis showed a significant and dose dependent effect at 100mg/kg and 200mg/kg p.o. in both actophotometer and rotarod model. The ethanolic extract of Melissa officinalis also showed a significant in-vivo antioxidant potential by restoring the levels of catalase and SOD. The results of the present study clearly demonstrate the potential antiparkinson’s properties of the ethanol extract.Keywords
MPTP, Parkinsons Disease, Melissa officinalis, Complex I, Antioxidants.References
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